JPS6447391A - Monoclonal antibody and use thereof - Google Patents

Monoclonal antibody and use thereof

Info

Publication number
JPS6447391A
JPS6447391A JP63074290A JP7429088A JPS6447391A JP S6447391 A JPS6447391 A JP S6447391A JP 63074290 A JP63074290 A JP 63074290A JP 7429088 A JP7429088 A JP 7429088A JP S6447391 A JPS6447391 A JP S6447391A
Authority
JP
Japan
Prior art keywords
monoclonal antibody
human thrombomodulin
hybridoma
mammal
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63074290A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0542920B2 (esLanguage
Inventor
Jiro Tsubouchi
Mutsumi Kazama
Hidemi Ishii
Masahiko Nakano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Gas Chemical Co Inc
Original Assignee
Mitsubishi Gas Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Gas Chemical Co Inc filed Critical Mitsubishi Gas Chemical Co Inc
Priority to JP63074290A priority Critical patent/JPS6447391A/ja
Publication of JPS6447391A publication Critical patent/JPS6447391A/ja
Publication of JPH0542920B2 publication Critical patent/JPH0542920B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7452—Thrombomodulin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP63074290A 1987-04-01 1988-03-30 Monoclonal antibody and use thereof Granted JPS6447391A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63074290A JPS6447391A (en) 1987-04-01 1988-03-30 Monoclonal antibody and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7750787 1987-04-01
JP63074290A JPS6447391A (en) 1987-04-01 1988-03-30 Monoclonal antibody and use thereof

Publications (2)

Publication Number Publication Date
JPS6447391A true JPS6447391A (en) 1989-02-21
JPH0542920B2 JPH0542920B2 (esLanguage) 1993-06-30

Family

ID=13635877

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63074290A Granted JPS6447391A (en) 1987-04-01 1988-03-30 Monoclonal antibody and use thereof

Country Status (3)

Country Link
EP (1) EP0285511B1 (esLanguage)
JP (1) JPS6447391A (esLanguage)
DE (1) DE3876124T2 (esLanguage)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6445398A (en) * 1987-08-13 1989-02-17 Kowa Co Antithrombin-binding substance monoclonal antibody, hybridoma producing said antibody and method for purifying and measuring thrombin-binding substance utilizing said monoclonal antibody
WO1991006857A1 (en) * 1989-11-02 1991-05-16 Teijin Limited Immunoassay of human thrombomodulin, and reagent and kit therefor
WO1991009969A1 (fr) * 1989-12-27 1991-07-11 Fuji Yakuhin Kogyo Kabushiki Kaisha Nouvel anticorps monoclonal antihumain de thrombomoduline et diagnostic de troubles endotheliaux par immuno-analyse enzymatique
JP2509001B2 (ja) * 1989-11-02 1996-06-19 帝人株式会社 ヒト・トロンボモジユリンの免疫学的測定方法、そのための試薬及びそのためのキツト
WO2001048479A1 (fr) * 1999-12-28 2001-07-05 Fuji Chemical Industries, Ltd. Procede de determination de la possibilite d'avortement spontane ou d'accouchement premature et reactif associe

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0949507A4 (en) * 1996-12-26 2000-03-22 Fuji Yakuhin Kogyo Kk AGENTS FOR TREATING URINE SAMPLES
BRPI0720158A2 (pt) 2006-10-06 2014-05-20 Asahi Kasei Pharma Corp Agentes para terapia e/ou melhora de coagulação intravascular disseminada, para reduzir a probabilidade de morte em pacientes sofrendo da mesma, métodos para selecionar pacientes, e, para tratar e/ou melhorar coagulação intravascular disseminada
PT2781221T (pt) 2011-11-15 2020-06-01 Asahi Kasei Pharma Corp Medicamento para tratamento e/ou melhoria de sepsia
PL2857037T3 (pl) 2012-05-31 2019-12-31 Kinki University Środek do leczenia profilaktycznego i/lub terapeutycznego obwodowego bólu neuropatycznego wywoływanego przez środek przeciwnowotworowy
CN112839669A (zh) 2018-09-28 2021-05-25 旭化成制药株式会社 用于减轻由抗恶性肿瘤剂引起的末梢神经障碍的症状和/或抑制其发病的药物
KR20210060574A (ko) 2018-10-22 2021-05-26 아사히 가세이 파마 가부시키가이샤 응고 이상을 수반하는 패혈증의 치료 및/또는 개선을 위한 의약

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0239644A4 (en) * 1985-06-28 1987-10-27 Asahi Chemical Ind NEW PHYSIOLOGICALLY ACTIVE AGENTS WITH A BLOOD COAGULATING REGULATORY EFFECT.
DE3750664T2 (de) * 1986-07-15 1995-06-22 Kowa Co Throminbindende Substanz und Verfahren zu ihrer Herstellung.

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CLINICAL INVESTIGATION=1985 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY=1985 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY=1987 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6445398A (en) * 1987-08-13 1989-02-17 Kowa Co Antithrombin-binding substance monoclonal antibody, hybridoma producing said antibody and method for purifying and measuring thrombin-binding substance utilizing said monoclonal antibody
JPH05304953A (ja) * 1987-08-13 1993-11-19 Kowa Co 抗トロンビン結合性物質モノクローナル抗体を産生するハイブリドーマ
WO1991006857A1 (en) * 1989-11-02 1991-05-16 Teijin Limited Immunoassay of human thrombomodulin, and reagent and kit therefor
JP2509001B2 (ja) * 1989-11-02 1996-06-19 帝人株式会社 ヒト・トロンボモジユリンの免疫学的測定方法、そのための試薬及びそのためのキツト
WO1991009969A1 (fr) * 1989-12-27 1991-07-11 Fuji Yakuhin Kogyo Kabushiki Kaisha Nouvel anticorps monoclonal antihumain de thrombomoduline et diagnostic de troubles endotheliaux par immuno-analyse enzymatique
JPH03198793A (ja) * 1989-12-27 1991-08-29 Fuji Yakuhin Kogyo Kk 新規な抗ヒトトロンボモジユリンモノクローナル抗体および酸素免疫測定法による血管内皮障害の診断方法
WO2001048479A1 (fr) * 1999-12-28 2001-07-05 Fuji Chemical Industries, Ltd. Procede de determination de la possibilite d'avortement spontane ou d'accouchement premature et reactif associe

Also Published As

Publication number Publication date
JPH0542920B2 (esLanguage) 1993-06-30
EP0285511A3 (en) 1988-12-28
DE3876124T2 (de) 1993-05-06
EP0285511A2 (en) 1988-10-05
DE3876124D1 (en) 1993-01-07
EP0285511B1 (en) 1992-11-25

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Legal Events

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