JPS6485931A - Production of stabilized antibody complex - Google Patents

Production of stabilized antibody complex

Info

Publication number
JPS6485931A
JPS6485931A JP62240995A JP24099587A JPS6485931A JP S6485931 A JPS6485931 A JP S6485931A JP 62240995 A JP62240995 A JP 62240995A JP 24099587 A JP24099587 A JP 24099587A JP S6485931 A JPS6485931 A JP S6485931A
Authority
JP
Japan
Prior art keywords
antibody
fragment
water
soluble amine
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62240995A
Other languages
Japanese (ja)
Other versions
JPH0610140B2 (en
Inventor
Naoji Umemoto
Noriaki Endo
Kazuo Kishida
Takeshi Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP62240995A priority Critical patent/JPH0610140B2/en
Publication of JPS6485931A publication Critical patent/JPS6485931A/en
Publication of JPH0610140B2 publication Critical patent/JPH0610140B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PURPOSE:To obtain a complex of an antibody or its fragment with a substance bearing an acylated group, by acylating an antibody or its fragment and treating the product with a water-soluble amine. CONSTITUTION:The reaction of an antibody or its fragment with a substance having an acylated functional group is carried out at pH6-10, at -4-40 deg.C, then the product is treated 0.001-5M, preferably 0.01-1M water-soluble amine, such as ammonia, hydroxylamine, lower alkylamine, lower alkylenediamine in an aqueous solution of 6-10, preferably pH7-10. The treatment with a water-soluble amine cleaves unstable complexes formed in the acylation by binding with other than amino groups such as hydroxyl, and leaves the stable antibody complex binding through an amino group.
JP62240995A 1987-09-28 1987-09-28 Method for producing stabilized antibody complex Expired - Lifetime JPH0610140B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62240995A JPH0610140B2 (en) 1987-09-28 1987-09-28 Method for producing stabilized antibody complex

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62240995A JPH0610140B2 (en) 1987-09-28 1987-09-28 Method for producing stabilized antibody complex

Publications (2)

Publication Number Publication Date
JPS6485931A true JPS6485931A (en) 1989-03-30
JPH0610140B2 JPH0610140B2 (en) 1994-02-09

Family

ID=17067757

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62240995A Expired - Lifetime JPH0610140B2 (en) 1987-09-28 1987-09-28 Method for producing stabilized antibody complex

Country Status (1)

Country Link
JP (1) JPH0610140B2 (en)

Also Published As

Publication number Publication date
JPH0610140B2 (en) 1994-02-09

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