JPWO2019158689A5 - - Google Patents
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- Publication number
- JPWO2019158689A5 JPWO2019158689A5 JP2020543919A JP2020543919A JPWO2019158689A5 JP WO2019158689 A5 JPWO2019158689 A5 JP WO2019158689A5 JP 2020543919 A JP2020543919 A JP 2020543919A JP 2020543919 A JP2020543919 A JP 2020543919A JP WO2019158689 A5 JPWO2019158689 A5 JP WO2019158689A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- activity inhibitor
- endoribonuclease activity
- ire1α
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102100030011 Endoribonuclease Human genes 0.000 claims 5
- 108010093099 Endoribonucleases Proteins 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 5
- 108091006081 Inositol-requiring enzyme-1 Proteins 0.000 claims 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
- 208000019423 liver disease Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- TVIVJHZHPKNDAQ-MHWRWJLKSA-N chembl3192687 Chemical group OC1=CC=C2C=CC=CC2=C1\C=N\S(=O)(=O)C1=CC=CS1 TVIVJHZHPKNDAQ-MHWRWJLKSA-N 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18305169.7 | 2018-02-16 | ||
| EP18305169 | 2018-02-16 | ||
| PCT/EP2019/053807 WO2019158689A1 (en) | 2018-02-16 | 2019-02-15 | Methods and compositions for treating liver diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021514365A JP2021514365A (ja) | 2021-06-10 |
| JPWO2019158689A5 true JPWO2019158689A5 (https=) | 2022-02-18 |
| JP2021514365A5 JP2021514365A5 (https=) | 2022-02-18 |
Family
ID=61283136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543919A Pending JP2021514365A (ja) | 2018-02-16 | 2019-02-15 | 肝疾患を処置するための方法及び組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20210085643A1 (https=) |
| EP (1) | EP3752135A1 (https=) |
| JP (1) | JP2021514365A (https=) |
| WO (1) | WO2019158689A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4355356A4 (en) * | 2021-06-15 | 2025-05-14 | Yale University | Compounds and methods for treating or preventing autosomal dominant polycystic kidney disease (ADPKD), autosomal dominant polycystic liver disease (ADPLD), and/or autosomal recessive polycystic kidney disease |
| CN113647359A (zh) * | 2021-08-15 | 2021-11-16 | 芜湖职业技术学院 | 注射衣霉素诱导急性肝损伤小鼠模型的构建方法 |
| KR102718502B1 (ko) * | 2021-10-13 | 2024-10-16 | 단국대학교 천안캠퍼스 산학협력단 | 쌍별귀뚜라미 가수분해물을 유효성분으로 함유하는 비알코올성 지방간 질환 예방 또는 개선용 식품 조성물 및 이의 제조방법 |
| CN114712514B (zh) * | 2022-03-03 | 2023-03-31 | 浙江大学 | 用于局部和全身性减脂的纳米制剂及其应用 |
| CN116549442A (zh) * | 2023-06-08 | 2023-08-08 | 复旦大学 | Stf-083010在制备防治主动脉夹层药物中的应用 |
| CN119185312B (zh) * | 2024-10-11 | 2026-04-21 | 浙江大学 | 盐酸胺苯吖啶在制备防治纤维化疾病的药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2555768B1 (en) * | 2010-04-05 | 2018-08-29 | Fosun Orinove Pharmatech, Inc. | Ire-1 inhibitors |
| WO2016004254A1 (en) * | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Combined modulation of ire1 |
| WO2020019107A1 (en) * | 2018-07-23 | 2020-01-30 | Fosun Orinove Pharmatech, Inc. | IRE1α INHIBITOR IN COMBINATION WITH CANCER THERAPEUTIC AGENT FOR CANCER TREATMENT |
-
2019
- 2019-02-15 JP JP2020543919A patent/JP2021514365A/ja active Pending
- 2019-02-15 US US16/970,031 patent/US20210085643A1/en not_active Abandoned
- 2019-02-15 WO PCT/EP2019/053807 patent/WO2019158689A1/en not_active Ceased
- 2019-02-15 EP EP19705960.3A patent/EP3752135A1/en not_active Withdrawn
-
2023
- 2023-06-02 US US18/328,042 patent/US20240024281A1/en not_active Abandoned
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