JPS6447747A - Method for collecting 7-dimethylamino-6-demethyl-6-deoxytetracycline - Google Patents

Method for collecting 7-dimethylamino-6-demethyl-6-deoxytetracycline

Info

Publication number
JPS6447747A
JPS6447747A JP20354087A JP20354087A JPS6447747A JP S6447747 A JPS6447747 A JP S6447747A JP 20354087 A JP20354087 A JP 20354087A JP 20354087 A JP20354087 A JP 20354087A JP S6447747 A JPS6447747 A JP S6447747A
Authority
JP
Japan
Prior art keywords
minocycline
aqueous solution
deoxytetracycline
demethyl
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP20354087A
Other languages
Japanese (ja)
Other versions
JPH0737434B2 (en
Inventor
Hiroaki Ono
Ryoichi Hasegawa
Kazuaki Sano
Yoshinori Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP20354087A priority Critical patent/JPH0737434B2/en
Priority to US07/222,886 priority patent/US4918208A/en
Publication of JPS6447747A publication Critical patent/JPS6447747A/en
Priority to US07/758,274 priority patent/US5202449A/en
Publication of JPH0737434B2 publication Critical patent/JPH0737434B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To collect tetracycline based antibiotics without requiring special reagent and organic solvent in high purity and yield by subjecting a minocycline- containing aqueous solution to one absorption-elution treatment by a nonpolar and high-porous polymer. CONSTITUTION:An aqueous solution containing 7-dimethylamino-6-demethyl-6- deoxytetracycline (hereafter described as minocycline) is absorbed using a nonpolar and high-porous polymer as an absorbent at ambient temperature. Then minocycline is eluted with a polar organic solvent (e.g. methanol) mixable with water. The absorbent is used at 10-100 times amount (cc/g) based on an amount of minocycline in minocycline-containing aqueous solution. The minocycline-containing aqueous solution is preferably absorbed after adjusting pH to 3-9 by adding water thereto.
JP20354087A 1987-07-28 1987-08-18 Method for collecting 7-dimethylamino-6-demethyl-6-deoxytetracycline Expired - Fee Related JPH0737434B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP20354087A JPH0737434B2 (en) 1987-08-18 1987-08-18 Method for collecting 7-dimethylamino-6-demethyl-6-deoxytetracycline
US07/222,886 US4918208A (en) 1987-07-28 1988-07-22 Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
US07/758,274 US5202449A (en) 1987-07-28 1991-08-27 Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20354087A JPH0737434B2 (en) 1987-08-18 1987-08-18 Method for collecting 7-dimethylamino-6-demethyl-6-deoxytetracycline

Publications (2)

Publication Number Publication Date
JPS6447747A true JPS6447747A (en) 1989-02-22
JPH0737434B2 JPH0737434B2 (en) 1995-04-26

Family

ID=16475837

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20354087A Expired - Fee Related JPH0737434B2 (en) 1987-07-28 1987-08-18 Method for collecting 7-dimethylamino-6-demethyl-6-deoxytetracycline

Country Status (1)

Country Link
JP (1) JPH0737434B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008293931A (en) * 2007-05-28 2008-12-04 Panasonic Electric Works Co Ltd Opening and closing face guide method and lighting fixture used for this
JP2018506539A (en) * 2015-02-13 2018-03-08 ホビオネ サイエンティア リミテッド Novel polymorph of minocycline base and process for producing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008293931A (en) * 2007-05-28 2008-12-04 Panasonic Electric Works Co Ltd Opening and closing face guide method and lighting fixture used for this
JP2018506539A (en) * 2015-02-13 2018-03-08 ホビオネ サイエンティア リミテッド Novel polymorph of minocycline base and process for producing the same

Also Published As

Publication number Publication date
JPH0737434B2 (en) 1995-04-26

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees