JPS6445390A - Production of beta-hyroxyphosphorus compounds - Google Patents
Production of beta-hyroxyphosphorus compoundsInfo
- Publication number
- JPS6445390A JPS6445390A JP20006787A JP20006787A JPS6445390A JP S6445390 A JPS6445390 A JP S6445390A JP 20006787 A JP20006787 A JP 20006787A JP 20006787 A JP20006787 A JP 20006787A JP S6445390 A JPS6445390 A JP S6445390A
- Authority
- JP
- Japan
- Prior art keywords
- beta
- oxide derivative
- nucleophilic reaction
- epoxyphosphine
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE:To readily obtain the titled compound, having physiological activity, such as anticancer action, and useful as a medicine in high yield and purity, by reducing an alpha,beta-epoxyphosphine oxide derivative through nucleophilic reaction. CONSTITUTION:(A) An alpha,beta-epoxyphosphine oxide derivative expressed by formula I (R<1> and R<2> are H, 1-12C aliphatic or aromatic hydrocarbon residue, crosslinkable to form a ring and containing N or S in the backbone chain; R<3> and R<4> are <=12C aryl or alkaryl) is reduced through nucleophilic reaction to cleave the epoxy ring thereof and then passed through a step of conversion into (B) a beta-hydroxyphosphine oxide derivative expressed by formula II [Nu is atom (atomic group) introduced by the nucleophilic reaction] to afford the aimed compound. Furthermore, in the reduction, e.g. lithium aluminum hydride is preferably added to a nucleophilic reagent in the presence of a water-miscible organic solvent (e.g. THF) at about 0 deg.C temperature while stirring.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20006787A JPS6445390A (en) | 1987-08-12 | 1987-08-12 | Production of beta-hyroxyphosphorus compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20006787A JPS6445390A (en) | 1987-08-12 | 1987-08-12 | Production of beta-hyroxyphosphorus compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6445390A true JPS6445390A (en) | 1989-02-17 |
JPH0529360B2 JPH0529360B2 (en) | 1993-04-30 |
Family
ID=16418292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20006787A Granted JPS6445390A (en) | 1987-08-12 | 1987-08-12 | Production of beta-hyroxyphosphorus compounds |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6445390A (en) |
-
1987
- 1987-08-12 JP JP20006787A patent/JPS6445390A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0529360B2 (en) | 1993-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
EXPY | Cancellation because of completion of term |