JPWO2019199165A5 - - Google Patents
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- Publication number
- JPWO2019199165A5 JPWO2019199165A5 JP2020555518A JP2020555518A JPWO2019199165A5 JP WO2019199165 A5 JPWO2019199165 A5 JP WO2019199165A5 JP 2020555518 A JP2020555518 A JP 2020555518A JP 2020555518 A JP2020555518 A JP 2020555518A JP WO2019199165 A5 JPWO2019199165 A5 JP WO2019199165A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- chimeric receptor
- subject
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 21
- 210000001744 T-lymphocyte Anatomy 0.000 claims 20
- 108700010039 chimeric receptor Proteins 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 238000000034 method Methods 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 238000009169 immunotherapy Methods 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 108020001756 ligand binding domains Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000003915 cell function Effects 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 102000005650 Notch Receptors Human genes 0.000 claims 2
- 108010070047 Notch Receptors Proteins 0.000 claims 2
- 101710160107 Outer membrane protein A Proteins 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18166498.8 | 2018-04-10 | ||
| EP18166498 | 2018-04-10 | ||
| PCT/NL2019/050212 WO2019199165A1 (en) | 2018-04-10 | 2019-04-10 | Chimeric notch receptors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021520813A JP2021520813A (ja) | 2021-08-26 |
| JP2021520813A5 JP2021520813A5 (https=) | 2022-04-19 |
| JPWO2019199165A5 true JPWO2019199165A5 (https=) | 2022-04-19 |
| JP7562417B2 JP7562417B2 (ja) | 2024-10-07 |
Family
ID=62063276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555518A Active JP7562417B2 (ja) | 2018-04-10 | 2019-04-10 | キメラノッチ受容体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210139556A1 (https=) |
| EP (1) | EP3774867A1 (https=) |
| JP (1) | JP7562417B2 (https=) |
| KR (1) | KR20210008840A (https=) |
| CN (1) | CN112243442A (https=) |
| AU (1) | AU2019252878B2 (https=) |
| CA (1) | CA3096812A1 (https=) |
| IL (1) | IL277859A (https=) |
| WO (1) | WO2019199165A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116790647B (zh) * | 2023-02-06 | 2024-04-16 | 森瑞斯生物科技(深圳)有限公司 | 一种低背景、高信号强度的2-吡咯烷酮生物传感器及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047878A1 (en) * | 2004-11-03 | 2006-05-11 | British Columbia Cancer Agency Branch | Cancer therapeutics and methods for their use |
| CN104402998A (zh) * | 2008-07-08 | 2015-03-11 | 昂考梅德药品有限公司 | 分离的抗体 |
| SG191039A1 (en) * | 2010-12-15 | 2013-08-30 | Wyeth Llc | Anti-notch1 antibodies |
| EP2970479B1 (en) * | 2013-03-14 | 2019-04-24 | Novartis AG | Antibodies against notch 3 |
| BR112016028537A2 (pt) * | 2014-06-04 | 2017-08-22 | Hutchinson Fred Cancer Res | expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2 |
| FR3026744B1 (fr) * | 2014-10-06 | 2024-04-19 | Hopitaux Paris Assist Publique | Methode de generation de progeniteurs de cellules t |
| WO2016138034A1 (en) * | 2015-02-24 | 2016-09-01 | The Regents Of The University Of California | Binding-triggered transcriptional switches and methods of use thereof |
| WO2017123559A2 (en) * | 2016-01-11 | 2017-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric proteins and methods of regulating gene expression |
| JP7500195B2 (ja) * | 2016-08-23 | 2024-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
| US11325957B2 (en) * | 2017-06-19 | 2022-05-10 | Cell Design Labs, Inc. | Methods and compositions for reducing the immunogenicity of chimeric notch receptors |
-
2019
- 2019-04-10 AU AU2019252878A patent/AU2019252878B2/en active Active
- 2019-04-10 EP EP19720197.3A patent/EP3774867A1/en active Pending
- 2019-04-10 WO PCT/NL2019/050212 patent/WO2019199165A1/en not_active Ceased
- 2019-04-10 KR KR1020207032411A patent/KR20210008840A/ko not_active Abandoned
- 2019-04-10 CA CA3096812A patent/CA3096812A1/en active Pending
- 2019-04-10 CN CN201980038222.3A patent/CN112243442A/zh active Pending
- 2019-04-10 JP JP2020555518A patent/JP7562417B2/ja active Active
- 2019-04-10 US US17/045,829 patent/US20210139556A1/en not_active Abandoned
-
2020
- 2020-10-07 IL IL277859A patent/IL277859A/en unknown
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