JPS6450879A - Production of thianaphthene derivative - Google Patents

Production of thianaphthene derivative

Info

Publication number
JPS6450879A
JPS6450879A JP62207562A JP20756287A JPS6450879A JP S6450879 A JPS6450879 A JP S6450879A JP 62207562 A JP62207562 A JP 62207562A JP 20756287 A JP20756287 A JP 20756287A JP S6450879 A JPS6450879 A JP S6450879A
Authority
JP
Japan
Prior art keywords
compound
formula
solvent
vilsmeier reagent
dimethylformamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62207562A
Other languages
Japanese (ja)
Other versions
JPH0613504B2 (en
Inventor
Atsusuke Terada
Kazuyuki Wachi
Yoshiya Amamiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP62207562A priority Critical patent/JPH0613504B2/en
Publication of JPS6450879A publication Critical patent/JPS6450879A/en
Publication of JPH0613504B2 publication Critical patent/JPH0613504B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE:To obtain a thianaphthene useful as a synthetic intermediate for a compound having antithrombotic action readily and in high yield, by reacting a specific compound as a raw material with a Vilsmeier reagent. CONSTITUTION:A thiophene derivative shown by formula II [R1-R3 are H, lower alkyl or (substituted)aryl; R4 is carboxyl-protecting group] is reacted with a Vilsmeier reagent such as dimethylformamide and phosphorus oxychloride in a solvent such as methylene chloride to give a compound shown by formula III. This compound is subjected to ring closure in a solvent such as toluene in the presence of a base such as NaH to form a specific compound shown by formula IV as a raw material. The compound is further reacted with the same Vilsmeier reagent as the above-mentioned reagent in a solvent such as dimethylformamide to give the aimed compound shown by formula I useful as a synthetic intermediate for sodium 6-[4,5-dihydro-2-(1-imidazolyl) methylthianaphthene]carboxylate having excellent antithrombotic action.
JP62207562A 1987-08-21 1987-08-21 Method for producing thianaphthene derivative Expired - Lifetime JPH0613504B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62207562A JPH0613504B2 (en) 1987-08-21 1987-08-21 Method for producing thianaphthene derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62207562A JPH0613504B2 (en) 1987-08-21 1987-08-21 Method for producing thianaphthene derivative

Publications (2)

Publication Number Publication Date
JPS6450879A true JPS6450879A (en) 1989-02-27
JPH0613504B2 JPH0613504B2 (en) 1994-02-23

Family

ID=16541795

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62207562A Expired - Lifetime JPH0613504B2 (en) 1987-08-21 1987-08-21 Method for producing thianaphthene derivative

Country Status (1)

Country Link
JP (1) JPH0613504B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands

Also Published As

Publication number Publication date
JPH0613504B2 (en) 1994-02-23

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