JPS6419033A - New process for producing 1-(4-trifluoromethylphenyl)-1-propanone - Google Patents

New process for producing 1-(4-trifluoromethylphenyl)-1-propanone

Info

Publication number
JPS6419033A
JPS6419033A JP17394787A JP17394787A JPS6419033A JP S6419033 A JPS6419033 A JP S6419033A JP 17394787 A JP17394787 A JP 17394787A JP 17394787 A JP17394787 A JP 17394787A JP S6419033 A JPS6419033 A JP S6419033A
Authority
JP
Japan
Prior art keywords
oxidizing agent
trifluoromethylphenyl
propanol
solvent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17394787A
Other languages
Japanese (ja)
Other versions
JPH0796520B2 (en
Inventor
Hideo Sugimura
Akira Shiozawa
Koji Yanagiuchi
Kazuhisa Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP17394787A priority Critical patent/JPH0796520B2/en
Publication of JPS6419033A publication Critical patent/JPS6419033A/en
Publication of JPH0796520B2 publication Critical patent/JPH0796520B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To obtain the title compound which is a synthetic intermediate of a compound having muscle relaxant action, without problems on bad small, industrial waste and operability, by allowing a specific oxidizing agent to act on 1-(4-trifluoromethylphenyl)-1-propanol. CONSTITUTION:The subject compound is prepared by oxidizing 1-(4- trifluoromethylphenyl)-1-propanol with an oxidizing agent of the formula (M is alkali metal, alkaline earth metal; X is halogen; n is 1-3), preferably sodium hypochlorite, calcium hypochlorite, sodium hypobromite from an industrial point of view, in a solvent such as acetone at 0-50 deg.C. The amount of the oxidizing agent used is 0.8-10, preferably 1-6 equivalents based on the starting substance. If is preferred that the addition of a phosphate or acetic acid is added to effect the reaction, after the oxidizing agent is added to the starting material in the solvent.
JP17394787A 1987-07-14 1987-07-14 New method for producing 1- (4-trifluoromethylphenyl) -1-propanone Expired - Lifetime JPH0796520B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17394787A JPH0796520B2 (en) 1987-07-14 1987-07-14 New method for producing 1- (4-trifluoromethylphenyl) -1-propanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17394787A JPH0796520B2 (en) 1987-07-14 1987-07-14 New method for producing 1- (4-trifluoromethylphenyl) -1-propanone

Publications (2)

Publication Number Publication Date
JPS6419033A true JPS6419033A (en) 1989-01-23
JPH0796520B2 JPH0796520B2 (en) 1995-10-18

Family

ID=15970018

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17394787A Expired - Lifetime JPH0796520B2 (en) 1987-07-14 1987-07-14 New method for producing 1- (4-trifluoromethylphenyl) -1-propanone

Country Status (1)

Country Link
JP (1) JPH0796520B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194606A (en) * 1990-02-08 1993-03-16 Mitsui Toatsu Chemicals, Incorporated Preparation process of aminoketones
CN112592265A (en) * 2020-12-21 2021-04-02 安达兰泽科技有限公司 Preparation method of 3, 3-dimethyl-2-oxobutyric acid and sodium salt thereof
CN115894205A (en) * 2021-09-30 2023-04-04 迈克斯(如东)化工有限公司 Method for preparing 1-phenyl-3- (3-trifluoromethylphenyl) -2-acetone, intermediate and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101891601A (en) * 2010-07-06 2010-11-24 沈阳药科大学 Preparation method of 1-[3-(trifluoromethyl) phenyl]-2-acetone

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194606A (en) * 1990-02-08 1993-03-16 Mitsui Toatsu Chemicals, Incorporated Preparation process of aminoketones
CN112592265A (en) * 2020-12-21 2021-04-02 安达兰泽科技有限公司 Preparation method of 3, 3-dimethyl-2-oxobutyric acid and sodium salt thereof
CN112592265B (en) * 2020-12-21 2023-09-01 安达兰泽科技有限公司 Preparation method of 3, 3-dimethyl-2-oxo-butyric acid and sodium salt thereof
CN115894205A (en) * 2021-09-30 2023-04-04 迈克斯(如东)化工有限公司 Method for preparing 1-phenyl-3- (3-trifluoromethylphenyl) -2-acetone, intermediate and application thereof

Also Published As

Publication number Publication date
JPH0796520B2 (en) 1995-10-18

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