JPWO2017057718A1 - 難消化性成分を含む飲食品および大腸内水素ガス産生剤 - Google Patents
難消化性成分を含む飲食品および大腸内水素ガス産生剤 Download PDFInfo
- Publication number
- JPWO2017057718A1 JPWO2017057718A1 JP2017543634A JP2017543634A JPWO2017057718A1 JP WO2017057718 A1 JPWO2017057718 A1 JP WO2017057718A1 JP 2017543634 A JP2017543634 A JP 2017543634A JP 2017543634 A JP2017543634 A JP 2017543634A JP WO2017057718 A1 JPWO2017057718 A1 JP WO2017057718A1
- Authority
- JP
- Japan
- Prior art keywords
- indigestible
- hydrogen gas
- food
- combination
- glucomannan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title claims abstract description 100
- 235000013305 food Nutrition 0.000 title claims abstract description 50
- 230000000968 intestinal effect Effects 0.000 title claims abstract description 29
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 28
- 239000004615 ingredient Substances 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 23
- 210000002429 large intestine Anatomy 0.000 claims abstract description 19
- 235000013361 beverage Nutrition 0.000 claims abstract description 11
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 34
- 229920002581 Glucomannan Polymers 0.000 claims description 34
- 229940046240 glucomannan Drugs 0.000 claims description 34
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 34
- 235000010449 maltitol Nutrition 0.000 claims description 34
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 33
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 33
- 239000000845 maltitol Substances 0.000 claims description 33
- 229940035436 maltitol Drugs 0.000 claims description 33
- 229920001353 Dextrin Polymers 0.000 claims description 18
- 239000004375 Dextrin Substances 0.000 claims description 18
- 235000019425 dextrin Nutrition 0.000 claims description 18
- 235000020124 milk-based beverage Nutrition 0.000 claims description 17
- 239000006041 probiotic Substances 0.000 claims description 16
- 235000018291 probiotics Nutrition 0.000 claims description 16
- 229920000294 Resistant starch Polymers 0.000 claims description 11
- 235000021254 resistant starch Nutrition 0.000 claims description 11
- 235000010987 pectin Nutrition 0.000 claims description 10
- 239000001814 pectin Substances 0.000 claims description 10
- 229920001277 pectin Polymers 0.000 claims description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 9
- 239000008101 lactose Substances 0.000 claims description 9
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 8
- 235000013365 dairy product Nutrition 0.000 claims description 8
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 239000004386 Erythritol Substances 0.000 claims description 7
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 7
- 235000019414 erythritol Nutrition 0.000 claims description 7
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 7
- 229940009714 erythritol Drugs 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 7
- 235000010356 sorbitol Nutrition 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 229960002920 sorbitol Drugs 0.000 claims description 7
- 235000010447 xylitol Nutrition 0.000 claims description 7
- 239000000811 xylitol Substances 0.000 claims description 7
- 229960002675 xylitol Drugs 0.000 claims description 7
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 7
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 229960001855 mannitol Drugs 0.000 claims description 6
- 229960000292 pectin Drugs 0.000 claims description 6
- 235000015243 ice cream Nutrition 0.000 claims description 3
- 230000000529 probiotic effect Effects 0.000 claims description 3
- 235000013351 cheese Nutrition 0.000 claims description 2
- 235000015140 cultured milk Nutrition 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 abstract description 30
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 30
- 235000013336 milk Nutrition 0.000 description 29
- 239000008267 milk Substances 0.000 description 29
- 210000004080 milk Anatomy 0.000 description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 238000012360 testing method Methods 0.000 description 15
- 239000000203 mixture Substances 0.000 description 13
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 239000002953 phosphate buffered saline Substances 0.000 description 12
- 239000007789 gas Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 8
- 244000005700 microbiome Species 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 241000186000 Bifidobacterium Species 0.000 description 7
- 230000002550 fecal effect Effects 0.000 description 7
- 210000003608 fece Anatomy 0.000 description 7
- 241001134770 Bifidobacterium animalis Species 0.000 description 6
- 229940118852 bifidobacterium animalis Drugs 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000037406 food intake Effects 0.000 description 5
- 241000186660 Lactobacillus Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 229940039696 lactobacillus Drugs 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 229920001542 oligosaccharide Polymers 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000020183 skimmed milk Nutrition 0.000 description 4
- 244000163122 Curcuma domestica Species 0.000 description 3
- 235000003392 Curcuma domestica Nutrition 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 235000003373 curcuma longa Nutrition 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 150000002482 oligosaccharides Chemical class 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 235000020185 raw untreated milk Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 235000013976 turmeric Nutrition 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 229920002670 Fructan Polymers 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 239000004368 Modified starch Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 102000004139 alpha-Amylases Human genes 0.000 description 2
- 108090000637 alpha-Amylases Proteins 0.000 description 2
- 229940024171 alpha-amylase Drugs 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 235000019543 dairy drink Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019426 modified starch Nutrition 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 235000011962 puddings Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241000186012 Bifidobacterium breve Species 0.000 description 1
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000012905 Brassica oleracea var viridis Nutrition 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- ZCLAHGAZPPEVDX-UHFFFAOYSA-N D-panose Natural products OC1C(O)C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC1COC1C(O)C(O)C(O)C(CO)O1 ZCLAHGAZPPEVDX-UHFFFAOYSA-N 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 240000001929 Lactobacillus brevis Species 0.000 description 1
- 235000013957 Lactobacillus brevis Nutrition 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241000186606 Lactobacillus gasseri Species 0.000 description 1
- 240000002605 Lactobacillus helveticus Species 0.000 description 1
- 235000013967 Lactobacillus helveticus Nutrition 0.000 description 1
- 241000186605 Lactobacillus paracasei Species 0.000 description 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 1
- 241000186604 Lactobacillus reuteri Species 0.000 description 1
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 241000191996 Pediococcus pentosaceus Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- VLSOAXRVHARBEQ-UHFFFAOYSA-N [4-fluoro-2-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=C(F)C=C1CO VLSOAXRVHARBEQ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- FYGDTMLNYKFZSV-ANKSBSNASA-N alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-ANKSBSNASA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 229940004120 bifidobacterium infantis Drugs 0.000 description 1
- 229940009291 bifidobacterium longum Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- -1 cyclic oligosaccharide Chemical class 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 238000009408 flooring Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- DBTMGCOVALSLOR-AXAHEAMVSA-N galactotriose Natural products OC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](CO)O[C@@H](O[C@H]3[C@@H](O)[C@H](O)O[C@@H](CO)[C@@H]3O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O DBTMGCOVALSLOR-AXAHEAMVSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- FBJQEBRMDXPWNX-FYHZSNTMSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)C(O)O2)O)O1 FBJQEBRMDXPWNX-FYHZSNTMSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 229940054346 lactobacillus helveticus Drugs 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 229940001882 lactobacillus reuteri Drugs 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000006872 mrs medium Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- ZCLAHGAZPPEVDX-MQHGYYCBSA-N panose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@@H]1CO[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ZCLAHGAZPPEVDX-MQHGYYCBSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 150000003742 xyloses Chemical class 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
- A23C19/09—Other cheese preparations; Mixtures of cheese with other foodstuffs
- A23C19/0925—Addition, to cheese or curd, of colours, synthetic flavours or artificial sweeteners, including sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
- A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
- A23G9/44—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by shape, structure or physical form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
- A23G9/52—Liquid products; Solid products in the form of powders, flakes or granules for making liquid products ; Finished or semi-finished solid products, frozen granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/231—Pectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/24—Cellulose or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
- Confectionery (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
Description
[2]難消化性成分の組合せが、以下:
(a)マルチトール、ガラクトオリゴ糖およびグルコマンナンからなる群より選択される2種類の難消化性成分の組合せ;または
(b)マルチトール、ガラクトオリゴ糖およびグルコマンナン;
である、上記[1]に記載の飲食品。
[3]難消化性成分の組合せを、0.01%w/w〜20%w/w含む、上記[1]または[2]に記載の飲食品。
[4]さらにプロバイオティクスを含む、[1]ないし[3]のいずれか1項に記載の飲食品。
[5]大腸内で水素ガスを産生させるためのものである、上記[1]〜[4]のいずれか1項に記載の飲食品。
[6]飲食品が乳製品である、上記[1]〜[5]のいずれか1項に記載の飲食品。
[7]乳製品が、乳飲料、ヨーグルト、アイスクリームおよびプリンからなる群より選択される、上記[6]に記載の飲食品。
[8]イソマルトオリゴ等、ラクトース、ガラクトオリゴ糖、セロビオース、キシロオリゴ糖、キシリトール、ソルビトール、エリトリトール、マルチトール、マンニトール、ペクチン、グルコマンナン、レジスタントスターチ、難消化性デキストリンおよび還元難消化性デキストリンからなる群より選択される2以上の難消化性成分の組合せを含む、大腸内水素ガス産生剤。
[9]難消化性成分の組合せが、以下:
(a)マルチトール、ガラクトオリゴ糖およびグルコマンナンからなる群より選択される2種類の難消化性成分の組合せ;または
(b)マルチトール、ガラクトオリゴ糖およびグルコマンナン;
である、上記[8]に記載の大腸内水素ガス産生剤。
[10]さらにプロバイオティクスを含む、[8]または[9]に記載の大腸内水素ガス産生剤。
本発明は、2種類以上の難消化性成分が配合された飲食品に関する。
本発明は、2種類以上の難消化性成分を含む大腸内水素ガス産生剤に関する。本発明の大腸内水素ガス産生剤に含まれる2種類以上の難消化性成分の組合せについては、上記飲食品の項目において定義したとおりである。
本発明はまた、本発明の飲食品または大腸内水素ガス産生剤を、対象に摂取させるもしくは投与することを含む、対象の大腸内で水素ガスを産生させる方法に関する。
<試薬>
23種類の難消化性成分のそれぞれ(セルロース、イソマルトオリゴ糖、ラクトース、フラクトオリゴ等、ガラクトオリゴ糖、セロビオース、キシロオリゴ糖、キシリトール、ソルビトール、エリトリトール、マルチトール、マンニトール、ペクチン、アルギン酸ナトリウム、グルコマンナン、リグニン、キチン、キトサン、レジスタントスターチ、難消化性デキストリン、還元難消化性デキストリン、ケールまたは大麦若葉)をリン酸緩衝液生理食塩水(PBS)で2.5%(w/v)になるように調製した。その際、完全に溶解しなかった成分においては、懸濁した状態で使用した。対照はこれら成分を含まないPBSを使用した。
糞便は健常成人10名(男性7名、女性3名、平均年齢35.8歳)から回収し、排便後5時間以内に使用した。
糞便5gに20mlの嫌気性希釈液(KH2PO4、Na2HPO4、L−システイン塩酸塩、Tween80、0.1%レサズリンを溶解し、N2・CO2(80%・20%)を噴射注入しブチル栓で封をしてオートクレーブ処理したもの)を加え、ボルテックスで撹拌した後、遠心分離(1000g×1分間)にて未消化の食べかす等の固形物を除去した。糞便菌が存在する上層部の糞便懸濁液をエッペンドルフチューブに160μlずつ分注し、そこに調製した難消化性成分のPBS溶液を40μlずつ添加した(難消化性成分の終濃度は0.5%)。糞便懸濁液と難消化性成分の混ざったエッペンドルフチューブをバイアルビン(40mm×75mm、50ml)に蓋を開けた状態で入れ、嫌気性菌培養装置(AG−2)にてN2・CO2(79.8%・20.2%)混合ガスを噴射注入し、エッペンドルフチューブ内およびビン内を嫌気状態にした。ブチル栓で密封して、インキュベーターにて培養した(37℃、24時間)。また、1サンプル当たり2連で、3回繰り返し実験を行った。
1.0mlのガスタイトシリンジ(ハミルトン)でバイアルビン内のガスを0.5ml採取し、TRIlyzer(太陽日酸株式会社)で測定した。その際、濃度が検出限界を超えた場合は50mlのバイアルビンにサンプル1mlを注入して、50倍希釈し、値を測定した。なお、採取前にはシリンジで5回ビン内の空気を撹拌させた。
各試料の水素ガス産生濃度の対照比を算出し、対照比が10倍以上となった値に網掛けした(表1)。10名中、イソマルオリゴ糖は5名、ラクトースは4名、フラクトオリゴ糖は7名、ガラクトオリゴ糖は5名、セロビオースは7名、キシロオリゴ糖は1名、キシリトールは6名、ソルビトールは4名、エリトリトールは2名、マルチトールは6名、マンニトールは5名、ペクチンは1名、グルコマンナンは3名、レジスタントスターチは1名、難消化性デキストリンは2名、還元難消化性デキストリンは2名の糞便が10倍以上となった。
<試薬>
マルチトール、ガラクトオリゴ糖、グルコマンナンをそれぞれ0.8%溶液となるようにPBSに溶解した。同様に3種混合液として、3種類の成分を0.8%量ずつ混合してPBSに溶解した。対照は成分を含まないPBSを使用した。
14名(男性11名、女性3名、平均年齢40.9歳)の健常成人の糞便を用いた。
実施例1と同様の方法で行った
<結果>
各成分を3種混合で添加した場合に、単独成分を添加した場合と比較して水素ガス産生量が増加した(図1)。また、単独成分添加で水素ガス産生濃度の対照比が2倍以上となった糞便は被験者14名中、マルチトールは9名、ガラクトオリゴ糖は8名、グルコマンナンは4名の糞便である一方、3種混合添加で水素ガス産生濃度の対照比が2倍以上となった糞便は、被験者14名中13名の糞便であった(図2)。同様に、被験者14名中、水素ガス産生濃度の対照比が3倍以上となった糞便は、単独成分添加の場合、マルチトールは5名、ガラクトオリゴ糖は0名、グルコマンナンは1名の糞便である一方、3種混合添加では11名の糞便であり、さらに、水素ガス産生濃度の対照比が5倍以上となった糞便は、単独成分添加の場合、マルチトールは2名、ガラクトオリゴ糖は0名、グルコマンナンは0名の糞便である一方、3種混合添加では9名の糞便であった。以上の結果より、これら難消化性成分を組み合わせることによって適応範囲の広い水素ガス産生促進効果が認められた。
<被験者>
牛乳を飲んで下痢になることはない健常成人6名を被験者とした。
水200ml(対照)、牛乳200ml、難消化性成分添加牛乳(200mlの牛乳にマルチトール、ガラクトオリゴ糖、グルコマンナンをそれぞれ2gずつ溶解させた)合計3種類を試験食とし、比較に用いた。
12時間の絶食(水のみ自由摂取)後、200mlの牛乳を1分間かけて摂取させた。別日に試験食である、水(対照)、難消化性成分添加牛乳を摂取させ、試験を実施した。体の負担を考え、各試験は2日間以上の間隔をあけて実施した。摂取後、12時間後まで、1時間毎に呼気を採取した。試験食摂取直前にも採取し、これを試験食摂取後0hの呼気サンプルとした。
呼気採取前に、被験者を5分間安静に座らせた。呼気の採取は、被験者による次の一連の操作により行った:5分間椅子に座って安静にした後、鼻から大きく息を吸い込み、15秒間息を止めてからゆっくり吐き出した後の肺胞末端中の呼気(すなわち終末呼気)を呼気採取バッグ(大塚製薬)に吹き込む。
ガスタイトシリンジで呼気採取バッグ中の呼気を5回撹拌した後、当該シリンジでバッグ中の呼気を0.5mL採取した。当該シリンジで採取した呼気サンプルについて、生体ガス測定システムであるTRIlyzer(株式会社タイヨウ)を用いて当該サンプル中の水素濃度を測定した。
牛乳単体を摂取した際と比較して、難消化性成分添加牛乳を摂取した際の呼気中水素ガス量が増加した(図3)。AUC(曲線下面積)値においても、難消化性成分添加牛乳での水素ガス産生促進効果が高いことを示した。
<実験動物>
9週齢のICR(雄)マウス10匹を、ビフィドバクテリウム・アニマリス亜種ラクティス(Bifidobacterium animalis subsp.lactis)LKM512株(本明細書において単にLKM512とも記載する)懸濁液投与群およびPBS投与群(対照)の2群(各5匹)に分けた。LKM512懸濁液及びPBSを1日300μl、週に5回、3週間に渡り胃ゾンデで強制経口投与した。LKM512懸濁液中のLKM512菌数は7.0×108 cfu / 300μlとした。3週間の投与期間を終えた21日目に難消化性成分添加牛乳(実施例3と同様に調製したもの)を投与し、水素ガス産生量を測定した。
15時間マウスを絶食させた後、待機ケージ(餌、水、床敷きなし)に2時間入れて環境に順化させた。その後、難消化性成分添加牛乳を360μl強制経口投与した。測定は難消化性成分添加牛乳投与前、投与2時間後に2回ずつ行い、それぞれ2つの数値の平均をとった。
ブチル栓製空気回収口付アクリルボックスにマウスを5分間閉じ込め、マウスの体内から発生するガス(呼気ガス、屁)をボックス中に溜めた。その後、ブチルゴム栓部からガスタイトシリンジでボックス中の空気を0.5mL採取した。その際、ボックス内に設置したファンを回すことで中の空気を撹拌させた。採取した空気サンプルは生体ガス測定システムであるTRIlyzer (株式会社タイヨウ)を用いて水素ガス濃度を測定した。
<結果>
難消化性成分添加牛乳投与前に水素ガス産生量に差はなかったが、難消化性成分添加牛乳投与後の水素ガス産生量は、LKM512懸濁液投与群の方がPBS投与群と比較して約3.2倍多い結果となった(図4)。
<試験方法>
牛乳を飲んで下痢になることはない健常成人7名で、単群・群内比較・オープン試験を実施した。試験食は、難消化性成分添加乳飲料(生乳および脱脂粉乳を含む乳飲料に1.6%ガラクトオリゴ糖、1.1%マルチトール、および0.1%グルコマンナンとなるよう難消化性成分を添加して得た)、成分無調整牛乳、市販水素水(メロディアン)を用い、入院による終日観察により測定を行った。入院は1週間毎に3回行い、初回に難消化性成分添加乳飲料、2回目に成分無調整牛乳、3回目に水素水をそれぞれ200 ml摂取し、呼気中水素濃度に及ぼす影響を比較した。
成分無調整牛乳を摂取した際と比較して、難消化性成分添加乳飲料を摂取した際の呼気中水素ガス濃度の増加は高く、添加成分の有効性が確認できた(図5)。また、市販水素水と比較しても、摂取20分間は水素水摂取時の方が高かったが、その後は、難消化成分添加乳飲料の方が圧倒的に高い結果を示した。AUC(曲線下面積)値においても、難消化性成分添加乳飲料は、成分無調整乳および水素水と比較して、それぞれ2.5倍および6.7倍高い値を示した。
Claims (10)
- マルチトール、ガラクトオリゴ糖、グルコマンナン、イソマルトオリゴ等、ラクトース、セロビオース、キシロオリゴ糖、キシリトール、ソルビトール、エリトリトール、マンニトール、ペクチン、レジスタントスターチ、難消化性デキストリンおよび還元難消化性デキストリンからなる群より選択される2以上の難消化性成分の組合せが配合された、飲食品。
- 難消化性成分の組合せが、以下:
(a)マルチトール、ガラクトオリゴ糖およびグルコマンナンからなる群より選択される2種類の難消化性成分の組合せ;または
(b)マルチトール、ガラクトオリゴ糖およびグルコマンナン;
である、請求項1に記載の飲食品。 - 難消化性成分の組合せを、0.01%w/w〜20%w/w含む、請求項1または2に記載の飲食品。
- さらにプロバイオティクスを含む、請求項1ないし3のいずれか1項に記載の飲食品。
- 大腸内で水素ガスを産生させるためのものである、請求項1〜4のいずれか1項に記載の飲食品。
- 飲食品が乳製品である、請求項1〜5のいずれか1項に記載の飲食品。
- 乳製品が、乳飲料、チーズ、発酵乳、およびアイスクリーム類からなる群より選択される、請求項6項に記載の飲食品。
- イソマルトオリゴ等、ラクトース、ガラクトオリゴ糖、セロビオース、キシロオリゴ糖、キシリトール、ソルビトール、エリトリトール、マルチトール、マンニトール、ペクチン、グルコマンナン、レジスタントスターチ、難消化性デキストリンおよび還元難消化性デキストリンからなる群より選択される2以上の難消化性成分の組合せを含む、大腸内水素ガス産生剤。
- 難消化性成分の組合せが、以下:
(a)マルチトール、ガラクトオリゴ糖およびグルコマンナンからなる群より選択される2種類の難消化性成分の組合せ;または
(b)マルチトール、ガラクトオリゴ糖およびグルコマンナン;
である、請求項8に記載の大腸内水素ガス産生剤。 - さらにプロバイオティクスを含む、請求項8または9に記載の大腸内水素ガス産生剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015192937 | 2015-09-30 | ||
JP2015192937 | 2015-09-30 | ||
PCT/JP2016/079102 WO2017057718A1 (ja) | 2015-09-30 | 2016-09-30 | 難消化性成分を含む飲食品および大腸内水素ガス産生剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2017057718A1 true JPWO2017057718A1 (ja) | 2018-07-26 |
JP6796070B2 JP6796070B2 (ja) | 2020-12-02 |
Family
ID=58427571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017543634A Active JP6796070B2 (ja) | 2015-09-30 | 2016-09-30 | 難消化性成分を含む飲食品および大腸内水素ガス産生剤 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20190126075A1 (ja) |
JP (1) | JP6796070B2 (ja) |
WO (1) | WO2017057718A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019054491A1 (ja) * | 2017-09-14 | 2019-03-21 | 協同乳業株式会社 | 涙液分泌能・涙液安定性を改善するための飲食品または製剤 |
CN107772476A (zh) * | 2017-11-08 | 2018-03-09 | 烟台欧顺生物科技有限公司 | 一种海参酵素及其制备方法 |
EP3530743A1 (en) | 2018-02-21 | 2019-08-28 | Cambridge Glycoscience Ltd | Method of production |
EP3760051A4 (en) * | 2018-02-28 | 2021-11-24 | Otsuka Pharmaceutical Co., Ltd. | COMPOSITION FOR ICE DESSERT |
JP7093262B2 (ja) * | 2018-08-03 | 2022-06-29 | 協同乳業株式会社 | 高強度運動による疲労軽減・回復用組成物 |
CA3109239A1 (en) * | 2018-08-15 | 2020-02-20 | Cambridge Glycoscience Ltd | Novel compositions, their use, and methods for their formation |
CN110250548B (zh) * | 2019-07-03 | 2020-10-27 | 浙江大学 | 一种重组复合物产氢微胶囊及其制备方法 |
EP4013240A1 (en) | 2019-08-16 | 2022-06-22 | Cambridge Glycoscience Ltd | Methods of treating biomass to produce oligosaccharides and related compositions |
WO2021116437A2 (en) | 2019-12-12 | 2021-06-17 | Cambridge Glycoscience Ltd | Low sugar multiphase foodstuffs |
KR102441174B1 (ko) * | 2020-01-31 | 2022-09-08 | 부경대학교 산학협력단 | 쌀가루를 이용한 이소말토올리고당을 함유하는 신바이오틱스의 제조방법 |
CN111990653B (zh) * | 2020-09-04 | 2023-06-20 | 内蒙古蒙牛乳业(集团)股份有限公司 | 一种富含膳食纤维的纤维粉及其制备方法 |
CN115918907B (zh) * | 2022-12-20 | 2024-04-19 | 上海交通大学 | 内源氢膳食营养补充剂 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008237162A (ja) * | 2007-03-28 | 2008-10-09 | Nagasakiken Koritsu Daigaku Hojin | 腸内環境改善組成物、甘味組成物および機能性食品 |
JP2012075382A (ja) * | 2010-10-01 | 2012-04-19 | Yakult Honsha Co Ltd | 発酵食品およびその製造方法 |
WO2014133060A1 (ja) * | 2013-03-01 | 2014-09-04 | 株式会社林原 | 抗生活習慣病用剤及びそれを含んでなる経口組成物 |
WO2014144458A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Methods of maintaining and improving muscle function |
JP2014233249A (ja) * | 2013-06-03 | 2014-12-15 | 株式会社 Good Luck | 水素発生食品 |
-
2016
- 2016-09-30 US US15/764,577 patent/US20190126075A1/en not_active Abandoned
- 2016-09-30 JP JP2017543634A patent/JP6796070B2/ja active Active
- 2016-09-30 WO PCT/JP2016/079102 patent/WO2017057718A1/ja active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008237162A (ja) * | 2007-03-28 | 2008-10-09 | Nagasakiken Koritsu Daigaku Hojin | 腸内環境改善組成物、甘味組成物および機能性食品 |
JP2012075382A (ja) * | 2010-10-01 | 2012-04-19 | Yakult Honsha Co Ltd | 発酵食品およびその製造方法 |
WO2014133060A1 (ja) * | 2013-03-01 | 2014-09-04 | 株式会社林原 | 抗生活習慣病用剤及びそれを含んでなる経口組成物 |
WO2014144458A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Methods of maintaining and improving muscle function |
JP2014233249A (ja) * | 2013-06-03 | 2014-12-15 | 株式会社 Good Luck | 水素発生食品 |
Non-Patent Citations (2)
Title |
---|
J. JPN. ASSOC. DIETARY FIBER RES., vol. 9, no. 1, JPN6016049243, 2005, pages 34 - 46, ISSN: 0004224872 * |
NIPPON SHOKUHIN KAGAKU KAISHI, vol. 51, no. 1, JPN6016049244, 2004, pages 28 - 33, ISSN: 0004224873 * |
Also Published As
Publication number | Publication date |
---|---|
US20190126075A1 (en) | 2019-05-02 |
WO2017057718A1 (ja) | 2017-04-06 |
JP6796070B2 (ja) | 2020-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6796070B2 (ja) | 難消化性成分を含む飲食品および大腸内水素ガス産生剤 | |
JP7273725B2 (ja) | 新規ビフィドバクテリウム属細菌及び当該細菌を含む組成物 | |
Leahy et al. | Getting better with bifidobacteria | |
Russell et al. | Metabolic activities and probiotic potential of bifidobacteria | |
Rowland et al. | Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. | |
Lin | Probiotics as functional foods | |
RU2291899C2 (ru) | Композиция микроорганизмов (варианты) | |
US11607435B2 (en) | Probiotics Bifidobacteria strains | |
Kumari et al. | Clinical importance of lactic acid bacteria: a short review | |
EP1972208A1 (en) | Composition for improving intestinal microflora | |
JP2006522766A (ja) | シンビオティックな組み合わせ | |
BRPI0007481B1 (pt) | formulação contendo cepa de bifidobacterium e uso da mesma | |
Raman et al. | Probiotics and bioactive carbohydrates in colon cancer management | |
Kumari et al. | Probiotics, prebiotics, and synbiotics: Current status and future uses for human health | |
WO2020008149A1 (fr) | Utilisation d'une souche de roseburia intestinalis pour la prévention et le traitement de l'inflammation de l'intestin | |
Holzapfel | Introduction to prebiotics and probiotics | |
Liu et al. | Efficacy of pasteurised yoghurt in improving chronic constipation: A randomised, double-blind, placebo-controlled trial | |
Yakoob et al. | Bifidobacterium sp as Probiotic Agent-Roles and Applications. | |
Sip et al. | Probiotics and prebiotics | |
Nagpal et al. | Probiotics, prebiotics and synbiotics: An introduction | |
KR100868777B1 (ko) | Rs3 유형의 저항 전분에 대해 분해능이 있는비피도박테리움 아도레스센티스를 유효성분으로 함유하는것을 특징으로 하는 식품 조성물 | |
Konuray et al. | Antimicrobial Effect of Probiotics, Prebiotics, and Synbiotics | |
CN112236154A (zh) | 一种组合物及其应用 | |
Gupta et al. | Synbiotics: promoting gastrointestinal health | |
Irokanulo et al. | Probiotics for Gastrointestinal Health and General Wellbeing. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190411 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200303 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200501 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201028 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201113 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6796070 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |