JPWO2019200129A5 - - Google Patents

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Publication number
JPWO2019200129A5
JPWO2019200129A5 JP2020554154A JP2020554154A JPWO2019200129A5 JP WO2019200129 A5 JPWO2019200129 A5 JP WO2019200129A5 JP 2020554154 A JP2020554154 A JP 2020554154A JP 2020554154 A JP2020554154 A JP 2020554154A JP WO2019200129 A5 JPWO2019200129 A5 JP WO2019200129A5
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JP
Japan
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cells
cell
neuronal
composition according
composition
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Pending
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JP2020554154A
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English (en)
Japanese (ja)
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JP2021520200A (ja
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Priority claimed from PCT/US2019/027027 external-priority patent/WO2019200129A1/en
Publication of JP2021520200A publication Critical patent/JP2021520200A/ja
Publication of JPWO2019200129A5 publication Critical patent/JPWO2019200129A5/ja
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JP2020554154A 2018-04-11 2019-04-11 非神経細胞のニューロンへの再プログラミング、及び神経変性疾患または障害を治療するための方法と組成物 Pending JP2021520200A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862656322P 2018-04-11 2018-04-11
US62/656,322 2018-04-11
US201862718774P 2018-08-14 2018-08-14
US62/718,774 2018-08-14
PCT/US2019/027027 WO2019200129A1 (en) 2018-04-11 2019-04-11 Reprogramming of non-neuronal cells into neurons and methods and compositions to treat neurodegenerative diseases and disorders

Publications (2)

Publication Number Publication Date
JP2021520200A JP2021520200A (ja) 2021-08-19
JPWO2019200129A5 true JPWO2019200129A5 (enExample) 2022-03-22

Family

ID=68164570

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020554154A Pending JP2021520200A (ja) 2018-04-11 2019-04-11 非神経細胞のニューロンへの再プログラミング、及び神経変性疾患または障害を治療するための方法と組成物

Country Status (9)

Country Link
US (2) US11702656B2 (enExample)
EP (1) EP3773749A4 (enExample)
JP (1) JP2021520200A (enExample)
KR (1) KR20200142537A (enExample)
CN (1) CN112312928A (enExample)
AU (1) AU2019252534A1 (enExample)
CA (1) CA3096691A1 (enExample)
GB (2) GB202017810D0 (enExample)
WO (1) WO2019200129A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112386699A (zh) * 2019-08-16 2021-02-23 中国科学院脑科学与智能技术卓越创新中心 Ptbp1抑制剂在预防和/或治疗功能性神经元死亡相关的神经系统疾病中的应用
EP4039801A4 (en) * 2019-08-16 2023-10-18 Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences USE OF PTBP1 INHIBITORS TO PREVENT AND/OR TREAT NERVOUS SYSTEM DISEASES ASSOCIATED WITH FUNCTIONAL NEURONAL DEATH
WO2021232062A1 (en) * 2020-05-13 2021-11-18 Figene, Llc Fibroblast based therapy for treatment of parkinson's disease
WO2022134107A1 (en) * 2020-12-25 2022-06-30 Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences Treatment of neurological diseases
CN112661828B (zh) * 2021-01-15 2022-04-01 武汉大学 一种突触素的抗原肽及其抗体与应用
CN117279668A (zh) * 2021-02-10 2023-12-22 上海鲸奇生物科技有限公司 胶质细胞向神经元转分化用于预防或治疗神经元功能缺失或死亡相关疾病
CN112941019B (zh) * 2021-03-18 2023-01-06 浙江大学 一种促进体细胞重编程的方法
CN116162591A (zh) * 2021-03-26 2023-05-26 广西大学 一种体外高效诱导人体细胞重编程为神经元细胞的方法
CN113171369A (zh) * 2021-04-16 2021-07-27 南通大学 多聚嘧啶序列结合蛋白在制备脊髓损伤的修复药物中的应用
US20240207324A1 (en) * 2021-04-21 2024-06-27 Shanghai Unixell Biotechnology Co., Ltd. Method for quality control and enrichment of human dopaminergic neural precursor cells
CN120754249A (zh) * 2021-09-30 2025-10-10 上海鲸奇生物科技有限公司 直接转分化治疗神经系统疾病
KR102712694B1 (ko) * 2021-10-20 2024-10-02 서울시립대학교 산학협력단 자가조립된 rna 구조체를 포함하는 직접교차분화 유도용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011091048A1 (en) 2010-01-19 2011-07-28 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
US9206426B2 (en) * 2010-03-05 2015-12-08 The Trustees Of Columbia University In The City Of New York Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof
WO2012118988A1 (en) 2011-03-01 2012-09-07 The Scripps Research Institute Direct reprogramming of human fibroblasts to functional neurons under defined conditions
US10561742B2 (en) * 2012-07-19 2020-02-18 The Penn State Research Foundation Methods and compositions for treatment of disease or injury of the nervous system
WO2014071157A1 (en) * 2012-11-01 2014-05-08 The Regents Of The University Of California Methods for engineering non-neuronal cells into neurons and using newly engineered neurons to treat neurodegenerative diseases
CN107208045B (zh) * 2014-11-25 2018-11-02 宾州研究基金会 人神经胶质细胞转化成用于大脑和脊髓修复的神经细胞的化学重编程
WO2017003466A1 (en) * 2015-06-30 2017-01-05 University Of South Florida Conversion of non-neuronal cells into neurons
WO2017079547A2 (en) * 2015-11-04 2017-05-11 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
CN105950557B (zh) * 2016-04-22 2019-10-25 中国科学院生物物理研究所 一种控制人神经细胞重编程的信号通路及其应用

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