JPWO2010147169A1 - 溶出性の改善された医薬組成物 - Google Patents

溶出性の改善された医薬組成物 Download PDF

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Publication number
JPWO2010147169A1
JPWO2010147169A1 JP2011519828A JP2011519828A JPWO2010147169A1 JP WO2010147169 A1 JPWO2010147169 A1 JP WO2010147169A1 JP 2011519828 A JP2011519828 A JP 2011519828A JP 2011519828 A JP2011519828 A JP 2011519828A JP WO2010147169 A1 JPWO2010147169 A1 JP WO2010147169A1
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
compound
weight
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011519828A
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English (en)
Japanese (ja)
Inventor
信 釜田
信 釜田
資典 木所
資典 木所
学 関口
学 関口
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Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
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Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of JPWO2010147169A1 publication Critical patent/JPWO2010147169A1/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2011519828A 2009-06-18 2010-06-17 溶出性の改善された医薬組成物 Pending JPWO2010147169A1 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009145112 2009-06-18
JP2009145112 2009-06-18
PCT/JP2010/060261 WO2010147169A1 (ja) 2009-06-18 2010-06-17 溶出性の改善された医薬組成物

Publications (1)

Publication Number Publication Date
JPWO2010147169A1 true JPWO2010147169A1 (ja) 2012-12-06

Family

ID=43356485

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011519828A Pending JPWO2010147169A1 (ja) 2009-06-18 2010-06-17 溶出性の改善された医薬組成物

Country Status (14)

Country Link
US (1) US8449896B2 (zh)
EP (1) EP2444087B1 (zh)
JP (1) JPWO2010147169A1 (zh)
KR (1) KR20120037396A (zh)
CN (2) CN103330690A (zh)
BR (1) BRPI1011804A2 (zh)
CA (1) CA2765522A1 (zh)
ES (1) ES2605034T3 (zh)
MY (1) MY155256A (zh)
RU (1) RU2012101649A (zh)
SG (1) SG176934A1 (zh)
TW (1) TW201102064A (zh)
WO (1) WO2010147169A1 (zh)
ZA (1) ZA201109138B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101652139A (zh) 2007-03-29 2010-02-17 第一三共株式会社 药物组合物
EP2407450B1 (en) 2009-03-13 2015-04-22 Daiichi Sankyo Company, Limited Method for producing optically active diamine derivative
ES2706880T3 (es) 2010-02-22 2019-04-01 Daiichi Sankyo Co Ltd Preparación sólida de liberación sostenida para uso oral
WO2011115067A1 (ja) 2010-03-19 2011-09-22 第一三共株式会社 抗凝固剤の溶出改善方法
WO2013022059A1 (ja) 2011-08-10 2013-02-14 第一三共株式会社 ジアミン誘導体含有医薬組成物
CN103919746A (zh) * 2014-04-17 2014-07-16 山东省医药工业研究所 依度沙班缓释片及其制备方法
US20170231969A1 (en) * 2014-08-06 2017-08-17 Sandoz Ag Pharmaceutical Compositions of Edoxaban
TWI826474B (zh) 2018-06-27 2023-12-21 日商第一三共股份有限公司 包含二胺衍生物之顆粒劑、以及其用途及製造方法
CN112955146A (zh) * 2018-10-31 2021-06-11 富士胶片株式会社 包含抗肿瘤剂的医药组合物
EP3744320A1 (en) 2019-05-29 2020-12-02 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising edoxaban
WO2022129535A1 (en) 2020-12-18 2022-06-23 Krka, D.D., Novo Mesto Edoxaban formulation containing no sugar alcohols
WO2024121413A1 (en) 2022-12-09 2024-06-13 Synthon B.V. Formulation comprising edoxaban and preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237001A (ja) * 1984-05-10 1985-11-25 Nissan Chem Ind Ltd 水処理用成形組成物
WO2008129846A1 (ja) * 2007-03-29 2008-10-30 Daiichi Sankyo Company, Limited 医薬組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149855A (en) 1989-12-26 1992-09-22 Mitsubishi Rayon Co., Ltd. Process for racemizing optically active carboxylic acid esters
US5055600A (en) 1990-04-24 1991-10-08 Rockwell International Corporation Glycidyl azide polymer (gap) synthesis by molten salt method
US5677469A (en) 1995-05-18 1997-10-14 Sepracor, Inc. Process for resolving chiral acids with 1-aminoindan-2-ols
JPH11180899A (ja) 1997-12-15 1999-07-06 Mitsui Chem Inc 活性メチレンアルキル化化合物の製造法
JP3680203B2 (ja) 1999-06-01 2005-08-10 東洋化成工業株式会社 ４−アセチルアミノベンゼンスルホニルアジドの製造方法
JP2001151724A (ja) 1999-11-19 2001-06-05 Kuraray Co Ltd 光学活性な２，２，４−トリメチル−３−シクロヘキセンカルボン酸の製造方法
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
CA2451605C (en) 2001-06-20 2010-08-10 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
AU2002328596B2 (en) 2001-08-09 2007-09-20 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
AU2003292828B9 (en) 2002-12-25 2009-10-01 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
EP2316431B1 (en) * 2003-04-08 2015-09-30 Novartis AG Solid oral composition comprising a S1P receptor agonist and a sugar alcohol
KR101215153B1 (ko) 2003-11-12 2012-12-24 다이이찌 산쿄 가부시키가이샤 티아졸 유도체의 제조법
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
HUE029336T2 (en) 2005-09-16 2017-02-28 Daiichi Sankyo Co Ltd For the preparation of an optically active diamine derivative and process
JP4227629B2 (ja) 2006-04-28 2009-02-18 達實 小野 過熱蒸気を応用した塗装用乾燥焼付装置
TW200909437A (en) 2007-06-21 2009-03-01 Daiichi Sankyo Co Ltd Process for the preparation of diamine-derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237001A (ja) * 1984-05-10 1985-11-25 Nissan Chem Ind Ltd 水処理用成形組成物
WO2008129846A1 (ja) * 2007-03-29 2008-10-30 Daiichi Sankyo Company, Limited 医薬組成物

Also Published As

Publication number Publication date
EP2444087B1 (en) 2016-09-07
EP2444087A1 (en) 2012-04-25
ES2605034T3 (es) 2017-03-10
CN103330690A (zh) 2013-10-02
TW201102064A (en) 2011-01-16
US8449896B2 (en) 2013-05-28
ZA201109138B (en) 2012-08-29
KR20120037396A (ko) 2012-04-19
MY155256A (en) 2015-09-30
BRPI1011804A2 (pt) 2018-02-27
US20120114711A1 (en) 2012-05-10
EP2444087A4 (en) 2013-05-01
SG176934A1 (en) 2012-01-30
RU2012101649A (ru) 2013-07-27
WO2010147169A1 (ja) 2010-12-23
CA2765522A1 (en) 2010-12-23
CN102481296A (zh) 2012-05-30

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