JPWO2018168977A1 - Liquid composition for sterilization or bacteriostasis - Google Patents
Liquid composition for sterilization or bacteriostasis Download PDFInfo
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- JPWO2018168977A1 JPWO2018168977A1 JP2019506245A JP2019506245A JPWO2018168977A1 JP WO2018168977 A1 JPWO2018168977 A1 JP WO2018168977A1 JP 2019506245 A JP2019506245 A JP 2019506245A JP 2019506245 A JP2019506245 A JP 2019506245A JP WO2018168977 A1 JPWO2018168977 A1 JP WO2018168977A1
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- liquid composition
- composition
- emulsifier
- phytic acid
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- 239000000203 mixture Substances 0.000 title claims abstract description 163
- 239000007788 liquid Substances 0.000 title claims abstract description 86
- 230000001954 sterilising effect Effects 0.000 title claims description 20
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 16
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 58
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 57
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000000467 phytic acid Substances 0.000 claims abstract description 57
- 229940068041 phytic acid Drugs 0.000 claims abstract description 57
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 55
- 230000003385 bacteriostatic effect Effects 0.000 claims abstract description 52
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 38
- 230000000249 desinfective effect Effects 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 19
- 239000003125 aqueous solvent Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 8
- 238000005507 spraying Methods 0.000 claims description 8
- -1 glycerin fatty acid ester Chemical class 0.000 claims description 7
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 230000000845 anti-microbial effect Effects 0.000 claims description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 3
- 235000013305 food Nutrition 0.000 description 30
- 241000894006 Bacteria Species 0.000 description 18
- 244000005700 microbiome Species 0.000 description 18
- 239000000243 solution Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000000463 material Substances 0.000 description 12
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 230000001580 bacterial effect Effects 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 150000001298 alcohols Chemical class 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000012046 mixed solvent Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 239000013077 target material Substances 0.000 description 5
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 241000222290 Cladosporium Species 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 241000192132 Leuconostoc Species 0.000 description 1
- 241001468192 Leuconostoc citreum Species 0.000 description 1
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 241000186882 Weissella viridescens Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003084 food emulsifier Nutrition 0.000 description 1
- 239000005452 food preservative Substances 0.000 description 1
- 235000019249 food preservative Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
- A23L3/3517—Carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3553—Organic compounds containing phosphorus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Polymers & Plastics (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Abstract
液状を呈し、かつ高い殺菌又は静菌効果を有しながらも安全性の高い組成物の提供。乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、殺菌又は静菌用液状組成物。Provided is a highly safe composition which is liquid and has a high bactericidal or bacteriostatic effect. A disinfecting or bacteriostatic liquid composition comprising an emulsifier and phytic acid and having a pH of 3.5 or less.
Description
本発明は、殺菌又は静菌用組成物に関する。 The present invention relates to a disinfecting or bacteriostatic composition.
従来、食品製造においては、微生物の増殖による食品の腐敗や変質を防ぐための組成物が使用されている。特許文献１には、脂肪酸モノエステル、酸またはキレート化剤、食品グレードの界面活性剤及び媒体を含有する食品用殺菌剤組成物が記載されている。特許文献２には、フィチン酸及び乳化剤を含有する乳入り飲料用乳化安定剤が記載されている。特許文献３には、ホースラディッシュ由来の抗菌性物質と、有機酸又はその塩、アミノ酸、低級脂肪酸エステル、シュガーエステル、ビタミンＢ１エステル、重合リン酸塩、フィチン酸、エタノール等から選択される１種又は２種以上とを含有する食品用保存剤が記載されている。特許文献４には、エタノール、グルコン酸ナトリウム、カプリン酸、カプリル酸モノグリセリド及びカプリン酸モノグリセリド、ｐＨ調整剤、水を含有し、水溶液の酸度が０．１〜０．９である殺菌剤組成物が記載されている。 2. Description of the Related Art Conventionally, in food production, a composition for preventing spoilage or deterioration of food due to proliferation of microorganisms has been used. Patent Literature 1 describes a food fungicide composition containing a fatty acid monoester, an acid or a chelating agent, a food-grade surfactant, and a medium. Patent Document 2 describes an emulsion stabilizer for milk-containing beverages containing phytic acid and an emulsifier. Patent Document 3 discloses an antibacterial substance derived from horseradish and one selected from an organic acid or a salt thereof, an amino acid, a lower fatty acid ester, a sugar ester, a vitamin B1 ester, a polymerized phosphate, phytic acid, ethanol and the like. Or, a food preservative containing two or more types is described. Patent Document 4 discloses a disinfectant composition containing ethanol, sodium gluconate, capric acid, caprylic acid monoglyceride and capric acid monoglyceride, a pH adjuster, and water, wherein the acidity of the aqueous solution is 0.1 to 0.9. Has been described.
食品、又はそれを取り扱う機器もしくはそれが存在する環境の殺菌又は静菌のための組成物においては、その殺菌又は静菌効果が重要であるだけでなく、安全性も無視できない。一方で、食品分野で微生物の増殖制御に従来使用されている組成物は、安全性の基準は満たすが、水溶性が低く均質な液状とすることが難しいため、機器等の洗浄や殺菌には使いづらいことが多い。したがって、均質な液状を呈し、高い殺菌又は静菌効果を有しながらも生体に対する安全性は高く、食品、又はそれを取り扱う機器もしくはそれが存在する環境の殺菌又は静菌に有用な組成物が求められている。 In a composition for disinfecting or bacteriostatic of a food or a device for handling the same or the environment in which it is present, not only its disinfecting or bacteriostatic effect is important, but also its safety cannot be ignored. On the other hand, compositions conventionally used to control the growth of microorganisms in the food field meet safety standards, but have low water solubility and are difficult to make into a homogeneous liquid. Often difficult to use. Therefore, it exhibits a homogeneous liquid, has a high bactericidal or bacteriostatic effect, but is highly safe for living organisms, and a composition useful for bactericidal or bacteriostatic treatment of food or equipment handling it or the environment where it is present. It has been demanded.
さらに、食品を取り扱う機器においては、殺菌処理直後だけでなく、機器の使用中にわたって減菌された状態を維持することが望まれる。したがって、素材についた微生物を殺菌又は静菌した後、そのまま継続的に該素材における微生物の増殖を抑えることを可能にする組成物の開発は、非常に有用であると考えられる。 Further, it is desired to maintain a sterilized state of food handling equipment not only immediately after sterilization processing but also during use of the equipment. Therefore, it is considered that development of a composition capable of continuously suppressing the growth of microorganisms in the material after sterilizing or bacteriostatic the microorganisms attached to the material is very useful.
本発明者らは、乳化剤とフィチン酸を含み、かつｐＨが３．５以下である液状組成物が、扱いやすく、また高い殺菌又は静菌作用を有することを見出した。さらに本発明者らは、当該液状組成物を素材に噴霧又は塗布することで、該素材における微生物の増殖を長時間にわたって抑制できることを見出した。 The present inventors have found that a liquid composition containing an emulsifier and phytic acid and having a pH of 3.5 or less is easy to handle and has a high bactericidal or bacteriostatic action. Furthermore, the present inventors have found that by spraying or applying the liquid composition to a material, the growth of microorganisms in the material can be suppressed for a long time.
したがって、本発明は、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、殺菌又は静菌用液状組成物を提供する。
また本発明は、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、対象への抗菌性付与用液状組成物を提供する。Accordingly, the present invention provides a sterilizing or bacteriostatic liquid composition comprising an emulsifier and phytic acid and having a pH of 3.5 or less.
Further, the present invention provides a liquid composition for imparting antibacterial property to a subject, comprising an emulsifier and phytic acid and having a pH of 3.5 or less.
さらに本発明は、液状組成物を対象に噴霧もしくは塗布するか、又は該液状組成物に対象を浸漬させることを含み、
該液状組成物が、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、
殺菌又は静菌方法を提供する。
さらに本発明は、液状組成物を対象に噴霧もしくは塗布するか、又は該液状組成物に対象を浸漬させることを含み、
該液状組成物が、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、
対象への抗菌性付与方法を提供する。The present invention further comprises spraying or applying the liquid composition to the subject, or immersing the subject in the liquid composition,
The liquid composition contains an emulsifier and phytic acid, and has a pH of 3.5 or less;
A sterilization or bacteriostatic method is provided.
The present invention further comprises spraying or applying the liquid composition to the subject, or immersing the subject in the liquid composition,
The liquid composition contains an emulsifier and phytic acid, and has a pH of 3.5 or less;
Provided is a method for imparting antibacterial property to a subject.
さらに本発明は、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である液状組成物の、殺菌又は静菌のための使用を提供する。
さらに本発明は、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である液状組成物の、対象への抗菌性付与のための使用を提供する。Furthermore, the present invention provides the use of a liquid composition comprising an emulsifier and phytic acid and having a pH of 3.5 or less for sterilization or bacteriostasis.
Further, the present invention provides a use of a liquid composition containing an emulsifier and phytic acid and having a pH of 3.5 or less for imparting antibacterial property to a subject.
さらに本発明は、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である液状組成物の、殺菌又は静菌用液状組成物の製造のための使用を提供する。
さらに本発明は、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である液状組成物の、対象への抗菌性付与用液状組成物の製造のための使用を提供する。The present invention further provides the use of a liquid composition comprising an emulsifier and phytic acid and having a pH of 3.5 or less for producing a liquid composition for sterilization or bacteriostasis.
Further, the present invention provides a use of a liquid composition containing an emulsifier and phytic acid and having a pH of 3.5 or less for producing a liquid composition for imparting antibacterial property to a subject.
本発明の液状組成物は、液状であるため使用しやすく、また高い殺菌又は静菌効果を有しながらも生体に対する安全性が高い。また、本発明の液状組成物は、素材に適用すれば、該素材についた微生物を殺菌又は静菌することができ、さらに長時間にわたって該素材における微生物の増殖を継続的に抑えることができる。したがって、本発明は、恒常的に微生物増殖抑制が望まれる分野、例えば、食品の製造、加工、保存等の分野において有効である。 The liquid composition of the present invention is easy to use because it is liquid, and has high safety for living bodies while having a high bactericidal or bacteriostatic effect. In addition, when the liquid composition of the present invention is applied to a material, microorganisms attached to the material can be sterilized or bacteriostatic, and the growth of microorganisms in the material can be continuously suppressed for a long time. Therefore, the present invention is effective in fields where microorganism growth suppression is constantly desired, for example, in fields such as food production, processing, and storage.
本発明は、殺菌又は静菌用組成物を提供する。本発明の殺菌又は静菌用組成物は、乳化剤とフィチン酸とを含有する。 The present invention provides a disinfecting or bacteriostatic composition. The composition for bactericidal or bacteriostatic of the present invention contains an emulsifier and phytic acid.
本発明で使用される乳化剤としては、食品に使用可能な乳化剤、例えば、カプリル酸モノグリセリド、カプリン酸モノグリセリド等のグリセリン脂肪酸エステルが挙げられ、好ましくは、カプリル酸モノグリセリド及びカプリン酸モノグリセリドから選択される少なくとも１種である。これら食品用の乳化剤は、市販されている。例えば、カプリル酸モノグリセリドは、サンソフト（登録商標）７００ｐ−２（太陽化学株式会社）、ポエムＭ−１００（理研ビタミン株式会社）など、カプリン酸モノグリセリドは、サンソフト（登録商標）７６０（太陽化学株式会社）、ポエムＭ−２００（理研ビタミン株式会社）などの商品名で販売されている。 Examples of the emulsifier used in the present invention include emulsifiers usable in foods, for example, glycerin fatty acid esters such as caprylic acid monoglyceride and capric acid monoglyceride, and are preferably at least selected from caprylic acid monoglyceride and capric acid monoglyceride. One kind. These food emulsifiers are commercially available. For example, caprylic acid monoglyceride is Sunsoft (registered trademark) 700p-2 (Taiyo Kagaku Co., Ltd.), Poem M-100 (RIKEN Vitamin Co., Ltd.), and capric acid monoglyceride is Sunsoft (registered trademark) 760 (Taiyo Kagaku). Co., Ltd.) and Poem M-200 (RIKEN Vitamin Co., Ltd.).
本発明の組成物における乳化剤の濃度は、その種類によって変動はあり得るが、該組成物全量中、０．００５質量％以上であるとよく、好ましくは０．０１質量％以上、より好ましくは０．０５質量％以上、さらに好ましくは０．１質量％以上、なお好ましくは０．１５質量％以上である。乳化剤の濃度が低いと、本発明の組成物は充分な殺菌又は静菌特性を得られない。一方、本発明の組成物における乳化剤の濃度は、溶解性及び経済性の観点から、好ましくは１０．０質量％以下、より好ましくは５．０質量％以下、さらに好ましくは２．０質量％以下、なお好ましくは１．０質量％以下である。 The concentration of the emulsifier in the composition of the present invention may vary depending on the type, but it is preferably at least 0.005% by mass, preferably at least 0.01% by mass, more preferably at least 0% by mass in the total amount of the composition. 0.05% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.15% by mass or more. If the concentration of the emulsifier is low, the composition of the present invention will not have sufficient bactericidal or bacteriostatic properties. On the other hand, the concentration of the emulsifier in the composition of the present invention is preferably 10.0% by mass or less, more preferably 5.0% by mass or less, still more preferably 2.0% by mass or less from the viewpoint of solubility and economy. , More preferably 1.0% by mass or less.
フィチン酸は、従来、結着剤、酸味料等として食品等に適用されている。フィチン酸は、市販されており、例えばフィチン酸５０％水溶液（ＩＰ６）（築野食品株式会社）などの商品名で販売されている。本発明の組成物におけるフィチン酸の濃度は、乳化剤の濃度によっても異なり得るが、該組成物全量中、０．００５質量％以上であるとよく、好ましくは０．０１質量％以上、より好ましくは０．０５質量％以上、さらに好ましくは０．１質量％以上である。フィチン酸の濃度が低いと、本発明の組成物が充分な殺菌又は静菌特性を得られない。一方、本発明の組成物におけるフィチン酸の濃度は、好ましくは５質量％以下である。フィチン酸の濃度が高すぎると、本発明の組成物のｐＨが低くなり、金属の腐食など、本発明の組成物の適用環境に悪影響を及ぼすおそれがある。 Phytic acid has been conventionally applied to foods and the like as a binder, an acidulant and the like. Phytic acid is commercially available, and is sold, for example, under a trade name such as a 50% aqueous solution of phytic acid (IP6) (Tsukino Foods Co., Ltd.). The concentration of phytic acid in the composition of the present invention may vary depending on the concentration of the emulsifier, but it is preferably at least 0.005% by mass, preferably at least 0.01% by mass, more preferably at least 0.01% by mass, based on the total amount of the composition. It is at least 0.05% by mass, more preferably at least 0.1% by mass. If the concentration of phytic acid is low, the composition of the present invention will not have sufficient bactericidal or bacteriostatic properties. On the other hand, the concentration of phytic acid in the composition of the present invention is preferably 5% by mass or less. If the concentration of phytic acid is too high, the pH of the composition of the present invention is lowered, which may adversely affect the application environment of the composition of the present invention such as corrosion of a metal.
本発明の組成物において、乳化剤とフィチン酸との比率は、質量比で、好ましくは１：０．００５〜１：２００、好ましくは１：０．１〜１：２００、より好ましくは１：０．１〜１：４０、さらに好ましくは１：０．３〜１：４０である。上記比率を外れると、本発明の組成物が、品質、コスト面で許容できないものになることがある。 In the composition of the present invention, the ratio of emulsifier to phytic acid is preferably 1: 0.005 to 1: 200, preferably 1: 0.1 to 1: 200, more preferably 1: 0, by mass ratio. 0.1 to 1:40, more preferably 1: 0.3 to 1:40. If the ratio is out of the above range, the composition of the present invention may become unacceptable in quality and cost.
本発明の殺菌又は静菌用組成物に含まれる乳化剤及びフィチン酸は、いずれも食品添加物として許容されている物質である。したがって、本発明の組成物は、一般的な洗浄剤や殺菌剤と比べて人体に対する安全性が高い。したがって、本発明の組成物は、食品関連分野への適用、例えば、食品、又はそれを取り扱う機器もしくはそれが存在する環境の殺菌又は静菌に有用である。 The emulsifier and phytic acid contained in the composition for bactericidal or bacteriostatic of the present invention are both substances that are acceptable as food additives. Therefore, the composition of the present invention has higher safety for the human body than general cleaning agents and disinfectants. Therefore, the composition of the present invention is useful for application in the food-related field, for example, sterilization or bacteriostasis of food, or equipment handling the same, or the environment in which it is present.
本発明の組成物は、乳化剤及びフィチン酸以外の他の成分、例えば、フィチン酸以外のリン酸（ウルトラリン酸、ポリリン酸、ピロリン酸、メタリン酸）、クエン酸、グルコン酸、フマル酸、マレイン酸、マロン酸、酒石酸、コハク酸、リンゴ酸、アジピン酸、塩酸等の有機酸及び無機酸、ならびにそれらの塩からなる群より選択される少なくとも１種、食品に使用可能なｐＨ調整剤などを含有していてもよい。ただし、これらの他の成分の種類及び含有量は、本発明の組成物に必要な殺菌又は静菌特性が失われない範囲に制限される。好ましくは、本発明の組成物における当該他の成分の含有量は、５質量％以下である。 The composition of the present invention comprises an emulsifier and other components other than phytic acid, for example, phosphoric acids other than phytic acid (ultraphosphoric acid, polyphosphoric acid, pyrophosphoric acid, metaphosphoric acid), citric acid, gluconic acid, fumaric acid, maleic acid Acid, malonic acid, tartaric acid, succinic acid, malic acid, adipic acid, at least one selected from the group consisting of organic acids and inorganic acids such as hydrochloric acid, and salts thereof, and a pH adjuster usable for food. It may be contained. However, the type and content of these other components are limited to the extent that the bactericidal or bacteriostatic properties required for the composition of the present invention are not lost. Preferably, the content of the other component in the composition of the present invention is 5% by mass or less.
本発明の組成物は、さらにアルコール類を含有していてもよい。本発明の組成物に使用されるアルコール類としては、例えばエタノールなどの食品に使用可能なアルコール類が挙げられる。アルコール類の添加により、乳化剤の溶解性が向上し、本発明の組成物が扱いやすくなる。本発明の組成物におけるアルコール類の含有量は、上述した乳化剤、フィチン酸及び他の成分の残部以下であればよく、好ましくは該乳化剤、フィチン酸及び他の成分の残部であり、より好ましくは、該組成物全量中２０〜６０質量％である。 The composition of the present invention may further contain alcohols. Examples of the alcohol used in the composition of the present invention include alcohols that can be used in foods such as ethanol. The addition of alcohols improves the solubility of the emulsifier and makes the composition of the present invention easier to handle. The content of alcohols in the composition of the present invention may be the emulsifier described above, the phytic acid and the balance of the other components or less, preferably the emulsifier, phytic acid and the balance of the other components, more preferably 20 to 60% by mass of the total amount of the composition.
あるいは、本発明の組成物は、さらに水性溶媒を含有していてもよい。好ましい水性溶媒としては、例えば水が挙げられる。本発明の組成物における該水性溶媒の含有量は、上述した乳化剤、フィチン酸及び他の成分の残部以下であればよく、好ましくは該乳化剤、フィチン酸、他の成分及びアルコール類の残部であり、さらに好ましくは２０質量％以上である。 Alternatively, the composition of the present invention may further contain an aqueous solvent. Preferred aqueous solvents include, for example, water. The content of the aqueous solvent in the composition of the present invention may be the emulsifier, phytic acid and other components as described above or less, and preferably the emulsifier, phytic acid, other components and the balance of alcohols. , More preferably 20% by mass or more.
本発明の組成物の一例は、上記水性溶媒に、乳化剤及びフィチン酸が溶解した液状組成物である。本発明の組成物の別の一例は、上記アルコール類に、乳化剤及びフィチン酸が溶解した液状組成物である。本発明の組成物の別の一例は、上記アルコール類と水性溶媒との混合溶媒に、乳化剤及びフィチン酸が溶解した液状組成物である。本発明の組成物の好ましい一例は、エタノール／水の混合溶媒に、乳化剤及びフィチン酸が溶解したエタノール水溶液である。該エタノール／水の混合溶媒としては、２０〜６０質量％エタノール水溶液が好ましい。該アルコール類と水性溶媒との混合溶媒、又は該エタノール／水の混合溶媒の本発明の組成物における含有量は、上述した乳化剤、フィチン酸及び他の成分の残部であればよい。 One example of the composition of the present invention is a liquid composition in which an emulsifier and phytic acid are dissolved in the aqueous solvent. Another example of the composition of the present invention is a liquid composition in which an emulsifier and phytic acid are dissolved in the above-mentioned alcohols. Another example of the composition of the present invention is a liquid composition in which an emulsifier and phytic acid are dissolved in a mixed solvent of the above alcohol and an aqueous solvent. One preferred example of the composition of the present invention is an aqueous ethanol solution in which an emulsifier and phytic acid are dissolved in a mixed solvent of ethanol / water. As the mixed solvent of ethanol / water, a 20 to 60% by mass aqueous ethanol solution is preferable. The content of the mixed solvent of the alcohol and the aqueous solvent or the mixed solvent of the ethanol / water in the composition of the present invention may be the balance of the above-mentioned emulsifier, phytic acid and other components.
本発明の組成物のｐＨは、好ましくは３．５以下、より好ましくは３．０以下である。ｐＨが高くなると、本発明の組成物が充分な殺菌又は静菌特性を得られないことがあり、他方、ｐＨが低くなりすぎると、金属の腐食など、本発明の組成物の適用環境に悪影響を及ぼすおそれがある。本発明の組成物のｐＨの調整は、主にフィチン酸の添加によって行うことができるが、上述したフィチン酸以外の他の酸や、食品に使用可能なｐＨ調整剤を用いてもよい。好ましくは、本発明の組成物は、フィチン酸以外の他の酸やｐＨ調整剤を含有しない。 The pH of the composition of the present invention is preferably 3.5 or less, more preferably 3.0 or less. If the pH is too high, the composition of the present invention may not have sufficient bactericidal or bacteriostatic properties.On the other hand, if the pH is too low, the environment in which the composition of the present invention is applied, such as corrosion of metals, may be adversely affected. May be exerted. The pH of the composition of the present invention can be adjusted mainly by adding phytic acid. However, an acid other than the above-mentioned phytic acid or a pH adjuster usable for food may be used. Preferably, the composition of the present invention does not contain other acids or pH adjusters other than phytic acid.
好ましい本発明の組成物の例としては、乳化剤０．０１質量％以上、フィチン酸０．００５質量％以上を含有し、かつｐＨ３．０以下である組成物が挙げられる。好ましい本発明の組成物の別の例としては、乳化剤０．１５％以上、フィチン酸０．００５質量％以上を含有し、かつｐＨ３．５以下である組成物が挙げられる。好ましくは、本発明の組成物は２０〜６０質量％のエタノールを含有する。 Preferred examples of the composition of the present invention include a composition containing 0.01% by mass or more of an emulsifier and 0.005% by mass or more of phytic acid and having a pH of 3.0 or less. Another example of a preferred composition of the present invention includes a composition containing 0.15% or more of an emulsifier, 0.005% by mass or more of phytic acid, and having a pH of 3.5 or less. Preferably, the composition according to the invention contains from 20 to 60% by weight of ethanol.
本発明の組成物は、優れた殺菌又は静菌作用を有しており、各種物質の殺菌又は静菌に使用することができる。本明細書において、殺菌とは、微生物を死滅させること（但し完全な死滅に限られない）をいい、また静菌とは、微生物の増殖を抑制することをいう。したがって、本発明の殺菌又は静菌用組成物を適用された対象においては、微生物の増殖が抑制されるか、又は微生物の数が減少する。 The composition of the present invention has an excellent bactericidal or bacteriostatic action, and can be used for bactericidal or bacteriostatic of various substances. In the present specification, sterilization refers to killing (but not limited to complete killing) microorganisms, and bacteriostasis refers to suppressing the growth of microorganisms. Therefore, in a subject to which the composition for bactericidal or bacteriostatic of the present invention is applied, the growth of microorganisms is suppressed or the number of microorganisms is reduced.
本発明の組成物により殺菌又は静菌される微生物の種類としては、特に限定されないが、例えば、Ｗｅｉｓｓｅｌｌａ属、Ｌｅｕｃｏｎｏｓｔｏｃ属等の乳酸菌、Ｋｌｅｂｓｉｅｌｌａ属、Ｅｎｔｅｒｏｂａｃｔｅｒ属等の大腸菌群、Ｃａｎｄｉｄａ属、Ｃｒｙｐｔｏｃｏｃｃｕｓ属等の酵母、Ｃｌａｄｏｓｐｏｒｉｕｍ属等のカビ、大腸菌（Ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ）、サルモネラ菌（Ｓａｌｍｏｎｅｌｌａ ｅｎｔｅｒｉｃａ）、黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）、緑膿菌（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）、リステリア菌（Ｌｉｓｔｅｒｉａ ｍｏｎｏｃｙｔｏｇｅｎｅｓ）、腸炎ビブリオ（Ｖｉｂｒｉｏ ｐａｒａｈａｅｍｏｌｙｔｉｃｕｓ）、などが挙げられる。特に、乳酸菌等の耐酸性菌は、通常の微生物が生育を阻害される低ｐＨ領域でも生存するため従来除去又は増殖抑制しにくいものであったが、これらも本発明の組成物により殺菌又は静菌することができる。このように、本発明の組成物は、耐酸性菌等の従来除去しにくかった微生物種にも有効であるため、利用価値が高い。 The kind of microorganisms to be sterilized or bacteriostatic by the composition of the present invention is not particularly limited. Yeasts, molds of the genus Cladosporium, Escherichia coli, Salmonella enterica, Staphylococcus aureus, Pseudomonas aeruginosa eruginosa eruginosa eruginosa eruginosa lysium terrier lysium terrier lysium terrier seromycota (Pseudomonas aeruginosa lyseri) , And the like. In particular, acid-resistant bacteria such as lactic acid bacteria have conventionally been difficult to remove or suppress growth because they survive even in a low pH region where growth of normal microorganisms is inhibited, but they are also sterilized or statically treated by the composition of the present invention. Can be fungi. As described above, the composition of the present invention is effective for microorganism species such as acid-resistant bacteria which have been conventionally difficult to remove, and thus has high utility value.
本発明の組成物は、各種素材の殺菌又は静菌に使用することができる。本発明の組成物の適用対象は、本発明の組成物との接触が許容されるものである限り、特に限定されない。本発明の組成物の適用対象の好ましい例としては、食品、食品を取り扱う機器、及び食品が存在する環境が挙げられる。該食品を取り扱う機器としては、製造、加工、流通、保存、調理等の過程で食品と接触する可能性のある機器、例えば、食品の製造もしくは加工工場の製造ラインの機器、食品の保存もしくは運搬用の容器、調理器具、調理台、作業者の手袋やエプロン、作業着、などが挙げられる。食品が存在する環境としては、食品を取り扱う環境、例えば食品の製造、加工、流通、保存、調理などが行われる環境、より詳細には、食品の製造もしくは加工工場、食品保管庫、調理場等の壁、床、天井、柱、ドア、窓、換気孔などが挙げられる。 The composition of the present invention can be used for sterilization or bacteriostasis of various materials. The application target of the composition of the present invention is not particularly limited as long as contact with the composition of the present invention is allowed. Preferred examples of the target to which the composition of the present invention is applied include a food, a device for handling the food, and an environment where the food is present. The equipment that handles the food includes equipment that may come into contact with food in the process of manufacturing, processing, distributing, storing, cooking, etc., for example, equipment on a production line of a food production or processing factory, storage or transportation of food. Containers, cooking utensils, worktops, worker gloves and aprons, work clothes, and the like. The environment where food exists is an environment where food is handled, for example, an environment in which food is manufactured, processed, distributed, preserved, cooked, etc., and more specifically, a food manufacturing or processing plant, a food storage, a kitchen, etc. Walls, floors, ceilings, columns, doors, windows, ventilation holes and the like.
本発明の殺菌又は静菌用組成物による対象の殺菌又は静菌は、該本発明の組成物を該対象に接触させることによって行われ得る。本発明の殺菌又は静菌用組成物は、液状であるため、殺菌又は静菌すべき対象への適用が容易である。例えば、本発明の液状組成物は、殺菌又は静菌対象の物質（例えば食品など）中に混合されてもよい。また例えば、本発明の液状組成物を、殺菌又は静菌対象の物質に噴霧もしくは塗布するか、又は本発明の液状組成物に該対象の物質を浸漬させてもよい。好ましくは、本発明の液状組成物は、殺菌又は静菌すべき対象に対して噴霧又は塗布される。本発明の液状組成物と接触した対象は、殺菌又は静菌される。 Sterilization or bacteriostasis of a subject with the bactericidal or bacteriostatic composition of the present invention can be performed by bringing the composition of the present invention into contact with the subject. Since the composition for sterilization or bacteriostasis of the present invention is in a liquid state, it can be easily applied to an object to be sterilized or bacteriostatic. For example, the liquid composition of the present invention may be mixed in a substance to be sterilized or bacteriostatic (for example, food). Further, for example, the liquid composition of the present invention may be sprayed or applied to a substance to be sterilized or bacteriostatic, or the substance of the present invention may be immersed in the liquid composition of the present invention. Preferably, the liquid composition of the present invention is sprayed or applied to a subject to be sterilized or bacteriostatic. The subject in contact with the liquid composition of the present invention is sterilized or bacteriostatic.
本発明の好ましい態様においては、殺菌又は静菌すべき対象に対して本発明の組成物を噴霧もしくは塗布するか、又は浸漬させることで、該本発明の組成物と該対象とを接触させる。さらに、該本発明の組成物と接触させた対象を乾燥させてもよい。乾燥の方法としては、静置による乾燥、風乾、乾燥機による乾燥などが挙げられるが、特に限定されない。該乾燥により、本発明の組成物に含まれる揮発性成分、例えば水性溶媒やエタノールは、揮発して該対象から除去される。該揮発性成分が除去された後でも、本発明の組成物を適用した対象においては、殺菌又は静菌作用が持続する。したがって、本態様において、本発明の組成物は、液体の状態で対象に対して殺菌又は静菌力を発揮するだけでなく、乾燥物状態でも、該対象における微生物の増殖を抑える。 In a preferred embodiment of the present invention, the composition of the present invention is brought into contact with the subject to be sterilized or bacteriostatic by spraying, applying, or immersing the composition to the subject. Further, the subject that has been brought into contact with the composition of the present invention may be dried. Examples of the drying method include, but are not particularly limited to, drying by standing, air drying, and drying by a dryer. By the drying, volatile components contained in the composition of the present invention, such as an aqueous solvent and ethanol, are volatilized and removed from the object. Even after the removal of the volatile components, the bactericidal or bacteriostatic action continues in the subject to which the composition of the present invention has been applied. Therefore, in this embodiment, the composition of the present invention not only exerts bactericidal or bacteriostatic activity on a subject in a liquid state, but also suppresses the growth of microorganisms in the subject even in a dry state.
したがって、本発明の組成物の別の態様は、対象への抗菌性付与用液状組成物であり得る。本発明の組成物を、抗菌性を付与したい対象に噴霧、塗布、浸漬等により付着させることにより、該対象に抗菌性が付与される。必要に応じて又は好ましくは、さらに該本発明の組成物を付着させた対象を乾燥させる。本明細書において、対象の「抗菌性」とは、該対象の表面に付着又は内部に侵入した微生物を殺菌又は静菌することができるという、該対象の性質をいう。本態様は、恒常的に微生物増殖を防止したい環境、又はそこで使用される素材や機器、例えば、食品を取り扱う環境又はそこで使用される食品取り扱い用機器に対して、非常に有用である。 Therefore, another embodiment of the composition of the present invention may be a liquid composition for imparting antimicrobial properties to a subject. By applying the composition of the present invention to a subject to which antibacterial property is to be imparted by spraying, coating, dipping, or the like, the subject is imparted with antibacterial property. If necessary or preferable, the object to which the composition of the present invention is further applied is dried. As used herein, the term "antibacterial" of a subject refers to the property of the subject that the microorganism that adheres to or invades the surface of the subject can be sterilized or bacteriostatic. This embodiment is very useful for an environment where it is desired to constantly prevent the growth of microorganisms, or a material or equipment used therefor, for example, an environment where food is handled or a food handling equipment used therefor.
本発明の組成物は、対象の殺菌又は静菌に用いる場合、及び対象への抗菌性付与に用いる場合のいずれにおいても、対象の面積１００ｃｍ2あたり０．１〜５．０ｍＬ程度の用量で使用されることが好ましく、対象の面積１００ｃｍ2あたり０．５〜１．０ｍＬ程度の用量で使用されることがより好ましい。好ましくは、この用量の組成物を、対象に対して、好ましくは噴霧又は塗布により、均等に付着させる。The composition of the present invention is used at a dose of about 0.1 to 5.0 mL per 100 cm 2 of a target area in both cases where it is used for sterilization or bacteriostasis of a subject and when it is used for imparting antimicrobial properties to a subject. Preferably, it is used at a dose of about 0.5 to 1.0 mL per 100 cm 2 of the area of the subject. Preferably, this dose of the composition is evenly applied to the subject, preferably by spraying or painting.
以下、実施例を挙げて、本発明をさらに詳細に説明するが、本発明はこれらの実施例にのみ限定されるものではない。 Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.
試験例１
〔液状組成物の調製〕
室温下で、乳化剤（カプリル酸モノグリセリド又はカプリン酸モノグリセリド）、エタノール及び滅菌済み精製水を１：２：２の割合で混合して溶液を調製し、これに各種有機酸、及び残余のエタノールと滅菌済み精製水を添加して、表１記載の液状組成物（溶液）を調製した。得られた液状組成物のｐＨを測定した。また、下記の手順で各液状組成物の殺菌又は静菌特性を評価した。Test example 1
(Preparation of liquid composition)
At room temperature, an emulsifier (caprylic acid monoglyceride or capric acid monoglyceride), ethanol and sterilized purified water are mixed at a ratio of 1: 2: 2 to prepare a solution, which is then sterilized with various organic acids and the remaining ethanol. Spent purified water was added to prepare a liquid composition (solution) shown in Table 1. The pH of the obtained liquid composition was measured. Further, the sterilization or bacteriostatic properties of each liquid composition were evaluated by the following procedure.
〔殺菌又は静菌特性評価〕
（１）サンプル菌液の調製
対象菌には、４種の乳酸菌Ｗｅｉｓｓｅｌｌａ ｖｉｒｉｄｅｓｃｅｎｓ、Ｌｅｕｃｏｎｏｓｔｏｃ ｍｅｓｅｎｔｅｒｏｉｄｅｓ、Ｌｅｕｃｏｎｏｓｔｏｃ ｃｉｔｒｅｕｍ、及びＬｅｕｃｏｎｏｓｔｏｃ ｐｓｅｕｄｏｍｅｓｅｎｔｅｒｏｉｄｅｓを用いた。対象菌のシングルコロニーを、白金耳を用いて数コロニー釣菌し、ＴＳＢ培地に植菌して３０℃で２０時間種培養したものを乳酸菌液（１０7ｃｆｕ／ｍＬ）とした。得られた乳酸菌液を、滅菌済み精製水１０ｍＬに０．１ｍＬ混合し、さらにこれを１０倍希釈した。４種の乳酸菌の１０倍希釈液を等量混合してサンプル菌液を調製した。(Sterilization or bacteriostatic property evaluation)
(1) Preparation of Sample Bacterial Solution As the target bacteria, four kinds of lactic acid bacteria Weissella viridescens, Leuconostoc mesenteroides, Leuconostoc citreum, and Leuconostoc pseudomesonoides were used. A single colony of the target bacterium was picked for several colonies using a platinum loop, inoculated on a TSB medium, and seed-cultured at 30 ° C. for 20 hours to obtain a lactic acid bacterium solution (10 7 cfu / mL). 0.1 mL of the obtained lactic acid bacteria solution was mixed with 10 mL of sterilized purified water, and further diluted 10-fold. Sample bacterial solutions were prepared by mixing equal amounts of 10-fold diluted solutions of the four lactic acid bacteria.
（２）液状組成物の適用及び菌数測定
塗布直後及び１８時間後の液状組成物による静菌特性を調べた。
滅菌プラスチックシャーレを二群に分けた。一方の群では、各液状組成物を１．０ｍＬずつ空のシャーレに入れ、コンラージ棒で均一に塗布し、次いでこれにサンプル菌液を１．０ｍＬ接種し、２０秒間コンラージ棒で混合しながら塗り広げた（０ｈ群）。もう一方の群では、各液状組成物を１．０ｍＬずつ空のシャーレに入れ、コンラージ棒で均一に塗布した後、安全キャビネット内で１８時間風乾し、水分とエタノールを完全に蒸発させた。これにサンプル菌液を１．０ｍＬ接種し、２０秒間コンラージ棒で混合しながら塗り広げた（１８ｈ群）。初発菌数は１０5〜１０6ｃｆｕ/ｍＬに調整した。
サンプル菌液を塗布したシャーレを、５分間静置後、シャーレ内の液体を採取し、ＭＲＳ寒天培地を用いて菌数を測定した。(2) Application of liquid composition and measurement of bacterial count Immediately after application and 18 hours later, the bacteriostatic properties of the liquid composition were examined.
The sterile plastic dishes were divided into two groups. In one group, 1.0 mL of each liquid composition was placed in an empty Petri dish and evenly applied with a conical rod. Then, 1.0 mL of the sample bacterium solution was inoculated on this, and applied while mixing with a conical rod for 20 seconds. Spread out (0h group). In the other group, 1.0 mL of each liquid composition was placed in an empty petri dish, uniformly applied with a conical rod, and then air-dried in a safety cabinet for 18 hours to completely evaporate water and ethanol. To this, 1.0 mL of the sample bacterial solution was inoculated and spread while mixing with a conical rod for 20 seconds (18 h group). Initial number of bacteria was adjusted to 10 5 ~10 6 cfu / mL.
After the petri dish to which the sample bacterial solution was applied was allowed to stand for 5 minutes, the liquid in the petri dish was collected, and the number of bacteria was measured using an MRS agar medium.
（３）殺菌又は静菌特性評価
（２）で測定した菌数をもとに、下記評価基準にて各組成物（液体群及び乾燥群）の殺菌又は静菌特性を評価した。
Ａ：初発の１／１０００以下に菌数が減少
Ｂ：初発の１／１００以下〜１／１０００超に菌数が減少
Ｃ：初発の１／１０以下〜１／１００超に菌数が減少
Ｄ：菌数が初発の１／１０よりも多い(3) Evaluation of bactericidal or bacteriostatic properties Based on the number of bacteria measured in (2), the bactericidal or bacteriostatic properties of each composition (liquid group and dried group) were evaluated according to the following evaluation criteria.
A: The number of bacteria decreases to 1/1000 or less of the first time B: The number of bacteria decreases to 1/100 or less of the first time to more than 1/1000 C: The number of bacteria decreases to 1/10 or less of the first time to more than 1/100 D : More than 1/10 of the initial count
結果を表１に示す。フィチン酸を含む液状組成物は、塗布直後（０ｈ群）及び塗布後時間が経過した場合（１８ｈ群）のいずれでも高い殺菌又は静菌作用を示したが、フィチン酸以外の酸を含む組成物は、塗布後時間が経過すると、殺菌又は静菌作用を示さなかった。 Table 1 shows the results. The liquid composition containing phytic acid showed a high bactericidal or bacteriostatic action immediately after the application (group 0h) and when the time elapsed after the application (group 18h), but a composition containing an acid other than phytic acid Showed no bactericidal or bacteriostatic action over time after application.
試験例２
試験例１と同様の手順で、但しフィチン酸の濃度を変えて、表２〜３の液状組成物（溶液）を調製し、殺菌又は静菌特性を評価した。Test example 2
Liquid compositions (solutions) in Tables 2 and 3 were prepared in the same procedure as in Test Example 1 except that the concentration of phytic acid was changed, and the bactericidal or bacteriostatic properties were evaluated.
結果を表２〜３に示す。フィチン酸の濃度が低くｐＨが３．５より高い組成物は、塗布後時間が経過すると、殺菌又は静菌作用を示さなかった。 The results are shown in Tables 2 and 3. Compositions with a low phytic acid concentration and a pH higher than 3.5 did not show bactericidal or bacteriostatic action over time after application.
試験例３
試験例１と同様の手順で、但し乳化剤の濃度を変えて、表４〜５の液状組成物（溶液）を調製し、殺菌又は静菌特性を評価した。Test example 3
Liquid compositions (solutions) in Tables 4 to 5 were prepared in the same procedure as in Test Example 1 except that the concentration of the emulsifier was changed, and the bactericidal or bacteriostatic properties were evaluated.
結果を表４〜５に示す。いずれの組成物も、塗布直後（０ｈ群）だけでなく、塗布後時間が経過した場合（１８ｈ群）も殺菌又は静菌作用を維持していた。 The results are shown in Tables 4 and 5. All the compositions maintained the bactericidal or bacteriostatic action not only immediately after application (group 0h), but also after a lapse of time after application (group 18h).
試験例４
様々な素材上における液状組成物の殺菌又は静菌作用を調べた。
試験例１と同様の手順で、液状組成物（カプリル酸モノグリセリド ０．１５％、フィチン酸 ０．４０％、エタノール ４０．００％、水 残余；単位は質量％；ｐＨ２．００）、及びサンプル菌液を調製した。
対象素材として、金属（ステンレス板）、ゴム（ゴム手袋）、プラスチック（番重ふた）を準備した。ステンレス板及び番重ふたは、１０ｃｍ四方に切断して使用した。ゴム手袋は、１０ｃｍ四方のプラスチック板に皺のないように伸ばして両面テープで貼り、余った部分はカットして使用した。Test example 4
The bactericidal or bacteriostatic action of the liquid composition on various materials was investigated.
In the same procedure as in Test Example 1, the liquid composition (caprylic acid monoglyceride 0.15%, phytic acid 0.40%, ethanol 40.00%, water balance; unit is% by mass; pH 2.00), and sample bacteria A liquid was prepared.
Metals (stainless steel plate), rubber (rubber gloves), and plastic (banju lid) were prepared as target materials. The stainless steel plate and the lid were cut into 10 cm squares for use. The rubber gloves were stretched on a 10 cm square plastic plate without wrinkles, stuck with double-sided tape, and the remaining portions were cut and used.
菌数の測定は、各素材につき以下の手順で行った。各対象素材を３群に分けた。第一の群では、液状組成物０．５ｍＬをコンラージ棒で対象素材の上に均一に塗布し、次いでサンプル菌液０．１ｍＬを接種し、４０秒間コンラージ棒で混合しながら塗り広げた（０ｈ群）。残りの２群では、液状組成物０．５ｍＬ又は１．０ｍＬを、コンラージ棒で対象素材の上に均一に塗布した後、安全キャビネット内で１８時間風乾し、水分とエタノールを完全に蒸発させた。これにサンプル菌液１．０ｍＬを接種し、４０秒間コンラージ棒で混合しながら塗り広げた（１８ｈ群）。サンプル初発菌数は１０5〜１０6ｃｆｕ/ｍＬに調整した。
サンプル菌液を塗布した対象素材を５分間静置後、無菌パウチに入れ、上から滅菌水１０ｍＬを加え、熱シールして上下に５回程度軽く振った。パウチを開封して中の液体を採取し、ＭＲＳ寒天培地で菌数を測定し、試験例１と同様の基準で殺菌又は静菌特性を評価した。The number of bacteria was measured for each material according to the following procedure. Each target material was divided into three groups. In the first group, 0.5 mL of the liquid composition was uniformly applied on the target material using a conn bar, then 0.1 mL of the sample bacterial solution was inoculated, and spread while mixing with the conn bar for 40 seconds (0 h). group). In the remaining two groups, 0.5 mL or 1.0 mL of the liquid composition was uniformly applied on the target material with a contra rod, and then air-dried in a safety cabinet for 18 hours to completely evaporate the water and ethanol. . This was inoculated with 1.0 mL of the sample bacterial solution, and spread while mixing with a conical rod for 40 seconds (18 h group). The initial bacterial count of the sample was adjusted to 10 5 to 10 6 cfu / mL.
After the target material coated with the sample bacterial solution was allowed to stand for 5 minutes, it was placed in a sterile pouch, 10 mL of sterile water was added from above, heat sealed, and lightly shaken up and down five times. The pouch was opened, the liquid inside was collected, the number of bacteria was measured on an MRS agar medium, and the bactericidal or bacteriostatic properties were evaluated according to the same criteria as in Test Example 1.
結果を表６に示す。本発明の組成物が、塗布直後（０ｈ群）及び塗布後時間が経過した場合（１８ｈ群）のいずれにおいても、各種素材の殺菌又は静菌に有効であることが分かった。 Table 6 shows the results. It was found that the composition of the present invention was effective in sterilizing or bacteriostatic various materials both immediately after application (group 0h) and when the time elapsed after application (group 18h).
Claims (38)
該液状組成物が、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、
殺菌又は静菌方法。Spraying or applying the liquid composition to the subject, or immersing the subject in the liquid composition,
The liquid composition contains an emulsifier and phytic acid, and has a pH of 3.5 or less;
Sterilization or bacteriostatic method.
該液状組成物が、乳化剤とフィチン酸とを含み、かつｐＨ３．５以下である、
対象への抗菌性付与方法。Spraying or applying the liquid composition to the subject, or immersing the subject in the liquid composition,
The liquid composition contains an emulsifier and phytic acid, and has a pH of 3.5 or less;
A method for imparting antimicrobial properties to a subject.
38. Use according to any one of claims 22 to 37, wherein the liquid composition further comprises an aqueous solvent.
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| JPH07298862A (en) * | 1994-05-10 | 1995-11-14 | Okuno Chem Ind Co Ltd | Alcohol preparation for sterilization at low temperature and sterilizing method |
| JPH09502608A (en) * | 1993-09-14 | 1997-03-18 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | Fungicide composition |
| JPH1192306A (en) * | 1997-09-16 | 1999-04-06 | Riken Vitamin Co Ltd | Antimicrobial agent for fiber and antimicrobial and deodorizing-processed textile product |
| JP2003183105A (en) * | 2001-12-20 | 2003-07-03 | Ueno Seiyaku Oyo Kenkyusho:Kk | Sterilizer composition |
| JP2012162480A (en) * | 2011-02-05 | 2012-08-30 | Riken Vitamin Co Ltd | Antibacterial agent for methicillin-resistant staphylococcus aureus |
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| JPH07298862A (en) * | 1994-05-10 | 1995-11-14 | Okuno Chem Ind Co Ltd | Alcohol preparation for sterilization at low temperature and sterilizing method |
| JPH1192306A (en) * | 1997-09-16 | 1999-04-06 | Riken Vitamin Co Ltd | Antimicrobial agent for fiber and antimicrobial and deodorizing-processed textile product |
| JP2003183105A (en) * | 2001-12-20 | 2003-07-03 | Ueno Seiyaku Oyo Kenkyusho:Kk | Sterilizer composition |
| JP2012162480A (en) * | 2011-02-05 | 2012-08-30 | Riken Vitamin Co Ltd | Antibacterial agent for methicillin-resistant staphylococcus aureus |
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