JPWO2019175217A5 - - Google Patents
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- JPWO2019175217A5 JPWO2019175217A5 JP2020547399A JP2020547399A JPWO2019175217A5 JP WO2019175217 A5 JPWO2019175217 A5 JP WO2019175217A5 JP 2020547399 A JP2020547399 A JP 2020547399A JP 2020547399 A JP2020547399 A JP 2020547399A JP WO2019175217 A5 JPWO2019175217 A5 JP WO2019175217A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- acd25
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 6
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 6
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 102000000588 Interleukin-2 Human genes 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 3
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 3
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 3
- 229940124060 PD-1 antagonist Drugs 0.000 claims 2
- 230000009824 affinity maturation Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642232P | 2018-03-13 | 2018-03-13 | |
| US201862642230P | 2018-03-13 | 2018-03-13 | |
| US201862642218P | 2018-03-13 | 2018-03-13 | |
| US201862642243P | 2018-03-13 | 2018-03-13 | |
| US201862642248P | 2018-03-13 | 2018-03-13 | |
| US62/642248 | 2018-03-13 | ||
| GBGB1804028.7A GB201804028D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| US62/642232 | 2018-03-13 | ||
| US62/642218 | 2018-03-13 | ||
| GBGB1804029.5A GB201804029D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| PCT/EP2018/056312 WO2018167104A1 (fr) | 2017-03-17 | 2018-03-13 | Anti-cd25 à optimisation fc pour épuisement de cellules spécifiques tumorales |
| GBGB1804027.9A GB201804027D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| EPPCT/EP2018/056312 | 2018-03-13 | ||
| GB1804027.9 | 2018-03-13 | ||
| GB1804029.5 | 2018-03-13 | ||
| GB1804028.7 | 2018-03-13 | ||
| US62/642230 | 2018-03-13 | ||
| US62/642243 | 2018-03-13 | ||
| PCT/EP2019/056249 WO2019175217A1 (fr) | 2018-03-13 | 2019-03-13 | Anticorps anti-cd25 pour la déplétion de cellules spécifiques d'une tumeur |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021533726A JP2021533726A (ja) | 2021-12-09 |
| JPWO2019175217A5 true JPWO2019175217A5 (fr) | 2022-03-18 |
| JP7451415B2 JP7451415B2 (ja) | 2024-03-18 |
Family
ID=67903878
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547399A Active JP7451415B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547331A Pending JP2021515565A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547332A Pending JP2021516974A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗ｃｄ２５抗体剤 |
| JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体 |
| JP2020547326A Pending JP2021516973A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547333A Pending JP2021515566A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547331A Pending JP2021515565A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547332A Pending JP2021516974A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗ｃｄ２５抗体剤 |
| JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体 |
| JP2020547326A Pending JP2021516973A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547333A Pending JP2021515566A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
Country Status (14)
| Country | Link |
|---|---|
| US (11) | US11873341B2 (fr) |
| EP (8) | EP3765503B1 (fr) |
| JP (8) | JP7451415B2 (fr) |
| KR (3) | KR20200131861A (fr) |
| CN (8) | CN112020513A (fr) |
| AU (3) | AU2019233581A1 (fr) |
| BR (3) | BR112020016501A2 (fr) |
| CA (3) | CA3088671A1 (fr) |
| CR (3) | CR20200466A (fr) |
| MA (1) | MA51993A (fr) |
| PE (3) | PE20210288A1 (fr) |
| SG (3) | SG11202008733YA (fr) |
| TW (3) | TW201940515A (fr) |
| WO (8) | WO2019175216A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11371066B2 (en) | 2015-07-13 | 2022-06-28 | Modular Genetics, Inc. | Generation of acyl alcohols |
| CN108795858A (zh) * | 2017-04-28 | 2018-11-13 | 深圳宾德生物技术有限公司 | 高抗癌活性t细胞的筛选方法和应用 |
| US11873341B2 (en) | 2018-03-13 | 2024-01-16 | Tusk Therapeutics Ltd. | Anti-CD25 for tumour specific cell depletion |
| WO2020234399A1 (fr) * | 2019-05-20 | 2020-11-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nouveaux anticorps anti-cd25 |
| TW202138388A (zh) | 2019-12-30 | 2021-10-16 | 美商西根公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| US20230174670A1 (en) * | 2020-05-14 | 2023-06-08 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-cd25 antibodies, antigen-binding fragments thereof, and medical uses thereof |
| US20240002521A1 (en) * | 2020-11-20 | 2024-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-cd25 antibodies |
| CA3199006A1 (fr) * | 2020-11-20 | 2022-05-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anticorps anti-cd25 |
| WO2022117572A2 (fr) | 2020-12-02 | 2022-06-09 | Oncurious Nv | Agoniste de ltbr utilisé pour la polythérapie contre le cancer |
| WO2022182483A1 (fr) | 2021-02-02 | 2022-09-01 | Rakuten Medical, Inc. | Procédés de traitement local et systémique des cancers, des tumeurs et des cellules tumorales |
| KR20230154012A (ko) | 2021-03-01 | 2023-11-07 | 에프. 호프만-라 로슈 아게 | 신규 바이오마커 및 이의 용도 |
| CN115724971A (zh) | 2021-08-09 | 2023-03-03 | 南京诺艾新生物技术有限公司 | 重组抗人cd25抗体及其应用 |
| CN117916266A (zh) | 2021-09-02 | 2024-04-19 | 弗哈夫曼拉罗切有限公司 | 用于治疗aml的抗体 |
| AU2022337286A1 (en) * | 2021-09-03 | 2024-02-29 | Novarock Biotherapeutics, Ltd. | Bispecific binding proteins that bind cd137 and a tumor associated antigen |
| WO2023208990A1 (fr) | 2022-04-26 | 2023-11-02 | F. Hoffmann-La Roche Ag | Polythérapie pour le traitement du cancer comprenant un antagoniste de l'axe fas et un antagoniste d'agent de déplétion des lymphocytes t-reg, |
| CN115197321B (zh) * | 2022-06-02 | 2023-08-18 | 四川大学 | 靶向cd25的抗体及其用途 |
| CN115181181B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种抗cd25的单域抗体及其应用 |
| CN115181182B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种人源化的抗cd25的单域抗体及其应用 |
| WO2024006965A1 (fr) * | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anticorps spécifiques de cd25 et leurs utilisations |
| WO2024040194A1 (fr) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditionnement pour l'ingénierie de cellules immunitaires in vivo |
| WO2024088987A1 (fr) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Polythérapie pour le traitement du cancer |
| CN116004636B (zh) * | 2023-01-10 | 2024-03-12 | 广西师范大学 | 一种不结合红细胞的差异化cd47核酸适体及其应用 |
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-
2019
- 2019-03-13 US US16/979,932 patent/US11873341B2/en active Active
- 2019-03-13 JP JP2020547399A patent/JP7451415B2/ja active Active
- 2019-03-13 CN CN201980019247.9A patent/CN112020513A/zh active Pending
- 2019-03-13 US US16/979,935 patent/US11697688B2/en active Active
- 2019-03-13 EP EP19709955.9A patent/EP3765503B1/fr active Active
- 2019-03-13 CN CN201980019249.8A patent/CN112020515A/zh active Pending
- 2019-03-13 MA MA051993A patent/MA51993A/fr unknown
- 2019-03-13 BR BR112020016501-8A patent/BR112020016501A2/pt unknown
- 2019-03-13 US US16/352,709 patent/US10752691B2/en active Active
- 2019-03-13 BR BR112020016519-0A patent/BR112020016519A2/pt not_active Application Discontinuation
- 2019-03-13 KR KR1020207029221A patent/KR20200131861A/ko not_active Application Discontinuation
- 2019-03-13 CN CN201980019235.6A patent/CN112041345A/zh active Pending
- 2019-03-13 JP JP2020547331A patent/JP2021515565A/ja active Pending
- 2019-03-13 WO PCT/EP2019/056248 patent/WO2019175216A1/fr active Application Filing
- 2019-03-13 US US16/979,931 patent/US11851494B2/en active Active
- 2019-03-13 AU AU2019233581A patent/AU2019233581A1/en active Pending
- 2019-03-13 CR CR20200466A patent/CR20200466A/es unknown
- 2019-03-13 CN CN201980019234.1A patent/CN112074536A/zh active Pending
- 2019-03-13 PE PE2020001299A patent/PE20210288A1/es unknown
- 2019-03-13 BR BR112020016499-2A patent/BR112020016499A2/pt not_active Application Discontinuation
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