JPWO2009142186A1 - 細胞障害性組成物 - Google Patents

細胞障害性組成物 Download PDF

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Publication number
JPWO2009142186A1
JPWO2009142186A1 JP2010513017A JP2010513017A JPWO2009142186A1 JP WO2009142186 A1 JPWO2009142186 A1 JP WO2009142186A1 JP 2010513017 A JP2010513017 A JP 2010513017A JP 2010513017 A JP2010513017 A JP 2010513017A JP WO2009142186 A1 JPWO2009142186 A1 JP WO2009142186A1
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Japan
Prior art keywords
antibody
cytotoxic composition
cells
composition according
transgenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010513017A
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English (en)
Japanese (ja)
Inventor
敬 山下
敬 山下
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Kaneka Corp
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Kaneka Corp
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Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of JPWO2009142186A1 publication Critical patent/JPWO2009142186A1/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/11—Immunoglobulins specific features characterized by their source of isolation or production isolated from eggs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2010513017A 2008-05-20 2009-05-19 細胞障害性組成物 Pending JPWO2009142186A1 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008131596 2008-05-20
JP2008131596 2008-05-20
PCT/JP2009/059161 WO2009142186A1 (ja) 2008-05-20 2009-05-19 細胞障害性組成物

Publications (1)

Publication Number Publication Date
JPWO2009142186A1 true JPWO2009142186A1 (ja) 2011-09-29

Family

ID=41340119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010513017A Pending JPWO2009142186A1 (ja) 2008-05-20 2009-05-19 細胞障害性組成物

Country Status (5)

Country Link
US (1) US20110112281A1 (de)
EP (1) EP2311493A4 (de)
JP (1) JPWO2009142186A1 (de)
CN (1) CN102036683A (de)
WO (1) WO2009142186A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8815242B2 (en) * 2009-05-27 2014-08-26 Synageva Biopharma Corp. Avian derived antibodies
JP2013177317A (ja) * 2010-06-24 2013-09-09 Meneki Seibutsu Kenkyusho:Kk 抗ｐｄｇｆ受容体抗体

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05507418A (ja) * 1990-12-21 1993-10-28 セルテック　リミテッド ＴＮＦ―αに特異的な組換え抗体
JPH06506120A (ja) * 1991-03-18 1994-07-14 ニューヨーク・ユニバーシティ ヒト腫瘍壊死因子に特異的なモノクローナルなキメラ抗体
JP2000507810A (ja) * 1996-02-09 2000-06-27 ベーアーエスエフ アクツィエンゲゼルシャフト ヒトＴＮＦαに結合するヒト抗体
WO2002031140A1 (fr) * 2000-10-06 2002-04-18 Kyowa Hakko Kogyo Co., Ltd. Cellules produisant des compositions d'anticorps
WO2004016081A1 (ja) * 2002-08-13 2004-02-26 Kaneka Corporation レトロウイルスベクターによる遺伝子導入鳥類での遺伝子発現法およびそれによって得られる遺伝子導入鳥類
WO2005065450A1 (ja) * 2004-01-08 2005-07-21 Kaneka Corporation 遺伝子導入鳥類及びその作製法
JP2005535331A (ja) * 2002-08-09 2005-11-24 オリジェン セラピューティクス トランスジェニックニワトリにおける外因性タンパク質の組織特異的発現
JP2007126481A (ja) * 1994-03-08 2007-05-24 Dana-Farber Cancer Inst Inc Ｔ細胞の不応答性を調節する方法
JP2008530243A (ja) * 2005-02-18 2008-08-07 メダレックス， インク． フコシル残基を欠く前立腺特異的膜抗原（ｐｓｍａ）に対するモノクローナル抗体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US6136597A (en) 1997-09-18 2000-10-24 The Salk Institute For Biological Studies RNA export element
AU7491800A (en) * 1999-09-15 2001-04-17 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purifiedfrom genetically engineered birds
US20020108132A1 (en) * 2001-02-02 2002-08-08 Avigenics Inc. Production of a monoclonal antibody by a transgenic chicken
US20060191026A1 (en) * 2005-02-18 2006-08-24 Origen Therapeutics, Inc. Tissue specific expression of antibodies in chickens
EP1480675A4 (de) * 2002-02-08 2005-10-26 Tranxenogen Inc Immunoglobulin-reinigung
BRPI0607203A2 (pt) * 2005-02-18 2009-08-25 Medarex Inc anticorpo anti-cd30 isolado, célula hospedeira, métodos para inibir o crescimento de células cd30+, e, uso de um anticorpo anti-cd30 desfucosilado
WO2007011041A1 (ja) 2005-07-22 2007-01-25 Kyowa Hakko Kogyo Co., Ltd. 遺伝子組換え抗体組成物

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05507418A (ja) * 1990-12-21 1993-10-28 セルテック　リミテッド ＴＮＦ―αに特異的な組換え抗体
JPH06506120A (ja) * 1991-03-18 1994-07-14 ニューヨーク・ユニバーシティ ヒト腫瘍壊死因子に特異的なモノクローナルなキメラ抗体
JP2007126481A (ja) * 1994-03-08 2007-05-24 Dana-Farber Cancer Inst Inc Ｔ細胞の不応答性を調節する方法
JP2000507810A (ja) * 1996-02-09 2000-06-27 ベーアーエスエフ アクツィエンゲゼルシャフト ヒトＴＮＦαに結合するヒト抗体
WO2002031140A1 (fr) * 2000-10-06 2002-04-18 Kyowa Hakko Kogyo Co., Ltd. Cellules produisant des compositions d'anticorps
JP2005535331A (ja) * 2002-08-09 2005-11-24 オリジェン セラピューティクス トランスジェニックニワトリにおける外因性タンパク質の組織特異的発現
WO2004016081A1 (ja) * 2002-08-13 2004-02-26 Kaneka Corporation レトロウイルスベクターによる遺伝子導入鳥類での遺伝子発現法およびそれによって得られる遺伝子導入鳥類
WO2005065450A1 (ja) * 2004-01-08 2005-07-21 Kaneka Corporation 遺伝子導入鳥類及びその作製法
JP2008530243A (ja) * 2005-02-18 2008-08-07 メダレックス， インク． フコシル残基を欠く前立腺特異的膜抗原（ｐｓｍａ）に対するモノクローナル抗体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOTECHNOLOGY AND BIOENGINEERING, vol. 93, JPN6014018745, 2006, pages 851 - 861, ISSN: 0002806659 *
JOURNAL OF IMMUNOLOGICAL METHODS, vol. 306, JPN6014018744, 2005, pages 151 - 160, ISSN: 0002806658 *
河辺佳典他, 化学工学会年会研究発表講演要旨集, トランスジェニックニワトリが生産したヒト型抗体の解析,, JPN6009033385, ISSN: 0002591399 *

Also Published As

Publication number Publication date
EP2311493A4 (de) 2012-09-26
WO2009142186A1 (ja) 2009-11-26
CN102036683A (zh) 2011-04-27
US20110112281A1 (en) 2011-05-12
EP2311493A1 (de) 2011-04-20

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