JPS6461476A - Production of macrocyclic lactone - Google Patents
Production of macrocyclic lactoneInfo
- Publication number
- JPS6461476A JPS6461476A JP21537687A JP21537687A JPS6461476A JP S6461476 A JPS6461476 A JP S6461476A JP 21537687 A JP21537687 A JP 21537687A JP 21537687 A JP21537687 A JP 21537687A JP S6461476 A JPS6461476 A JP S6461476A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- cyclizing
- omega
- sulfonic acid
- hydroxy fatty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrane Compounds (AREA)
Abstract
PURPOSE:To readily and advantageously obtain the titled compound useful as an intermediate for producing higher perfume ingredient or medicine in high yield, by cyclizing omega-hydroxy fatty acid ester used as a starting substance in the presence of an acid. CONSTITUTION:The aimed compound such as 1,15-pentadecanolide is obtained by cyclizing omega-hydroxy fatty acid ester expressed by the formula (R is lower alkyl; n is 8-17) such as 15-hydroxypentadecanoic acid methyl ester, readily obtained at a low cost by converting a long-chain diacid monoester into an acid halide and then catalytically reducing the acid halide, preferably in a solvent such as p-xylene or toluene in the presence of catalytic amount of acid - excess acid, e.g. organic sulfonic acid such as p-toluene sulfonic acid or methane sulfonic acid at 50-200 deg.C, preferably 100-170 deg.C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21537687A JPS6461476A (en) | 1987-08-31 | 1987-08-31 | Production of macrocyclic lactone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21537687A JPS6461476A (en) | 1987-08-31 | 1987-08-31 | Production of macrocyclic lactone |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6461476A true JPS6461476A (en) | 1989-03-08 |
Family
ID=16671273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP21537687A Pending JPS6461476A (en) | 1987-08-31 | 1987-08-31 | Production of macrocyclic lactone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6461476A (en) |
-
1987
- 1987-08-31 JP JP21537687A patent/JPS6461476A/en active Pending
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