JPWO2018061854A1 - Cosmetic composition - Google Patents
Cosmetic composition Download PDFInfo
- Publication number
- JPWO2018061854A1 JPWO2018061854A1 JP2018542415A JP2018542415A JPWO2018061854A1 JP WO2018061854 A1 JPWO2018061854 A1 JP WO2018061854A1 JP 2018542415 A JP2018542415 A JP 2018542415A JP 2018542415 A JP2018542415 A JP 2018542415A JP WO2018061854 A1 JPWO2018061854 A1 JP WO2018061854A1
- Authority
- JP
- Japan
- Prior art keywords
- component
- mass
- cosmetic composition
- cosmetics
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 121
- 239000000203 mixture Substances 0.000 title claims abstract description 100
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229930182558 Sterol Natural products 0.000 claims abstract description 28
- 235000003702 sterols Nutrition 0.000 claims abstract description 28
- 150000003432 sterols Chemical class 0.000 claims abstract description 27
- -1 Polyoxyethylene Polymers 0.000 claims abstract description 24
- 229940106189 ceramide Drugs 0.000 claims abstract description 23
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 19
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 18
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 18
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 18
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 18
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 12
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract description 4
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- 238000002834 transmittance Methods 0.000 claims description 11
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 3
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- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 3
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- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 3
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
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- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
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- 229940083466 soybean lecithin Drugs 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
本発明は、下記成分A〜Fを含有し、上記成分Aに対する上記成分Bの質量比(B/A)が5.5〜18.0である、化粧料用組成物に関する;成分A:リン脂質;成分B:オキシエチレンの平均付加モル数が15〜50のポリオキシエチレンステロールエーテル及び/又はオキシエチレンの平均付加モル数が15〜50のポリオキシエチレンスタノールエーテル;成分C:分岐鎖を有する炭素数12〜24の1価の脂肪族アルコール;成分D:プロピレングリコール、ジプロピレングリコール及び1,3−ブチレングリコールからなる群より選ばれた一種以上の多価アルコール;成分E:水;成分F:セラミド及び/又はステロール。本発明の化粧料用組成物は、そのまま化粧料として、あるいは化粧水等への配合成分として使用することができる。 The present invention relates to a cosmetic composition containing the following components A to F and having a mass ratio (B / A) of the component B to the component A of 5.5 to 18.0; Lipid; Component B: Polyoxyethylene sterol ether having an average addition mole number of oxyethylene of 15 to 50 and / or Polyoxyethylene stanol ether having an average addition mole number of oxyethylene of 15 to 50; Component C: having a branched chain Monovalent aliphatic alcohol having 12 to 24 carbon atoms; Component D: One or more polyhydric alcohols selected from the group consisting of propylene glycol, dipropylene glycol and 1,3-butylene glycol; Component E: Water; Component F : Ceramide and / or sterol. The cosmetic composition of the present invention can be used as it is as a cosmetic or as a component for incorporation into a lotion.
Description
本発明はセラミド及び/又はステロールを含有する化粧料用組成物に関する。 The present invention relates to a cosmetic composition containing ceramide and / or sterol.
セラミドやステロールは皮膚のバリア機能に大きく寄与していることから、従来より化粧料への配合が試みられてきた。セラミドやステロールは水に難溶性であることから、水系の化粧料に配合する場合には、油剤に溶解させた後に乳化する、乳化系で用いられることが一般的である。例えば、特許文献1には、セラミド類を含有する皮膚用乳化化粧料が開示されている。また、特許文献2には、ステロール類化合物が配合された皮膚外用剤として、クリームや乳液が開示されている。 Ceramides and sterols have greatly contributed to the barrier function of the skin, and thus have been conventionally tried to be incorporated into cosmetics. Since ceramides and sterols are hardly soluble in water, when they are blended in water-based cosmetics, they are generally used in an emulsification system in which they are emulsified after being dissolved in an oil. For example, Patent Document 1 discloses an emulsified cosmetic for skin containing ceramides. Patent Document 2 discloses creams and emulsions as external preparations for skin containing a sterol compound.
しかしながら、セラミドやステロールを用いて透明な水系化粧料を調製することは極めて困難であった。加えて、セラミドやステロールは保存安定性が悪く析出を起こし易いという問題があった。特に、低粘度のローション剤型へのこれらの成分の配合は非常に困難であった。 However, it has been extremely difficult to prepare a transparent water-based cosmetic using ceramide or sterol. In addition, ceramide and sterol have a problem of poor storage stability and easy precipitation. In particular, it was very difficult to blend these components into a low viscosity lotion dosage form.
本発明の課題は、セラミドやステロールを含む化粧料用組成物であって、透明性及び保存安定性に優れる化粧料用組成物を提供することである。 An object of the present invention is to provide a cosmetic composition containing ceramide or sterol, which is excellent in transparency and storage stability.
即ち、本発明は、
下記成分Aと、下記成分Bと、下記成分Cと、下記成分Dと、下記成分Eと、下記成分Fとを含有し、
上記成分Aに対する上記成分Bの質量比(B/A)が5.5〜18.0である、化粧料用組成物に関する。
成分A:リン脂質
成分B:オキシエチレンの平均付加モル数が15〜50のポリオキシエチレンステロールエーテル及び/又はオキシエチレンの平均付加モル数が15〜50のポリオキシエチレンスタノールエーテル
成分C:分岐鎖を有する炭素数12〜24の1価の脂肪族アルコール
成分D:プロピレングリコール、ジプロピレングリコール及び1,3−ブチレングリコールからなる群より選ばれた一種以上の多価アルコール
成分E:水
成分F:セラミド及び/又はステロールThat is, the present invention
Contains the following component A, the following component B, the following component C, the following component D, the following component E, and the following component F,
It is related with the composition for cosmetics whose mass ratio (B / A) of the said component B with respect to the said component A is 5.5-18.0.
Component A: Phospholipid Component B: Polyoxyethylene sterol ether having an average addition mole number of oxyethylene of 15 to 50 and / or polyoxyethylene stanol ether having an average addition mole number of oxyethylene of 15 to 50 Component C: Branched chain C12-24 monovalent aliphatic alcohol having a component D: One or more polyhydric alcohols selected from the group consisting of propylene glycol, dipropylene glycol and 1,3-butylene glycol Component E: Water Component F: Ceramide and / or sterol
本発明によれば、セラミドやステロールを含む化粧料用組成物であって、透明性及び保存安定性に優れる化粧料用組成物を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, it is a composition for cosmetics containing ceramide and sterol, Comprising: The composition for cosmetics excellent in transparency and storage stability can be provided.
本発明の化粧料用組成物は、成分A〜Fを含有する化粧料用組成物である。 The cosmetic composition of the present invention is a cosmetic composition containing components A to F.
成分Aは「リン脂質」である。成分Aは、後述する成分Fとの親和性が高いため、保存安定性を向上させることができる。また、成分Aは、界面相互作用が強いため、成分Aを用いた化粧料組成物を希釈する場合に、安定性の低下が生じないため好ましい。 Component A is a “phospholipid”. Since component A has high affinity with component F described later, storage stability can be improved. In addition, Component A is preferable because it has strong interfacial interaction, and therefore, when a cosmetic composition using Component A is diluted, stability does not decrease.
成分Aとしては、リン酸残基を含む複合脂質であって、天然リン脂質、合成リン脂質、天然由来のリン脂質の不飽和炭素鎖を水素により飽和とした水素添加リン脂質等が挙げられる。上記リン脂質としては、例えば、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルイノシトール、リゾホスファチジルコリン、スフィンゴミエリン、卵黄レシチン、大豆レシチン等の天然リン脂質;ジラウロイルホスファチジルコリン、ジミリストイルホスファチジルコリン、ジパルミトイルホスファチジルコリン、ジステアロイルホスファチジルコリン、ジオレオイルホスファチジルコリン、パルミトイル・オレオイルホスファチジルコリン等の合成リン脂質;水素添加大豆レシチン、水素添加卵黄レシチン、水素添加ホスファチジルコリン、水素添加ホスファチジルセリン等の水素添加リン脂質等が挙げられる。このうち、保存安定性に優れる観点から、水素添加リン脂質が好ましく、水素添加大豆レシチンがより好ましい。成分Aは、1種のみを用いてもよいし、2種以上を用いてもよい。 Component A is a complex lipid containing a phosphate residue, and includes natural phospholipids, synthetic phospholipids, hydrogenated phospholipids in which unsaturated carbon chains of naturally derived phospholipids are saturated with hydrogen, and the like. Examples of the phospholipid include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin, soybean lecithin, and the like; dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, Examples include synthetic phospholipids such as stearoyl phosphatidylcholine, dioleoylphosphatidylcholine, palmitoyl oleoylphosphatidylcholine; hydrogenated phospholipids such as hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated phosphatidylcholine, and hydrogenated phosphatidylserine. Among these, from the viewpoint of excellent storage stability, hydrogenated phospholipid is preferable, and hydrogenated soybean lecithin is more preferable. Component A may be used alone or in combination of two or more.
成分Aとして市販品を用いてもよい。水素添加大豆レシチンの市販品としては、例えば、COATSOME NC−21(商品名、日油社製)、COATSOME NC−61(商品名、日油社製)、NIKKOL レシノールS−10EX(商品名、日光ケミカルズ社製)、NIKKOL レシノールS−10E(商品名、日光ケミカルズ社製)、NIKKOL レシノールS−10M(商品名、日光ケミカルズ社製)、ベイシス LS−60HR(商品名、日清オイリオグループ社製)等が挙げられる。 A commercial item may be used as component A. Examples of commercially available hydrogenated soybean lecithin include COATSOME NC-21 (trade name, manufactured by NOF Corporation), COATSOME NC-61 (trade name, manufactured by NOF Corporation), NIKKOL lecinol S-10EX (trade name, Nikko). Chemicals), NIKKOL Resinol S-10E (trade name, manufactured by Nikko Chemicals), NIKKOL Resinol S-10M (trade name, manufactured by Nikko Chemicals), Basis LS-60HR (trade name, manufactured by Nisshin Oillio Group) Etc.
本発明の化粧料用組成物100質量%中の成分Aの含有量は、十分な量の成分Fを安定に分散させる観点や保存安定性の観点から0.005質量%以上が好ましく、より好ましくは0.1質量%以上、さらに好ましくは0.2質量%以上であり、過度の粘度上昇を抑制し分散性を向上させる観点から、3.0質量%以下が好ましく、より好ましくは2.0質量%以下、さらに好ましくは1.5質量%以下である。なお、成分Aの含有量は、本発明の化粧料用組成物中に含まれる全ての成分Aの合計量である。 The content of Component A in 100% by mass of the cosmetic composition of the present invention is preferably 0.005% by mass or more, more preferably from the viewpoint of stably dispersing a sufficient amount of Component F and storage stability. Is 0.1% by mass or more, more preferably 0.2% by mass or more. From the viewpoint of suppressing an excessive increase in viscosity and improving dispersibility, 3.0% by mass or less is preferable, and more preferably 2.0%. It is not more than mass%, more preferably not more than 1.5 mass%. In addition, content of the component A is a total amount of all the components A contained in the composition for cosmetics of this invention.
成分Bは「オキシエチレンの平均付加モル数が15〜50のポリオキシエチレンステロールエーテル及び/又はオキシエチレンの平均付加モル数が15〜50のポリオキシエチレンスタノールエーテル」である。即ち、成分Bは、上記ポリオキシエチレンステロールエーテル及び上記ポリオキシエチレンスタノールエーテルのうちのいずれか一方又は両方である。成分Bは成分Aとの親和性が高く、形成されるミセルを安定化し、細かくすることができる。成分Bとしては、酸化安定性の観点から、ポリオキシエチレンスタノールエーテルがより好ましい。 Component B is “polyoxyethylene sterol ether having an average addition mole number of oxyethylene of 15 to 50 and / or polyoxyethylene stanol ether having an average addition mole number of oxyethylene of 15 to 50”. That is, Component B is one or both of the polyoxyethylene sterol ether and the polyoxyethylene stanol ether. Component B has a high affinity with Component A, and can stabilize and refine the micelles formed. Component B is more preferably polyoxyethylene stanol ether from the viewpoint of oxidation stability.
ポリオキシエチレンステロールエーテル又はポリオキシエチレンスタノールエーテルとは、ステロール又はスタノールにオキシエチレンを付加させたものである。ステロール又はスタノールに付加させるオキシエチレンの平均付加モル数は15〜50であり、20〜30が好ましい。 Polyoxyethylene sterol ether or polyoxyethylene stanol ether is obtained by adding oxyethylene to sterol or stanol. The average number of moles of oxyethylene added to sterol or stanol is 15 to 50, preferably 20 to 30.
成分Bとしては、例えば、ポリオキシエチレンフィトステロールエーテル、ポリオキシエチレンフィトスタノールエーテル、ポリオキシエチレンコレステロールエーテル、ポリオキシエチレンコレスタノールエーテル等が挙げられる。このうち、植物性である観点から、ポリオキシエチレンフィトステロールエーテル、ポリオキシエチレンフィトスタノールエーテルが好ましい。成分Bは、1種のみを用いてもよいし、2種以上を用いてもよい。 Examples of component B include polyoxyethylene phytosterol ether, polyoxyethylene phytostanol ether, polyoxyethylene cholesterol ether, polyoxyethylene cholestanol ether, and the like. Of these, polyoxyethylene phytosterol ether and polyoxyethylene phytostanol ether are preferred from the viewpoint of plant nature. Component B may use only 1 type and may use 2 or more types.
成分Bとして市販品を用いてもよい。成分Bの市販品としては、例えば、NIKKOL BPS−20(商品名、日光ケミカルズ社製)、NIKKOL BPS−30(商品名、日光ケミカルズ社製)、NIKKOL BPSH−25(商品名、日光ケミカルズ社製)等が挙げられる。 A commercial item may be used as component B. As a commercial item of component B, for example, NIKKOL BPS-20 (trade name, manufactured by Nikko Chemicals), NIKKOL BPS-30 (trade name, manufactured by Nikko Chemicals), NIKKOL BPSH-25 (trade name, manufactured by Nikko Chemicals) ) And the like.
本発明の化粧料用組成物100質量%中の成分Bの含有量は、透明性及び保存安定性の観点から0.03質量%以上が好ましく、より好ましくは1.0質量%以上であり、過度の粘度上昇を抑制し分散性を向上させる観点から、15.0質量%以下が好ましく、より好ましくは10.0質量%以下、さらに好ましくは8.0質量%以下である。なお、成分Bの含有量は、本発明の化粧料用組成物中に含まれる全ての成分Bの合計量である。 The content of Component B in 100% by mass of the cosmetic composition of the present invention is preferably 0.03% by mass or more, more preferably 1.0% by mass or more from the viewpoint of transparency and storage stability. From the viewpoint of suppressing an excessive increase in viscosity and improving dispersibility, it is preferably 15.0% by mass or less, more preferably 10.0% by mass or less, and still more preferably 8.0% by mass or less. In addition, content of the component B is the total amount of all the components B contained in the composition for cosmetics of this invention.
本発明の化粧料用組成物中の、成分Aに対する成分Bの質量比(B/A)は、透明性及び保存安定性の観点から5.5以上であり、好ましくは6.0以上、より好ましくは7.0以上であり、18.0以下であり、好ましくは15.0以下、より好ましくは10.0以下である。成分Aは極性が低いためミセルの粒径が大きくなり、成分Aを含む組成物の透明性が低下する傾向にあった。本発明においては、極性の高い界面活性剤成分である成分Bを上記質量比の範囲で併用することにより、ミセルを形成する膜の曲率が大きくなり、ミセルを微細化できる。これにより、透明性及び保存安定性が共に向上する。 The mass ratio (B / A) of component B to component A in the cosmetic composition of the present invention is 5.5 or more, preferably 6.0 or more, from the viewpoint of transparency and storage stability. Preferably it is 7.0 or more and 18.0 or less, Preferably it is 15.0 or less, More preferably, it is 10.0 or less. Since component A has low polarity, the particle size of micelles was increased, and the transparency of the composition containing component A tended to decrease. In the present invention, by using together component B, which is a highly polar surfactant component, in the above mass ratio range, the curvature of the film forming the micelle is increased and the micelle can be made finer. Thereby, both transparency and storage stability are improved.
成分Cは「分岐鎖を有する炭素数12〜24の1価の脂肪族アルコール」である。成分Cを使用することにより、成分Fの結晶化を抑制し、高温及び低温での析出を抑止し、保存安定性向上を達成できる。 Component C is a “branched monovalent aliphatic alcohol having 12 to 24 carbon atoms”. By using component C, crystallization of component F can be suppressed, precipitation at high and low temperatures can be suppressed, and storage stability can be improved.
成分Cとしては、例えば、オクチルドデカノール、デシルテトラデカノール、イソステアリルアルコール等が挙げられる。中でも、成分Fの結晶化の抑制効果が高いため、オクチルドデカノール、デシルテトラデカノールが好ましい。成分Cは、1種のみを用いてもよいし、2種以上を用いてもよい。 Examples of component C include octyldodecanol, decyltetradecanol, and isostearyl alcohol. Among them, octyldodecanol and decyltetradecanol are preferable because the effect of suppressing the crystallization of component F is high. Component C may use only 1 type and may use 2 or more types.
本発明の化粧料用組成物100質量%中の成分Cの含有量は、保存安定性の観点から0.005質量%以上が好ましく、より好ましくは0.05質量%以上、さらに好ましくは0.1質量%以上であり、透明性を向上する観点から、0.5質量%以下が好ましく、より好ましくは0.4質量%以下である。なお、成分Cの含有量は、本発明の化粧料用組成物中に含まれる全ての成分Cの合計量である。 The content of Component C in 100% by mass of the cosmetic composition of the present invention is preferably 0.005% by mass or more, more preferably 0.05% by mass or more, and still more preferably 0.005% by mass from the viewpoint of storage stability. It is 1 mass% or more, and 0.5 mass% or less is preferable from a viewpoint of improving transparency, More preferably, it is 0.4 mass% or less. In addition, content of the component C is a total amount of all the components C contained in the composition for cosmetics of this invention.
本発明の化粧料用組成物中の、成分Aに対する成分Cの質量比(C/A)は、保存安定性の観点から0.05以上が好ましく、より好ましくは0.1以上、さらに好ましくは0.15以上であり、透明性の観点から1.0以下が好ましく、より好ましくは0.7以下、さらに好ましくは0.5以下である。 In the cosmetic composition of the present invention, the mass ratio of component C to component A (C / A) is preferably 0.05 or more, more preferably 0.1 or more, and still more preferably from the viewpoint of storage stability. It is 0.15 or more, and 1.0 or less is preferable from the viewpoint of transparency, more preferably 0.7 or less, and still more preferably 0.5 or less.
成分Dは「プロピレングリコール、ジプロピレングリコール及び1,3−ブチレングリコールからなる群より選ばれた一種以上の多価アルコール」である。成分Dは化粧料用組成物の製造時の、油性成分の溶媒として機能する。特に、成分Dの特定3成分を用いることにより、他の成分を分散した場合の分散液の粘度上昇が抑えられ、分散性が向上する。成分Dは、1種のみを用いてもよいし、2種以上を用いてもよい。 Component D is “one or more polyhydric alcohols selected from the group consisting of propylene glycol, dipropylene glycol and 1,3-butylene glycol”. Component D functions as a solvent for the oil component during the production of the cosmetic composition. In particular, by using the specific three components of component D, an increase in the viscosity of the dispersion when other components are dispersed is suppressed, and dispersibility is improved. Component D may use only 1 type and may use 2 or more types.
本発明の化粧料用組成物100質量%中の成分Dの含有量は、透明性及び保存安定性の観点から0.25質量%以上が好ましく、より好ましくは3.0質量%以上、さらに好ましくは5.0質量%以上であり、30.0質量%以下が好ましく、より好ましくは25.0質量%以下、さらに好ましくは20.0質量%以下である。なお、成分Dの含有量は、本発明の化粧料用組成物中に含まれる全ての成分Dの合計量である。 The content of Component D in 100% by mass of the cosmetic composition of the present invention is preferably 0.25% by mass or more, more preferably 3.0% by mass or more, and still more preferably from the viewpoints of transparency and storage stability. Is 5.0% by mass or more, preferably 30.0% by mass or less, more preferably 25.0% by mass or less, and further preferably 20.0% by mass or less. In addition, content of the component D is the total amount of all the components D contained in the composition for cosmetics of this invention.
本発明の化粧料用組成物中の、成分Aに対するDの質量比(D/A)は、化粧料用組成物の白濁防止の観点から8.0以上が好ましく、より好ましくは10.0以上であり、60.0以下が好ましく、より好ましくは30.0以下、さらに好ましくは20.0以下である。 In the cosmetic composition of the present invention, the mass ratio of D to component A (D / A) is preferably 8.0 or more, more preferably 10.0 or more, from the viewpoint of preventing white turbidity of the cosmetic composition. And is preferably 60.0 or less, more preferably 30.0 or less, and still more preferably 20.0 or less.
成分Eは「水」である。水を使用することにより、本発明の化粧料用組成物にさっぱり感を付与することができ、さらには本発明の化粧料用組成物を水系ローション等の化粧料に適用することができる。 Component E is “water”. By using water, a refreshing feeling can be imparted to the cosmetic composition of the present invention, and furthermore, the cosmetic composition of the present invention can be applied to cosmetics such as aqueous lotions.
本発明の化粧料用組成物100質量%中の成分Eの含有量は、特に限定されるものではないが、水系ローションへ適用する際の簡便性及びさっぱりとした使用感の観点から、55.0質量%以上が好ましく、より好ましくは60.0質量%以上、さらに好ましくは65.0質量%以上であり、95.0質量%以下が好ましく、より好ましくは90.0質量%以下、さらに好ましくは85.0質量%以下である。 The content of component E in 100% by mass of the cosmetic composition of the present invention is not particularly limited, but from the viewpoint of simplicity when applied to an aqueous lotion and a refreshed feeling of use, 55. It is preferably 0% by mass or more, more preferably 60.0% by mass or more, further preferably 65.0% by mass or more, preferably 95.0% by mass or less, more preferably 90.0% by mass or less, still more preferably. Is 85.0 mass% or less.
成分Fは「セラミド及び/又はステロール」である。成分Fは皮膚のバリア機能向上等のための有効成分として配合される。即ち、成分Fは、セラミド及びステロールのうちのいずれか一方又は両方である。 Component F is “ceramide and / or sterol”. Component F is blended as an active ingredient for improving the skin barrier function. That is, the component F is one or both of ceramide and sterol.
上記セラミドとしては、例えば、スフィンゴシン、フィトスフィンゴシン;スフィンゴシン、フィトスフィンゴシンの長鎖脂肪酸アミドであるセラミド1、セラミド2、セラミド3、セラミド3B、セラミド4、セラミド5、セラミド6、セラミド6I、セラミド6II等の天然セラミド類;スフィンゴシン、フィトスフィンゴシンのリン脂質誘導体であるスフィンゴミエリン、フィトスフィンゴミエリン等のスフィンゴリン脂質及びフィトスフィンゴリン脂質;スフィンゴシン、フィトスフィンゴシンの配糖体であるセレブロシド、ガングリオシド等のスフィンゴ糖脂質及びフィトスフィンゴ糖脂質等が挙げられる。セラミドは、1種のみを用いてもよいし、2種以上を用いてもよい。 Examples of the ceramide include sphingosine, phytosphingosine; sphingosine, ceramide 1, ceramide 2, ceramide 3, ceramide 3B, ceramide 4, ceramide 5, ceramide 6, ceramide 6I, ceramide 6II, and the like, which are long-chain fatty acid amides of phytosphingosine. Natural ceramides; sphingosine, phospholipid derivatives of sphingosine, phytosphingomyelin, sphingophospholipids such as phytosphingomyelin, and phytosphingophospholipid; And phytosphingoglycolipids. Only one type of ceramide may be used, or two or more types may be used.
セラミドとして市販品を用いてもよい。セラミドの市販品としては、例えば、CERAMIDE 2(商品名、クローダジャパン社製)、CERAMIDE I(商品名、Evonik Nutrition & Care GmbH社製)、CERAMIDE III(商品名、Evonik Nutrition & Care GmbH社製)、CERAMIDE IIIB(商品名、Evonik Nutrition & Care GmbH社製)、CERAMIDE IV(商品名、Evonik Nutrition & Care GmbH社製)、CERAMIDE TIC−001(商品名、高砂香料H社製)等が挙げられる。 A commercially available product may be used as ceramide. Examples of commercially available ceramides include CERAMIDE 2 (trade name, manufactured by Croda Japan), CERAMIDE I (trade name, manufactured by Evonik Nutrition & Care GmbH), and CERAMIDE III (trade name, manufactured by Evonik Nutrition & Care GmbH). CERAMIDE IIIB (trade name, manufactured by Evonik Nutrition & Care GmbH), CERAMIDE IV (trade name, manufactured by Evonik Nutrition & Care GmbH), CERAMIDE TIC-001 (trade name, manufactured by Takasago Inc.)
上記ステロールとしては、例えば、動物ステロール、植物ステロール(フィトステロール)等が挙げられる。動物ステロールとしては、例えば、コレステロール、コレスタノール、7−デヒドロコレステロール等が挙げられる。また、植物ステロールとしては、例えば、シトステロール、スチグマステロール、フコステロール、スピナステロール、ブラシカステロール等が挙げられる。ステロールは、1種のみを用いてもよいし、2種以上を用いてもよい。 Examples of the sterol include animal sterols and plant sterols (phytosterols). Examples of animal sterols include cholesterol, cholestanol, 7-dehydrocholesterol and the like. Examples of plant sterols include sitosterol, stigmasterol, fucosterol, spinasterol, and brush castrol. Only one type of sterol may be used, or two or more types may be used.
ステロールとして市販品を用いてもよい。ステロールの市販品としては、例えば、コレステロールJSQI(商品名、日本精化社製)、日本薬局方コレステロール(商品名、日本精化社製)、フィトステロール(商品名、エーザイフード・ケミカル社製)、フィトステロール−SKP(商品名、タマ生化学社製)等が挙げられる。 A commercially available product may be used as the sterol. Examples of commercially available sterols include cholesterol JSQI (trade name, manufactured by Nippon Seika Co., Ltd.), Japanese Pharmacopoeia cholesterol (trade name, manufactured by Nippon Seika Co., Ltd.), phytosterol (trade name, manufactured by Eisai Food Chemical Co., Ltd.), And phytosterol-SKP (trade name, manufactured by Tama Seikagaku Co., Ltd.).
本発明の化粧料用組成物100質量%中の成分Fの含有量は、皮膚にバリア機能等を付与する観点から0.01質量%以上が好ましく、より好ましくは0.1質量%以上、さらに好ましくは0.2質量%以上であり、析出の抑制、保存安定性向上の観点から、2.0質量%以下が好ましく、より好ましくは1.0質量%以下、さらに好ましくは0.6質量%以下である。なお、成分Fの含有量は、本発明の化粧料用組成物中に含まれる全ての成分Fの合計量である。 The content of component F in 100% by mass of the cosmetic composition of the present invention is preferably 0.01% by mass or more, more preferably 0.1% by mass or more from the viewpoint of imparting a barrier function or the like to the skin. Preferably, it is 0.2% by mass or more, and from the viewpoint of suppressing precipitation and improving storage stability, it is preferably 2.0% by mass or less, more preferably 1.0% by mass or less, and further preferably 0.6% by mass. It is as follows. In addition, content of the component F is the total amount of all the components F contained in the composition for cosmetics of this invention.
本発明の化粧料用組成物は、さらに成分Gとして「炭素数5〜10の1,2−アルカンジオール」を含有することができる。成分Gを化粧料用組成物に使用することで透明性をさらに向上できる。成分Gとしては、例えば、1,2−ペンタンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール、1,2−デカンジオール等が挙げられる。成分Gは、1種のみを用いてもよいし、2種以上を用いてもよい。 The cosmetic composition of the present invention may further contain “1,2-alkanediol having 5 to 10 carbon atoms” as component G. Transparency can be further improved by using Component G in a cosmetic composition. Examples of component G include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and the like. Component G may be used alone or in combination of two or more.
本発明の化粧料用組成物100質量%中の成分Gの含有量は、透明性の観点から、0.01質量%以上が好ましく、より好ましくは0.1質量%以上、さらに好ましくは0.2質量%以上であり、低刺激性の観点から、2.0質量%以下が好ましく、より好ましくは1.0質量%以下、さらに好ましくは0.7質量%以下である。なお、成分Gの含有量は、本発明の化粧料用組成物中に含まれる全ての成分Gの合計量である。 From the viewpoint of transparency, the content of component G in 100% by mass of the cosmetic composition of the present invention is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and still more preferably 0.8%. From the viewpoint of low irritation, it is preferably 2.0% by mass or less, more preferably 1.0% by mass or less, and still more preferably 0.7% by mass or less. In addition, content of the component G is a total amount of all the components G contained in the composition for cosmetics of this invention.
本発明の化粧料用組成物は、さらに成分Hとして「グリセリンモノ2−エチルヘキシルエーテル」(「オクトキシグリセリン」とも称される。)を含有することができる。成分Hを化粧料用組成物に使用することで透明性をさらに向上できる。 The cosmetic composition of the present invention may further contain “glycerin mono 2-ethylhexyl ether” (also referred to as “octoxyglycerin”) as component H. Transparency can be further improved by using Component H in a cosmetic composition.
本発明の化粧料用組成物100質量%中の成分Hの含有量は、透明性の観点から、0.01質量%以上が好ましく、より好ましくは0.05質量%以上、さらに好ましくは0.1質量%以上であり、低刺激性の観点から、2.0質量%以下が好ましく、より好ましくは1.5質量%以下、さらに好ましくは1.0質量%以下である。 From the viewpoint of transparency, the content of component H in 100% by mass of the cosmetic composition of the present invention is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and still more preferably 0.8%. From the viewpoint of low irritation, it is preferably 2.0% by mass or less, more preferably 1.5% by mass or less, and still more preferably 1.0% by mass or less.
本発明の化粧料用組成物には、上記A〜H以外の成分がさらに含有されていても良い。上記成分としては、特に限定されないが、例えば、界面活性剤(カチオン界面活性剤、アニオン界面活性剤、両性界面活性剤等)、エステル油、油脂、炭化水素油、ロウ、高級脂肪酸、シリコーン油、低級アルコール、高級アルコール、多価アルコール、紫外線吸収剤、粉体、酸化防止剤、防腐剤、香料、着色剤、キレート剤、清涼剤、増粘剤、ビタミン類、中和剤、アミノ酸、pH調整剤、美白剤、抗炎症剤、消臭剤、動植物抽出物、金属イオン封鎖剤などの添加剤などが挙げられる。上記A〜H以外の成分は、1種のみを用いてもよいし、2種以上を用いてもよい。 The cosmetic composition of the present invention may further contain components other than the above A to H. Although it does not specifically limit as said component, For example, surfactant (cationic surfactant, anionic surfactant, amphoteric surfactant etc.), ester oil, fats and oils, hydrocarbon oil, wax, higher fatty acid, silicone oil, Lower alcohol, higher alcohol, polyhydric alcohol, UV absorber, powder, antioxidant, preservative, fragrance, colorant, chelating agent, cooling agent, thickener, vitamins, neutralizing agent, amino acid, pH adjustment And additives such as agents, whitening agents, anti-inflammatory agents, deodorants, animal and plant extracts, and sequestering agents. Only 1 type may be used for components other than said AH, and 2 or more types may be used for it.
本発明の化粧料用組成物は、美観の観点や保存安定性向上、希釈時の安定性向上の観点から、透明の状態のものが好ましい。本明細書における化粧料用組成物の透明性は、後述の実施例に記載の方法で測定される透過率で評価することができる。化粧料用組成物の透過率が高いほど、即ち100%に近いほど、化粧料用組成物が透明であることを意味し、望ましい。本発明の化粧料用組成物においては、透過率が90.0%以上が好ましく、92.0%以上がより好ましく、95.0%以上がさらに好ましい。 The cosmetic composition of the present invention is preferably in a transparent state from the viewpoint of aesthetics, improved storage stability, and improved stability upon dilution. The transparency of the cosmetic composition in the present specification can be evaluated by the transmittance measured by the method described in the examples described later. The higher the transmittance of the cosmetic composition, that is, the closer to 100%, the more transparent the cosmetic composition is, which is desirable. In the cosmetic composition of the present invention, the transmittance is preferably 90.0% or more, more preferably 92.0% or more, and further preferably 95.0% or more.
本発明の化粧料用組成物のpHは特に限定されないが、例えば、25℃において5.0〜8.0であることが好ましい。 The pH of the cosmetic composition of the present invention is not particularly limited, but is preferably 5.0 to 8.0 at 25 ° C, for example.
本発明の化粧料用組成物の粘度は特に限定されないが、例えば、25℃での粘度が0.5〜1000mPa・sであることが好ましく、0.5〜500mPa・sであることがより好ましい。粘度測定はB型粘度計を用い、粘度に合ったローターを選択し、回転数60r/minで実施する。 The viscosity of the cosmetic composition of the present invention is not particularly limited. For example, the viscosity at 25 ° C. is preferably 0.5 to 1000 mPa · s, and more preferably 0.5 to 500 mPa · s. . Viscosity measurement is performed using a B-type viscometer, selecting a rotor that matches the viscosity, and rotating at a rotational speed of 60 r / min.
本発明の化粧料用組成物は、常法により製造することができる。例えば、成分A、成分B、成分C、成分D及び成分F(必要により、さらに成分G及び/又は成分H)を加温溶解し、得られた溶解物と、加温した成分Eとを混合する方法により製造することができる。上記加温の際の温度は、80〜90℃が好ましい。 The cosmetic composition of the present invention can be produced by a conventional method. For example, component A, component B, component C, component D and component F (optionally further component G and / or component H) are dissolved by heating, and the resulting lysate and heated component E are mixed. It can manufacture by the method to do. As for the temperature in the case of the said heating, 80-90 degreeC is preferable.
本発明の化粧料用組成物中においては、リン脂質はミセルを形成しており、リポソームを形成していないことが好ましい。即ち、本発明の化粧料用組成物は、リン脂質から形成されたリポソームを含有していない非リポソーム組成物であることが好ましい。本発明の化粧料用組成物は、リポソーム組成物よりも透明性に優れているため好ましい。 In the cosmetic composition of the present invention, the phospholipid preferably forms micelles and does not form liposomes. That is, the cosmetic composition of the present invention is preferably a non-liposome composition not containing liposomes formed from phospholipids. The cosmetic composition of the present invention is preferable because it is more transparent than the liposome composition.
本発明の化粧料用組成物を、化粧料に使用される成分と共に混合等することによって、化粧水等の化粧料を製造することができる。即ち、本発明の化粧料用組成物は、化粧料の製造に用いる原料(所謂、中間原料)とすることができる。本発明の化粧料用組成物を用いることにより、水系や低粘度の分散媒にも安定して分散させることができるため、成分Fを簡便且つ安定して化粧料中に配合させることができる。また、本発明の化粧料用組成物は、それ自体で化粧料として使用することもできる。 Cosmetics such as skin lotions can be produced by mixing the cosmetic composition of the present invention with components used in cosmetics. That is, the cosmetic composition of the present invention can be used as a raw material (so-called intermediate raw material) used in the production of cosmetics. By using the cosmetic composition of the present invention, it can be stably dispersed in a water-based or low-viscosity dispersion medium, so that component F can be easily and stably blended in the cosmetic. Moreover, the cosmetic composition of the present invention can be used as a cosmetic by itself.
本発明においては、上記の本発明の化粧料組成物を含有する化粧料が得られる。なお、本明細書においては、上記「本発明の化粧料組成物を含有する化粧料」を「本発明の化粧料」と称する場合がある。本発明の化粧料100質量%中の本発明の化粧料用組成物の含有量は、特に限定されないが、好ましくは0.1〜100質量%、より好ましくは0.5〜10.0質量%とすることができる。 In the present invention, a cosmetic containing the cosmetic composition of the present invention is obtained. In the present specification, the above-mentioned “cosmetics containing the cosmetic composition of the present invention” may be referred to as “the cosmetics of the present invention”. The content of the cosmetic composition of the present invention in 100% by mass of the cosmetic of the present invention is not particularly limited, but is preferably 0.1 to 100% by mass, more preferably 0.5 to 10.0% by mass. It can be.
上記化粧料に使用される成分は、特に限定されないが、例えば、水、界面活性剤(カチオン界面活性剤、アニオン界面活性剤、両性界面活性剤等)、エステル油、油脂、炭化水素油、ロウ、高級脂肪酸、シリコーン油、低級アルコール、高級アルコール、多価アルコール、紫外線吸収剤、粉体、酸化防止剤、防腐剤、香料、着色剤、キレート剤、清涼剤、増粘剤、ビタミン類、中和剤、アミノ酸、pH調整剤、美白剤、抗炎症剤、消臭剤、動植物抽出物、金属イオン封鎖剤などの添加剤などが挙げられる。上記化粧料に使用される成分は、1種のみを用いてもよいし、2種以上を用いてもよい。 The ingredients used in the cosmetic are not particularly limited. For example, water, surfactants (cationic surfactants, anionic surfactants, amphoteric surfactants, etc.), ester oils, fats and oils, hydrocarbon oils, waxes , Higher fatty acids, silicone oils, lower alcohols, higher alcohols, polyhydric alcohols, UV absorbers, powders, antioxidants, preservatives, fragrances, colorants, chelating agents, cooling agents, thickeners, vitamins, medium Additives such as a compatibilizer, amino acid, pH adjuster, whitening agent, anti-inflammatory agent, deodorant, animal and plant extract, sequestering agent and the like can be mentioned. Only 1 type may be used for the component used for the said cosmetics, and 2 or more types may be used for it.
本発明の化粧料の剤型としては、特に限定されないが、例えば、化粧水(ローション)、クリーム、ジェル、乳液、エアゾールスプレー、ナチュラルスプレー、スティック、パウダー、ロールオン、シート(ペーパー)などの種々の剤型が挙げられる。中でも、化粧水(ローション)、クリーム、ジェル、乳液が好ましく、化粧水(ローション)がより好ましい。 Although it does not specifically limit as a dosage form of the cosmetics of this invention, For example, various kinds, such as lotion, cream, gel, emulsion, aerosol spray, natural spray, stick, powder, roll-on, sheet (paper), etc. Examples include dosage forms. Of these, lotions, creams, gels, and emulsions are preferable, and lotions are more preferable.
本発明の化粧料としては、特に限定されないが、例えば、保湿化粧料、美白化粧料、アクネケア用化粧料、アンチエージング化粧料(例えば、しわ抑制、たるみ抑制等を目的とする)等のスキンケア化粧料;スカルプケア化粧料(例えば、保湿、皮脂抑制等を目的とする);デオドラント化粧料;日焼け止め化粧料;シェービング化粧料;ボディ用洗浄料(例えば、ボディシャンプー、固形石鹸等);洗髪用化粧料(例えば、シャンプー、リンス等);整髪剤などが挙げられる。中でも、本発明の化粧料は、スキンケア化粧料、スカルプケア化粧料であることが好ましく、スキンケア化粧料であることがより好ましい。本発明の化粧料は、例えば、化粧品、医薬部外品、医薬品、雑貨のいずれであってもよい。 Although it does not specifically limit as cosmetics of this invention, For example, skin care cosmetics, such as moisturizing cosmetics, whitening cosmetics, cosmetics for acne care, anti-aging cosmetics (for the purpose of wrinkle control, sagging control, etc.) Scalp care cosmetics (for the purpose of moisturizing, sebum control, etc.); deodorant cosmetics; sunscreen cosmetics; shaving cosmetics; body cleansers (for example, body shampoos, solid soaps, etc.); Cosmetics (for example, shampoo, rinse, etc.); hairdressing agents and the like. Especially, it is preferable that the cosmetics of this invention are skin care cosmetics and scalp care cosmetics, and it is more preferable that they are skin care cosmetics. The cosmetic of the present invention may be any of cosmetics, quasi drugs, pharmaceuticals, and sundries, for example.
本発明の化粧料を適用する部位としては、特に限定されず、顔(例えば、額、目元、目じり、頬、口元等)、腕、肘、手の甲、指先、足、膝、かかと、首、脇、背中、頭皮、毛髪などが挙げられる。 The part to which the cosmetic of the present invention is applied is not particularly limited, and includes a face (for example, forehead, eyes, eyes, cheeks, mouth, etc.), arms, elbows, back of hands, fingertips, legs, knees, heels, neck, armpits. , Back, scalp, hair and the like.
本発明の化粧料を調製するには、上記各構成成分を混合し、公知の方法、例えばホモミキサーを用いて攪拌することにより製造することができる。 The cosmetic of the present invention can be prepared by mixing the above-described components and stirring them using a known method, for example, a homomixer.
以下、本発明を実施例に基づいて更に詳細に説明するが、本発明はこれら実施例にのみ限定されるものではない。尚、配合量及び含有量は、純分に換算した量であり、特記しない限り「質量%」を表す。 EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited only to these Examples. In addition, a compounding quantity and content are the quantity converted into the pure part, and represent "mass%" unless it mentions specially.
実施例1〜18及び比較例1〜9(化粧料用組成物の調製)
表1〜3に記した組成に従い、実施例1〜18及び比較例1〜9の各化粧料用組成物を常法に準じて調製した。表1〜3における各成分の値は質量%である。なお、実施例1の化粧料用組成物の25℃でのpHと、上記の測定方法に従い25℃での粘度を測定したところ、pHは6.5であった。Examples 1 to 18 and Comparative Examples 1 to 9 (Preparation of cosmetic compositions)
According to the composition described in Tables 1-3, each cosmetic composition of Examples 1-18 and Comparative Examples 1-9 was prepared according to a conventional method. The value of each component in Tables 1 to 3 is mass%. In addition, when the pH at 25 degreeC of the cosmetic composition of Example 1 and the viscosity at 25 degreeC were measured according to said measuring method, pH was 6.5.
試験例1(化粧料用組成物の透過率)
調製直後の、各実施例及び比較例の化粧料用組成物について、分光光度計(島津製作所社製、紫外可視分光光度計、UV−2600)を用い、波長660nmの条件で透過率を測定した。結果を表1〜3に示す。Test Example 1 (Transmissivity of cosmetic composition)
About the composition for cosmetics of each Example and comparative example immediately after preparation, the transmittance | permeability was measured on condition of wavelength 660nm using the spectrophotometer (The Shimadzu Corporation make, ultraviolet visible spectrophotometer, UV-2600). . The results are shown in Tables 1-3.
試験例2(化粧料用組成物の保存安定性)
各実施例及び比較例の化粧料用組成物を、5℃又は40℃で14日間保存した。保存後の各化粧料用組成物の外観を目視観察することによって、各化粧料用組成物の安定性を評価した。具体的には、分離の有無、析出物や澱の発生の有無を評価した。保存後の化粧料用組成物に、分離、析出物又は澱が全く見られなかった場合、保存安定性良好(○)と評価した。一方、保存後の化粧料用組成物に分離、析出物又は澱が見られた場合、保存安定性不良(×)と評価した。結果を表1〜3に示す。Test Example 2 (Storage stability of cosmetic composition)
The cosmetic compositions of each Example and Comparative Example were stored at 5 ° C. or 40 ° C. for 14 days. By visually observing the appearance of each cosmetic composition after storage, the stability of each cosmetic composition was evaluated. Specifically, the presence / absence of separation and the presence / absence of precipitates and starches were evaluated. When no separation, precipitate or starch was found in the cosmetic composition after storage, the storage stability was evaluated as good (◯). On the other hand, when separation, precipitate or starch was found in the cosmetic composition after storage, it was evaluated as poor storage stability (x). The results are shown in Tables 1-3.
なお、各成分の詳細は以下の通りである。
水添リン脂質:水素添加大豆レシチン
POE−25フィトスタノール:日光ケミカルズ社製、商品名「BPSH−25」
POE−20フィトステロール:日光ケミカルズ社製、商品名「BPS−20」
POE−30フィトステロール:日光ケミカルズ社製、商品名「BPS−30」
POE−5フィトステロール:日光ケミカルズ社製、商品名「BPS−5」
POE−10フィトステロール:日光ケミカルズ社製、商品名「BPS−10」
セラミド:セラミド2
ステロール:フィトステロールThe details of each component are as follows.
Hydrogenated phospholipid: Hydrogenated soybean lecithin POE-25 Phytostanol: Product name “BPSH-25” manufactured by Nikko Chemicals
POE-20 phytosterol: manufactured by Nikko Chemicals Co., Ltd., trade name “BPS-20”
POE-30 phytosterol: manufactured by Nikko Chemicals Co., Ltd., trade name “BPS-30”
POE-5 phytosterol: Nikko Chemicals, trade name “BPS-5”
POE-10 phytosterol: manufactured by Nikko Chemicals, Inc., trade name “BPS-10”
Ceramide: Ceramide 2
Sterol: Phytosterol
上記の表1〜3から以下のことが分かった。
成分Aを全く含まない組成物(比較例1)では、製造直後の透過率は高いものの、直ぐに凝集、析出が生じ、低温及び高温での析出物が見られた。成分Bを含まない組成物(比較例2〜4)では、分散物の粒径が大きく明らかに濁っており、透過率が極めて低いだけではなく、低温及び高温での析出物も見られた。成分Cを含まない組成物(比較例5〜6)では、製造直後の透過率は高いものの、経時的に析出が生じ、低温及び高温での析出物が見られた。成分Dに代えて多価アルコールのグリセリンを使用した組成物(比較例7)では、組成物の製造時に配合成分の溶解性が不良であり安定性が悪く、透過率は低く、低温及び高温での析出物も見られた。B/A値が本発明に規定された範囲外である組成物(比較例8〜9)では、組成物の分散性が低下し、透過率はやや不十分であり、低温及び高温での析出物が見られた。From the above Tables 1 to 3, the following was found.
In the composition containing no component A (Comparative Example 1), although the transmittance immediately after production was high, aggregation and precipitation occurred immediately, and precipitates at low and high temperatures were observed. In the composition containing no component B (Comparative Examples 2 to 4), the dispersion particle size was large and clearly turbid, not only the transmittance was extremely low, but also precipitates at low and high temperatures. In the composition containing no component C (Comparative Examples 5 to 6), although the transmittance immediately after production was high, precipitation occurred with time, and precipitates were observed at low and high temperatures. In the composition (Comparative Example 7) using polyhydric alcohol glycerin instead of component D, the solubility of the blended components is poor and the stability is poor at the time of producing the composition, the transmittance is low, at low and high temperatures. A precipitate was also observed. In the composition (Comparative Examples 8 to 9) having a B / A value outside the range defined in the present invention, the dispersibility of the composition is lowered, the transmittance is slightly insufficient, and precipitation at low and high temperatures. Things were seen.
一方、成分A〜Fを含有し、B/A値が5.5〜18.0の範囲である本発明の化粧料用組成物(実施例1〜18)は、透過率が高く、低温(5℃)及び高温(40℃)での析出物が全く見られなかった。即ち、本発明の化粧料用組成物は透明性に優れ、低温及び高温での保存安定性に優れていることが分かった。 On the other hand, the cosmetic compositions (Examples 1 to 18) of the present invention containing components A to F and having a B / A value in the range of 5.5 to 18.0 have high transmittance and low temperature ( No precipitates at 5 ° C. and high temperature (40 ° C.) were observed. That is, it was found that the cosmetic composition of the present invention was excellent in transparency and excellent in storage stability at low and high temperatures.
実施例19〜21(化粧水の調製)
表4に記した組成に従い、実施例19〜21の各化粧水を常法に準じて調製した。Examples 19 to 21 (Preparation of lotion)
According to the composition described in Table 4, each lotion of Examples 19 to 21 was prepared according to a conventional method.
各化粧水の安定性の評価を、試験例2と同じ方法によって実施した。その結果、実施例1〜3のいずれの化粧料用組成物を含有する化粧水も安定性に優れていることが分かった。このように、本発明によれば、水に富む化粧水にも安定して成分Fを配合できることが分かった。 The stability of each lotion was evaluated by the same method as in Test Example 2. As a result, it was found that the lotion containing any cosmetic composition of Examples 1 to 3 was also excellent in stability. Thus, according to this invention, it turned out that the component F can be mix | blended stably also with the lotion rich in water.
以下に、本発明の化粧料用組成物の処方例を示す。 Below, the formulation example of the composition for cosmetics of this invention is shown.
処方例1(本発明の化粧料用組成物)
水添リン脂質 0.6質量%
POE−25フィトスタノール 5.0質量%
オクチルドデカノール 0.2質量%
プロピレングリコール 10.0質量%
精製水 残部
セラミド−2 0.2質量%
フィトステロール 0.2質量%
オクトキシグリセリン 0.5質量%
1,2−デカンジオール 0.5質量%
フェノキシエタノール 0.2質量%
香料 0.03質量%
l−メントール 0.05質量%
コメ胚芽油 0.1質量%
合計 100質量%Formulation Example 1 (Cosmetic composition of the present invention)
Hydrogenated phospholipid 0.6% by mass
POE-25 phytostanol 5.0% by mass
Octyldodecanol 0.2% by mass
Propylene glycol 10.0% by mass
Purified water balance Ceramide-2 0.2% by mass
Phytosterol 0.2% by mass
Octoxyglycerin 0.5% by mass
1,2-decanediol 0.5% by mass
Phenoxyethanol 0.2% by mass
Perfume 0.03% by mass
l-Menthol 0.05% by mass
Rice germ oil 0.1% by mass
Total 100% by mass
以下に、本発明の化粧料用組成物を含有する化粧料の処方例を示す。 Below, the formulation example of the cosmetics containing the composition for cosmetics of this invention is shown.
処方例2(乳液)
精製水 残部
グリセリン 10.0質量%
1,3−ブチレングリコール 5.0質量%
キサンタンガム 0.05質量%
カルボマー 0.1質量%
水酸化カリウム 0.05質量%
ベヘニルアルコール 0.3質量%
ステアリン酸ポリグリセリル−10 1.5質量%
ステアリン酸グリセリル 0.5質量%
スクワラン 5.0質量%
トリ−2エチルヘキサン酸グリセリル 5.0質量%
ジメチコン 0.5質量%
フェノキシエタノール 0.2質量%
エタノール 5.0質量%
実施例1で得られた化粧料用組成物 5.0質量%
合計 100質量%Formulation example 2 (milky lotion)
Purified water balance Glycerin 10.0% by mass
1,3-butylene glycol 5.0% by mass
Xanthan gum 0.05% by mass
Carbomer 0.1% by mass
Potassium hydroxide 0.05% by mass
Behenyl alcohol 0.3% by mass
Polyglyceryl stearate-10 1.5% by mass
Glyceryl stearate 0.5% by mass
Squalane 5.0% by mass
Glyceryl tri-2-ethylhexanoate 5.0% by mass
Dimethicone 0.5% by mass
Phenoxyethanol 0.2% by mass
Ethanol 5.0% by mass
Cosmetic composition obtained in Example 1 5.0 mass%
Total 100% by mass
処方例3(クリーム)
精製水 残部
グリセリン 10.0質量%
1,3−ブチレングリコール 5.0質量%
キサンタンガム 0.08質量%
カルボマー 0.15質量%
水酸化カリウム 0.09質量%
ベヘニルアルコール 0.5質量%
ステアリン酸 1.0質量%
ステアリン酸ポリグリセリル−10 1.5質量%
ステアリン酸グリセリル 1.5質量%
スクワラン 7.0質量%
トリ−2エチルヘキサン酸グリセリル 5.0質量%
シア脂 1.5質量%
ジメチコン 1.0質量%
フェノキシエタノール 0.2質量%
エタノール 5.0質量%
実施例1で得られた化粧料用組成物 5.0質量%
合計 100質量%Formulation Example 3 (Cream)
Purified water balance Glycerin 10.0% by mass
1,3-butylene glycol 5.0% by mass
Xanthan gum 0.08% by mass
Carbomer 0.15% by mass
Potassium hydroxide 0.09% by mass
Behenyl alcohol 0.5% by mass
Stearic acid 1.0% by mass
Polyglyceryl stearate-10 1.5% by mass
Glyceryl stearate 1.5% by mass
Squalane 7.0% by mass
Glyceryl tri-2-ethylhexanoate 5.0% by mass
Shea fat 1.5% by mass
Dimethicone 1.0% by mass
Phenoxyethanol 0.2% by mass
Ethanol 5.0% by mass
Cosmetic composition obtained in Example 1 5.0 mass%
Total 100% by mass
本発明の化粧料用組成物は、そのまま化粧料として、あるいは化粧水等への配合成分として使用することができる。 The cosmetic composition of the present invention can be used as it is as a cosmetic or as a component for incorporation into a lotion.
Claims (7)
前記成分Aに対する前記成分Bの質量比(B/A)が5.5〜18.0である、化粧料用組成物。
成分A:リン脂質
成分B:オキシエチレンの平均付加モル数が15〜50のポリオキシエチレンステロールエーテル及び/又はオキシエチレンの平均付加モル数が15〜50のポリオキシエチレンスタノールエーテル
成分C:分岐鎖を有する炭素数12〜24の1価の脂肪族アルコール
成分D:プロピレングリコール、ジプロピレングリコール及び1,3−ブチレングリコールからなる群より選ばれた一種以上の多価アルコール
成分E:水
成分F:セラミド及び/又はステロールContains the following component A, the following component B, the following component C, the following component D, the following component E, and the following component F,
The composition for cosmetics whose mass ratio (B / A) of the said component B with respect to the said component A is 5.5-18.0.
Component A: Phospholipid Component B: Polyoxyethylene sterol ether having an average addition mole number of oxyethylene of 15 to 50 and / or polyoxyethylene stanol ether having an average addition mole number of oxyethylene of 15 to 50 Component C: Branched chain C12-24 monovalent aliphatic alcohol having a component D: One or more polyhydric alcohols selected from the group consisting of propylene glycol, dipropylene glycol and 1,3-butylene glycol Component E: Water Component F: Ceramide and / or sterol
成分G:炭素数5〜10の1,2−アルカンジオールFurthermore, the composition for cosmetics of any one of Claims 1-4 containing the following component G.
Component G: 1,2-alkanediol having 5 to 10 carbon atoms
成分H:グリセリンモノ2−エチルヘキシルエーテルFurthermore, the composition for cosmetics of any one of Claims 1-5 containing the following component H.
Component H: Glycerin mono 2-ethylhexyl ether
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11130651A (en) * | 1997-10-24 | 1999-05-18 | Kose Corp | Lipid dispersion composition and cosmetic containing the same |
JP2002338459A (en) * | 2001-05-16 | 2002-11-27 | Nikko Chemical Co Ltd | Method for solubilizing ceramide and ceramide- formulated skin care preparation obtained by using the method |
JP2011032229A (en) * | 2009-08-04 | 2011-02-17 | Mandom Corp | Emulsified skin cosmetic |
JP2013227294A (en) * | 2012-03-30 | 2013-11-07 | Kose Corp | Translucent to transparent composition |
JP2014208626A (en) * | 2013-03-27 | 2014-11-06 | 株式会社コーセー | Liposome composition |
WO2015136783A1 (en) * | 2014-03-14 | 2015-09-17 | 富士フイルム株式会社 | Dispersion composition and cosmetic material |
JP2016079171A (en) * | 2014-10-17 | 2016-05-16 | 株式会社アスター美容 | Amorphous composition and external preparations containing the same |
JP2016160242A (en) * | 2015-03-04 | 2016-09-05 | 杏林製薬株式会社 | Liposome dispersion liquid containing ceramides |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0899854A (en) | 1994-10-04 | 1996-04-16 | Pias Arise Kk | Skin external agent |
CN101874763A (en) * | 2009-04-29 | 2010-11-03 | 上海家化联合股份有限公司 | Resveratrol flexible liposome and preparation method thereof |
CN103565673A (en) * | 2013-10-30 | 2014-02-12 | 广州品赫化妆品有限公司 | Emollient lotion for moisturizing skin and controlling oil and preparation method of emollient lotion |
-
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11130651A (en) * | 1997-10-24 | 1999-05-18 | Kose Corp | Lipid dispersion composition and cosmetic containing the same |
JP2002338459A (en) * | 2001-05-16 | 2002-11-27 | Nikko Chemical Co Ltd | Method for solubilizing ceramide and ceramide- formulated skin care preparation obtained by using the method |
JP2011032229A (en) * | 2009-08-04 | 2011-02-17 | Mandom Corp | Emulsified skin cosmetic |
JP2013227294A (en) * | 2012-03-30 | 2013-11-07 | Kose Corp | Translucent to transparent composition |
JP2014208626A (en) * | 2013-03-27 | 2014-11-06 | 株式会社コーセー | Liposome composition |
WO2015136783A1 (en) * | 2014-03-14 | 2015-09-17 | 富士フイルム株式会社 | Dispersion composition and cosmetic material |
JP2016079171A (en) * | 2014-10-17 | 2016-05-16 | 株式会社アスター美容 | Amorphous composition and external preparations containing the same |
JP2016160242A (en) * | 2015-03-04 | 2016-09-05 | 杏林製薬株式会社 | Liposome dispersion liquid containing ceramides |
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KR20180101458A (en) | 2018-09-12 |
CN108697613A (en) | 2018-10-23 |
KR102084672B1 (en) | 2020-03-04 |
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