JPS6456681A - Novel macrolide compound - Google Patents

Novel macrolide compound

Info

Publication number
JPS6456681A
JPS6456681A JP21080587A JP21080587A JPS6456681A JP S6456681 A JPS6456681 A JP S6456681A JP 21080587 A JP21080587 A JP 21080587A JP 21080587 A JP21080587 A JP 21080587A JP S6456681 A JPS6456681 A JP S6456681A
Authority
JP
Japan
Prior art keywords
compound
formula
alkyl
acid residue
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP21080587A
Other languages
Japanese (ja)
Inventor
Yoshihisa Tsukamoto
Kazuo Sato
Toshiaki Yanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP21080587A priority Critical patent/JPS6456681A/en
Publication of JPS6456681A publication Critical patent/JPS6456681A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

NEW MATERIAL:The compound of formula I [X is H, OH or oxo; the dotted line is single or double bond (double bond exclusively in the case of X is H); R<1> is 4-8C alkyl, 2-8C alkenyl, 1-4C alkoxy, alkylthio-1-4C alkyl, 3-8C aycloalkyl, 3-6-membered heterocyclic group containing O or S, etc.; R<2> is =O or OR<4> (R<4> is H or ester-forming carboxylic acid residue or carbonic acid residue); R<3> is halogen]. EXAMPLE:13-Fluoro LL-F28249alpha. USE:An insecticidal, miticidal and anthelmintic agent. PREPARATION:The objective compound can be produced by selectively oxidizing the 5-hydroxyl group of a milbemycin-analog compound of formula II with active manganese dioxide, oxidizing the 13-position of the obtained 5-ketone compound of formula III to form 13-hydroxy-5-ketone compound of formula IV and reacting the compound with a halogenation agent.
JP21080587A 1987-08-25 1987-08-25 Novel macrolide compound Pending JPS6456681A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21080587A JPS6456681A (en) 1987-08-25 1987-08-25 Novel macrolide compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21080587A JPS6456681A (en) 1987-08-25 1987-08-25 Novel macrolide compound

Publications (1)

Publication Number Publication Date
JPS6456681A true JPS6456681A (en) 1989-03-03

Family

ID=16595426

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21080587A Pending JPS6456681A (en) 1987-08-25 1987-08-25 Novel macrolide compound

Country Status (1)

Country Link
JP (1) JPS6456681A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177063A (en) * 1991-03-11 1993-01-05 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system
JPH0597859A (en) * 1991-10-04 1993-04-20 Sankyo Co Ltd 15-hydroxymilbemycin derivative and its production

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177063A (en) * 1991-03-11 1993-01-05 Merck & Co., Inc. Avermectin compounds with a 6,5-spiroketal ring system
JPH0597859A (en) * 1991-10-04 1993-04-20 Sankyo Co Ltd 15-hydroxymilbemycin derivative and its production

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