JPS6452767A - 2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetic acid derivative and production thereof - Google Patents

2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetic acid derivative and production thereof

Info

Publication number
JPS6452767A
JPS6452767A JP62055536A JP5553687A JPS6452767A JP S6452767 A JPS6452767 A JP S6452767A JP 62055536 A JP62055536 A JP 62055536A JP 5553687 A JP5553687 A JP 5553687A JP S6452767 A JPS6452767 A JP S6452767A
Authority
JP
Japan
Prior art keywords
formula
salt
expressed
protecting group
novel substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62055536A
Other languages
Japanese (ja)
Inventor
Susumu Nakagawa
Kenichi Otake
Ryosuke Ushijima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP62055536A priority Critical patent/JPS6452767A/en
Publication of JPS6452767A publication Critical patent/JPS6452767A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound expressed by formula I (R<1> is H or amino- protecting group; R<2> and R<3> are H or carboxyl-protecting group) or salt thereof. USE:An intermediate for cephalosporin derivatives (antimicrobial agents). PREPARATION:A compound expressed by formula III or salt thereof is reacted with a novel substance expressed by formula II or salt thereof in a suitable solvent without affecting the reaction at 5-70 deg.C temperature and, as necessary, the protecting groups are removed to readily afford the aimed compound expressed by formula I or salt thereof in high yield. Furthermore, the novel substance expressed by specific II can be produced by, e.g. reacting a novel substance expressed by formula IV with hydrazine in a solvent, such as methanol, at -5-+40 deg.C temperature and used for the next reaction without isolation. The compound expressed by formula I or salt thereof is useful as an intermediate for compounds expressed by formula V (R is H, carboxyl-protecting group or anion; Q is H or nucleophilic residue) useful as the above-mentioned medicines.
JP62055536A 1986-03-19 1987-03-11 2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetic acid derivative and production thereof Pending JPS6452767A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62055536A JPS6452767A (en) 1986-03-19 1987-03-11 2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetic acid derivative and production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61059368 1986-03-19
JP62055536A JPS6452767A (en) 1986-03-19 1987-03-11 2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetic acid derivative and production thereof

Publications (1)

Publication Number Publication Date
JPS6452767A true JPS6452767A (en) 1989-02-28

Family

ID=26396425

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62055536A Pending JPS6452767A (en) 1986-03-19 1987-03-11 2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetic acid derivative and production thereof

Country Status (1)

Country Link
JP (1) JPS6452767A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61254584A (en) * 1985-05-07 1986-11-12 Ajinomoto Co Inc Novel thiazole derivative
JPS62158278A (en) * 1986-01-06 1987-07-14 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド Monosulfactams

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61254584A (en) * 1985-05-07 1986-11-12 Ajinomoto Co Inc Novel thiazole derivative
JPS62158278A (en) * 1986-01-06 1987-07-14 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド Monosulfactams

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