JPWO2019165116A5 - - Google Patents
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- JPWO2019165116A5 JPWO2019165116A5 JP2020544661A JP2020544661A JPWO2019165116A5 JP WO2019165116 A5 JPWO2019165116 A5 JP WO2019165116A5 JP 2020544661 A JP2020544661 A JP 2020544661A JP 2020544661 A JP2020544661 A JP 2020544661A JP WO2019165116 A5 JPWO2019165116 A5 JP WO2019165116A5
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- fusion protein
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Applications Claiming Priority (7)
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US201862635450P | 2018-02-26 | 2018-02-26 | |
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US201862676787P | 2018-05-25 | 2018-05-25 | |
US62/676,787 | 2018-05-25 | ||
US201862739792P | 2018-10-01 | 2018-10-01 | |
US62/739,792 | 2018-10-01 | ||
PCT/US2019/019014 WO2019165116A1 (en) | 2018-02-26 | 2019-02-21 | Compositions and methods for cellular immunotherapy |
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JP2021514631A JP2021514631A (ja) | 2021-06-17 |
JPWO2019165116A5 true JPWO2019165116A5 (ru) | 2022-03-01 |
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JP2020544661A Pending JP2021514631A (ja) | 2018-02-26 | 2019-02-21 | 細胞免疫療法のための組成物および方法 |
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EP (1) | EP3759130A1 (ru) |
JP (1) | JP2021514631A (ru) |
CN (1) | CN112041335A (ru) |
AU (1) | AU2019224051A1 (ru) |
CA (1) | CA3091138A1 (ru) |
WO (1) | WO2019165116A1 (ru) |
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CN110177803A (zh) | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
US20210371540A1 (en) * | 2018-03-16 | 2021-12-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Chimeric antigen receptors with mutated cd28 phosphorylation sites |
GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
EP4104840A4 (en) * | 2020-02-13 | 2023-08-23 | Beijing Immunochina Pharmaceuticals Co., Ltd. | OPTIMIZATION OF A CHEMERA ANTIGEN RECEPTOR |
AU2021312871A1 (en) * | 2020-07-21 | 2023-02-09 | Allogene Therapeutics, Inc. | Chimeric antigen receptors with enhanced signaling and activities and uses thereof |
KR20230153482A (ko) * | 2021-04-08 | 2023-11-06 | 임비라 바이오파마수티컬스 컴퍼니 리미티드 | 케모카인 및 종양 관련성/특이성 항원을 전달하는 유전자 변형된 종양 용해성 단순 헤르페스 바이러스 |
WO2023235819A1 (en) * | 2022-06-01 | 2023-12-07 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Recombinant receptors binding b cell activation factor receptor and uses thereof |
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US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
US5525503A (en) * | 1993-09-28 | 1996-06-11 | Dana-Farber Cancer Institute, Inc. | Signal transduction via CD28 |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
GB9518220D0 (en) | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
DK1485475T3 (da) | 2002-03-15 | 2008-01-21 | Cellectis | Hybrid meganuklease og enkeltkædet maganuklease og brug deraf |
EP3202899B1 (en) | 2003-01-28 | 2020-10-21 | Cellectis | Custom-made meganuclease and use thereof |
WO2006076678A2 (en) | 2005-01-13 | 2006-07-20 | The Johns Hopkins University | Prostate stem cell antigen vaccines and uses thereof |
US20070036773A1 (en) | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
WO2007047859A2 (en) | 2005-10-18 | 2007-04-26 | Precision Biosciences | Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity |
WO2007051077A2 (en) | 2005-10-28 | 2007-05-03 | The Regents Of The University Of California | Methods and compounds for lymphoma cell detection and isolation |
US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
US20110245167A1 (en) | 2008-12-12 | 2011-10-06 | The University Of Toledo | NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof |
EP2210903A1 (en) | 2009-01-21 | 2010-07-28 | Monoclonal Antibodies Therapeutics | Anti-CD160 monoclonal antibodies and uses thereof |
CA2759733C (en) | 2009-04-23 | 2019-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human ror1 antibodies |
EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
US9181527B2 (en) | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
DK2513146T3 (en) | 2009-12-18 | 2017-07-31 | Kancera Ab | Antibodies against ROR1 capable of inducing cell death by CLL |
CA2798988C (en) | 2010-05-17 | 2020-03-10 | Sangamo Biosciences, Inc. | Tal-effector (tale) dna-binding polypeptides and uses thereof |
WO2011159847A2 (en) | 2010-06-15 | 2011-12-22 | The Regents Of The University Of California | Receptor tyrosine kinase-like orphan receptor 1 (ror1) single chain fv antibody fragment conjugates and methods of use thereof |
US9228023B2 (en) | 2010-10-01 | 2016-01-05 | Oxford Biotherapeutics Ltd. | Anti-ROR1 antibodies and methods of use for treatment of cancer |
AU2011336650B2 (en) | 2010-12-01 | 2016-12-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric rabbit/human ROR1 antibodies |
ES2791716T3 (es) | 2010-12-14 | 2020-11-05 | Univ Maryland | Células T que expresan al receptor de antígeno quimérico antietiqueta universal y métodos para el tratamiento del cáncer |
DK3252076T3 (da) | 2011-01-14 | 2019-12-02 | Univ California | Diagnostisk anvendelse af antistoffer mod ror-1-protein |
US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
CA2845536A1 (en) | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
US9708384B2 (en) | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
PE20150336A1 (es) | 2012-05-25 | 2015-03-25 | Univ California | Metodos y composiciones para la modificacion de adn objetivo dirigida por arn y para la modulacion de la transcripcion dirigida por arn |
WO2014031687A1 (en) | 2012-08-20 | 2014-02-27 | Jensen, Michael | Method and compositions for cellular immunotherapy |
CN109369808B (zh) | 2012-08-24 | 2023-11-07 | 加利福尼亚大学董事会 | 用于治疗ror1癌症并抑制转移的抗体和疫苗 |
EP2848690B1 (en) | 2012-12-12 | 2020-08-19 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
EP2934575A2 (en) | 2012-12-19 | 2015-10-28 | Amplimmune, Inc. | B7-h4 specific antibodies, and compositions and methods of use thereof |
CA2930877A1 (en) | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
SG10201804439PA (en) | 2013-12-20 | 2018-06-28 | Hutchinson Fred Cancer Res | Tagged chimeric effector molecules and receptors thereof |
JP6560235B2 (ja) * | 2014-01-13 | 2019-08-14 | シティ・オブ・ホープCity of Hope | Fcスペーサー領域に変異を有するキメラ抗原受容体(CAR)及びそれらの使用方法 |
EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
JP6943760B2 (ja) | 2014-09-12 | 2021-10-06 | ジェネンテック, インコーポレイテッド | 抗b7−h4抗体及び免疫複合体 |
EP3201232A1 (en) | 2014-10-03 | 2017-08-09 | Dana-Farber Cancer Institute, Inc. | Glucocorticoid-induced tumor necrosis factor receptor (gitr) antibodies and methods of use thereof |
WO2016094873A2 (en) | 2014-12-12 | 2016-06-16 | Emergent Product Development Seattle, Llc | Receptor tyrosine kinase-like orphan receptor 1 binding proteins and related compositions and methods |
US20180100026A1 (en) | 2015-04-15 | 2018-04-12 | California Institute For Biomedical Research | Optimized chimeric receptor t cell switches and uses thereof |
EP3283113A4 (en) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
CA3001941A1 (en) | 2015-10-30 | 2017-05-04 | Nbe-Therapeutics Ag | Anti-ror1 antibodies |
US11535662B2 (en) * | 2017-01-26 | 2022-12-27 | Novartis Ag | CD28 compositions and methods for chimeric antigen receptor therapy |
SG11201911838UA (en) * | 2017-07-07 | 2020-01-30 | H Lee Moffitt Cancer Center And Research Institute Inc | Chimeric antigen receptors with mutated cd28 costimulatory domains |
CA3070861A1 (en) * | 2017-09-22 | 2019-03-28 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Chimeric antigen receptors with enhanced nfkb signaling |
-
2019
- 2019-02-21 US US16/976,040 patent/US20210079061A1/en active Pending
- 2019-02-21 WO PCT/US2019/019014 patent/WO2019165116A1/en unknown
- 2019-02-21 CN CN201980028403.8A patent/CN112041335A/zh active Pending
- 2019-02-21 JP JP2020544661A patent/JP2021514631A/ja active Pending
- 2019-02-21 CA CA3091138A patent/CA3091138A1/en active Pending
- 2019-02-21 EP EP19712062.9A patent/EP3759130A1/en active Pending
- 2019-02-21 AU AU2019224051A patent/AU2019224051A1/en active Pending
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