JPWO2017179602A1 - 新生児向けの脳機能改善用組成物 - Google Patents
新生児向けの脳機能改善用組成物 Download PDFInfo
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- JPWO2017179602A1 JPWO2017179602A1 JP2018512035A JP2018512035A JPWO2017179602A1 JP WO2017179602 A1 JPWO2017179602 A1 JP WO2017179602A1 JP 2018512035 A JP2018512035 A JP 2018512035A JP 2018512035 A JP2018512035 A JP 2018512035A JP WO2017179602 A1 JPWO2017179602 A1 JP WO2017179602A1
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Abstract
Description
[1]乳酸菌及び/又はビフィズス菌を有効成分として含んでなる、新生児向けの脳機能改善用組成物及び新生児向けの脳機能改善剤(以下、「本発明の組成物及び用剤」ということがある)。
[2]有効成分がビフィズス菌である、前記[1]に記載の組成物及び用剤。
[3]前記ビフィズス菌がビフィドバクテリウム・ビフィダム(Bifidobacterium bifidum)である、前記[1]又は[2]に記載の組成物及び用剤。
[4]前記ビフィズス菌がビフィドバクテリウム・ビフィダムOLB6378菌株(Bifidobacterium bifidum、受託番号:NITE BP−31)である、前記[1]〜[3]のいずれかに記載の組成物及び用剤。
[5]前記ビフィズス菌が加熱処理された菌体である、前記[1]〜[4]のいずれかに記載の組成物及び用剤。
[6]1日当たり108個以上の菌数の前記ビフィズス菌を1ヶ月以上連続して摂取させるか、あるいは投与する、前記[1]〜[5]のいずれかに記載の組成物及び用剤。
[7]食品である、前記[1]〜[6]のいずれかに記載の組成物及び用剤。
[8]新生児向けの脳機能改善用組成物又は新生児向けの脳機能改善剤の製造のための、乳酸菌及び/又はビフィズス菌の使用。
[9]新生児の脳機能改善に使用するための乳酸菌及び/又はビフィズス菌。
[10]有効量の乳酸菌及び/又はビフィズス菌を、それを必要としている対象に摂取させるか、あるいは投与することを含んでなる、新生児の脳機能改善方法。
本発明に使用される乳酸菌は、その種類や由来に制限がない。具体的には、例えば、サーモフィラス菌などのストレプトコッカス属、ブルガリア菌、ガセリ菌、アシドフィラス菌などのラクトバチルス属、ラクチス菌、クレモリス菌、ジアセチルラクチス菌などのラクトコッカス属、ロイコノストック属などが挙げられる。
本発明に使用されるビフィズス菌は、その種類や由来に制限がない。具体的には、例えば、ビフィドバクテリウム・ビフィダム(Bifidobacterium bifidum)、ビフィドバクテリウム・ロンガム(Bifidobacterium longum)、ビフィドバクテリウム・ブレーベ(B.breve)、ビフィドバクテリウム・アドレセンティス(B.adolescentis)、ビフィドバクテリウム・インファンティス(B.infantis)、ビフィドバクテリウム・シュードロンガム(B.pseudolongum)、ビフィドバクテリウム・テルモフィルム(B.thermophilum)等のビフィズス菌が挙げられる。
(1)寄託機関名:独立行政法人製品評価技術基盤機構 特許微生物寄託センター
(2)連絡先:〒292−0818 千葉県木更津市かずさ鎌足2−5−8(電話番号0438−20−5580)
(3)受託番号:NITE BP−31
(4)識別のための表示:Bifidobacterium bifidum OLB6378
(5)原寄託日:2004年10月26日
(6)ブダペスト条約に基づく寄託への移管日:2006年1月18日
Bifidobacterium bifidum OLB 6378株(受託番号:NITE BP−31)の原菌末(生菌数、3.9×1011cfu/g、商品名「明治ビフィピュア(登録商標)」、明治フードマテリア社)120gと顆粒デキストリン(松谷化学社)2880gを均一に混合し、各1gずつ分包し、試験食(生菌)とした。
試験例1では、試験食(生菌)を摂取した被験者群を「試験食(生菌)摂取群」とし、対照食(プラセボ)を摂取した被験者群を「対照食(プラセボ)摂取群」とした。被験者群は、新生児(出生体重1000g以上88名、出生体重1000g未満80名)を選択し、試験食(生菌)摂取群89名(出生体重1000g以上49名、出生体重1000g未満40名)、対照食(プラセボ)摂取群79名(出生体重1000g以上39名、出生体重1000g未満40名)選抜した。各群はいずれも1日1回、試験食(生菌)又は対照食(プラセボ)を摂取した。摂取期間は新生児の体重が2kgに到達した日までである。
試験例1の試験食(生菌)摂取群89名、対照食(プラセボ)摂取群79名それぞれに対し、1.5歳に到達した時点で、新版K式発達検査2001を用い、適宜対応可能な検査法で発達指数を確認した。具体的には、姿勢・運動(P−M)、認知・適応(C−A)、言語・社会(L−S)の領域を見て、総合的な見地から、全領域の発達年齢と発達指数を導き出した。実年齢に対する、得られた発達年齢のパーセントが発達指数となり、70未満、70以上85未満、85以上100未満、100以上に分類した。
Claims (10)
- 乳酸菌及び/又はビフィズス菌を有効成分として含んでなる、新生児向けの脳機能改善用組成物。
- 有効成分がビフィズス菌である、請求項1に記載の組成物。
- 前記ビフィズス菌がビフィドバクテリウム・ビフィダム(Bifidobacterium bifidum)である請求項1又は2に記載の組成物。
- 前記ビフィズス菌がビフィドバクテリウム・ビフィダムOLB6378菌株(Bifidobacterium bifidum、受託番号:NITE BP−31)である、請求項1〜3のいずれか一項に記載の組成物。
- 前記ビフィズス菌が加熱処理された菌体である、請求項1〜4のいずれか一項に記載の組成物。
- 1日当たり108個以上の菌数の前記ビフィズス菌を1ヶ月以上連続して摂取させる、請求項1〜5のいずれか一項に記載の組成物。
- 食品である、請求項1〜6のいずれか一項に記載の組成物。
- 新生児向けの脳機能改善用組成物の製造のための、乳酸菌及び/又はビフィズス菌の使用。
- 新生児の脳機能改善に使用するための乳酸菌及び/又はビフィズス菌。
- 有効量の乳酸菌及び/又はビフィズス菌を、それを必要としている対象に摂取させるか、あるいは投与することを含んでなる、新生児の脳機能改善方法。
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SG10202110501RA (en) | 2010-12-31 | 2021-11-29 | Abbott Lab | Methods For Decreasing The Incidence Of Necrotizing Enterocolitis In Infants, Toddlers, Or Children Using Human Milk Oligosaccharides |
CN107595860A (zh) | 2011-07-22 | 2018-01-19 | 雅培制药有限公司 | 用于预防胃肠道损伤和/或促进胃肠道修复的低聚半乳糖 |
SG2014013478A (en) | 2011-08-29 | 2014-05-29 | Abbott Lab | Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract |
AU2017251028A1 (en) | 2016-04-13 | 2018-11-29 | Meiji Co., Ltd. | Brain function-improving composition for newborns |
CN114206136A (zh) | 2019-08-08 | 2022-03-18 | 森永乳业株式会社 | 用于改善学龄期的记忆能力的婴幼儿用组合物 |
JP2023511678A (ja) * | 2020-01-24 | 2023-03-22 | 森永乳業株式会社 | 神経突起伸長改善用組成物 |
TW202241477A (zh) | 2020-12-16 | 2022-11-01 | 日商明治股份有限公司 | 腦組織之發炎改善用組成物 |
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