JPWO2005097091A1 - 還元型補酵素q10およびカロチノイド類を含有した組成物 - Google Patents
還元型補酵素q10およびカロチノイド類を含有した組成物 Download PDFInfo
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- JPWO2005097091A1 JPWO2005097091A1 JP2006512065A JP2006512065A JPWO2005097091A1 JP WO2005097091 A1 JPWO2005097091 A1 JP WO2005097091A1 JP 2006512065 A JP2006512065 A JP 2006512065A JP 2006512065 A JP2006512065 A JP 2006512065A JP WO2005097091 A1 JPWO2005097091 A1 JP WO2005097091A1
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- carotenoids
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Abstract
Description
生体内で発生した活性酸素及び/又はフリーラジカルを消去する効果は十分ではなく、従って、生体内で発揮される上記効果も十分満足されるものではなかった。
A/(B+C)×100 (評価式a)
にあてはめた場合に、100を超える、好ましくは105以上、より好ましくは110以上となることを意味する。
(A−C)/B×100 (評価式b)
にあてはめた場合に、100を超える、好ましくは105以上、より好ましくは110以上、更に好ましくは120以上、特に好ましくは130以上となることを意味する。
[抗酸化力の測定法]
(測定法1)
抗酸化力測定の第1法として、酸化反応により生じるチオバルビツール酸反応性物質(TBARS)の量を測定する手法を用いた(Buege J. A. and Aust S.D.; Methods Enzymol., 1978, 52, 302)。
TBARSは赤色物質のため、カロチノイドの種類によっては、上記測定法1では、正確な吸光度を測定することができない場合がある。そこで、DPPH(1,1-diphenyl-2-picrylhydrazyl)を用いた分光測定法も用いた(篠原和毅 鈴木建夫;食品機能研究法,2000,218)。
[評価式]
上記の測定法によって、還元型補酵素Q10とカロチノイドを併用した場合の抗酸化力(Aとする)、還元型補酵素Q10単独での抗酸化力(Bとする)、及び、カロチノイド単独での抗酸化力(Cとする)を測定する。そして、併用時の抗酸化力と、還元型補酵素Q10単独の抗酸化力とカロチノイド単独の抗酸化力の和(相加効果)を比較し、併用による相乗効果の有無を判定する。
(評価式a) A/(B+C)×100
(評価式b) (A−C)/B×100
式中、Aは還元型補酵素Q10とカロチノイドを併用した場合の抗酸化力、Bは還元型補酵素Q10単独での抗酸化力、Cはカロチノイド単独での抗酸化力を表す。
1000gのエタノール中に、100gの酸化型補酵素Q10、60gのL−アスコルビン酸を加え、78℃にて撹拌し、還元反応を行った。30時間後、50℃まで冷却し、同温を保持しながらエタノール400g、水100gを添加した。このエタノール溶液を撹拌しながら、10℃/時間の冷却速度で2℃まで冷却し、生成した結晶を濾別した。得られた湿結晶を冷エタノール、冷水の順で洗浄した後に圧乾燥することにより、白色の乾燥結晶95gを得た(有姿収率95モル%)。なお、減圧乾燥を除くすべての操作は窒素雰囲気下で実施した。得られた結晶の還元型補酵素Q10/酸化型補酵素Q10の重量比は99.5/0.5であった。
参考例1で得た還元型補酵素Q10及び/又はカロチノイド類の一つであるアスタキサンチンのエタノール溶液(各々100mM)を試料とし、上記測定法1にて、抗酸化力を測定した。各々の測定結果を上記評価式aおよび評価式bに当てはめ、相乗効果の有無を判定した。表1に示す通り、評価式aでは135、評価式bでは205となり、還元型補酵素Q10およびカロチノイド類が共存した場合の明らかな抗酸化力の相乗効果が確認された。
参考例1で得た還元型補酵素Q10及び/又はβ−カロチン、還元型補酵素Q10及び/又はリコペンのエタノール溶液(各々25μM)を試料とし、測定法2にて、抗酸化力を測定した。各々の測定結果を上記評価式aおよび評価式bにあてはめ、相乗効果の有無を判定した。表2に示す通り、還元型補酵素Q10とβ−カロチンの場合、評価式aでは107、評価式bでは114と算出された。また、還元型補酵素Q10とリコペンの場合、評価式aでは105、評価式bでは105と算出された。以上より、還元型補酵素Q10とβ−カロチン、あるいは、還元型補酵素Q10とリコペンが共存した場合の明らかな抗酸化力の相乗効果が確認された。
参考例1で得た還元型補酵素Q10およびビタミンEを使用し、実施例1と全く同様の検討を行った。その結果、評価式aでは90、評価式bでは82となり、還元型補酵素Q10とビタミンEの場合には、相乗効果は認められなかった。
米油、硬化油、蜜蝋、レシチン、ジグリセリンモノオレエートの混合物に参考例1で得た還元型補酵素Q10およびアスタキサンチンを添加し、常法により下記成分より成るゼラチンのソフトカプセル製剤を得た。
アスタキサンチン 10重量部
米油 500重量部
ジグリセリンモノオレエート 180重量部
硬化油 170重量部
蜜蝋 60重量部
レシチン 20重量部
中鎖脂肪酸トリグリセリド(MCT、炭素数8:炭素数10=6:4)に参考例1で得た還元型補酵素Q10およびビタミンAを添加し、常法により下記成分より成るゼラチンのソフトカプセル製剤を得た。
ビタミンA 5重量部
中鎖脂肪酸トリグリセリド 935重量部
参考例1で得た還元型補酵素Q10およびリコピン(トマト抽出物)をプロパノールに溶解し、これを微結晶セルロースに吸着させた後、減圧下で乾燥した。これに、窒素雰囲気下でトウモロコシ澱粉、乳糖、カルボキシメチルセルロース、ステアリン酸マグネシウムを混合し、次いでポリビニルピロリドンの水溶液を結合剤として加え、常法により顆粒化した。これに滑沢剤としてタルクを加えて混合した後、錠剤に打錠した。
リコピン 10重量部
トウモロコシ澱粉 200重量部
乳糖 120重量部
カルボキシメチルセルロース 80重量部
微結晶セルロース 300重量部
ポリビニルピロリドン 40重量部
ステアリン酸マグネシウム 20重量部
タルク 80重量部
参考例1で得た還元型補酵素Q10およびアスタキサンチンを含有する下記組成のクリームを常法により調製した。
アスタキサンチン 1重量部
グリセロールソルビタン脂肪酸エステル 60重量部
微結晶性ワックス 10重量部
オリーブオイル 30重量部
流動パラフィン 180重量部
ステアリン酸マグネシウム 10重量部
プロピレングリコール 37重量部
硫酸マグネシウム 7重量部
脱塩水 655重量部
Claims (10)
- 還元型補酵素Q10及びカロチノイド類を含有し、活性酸素及び/又はフリーラジカルの消去作用が相乗的に高められた組成物。
- 還元型補酵素Q10に対するカロチノイド類の重量比が0.001〜10である請求項1記載の組成物。
- さらに油脂を含有する請求項1記載の組成物。
- 油脂の重量に対する還元型補酵素Q10の重量比が0.1%以上である請求項3記載の組成物。
- 経口投与形態に加工された請求項1〜4のいずれかに記載の組成物。
- 皮膚に直接塗布する形態を有する請求項1〜4のいずれかに記載の組成物。
- 請求項1〜4のいずれかに記載の組成物を有効成分とする経口投与剤。
- 請求項1〜4のいずれかに記載の組成物を有効成分とする皮膚用剤。
- 請求項1〜4のいずれかに記載の組成物を用いることを特徴とする活性酸素及び/又はフリーラジカルの消去方法。
- 食品、医薬製品または化粧品の酸化防止方法であって、食品、医薬製品または化粧品に、還元型補酵素Q10とカロチノイド類を共に含有させることを特徴とする方法。
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US9655966B2 (en) * | 2002-08-28 | 2017-05-23 | Kedar N. Prasad | Micronutrient formulations for radiation applications |
ATE555674T1 (de) * | 2004-04-09 | 2012-05-15 | Kaneka Corp | Zusammensetzung mit der reduzierten form von coenzym q10 und carotenoid-verbindung |
JP2009501179A (ja) * | 2005-07-15 | 2009-01-15 | ディーエスエム アイピー アセッツ ビー.ブイ. | 有機化合物の新規使用 |
US20070078180A1 (en) * | 2005-10-04 | 2007-04-05 | Kern Dale G | Methods and compositions for stabilizing an antioxidant |
JPWO2008035757A1 (ja) * | 2006-09-22 | 2010-01-28 | 株式会社カネカ | ユビキノールを含有するゼリー状食品 |
JP4868587B2 (ja) * | 2006-09-26 | 2012-02-01 | ユニチカ株式会社 | クリプトキサンチン含有組成物 |
JP4717790B2 (ja) * | 2006-12-04 | 2011-07-06 | 理研ビタミン株式会社 | カロテノイド製剤 |
US8815567B2 (en) | 2007-11-30 | 2014-08-26 | E I Du Pont De Nemours And Company | Coenzyme Q10 production in a recombinant oleaginous yeast |
JP5674262B2 (ja) * | 2008-08-08 | 2015-02-25 | 花王株式会社 | 染毛剤組成物 |
JP6170231B1 (ja) * | 2016-12-22 | 2017-07-26 | 株式会社タイショーテクノス | 色素製剤及びその製造方法、並びに加工製品及びその製造方法 |
DE102019218241A1 (de) * | 2019-11-26 | 2021-05-27 | Beiersdorf Ag | Wirkstoffkombinationen aus Ubichinol und Carrageenan und kosmetische oder dermatologische Zubereitungen, solche Wirkstoffkombinationen enthaltend |
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