JPS6479190A - Production of gamma-substituted-alpha-siloxy-butenolide derivative - Google Patents
Production of gamma-substituted-alpha-siloxy-butenolide derivativeInfo
- Publication number
- JPS6479190A JPS6479190A JP23787087A JP23787087A JPS6479190A JP S6479190 A JPS6479190 A JP S6479190A JP 23787087 A JP23787087 A JP 23787087A JP 23787087 A JP23787087 A JP 23787087A JP S6479190 A JPS6479190 A JP S6479190A
- Authority
- JP
- Japan
- Prior art keywords
- alpha
- acid
- gamma
- trialkylsiloxy
- aldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Furan Compounds (AREA)
Abstract
PURPOSE:To obtain the titled compound useful as a synthetic intermediate for sialic acid, etc., from readily available raw materials by a simple method, by carrying out reaction in specific three steps using a (trialkylsiloxy)acrylic acid and aldehyde as starting raw materials. CONSTITUTION:An aldehyde and 2-(trialkylsiloxy)acrylic acid ester are initially reacted in the presence of a Lewis acid, preferably using dichloromethane as a solvent, normally at 0 deg.C and the resultant gamma-hydroxy-alpha-keto ester is lactonized in the presence of an acid catalyst (e.g., hydrochloric acid), normally at ambient temperature to afford an alpha-hydroxy-butenolide derivative, which is then preferably silylated with a tert-butyldimethylchlorosilane-imidazole based silylating agent to provide the aimed compound.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23787087A JPS6479190A (en) | 1987-09-22 | 1987-09-22 | Production of gamma-substituted-alpha-siloxy-butenolide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23787087A JPS6479190A (en) | 1987-09-22 | 1987-09-22 | Production of gamma-substituted-alpha-siloxy-butenolide derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6479190A true JPS6479190A (en) | 1989-03-24 |
Family
ID=17021636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP23787087A Pending JPS6479190A (en) | 1987-09-22 | 1987-09-22 | Production of gamma-substituted-alpha-siloxy-butenolide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6479190A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017165845A (en) * | 2016-03-15 | 2017-09-21 | 株式会社日本触媒 | Method for producing lactone ring-containing polymer, polymer and lactone ring-containing polymer |
-
1987
- 1987-09-22 JP JP23787087A patent/JPS6479190A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017165845A (en) * | 2016-03-15 | 2017-09-21 | 株式会社日本触媒 | Method for producing lactone ring-containing polymer, polymer and lactone ring-containing polymer |
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