JPWO2019020054A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019020054A5 JPWO2019020054A5 JP2020503285A JP2020503285A JPWO2019020054A5 JP WO2019020054 A5 JPWO2019020054 A5 JP WO2019020054A5 JP 2020503285 A JP2020503285 A JP 2020503285A JP 2020503285 A JP2020503285 A JP 2020503285A JP WO2019020054 A5 JPWO2019020054 A5 JP WO2019020054A5
- Authority
- JP
- Japan
- Prior art keywords
- optimization
- protein
- sequence
- proteins
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005457 optimization Methods 0.000 claims description 61
- 102000004169 proteins and genes Human genes 0.000 claims description 44
- 108090000623 proteins and genes Proteins 0.000 claims description 44
- 102000004965 antibodies Human genes 0.000 claims description 35
- 108090001123 antibodies Proteins 0.000 claims description 35
- 108020004705 Codon Proteins 0.000 claims description 16
- 230000002068 genetic Effects 0.000 claims description 14
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 9
- 229920001405 Coding region Polymers 0.000 claims description 5
- 210000004027 cells Anatomy 0.000 claims description 5
- 230000003612 virological Effects 0.000 claims description 4
- 230000000875 corresponding Effects 0.000 claims description 3
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 240000008371 Bacillus subtilis Species 0.000 claims description 2
- 229940075615 Bacillus subtilis Drugs 0.000 claims description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 230000036809 Fabs Effects 0.000 claims description 2
- 108091006004 Fc-tagged proteins Proteins 0.000 claims description 2
- 241000238631 Hexapoda Species 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 210000004897 N-terminal region Anatomy 0.000 claims description 2
- 102000007999 Nuclear Proteins Human genes 0.000 claims description 2
- 108010089610 Nuclear Proteins Proteins 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 108091006028 chimera Proteins 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000001086 cytosolic Effects 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037240 fusion proteins Human genes 0.000 claims description 2
- 102000034448 gene-regulatory proteins Human genes 0.000 claims description 2
- 108091006088 gene-regulatory proteins Proteins 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 102000035365 modified proteins Human genes 0.000 claims description 2
- 108091005569 modified proteins Proteins 0.000 claims description 2
- 230000001052 transient Effects 0.000 claims description 2
- 230000003248 secreting Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 description 5
- 102000038129 antigens Human genes 0.000 description 5
- 108091007172 antigens Proteins 0.000 description 5
- 230000002998 immunogenetic Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000000987 Immune System Anatomy 0.000 description 4
- 230000002708 enhancing Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 108010071919 Bispecific Antibodies Proteins 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001131 transforming Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710611752.5 | 2017-07-25 | ||
| CN201710611752.5A CN110070913B (zh) | 2017-07-25 | 2017-07-25 | 一种基于免疫算法的密码子优化方法 |
| PCT/CN2018/097040 WO2019020054A1 (zh) | 2017-07-25 | 2018-07-25 | 一种基于免疫算法的密码子优化方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020534794A JP2020534794A (ja) | 2020-12-03 |
| JPWO2019020054A5 true JPWO2019020054A5 (zh) | 2022-07-05 |
Family
ID=65039394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503285A Pending JP2020534794A (ja) | 2017-07-25 | 2018-07-25 | 免疫アルゴリズムに基づくコドン最適化方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210027858A1 (zh) |
| EP (1) | EP3660852B1 (zh) |
| JP (1) | JP2020534794A (zh) |
| KR (1) | KR20200038263A (zh) |
| CN (1) | CN110070913B (zh) |
| WO (1) | WO2019020054A1 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109979539B (zh) * | 2019-04-10 | 2020-10-02 | 电子科技大学 | 基因序列优化方法、装置及数据处理终端 |
| CN110580390B (zh) * | 2019-09-04 | 2021-05-11 | 电子科技大学 | 基于改进遗传算法与信息熵的地质统计学随机反演方法 |
| CN111243679B (zh) * | 2020-01-15 | 2023-03-31 | 重庆邮电大学 | 微生物群落物种多样性数据的存储检索方法 |
| CN112466393B (zh) * | 2020-11-12 | 2024-02-20 | 苏州大学 | 基于自适应免疫遗传算法的代谢标志物组群识别方法 |
| CN112735525B (zh) * | 2021-01-18 | 2023-12-26 | 苏州科锐迈德生物医药科技有限公司 | 一种基于分治法的mRNA序列优化的方法与装置 |
| CN113792877B (zh) * | 2021-09-18 | 2024-02-20 | 大连大学 | 基于双策略黑蜘蛛算法的dna存储编码优化方法 |
| CN116072231B (zh) * | 2022-10-17 | 2024-02-13 | 中国医学科学院病原生物学研究所 | 基于氨基酸序列的密码子优化设计mRNA疫苗的方法 |
| CN115440300B (zh) * | 2022-11-07 | 2023-01-20 | 深圳市瑞吉生物科技有限公司 | 一种密码子序列优化方法、装置、计算机设备及存储介质 |
| CN117497092B (zh) * | 2024-01-02 | 2024-05-14 | 微观纪元(合肥)量子科技有限公司 | 基于动态规划和量子退火的rna结构预测方法及系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10260805A1 (de) * | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
| GB0419424D0 (en) * | 2004-09-02 | 2004-10-06 | Viragen Scotland Ltd | Transgene optimisation |
| ES2534282T3 (es) * | 2006-06-29 | 2015-04-21 | Dsm Ip Assets B.V. | Un método para lograr la expresión polipeptídica mejorada |
| CN101885760B (zh) * | 2010-03-16 | 2012-12-05 | 王世霞 | 密码子优化的HIV-1gp120基因共有序列及gp120核酸疫苗 |
| SG10201602115PA (en) * | 2012-09-19 | 2016-05-30 | Univ Singapore | Codon optimization of a synthetic gene(s) for protein expression |
| CN106951726A (zh) * | 2017-02-20 | 2017-07-14 | 苏州金唯智生物科技有限公司 | 一种基因编码序列的优化方法及装置 |
-
2017
- 2017-07-25 CN CN201710611752.5A patent/CN110070913B/zh active Active
-
2018
- 2018-07-25 JP JP2020503285A patent/JP2020534794A/ja active Pending
- 2018-07-25 US US16/633,910 patent/US20210027858A1/en active Pending
- 2018-07-25 WO PCT/CN2018/097040 patent/WO2019020054A1/zh unknown
- 2018-07-25 EP EP18839139.5A patent/EP3660852B1/en active Active
- 2018-07-25 KR KR1020207005489A patent/KR20200038263A/ko not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020534794A (ja) | 免疫アルゴリズムに基づくコドン最適化方法 | |
| Rouached et al. | Structural and functional analysis of the C-terminal STAS (sulfate transporter and anti-sigma antagonist) domain of the Arabidopsis thaliana sulfate transporter SULTR1. 2 | |
| Tao et al. | Ustilago may dis KP6 Killer Toxin: Structure, Expression in Saccharomyces cerevisiae, and Relationship to Other Cellular Toxins | |
| US8816157B2 (en) | Plants and polynucleotides encoding truncated Cry34 proteins | |
| CA2339889A1 (en) | Identification of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests | |
| JPWO2019020054A5 (zh) | ||
| US11370815B2 (en) | Compositions and methods for producing high secreted yields of recombinant proteins | |
| CN110835366B (zh) | 促进蛋白质可溶性表达的标签多肽及其用途 | |
| Chen et al. | Overexpression of bacterio‐opsin in Escherichia coli as a water‐soluble fusion to maltose binding protein: efficient regeneration of the fusion protein and selective cleavage with trypsin | |
| US20140335622A1 (en) | Expression vector and method for producing protein | |
| CN110627908A (zh) | 一种针对猪流行性腹泻具有免疫原性的融合蛋白及其应用 | |
| WO2019216930A9 (en) | Self-assembling protein scaffolds and methods | |
| EP2990485A1 (en) | Fd chain gene or l chain gene each capable of increasing secretion amount of fab-type antibody | |
| KR102603693B1 (ko) | 소수성 테일 도메인이 제거된 먹장어 유래 vlrb 단백질에 폴돈 도메인이 연결된 융합 단백질 및 이의 용도 | |
| CN109971777B (zh) | 一种增强原核系统中蛋白质表达的方法 | |
| US8603780B2 (en) | Methods and compositions for enhanced expression and secretion of proteins | |
| KR102617593B1 (ko) | 바이러스 뉴클레오캡시드를 이용한 목적 단백질 발현 플랫폼 | |
| Ishikawa et al. | The endoplasmic reticulum membrane–bending protein RETICULON facilitates chloroplast relocation movement in Marchantia polymorpha | |
| Stephens et al. | Each yeast mitochondrial F1F0-ATP synthase complex contains a single copy of subunit 8 | |
| KR102603699B1 (ko) | 소수성 테일 도메인이 제거된 먹장어 유래 vlrb 단백질에 ab5 독소 유래 b 서브유닛이 연결된 융합 단백질 및 이의 용도 | |
| WO2017170418A1 (ja) | エンドヌクレアーゼ活性を有するポリペプチド及びその製造方法 | |
| Shimada et al. | Influences of amino acid features of glutathione S‐transferase fusion proteins on their solubility | |
| SE0303093D0 (sv) | Expression vector, host cell and method for producing fusion proteins | |
| KR20230163940A (ko) | 바이러스 뉴클레오캡시드를 이용한 결정성 단백질 기반 목적 단백질 융합 자가 조립 나노 입자 제조 플랫폼 | |
| US20180187205A1 (en) | Cloning vector |