JPWO2015133638A1 - 肺炎球菌感染予防剤 - Google Patents
肺炎球菌感染予防剤 Download PDFInfo
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- JPWO2015133638A1 JPWO2015133638A1 JP2016506207A JP2016506207A JPWO2015133638A1 JP WO2015133638 A1 JPWO2015133638 A1 JP WO2015133638A1 JP 2016506207 A JP2016506207 A JP 2016506207A JP 2016506207 A JP2016506207 A JP 2016506207A JP WO2015133638 A1 JPWO2015133638 A1 JP WO2015133638A1
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- infection
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- fermented product
- pneumococcal infection
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Abstract
Description
脱脂粉乳を主成分に調製した溶液(発酵乳Mix)に、ブルガリア菌R−1株をスターター菌として加えて、これを37℃で16時間発酵させた。この発酵物(発酵乳)の菌体外多糖類量を測定し、マウスへの投与量を算出した。なお、菌体外多糖類量の測定方法では、トリクロロ酢酸にて、発酵物を除タンパクし、エタノール沈殿法にて、多糖体(菌体外多糖類)を沈殿させ精製した。そして、ゲルろ過モードのHPLCにて、この沈殿させた多糖体(菌体外多糖類)量を測定した。また、この発酵物(発酵乳)は、725μg/gの菌体外多糖体と、1.7×109CFU/gの乳酸菌を含んでいた。
(マウスの肺への感染)
C57BL/6マウス(雌、8終齢、n=9又は10匹)のうち、発酵乳投与群には、試験の全期間に亘って連日で、ブルガリア菌R−1株の発酵物(菌体外多糖類量として50μg/mouse)を経口投与(1回/日、投与前の21日間及び投与後)した。なお、対照群には、脱脂粉乳を主成分に調製した溶液(発酵乳Mix)を経口投与した。これら経口投与の開始から22日目に、肺炎球菌(Streptococcus pneumoniae)D39株の懸濁液を50μlで経鼻接種(1×108 CFU/mouse)した。そして、肺炎球菌の接種後に、生存率及び肺内生菌数を群間で比較した。
(マウスの上気道への感染)
C57BL/6マウス(雌、8終齢、n=9匹又は10匹)のうち、発酵乳投与群には、試験の全期間に亘って連日で、ブルガリア菌R−1株の発酵物(菌体外多糖類量として50μg/mouse)を経口投与(1回/日、投与前の21日間及び投与後)した。なお、対照群には、脱脂粉乳を主成分に調製した溶液(発酵乳Mix)を経口投与した。これら経口投与の開始から22日目に、肺炎球菌(Streptococcus pneumoniae)1121株の懸濁液を50μlで経鼻接種(1×107 CFU/mouse)した。そして、肺炎球菌の接種後に、上気道内の定着菌数(上気道に定着した肺炎球菌数)を群間で比較した。
Claims (6)
- ラクトバチラス・デルブルッキー・サブスピーシス・ブルガリクス(Lactobacillus delbrueckii ssp. bulgaricus)OLL1073R−1の発酵物を有効成分として含む肺炎球菌感染予防剤。
- 少なくともラクトバチラス・デルブルッキー・サブスピーシス・ブルガリクス(Lactobacillus delbrueckii ssp. bulgaricus)OLL1073R−1の生菌を含む請求項1に記載の肺炎球菌感染予防剤。
- 前記発酵物は、ラクトバチラス・デルブルッキー・サブスピーシス・ブルガリクス(Lactobacillus delbrueckii ssp. bulgaricus)OLL1073R−1とサーモフィルス菌(Streptococcus thermophillus)による発酵物である請求項1又は2に記載の肺炎球菌感染予防剤。
- ラクトバチラス・デルブルッキー・サブスピーシス・ブルガリクス(Lactobacillus delbrueckii ssp. bulgaricus)OLL1073R−1の発酵物の医療行為又は非医療行為による摂取により、肺炎球菌の感染を予防、及び/又は、肺炎球菌の感染時の重篤化を防止や抑制する方法。
- 少なくともラクトバチラス・デルブルッキー・サブスピーシス・ブルガリクス(Lactobacillus delbrueckii ssp. bulgaricus)OLL1073R−1の生菌を含む請求項4に記載の方法。
- 前記発酵物は、ラクトバチラス・デルブルッキー・サブスピーシス・ブルガリクス(Lactobacillus delbrueckii ssp. bulgaricus)OLL1073R−1とサーモフィルス菌(Streptococcus thermophillus)による発酵物である請求項4又は5に記載の方法。
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