JPWO2019199867A5 - - Google Patents
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- JPWO2019199867A5 JPWO2019199867A5 JP2020555346A JP2020555346A JPWO2019199867A5 JP WO2019199867 A5 JPWO2019199867 A5 JP WO2019199867A5 JP 2020555346 A JP2020555346 A JP 2020555346A JP 2020555346 A JP2020555346 A JP 2020555346A JP WO2019199867 A5 JPWO2019199867 A5 JP WO2019199867A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024063287A JP7793675B2 (ja) | 2018-04-09 | 2024-04-10 | 抑制性ニューロンにおける電位開口型ナトリウムチャネルのレスキュー |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862655043P | 2018-04-09 | 2018-04-09 | |
| US62/655,043 | 2018-04-09 | ||
| US201862742835P | 2018-10-08 | 2018-10-08 | |
| US62/742,835 | 2018-10-08 | ||
| US201962810281P | 2019-02-25 | 2019-02-25 | |
| US62/810,281 | 2019-02-25 | ||
| PCT/US2019/026638 WO2019199867A1 (en) | 2018-04-09 | 2019-04-09 | Rescuing voltage-gated sodium channel function in inhibitory neurons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063287A Division JP7793675B2 (ja) | 2018-04-09 | 2024-04-10 | 抑制性ニューロンにおける電位開口型ナトリウムチャネルのレスキュー |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021521152A JP2021521152A (ja) | 2021-08-26 |
| JPWO2019199867A5 true JPWO2019199867A5 (https=) | 2022-03-30 |
| JP2021521152A5 JP2021521152A5 (https=) | 2022-03-30 |
| JP7472036B2 JP7472036B2 (ja) | 2024-04-22 |
Family
ID=68164495
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555346A Active JP7472036B2 (ja) | 2018-04-09 | 2019-04-09 | 抑制性ニューロンにおける電位開口型ナトリウムチャネルのレスキュー |
| JP2024063287A Active JP7793675B2 (ja) | 2018-04-09 | 2024-04-10 | 抑制性ニューロンにおける電位開口型ナトリウムチャネルのレスキュー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063287A Active JP7793675B2 (ja) | 2018-04-09 | 2024-04-10 | 抑制性ニューロンにおける電位開口型ナトリウムチャネルのレスキュー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12121563B2 (https=) |
| EP (1) | EP3781174A4 (https=) |
| JP (2) | JP7472036B2 (https=) |
| AU (2) | AU2019253700B2 (https=) |
| CA (1) | CA3096407A1 (https=) |
| WO (1) | WO2019199867A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3359685B1 (en) | 2015-10-09 | 2026-01-28 | University Of Southampton | Modulation of gene expression for deregulated protein expression |
| EP3933041B1 (en) | 2015-12-14 | 2024-01-31 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of autosomal dominant retardation |
| SG11202001590RA (en) | 2017-08-25 | 2020-03-30 | Stoke Therapeutics Inc | Antisense oligomers for treatment of conditions and diseases |
| US12060558B2 (en) | 2018-05-04 | 2024-08-13 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| JP7695192B2 (ja) | 2018-10-08 | 2025-06-18 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
| JP7624728B2 (ja) | 2019-02-25 | 2025-01-31 | ユニバーシティ オブ マサチューセッツ | Ｄｎａ結合ドメイントランスアクチベーター及びその使用 |
| KR20210134003A (ko) | 2019-02-27 | 2021-11-08 | 스톡 테라퓨틱스, 인크. | 병태 및 질환의 치료를 위한 안티센스 올리고머 |
| CA3173609A1 (en) * | 2020-03-27 | 2021-09-30 | Allen Institute | Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells |
| BR112022022889A2 (pt) | 2020-05-11 | 2023-04-04 | Stoke Therapeutics Inc | Oligômeros antissentido de opa1 para tratamento de condições e doenças |
| EP4162041A4 (en) * | 2020-06-04 | 2024-10-16 | Allen Institute | ARTIFICIAL EXPRESSION CONSTRUCTS TO SELECTIVELY MODULATE GENE EXPRESSION IN INHIBITORY NEOCORTICAL NEURONS |
| WO2022020706A1 (en) * | 2020-07-24 | 2022-01-27 | University Of Massachusetts | Dna-binding domain transactivators and uses thereof |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| US20240012004A1 (en) * | 2020-11-17 | 2024-01-11 | Merck Sharp & Dohme Llc | Increased voltage-gated sodium channel alpha protein subunit expression through viral 2a-mediated co-expression of nav beta subunits |
| US20250325704A1 (en) | 2020-12-23 | 2025-10-23 | Boehringer Ingelheim International Gmbh | Viral capsid proteins with specificity to heart tissue cells |
| CA3207224A1 (en) * | 2021-02-02 | 2022-08-11 | Bryan GORE | Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes |
| TW202313972A (zh) * | 2021-06-03 | 2023-04-01 | 荷蘭商美勒斯公司 | 新ｎｒｇ１融合物、融合接合處及檢測彼等之方法 |
| JP2025520385A (ja) * | 2022-06-13 | 2025-07-03 | アレン インスティテュート | 中枢神経系の非神経細胞において遺伝子発現を調節するための人工発現コンストラクト |
| AU2024214841A1 (en) * | 2023-02-01 | 2025-08-28 | Allen Institute | Intein-mediated reconstitution of voltage-gated sodium channel function |
| WO2025019685A2 (en) * | 2023-07-18 | 2025-01-23 | Allen Institute | Antisense oligonucleotides and artificial expression constructs for expressing rna in inhibitory neurons |
| WO2025038955A1 (en) * | 2023-08-16 | 2025-02-20 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Systems and methods for improving safety of split intein aav mediated gene therapy |
| WO2025092951A1 (en) * | 2023-11-03 | 2025-05-08 | Shanghai Vitalgen Biopharma Co., Ltd. | Recombinant adeno-associated viral vectors for treating fabry disease |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001036623A2 (en) | 1999-11-05 | 2001-05-25 | Avigen, Inc. | Ecdysone-inducible adeno-associated virus expression vectors |
| WO2002064804A2 (en) | 2001-02-13 | 2002-08-22 | University Of Florida | A bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
| WO2003072751A2 (en) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
| WO2009012176A2 (en) * | 2007-07-14 | 2009-01-22 | The University Of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| WO2013142337A1 (en) | 2012-03-20 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Human papillomavirus 16 (hpv16) - related epilepsy |
| EP2888368A1 (en) | 2012-08-27 | 2015-07-01 | Friedrich Miescher Institute for Biomedical Research | Retinal off circuit-specific promoter |
| DE102014207498A1 (de) | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| WO2016161124A1 (en) * | 2015-03-31 | 2016-10-06 | New York University | Compositions and method for reducing seizures |
| DK3081263T3 (da) | 2015-04-17 | 2020-03-16 | P&X Medical Nv | Sammensætninger og redskaber til behandling af glaukom |
| WO2016186772A2 (en) | 2015-05-16 | 2016-11-24 | Genzyme Corporation | Gene editing of deep intronic mutations |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| EA201992358A1 (ru) * | 2017-04-03 | 2020-03-24 | Инкоудид Терапьютикс, Инк. | Тканеселективная экспрессия трансгена |
| JP7695192B2 (ja) | 2018-10-08 | 2025-06-18 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
-
2019
- 2019-04-09 AU AU2019253700A patent/AU2019253700B2/en active Active
- 2019-04-09 WO PCT/US2019/026638 patent/WO2019199867A1/en not_active Ceased
- 2019-04-09 JP JP2020555346A patent/JP7472036B2/ja active Active
- 2019-04-09 CA CA3096407A patent/CA3096407A1/en active Pending
- 2019-04-09 US US17/044,232 patent/US12121563B2/en active Active
- 2019-04-09 EP EP19785199.1A patent/EP3781174A4/en active Pending
-
2024
- 2024-04-10 JP JP2024063287A patent/JP7793675B2/ja active Active
- 2024-10-18 US US18/920,747 patent/US20250041384A1/en active Pending
-
2025
- 2025-11-07 AU AU2025263840A patent/AU2025263840A1/en active Pending
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