JPWO2014119497A1 - 生化学用カートリッジ、生化学用カートリッジ及びカートリッジホルダのセット - Google Patents
生化学用カートリッジ、生化学用カートリッジ及びカートリッジホルダのセット Download PDFInfo
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/36—Means for collection or storage of gas; Gas holders
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/12—Actuating devices; Operating means; Releasing devices actuated by fluid
- F16K31/126—Actuating devices; Operating means; Releasing devices actuated by fluid the fluid acting on a diaphragm, bellows, or the like
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
- F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
- F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
- F16K7/17—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being actuated by fluid pressure
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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Abstract
Description
2・・・カートリッジホルダ
3・・・空気圧制御システム
5・・・スワブ
6・・・スワブ封入部屋
7・・・溶解液封入部屋
8・・・増幅試薬封入部屋
9・・・変性試薬封入部屋
10・・・分岐中継部屋
11・・・変性試薬混合部屋
12・・・温調部屋
13・・・キャピラリ接続部屋
14・・・一送液流路
15・・・分岐送液流路
16・・・微量試薬封入部
25・・・コントロールレーン
26・・・サンプル解析レーン
27・・・基準レーン
30・・・エアーポンプ
31・・・フィルタ
32・・・圧力調整弁
33・・・大気解放2方弁
34・・・サイレンサ
35・・・分岐管
36・・・加圧配管2方弁
37・・・負圧配管3方弁
38・・・3方弁マニホールド
39・・・3方弁
40・・・スピードコントローラ
41・・・大気解放部
45、46、47、48・・・空気圧流路
50・・・カートリッジ本体
51・・・メンブレン
52・・・フィルム
53・・・メンブレン貼り付け部
54・・・開口部
60・・・ホルダベース
61・・・ホルダトップ
62・・・ホルダ中板
63・・・ガスケット
64・・・プランジャ
65・・・パッキン
66・・・上昇空気圧ポート
67・・・降下空気圧ポート
68・・・流路加圧ポート
69・・・流路負圧ポート
70・・・流路突起
71・・・流路溝
Claims (9)
- 密閉された空間内で送液を行うカートリッジであって、
カートリッジ本体と、
該カートリッジ本体の内部に設けられた、液が入る複数の部屋と、
該カートリッジ本体の底面に貼られた弾性体であって、外部からの圧力変化に応じて変形し、前記複数の部屋の底面側を閉じる機能と、前記複数の部屋の間に流路を形成する機能とを有する弾性体と、
を備えることを特徴とするカートリッジ。 - 密閉された空間内で外部と非接触で送液を行うためのカートリッジであって、試薬の封入やサンプルを封入する部屋、反応、精製、攪拌等を行う部屋が形成され、流路となる溝等は形成されていないカートリッジ本体の底面に、弾性体であるメンブレン貼り付け、通常状態では流路が形成されておらず、流路となる部分はメンブレンの接合を行わず、圧力の変化でメンブレンを変形させたときに初めて流路が形成されることを特徴としたカートリッジ。
- 請求項1記載のカートリッジと当該カートリッジをセットするカートリッジホルダであって、流路形状は前記カートリッジホルダに形成され、その形状に従って前記生化学用カートリッジに流路が形成されることを特徴とした生化学用カートリッジ及びカートリッジホルダのセット。
- 請求項3において、前記流路に高さや幅に差を設け、メンブレンが密着させることができるカートリッジ及びカートリッジホルダのセット。
- 請求項3において、メンブレンへの圧力変化は加圧と負圧の両方を用いて、カートリッジとカートリッジホルダの流路の互いに密着させることで送液精度を向上させたカートリッジ及びカートリッジホルダのセット。
- 密閉された空間内で外部と非接触で送液を行うためのカートリッジにおいて、流路の幅や形状をカートリッジホルダに形成し、カートリッジホルダには流路を区切る突起が付いてあり、カートリッジにはその突起が入る溝があり、カートリッジホルダの突起をカートリッジの溝に入れ込んで流路を形成することで流路の精度向上、送液精度の向上、メンブレン接合物質と流体を非接触にし、メンブレンの座屈を防止することを特徴としたカートリッジ及びカートリッジホルダのセット。
- 密閉された空間内で外部と非接触で送液を行うためのカートリッジにおいて、一度送液した部屋や流路に処理の終わった試薬を戻し、余分な液を廃棄したり別の試薬と混合させることでコンパクト化したカートリッジ。
- 密閉された空間内で外部と非接触で送液を行うためのカートリッジにおいて、一つの試薬層から分岐送液を行うことで、レーン毎の解析結果の信頼性を向上させたカートリッジ。
- 密閉された空間内で外部と非接触で送液を行うためのカートリッジにおいて、微量試薬を保存する際に流路に直接封入しておき、送液と同時に混合することを特徴としたカートリッジ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013016328 | 2013-01-31 | ||
JP2013016328 | 2013-01-31 | ||
PCT/JP2014/051611 WO2014119497A1 (ja) | 2013-01-31 | 2014-01-27 | 生化学用カートリッジ、生化学用カートリッジ及びカートリッジホルダのセット |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2014119497A1 true JPWO2014119497A1 (ja) | 2017-01-26 |
JP6093783B2 JP6093783B2 (ja) | 2017-03-08 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014559660A Expired - Fee Related JP6093783B2 (ja) | 2013-01-31 | 2014-01-27 | 生化学用カートリッジ、生化学用カートリッジ及びカートリッジホルダのセット |
Country Status (5)
Country | Link |
---|---|
US (1) | US10246675B2 (ja) |
EP (1) | EP2952907B1 (ja) |
JP (1) | JP6093783B2 (ja) |
CN (1) | CN104969076B (ja) |
WO (1) | WO2014119497A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY188878A (en) * | 2015-11-04 | 2022-01-12 | Nitto Denko Corp | Apparatus and system for biofluid sample dispensing and/or assay |
JP6868639B2 (ja) * | 2016-03-18 | 2021-05-12 | クイデル カーディオバスキュラー インコーポレイテッド | マイクロ流体デバイス、システム、及び方法 |
JP6789889B2 (ja) * | 2017-06-26 | 2020-11-25 | 株式会社日立ハイテク | 試料処理装置 |
CN107858269A (zh) * | 2017-12-22 | 2018-03-30 | 苏州艾捷尔斯生物科技有限公司 | 一种便于调酸的微生物发酵罐 |
EP3556841A1 (en) * | 2018-04-19 | 2019-10-23 | Aglaris Ltd | Disposable cartridge cooperating with a platform in a flexible system for handling and/or manipulating fluids |
JP7150138B2 (ja) * | 2019-03-07 | 2022-10-07 | 株式会社日立ハイテク | 温度制御装置用送液カートリッジ |
WO2020225645A1 (en) * | 2019-05-07 | 2020-11-12 | Lonza Ltd. | Sampling system with a replaceable cassette assembly and methods of using the same |
Citations (5)
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JP2006234590A (ja) * | 2005-02-25 | 2006-09-07 | Shimadzu Corp | 反応容器 |
WO2009054473A1 (ja) * | 2007-10-26 | 2009-04-30 | Toppan Printing Co., Ltd. | 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置 |
WO2010073020A1 (en) * | 2008-12-24 | 2010-07-01 | Heriot-Watt University | A microfluidic system and method |
JP2011030522A (ja) * | 2009-08-04 | 2011-02-17 | Aida Engineering Ltd | マイクロ流体デバイス |
WO2011048521A1 (en) * | 2009-10-21 | 2011-04-28 | Koninklijke Philips Electronics N.V. | Microfluidic cartridge with parallel pneumatic interface plate |
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JPS63315956A (ja) | 1987-06-19 | 1988-12-23 | Nittec Co Ltd | 試料分注ロボット |
EP2404676A1 (en) * | 2002-12-30 | 2012-01-11 | The Regents of the University of California | Microfluidic Control Structures |
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JP4759451B2 (ja) | 2006-06-16 | 2011-08-31 | 株式会社日立ソリューションズ | 生体物質の前処理チップ及び前処理チップシステム |
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CN102740976B (zh) * | 2010-01-29 | 2016-04-20 | 精密公司 | 取样-应答微流体盒 |
EP2479466A1 (en) * | 2011-01-21 | 2012-07-25 | Biocartis SA | Micro-Pump or normally-off micro-valve |
-
2014
- 2014-01-27 EP EP14746499.4A patent/EP2952907B1/en active Active
- 2014-01-27 WO PCT/JP2014/051611 patent/WO2014119497A1/ja active Application Filing
- 2014-01-27 JP JP2014559660A patent/JP6093783B2/ja not_active Expired - Fee Related
- 2014-01-27 CN CN201480006607.9A patent/CN104969076B/zh not_active Expired - Fee Related
- 2014-01-27 US US14/762,301 patent/US10246675B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006234590A (ja) * | 2005-02-25 | 2006-09-07 | Shimadzu Corp | 反応容器 |
WO2009054473A1 (ja) * | 2007-10-26 | 2009-04-30 | Toppan Printing Co., Ltd. | 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置 |
WO2010073020A1 (en) * | 2008-12-24 | 2010-07-01 | Heriot-Watt University | A microfluidic system and method |
JP2011030522A (ja) * | 2009-08-04 | 2011-02-17 | Aida Engineering Ltd | マイクロ流体デバイス |
WO2011048521A1 (en) * | 2009-10-21 | 2011-04-28 | Koninklijke Philips Electronics N.V. | Microfluidic cartridge with parallel pneumatic interface plate |
Also Published As
Publication number | Publication date |
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CN104969076B (zh) | 2018-04-03 |
WO2014119497A1 (ja) | 2014-08-07 |
US20150361387A1 (en) | 2015-12-17 |
JP6093783B2 (ja) | 2017-03-08 |
CN104969076A (zh) | 2015-10-07 |
EP2952907A4 (en) | 2016-09-21 |
US10246675B2 (en) | 2019-04-02 |
EP2952907B1 (en) | 2020-03-11 |
EP2952907A1 (en) | 2015-12-09 |
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