JPS6411002B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION This invention relates to disinfectants, particularly those used on surfaces to clean, sanitize, deodorize and sterilize them, as well as the surfaces of animal skin or objects other than humans. sterilization method.

Chlorine peroxide (ClO ₂ ) has been tried in the past as a skin disinfectant, but with limited success. Such chlorine peroxide formulations are manufactured by International Dioxide and are called cryoclaves. However, rather than having an antimicrobial effect on the body, chlorine peroxide has been successful as a pharmaceutical additive for inhibiting the growth of microorganisms, as described in Canadian Patent No. 955,848.

The conventional method for using and incorporating chlorine peroxide gas has been to dissolve the gas in a liquid to create a solution. This method has a number of drawbacks. Chlorine peroxide gas has a relatively short shelf life compared to other dermatologic agents because of its tendency to volatilize from its solution. Applying the product to the skin in liquid form results in a short contact time due to lack of adhesion to the skin or lesions. For lesions affected by other types of fungal diseases, contact for a long period of time, such as several days, is required, and appropriate therapeutic effects cannot be ensured unless repeated use is strictly controlled.

The disadvantages of using chlorine peroxide on the skin can be overcome or substantially reduced by incorporating the gas into the gel matrix. These gels have a high viscosity and are sticky to the skin, which prevents the release of gas, especially when combined with a common closed-base barrier, such as a plastic film band for topical application. and can be kept in contact with the skin for long periods of time.

The method of acidifying sodium chlorite to produce chlorine peroxide in the gel is novel.
The gel material must not only be compatible with the strong oxidizing effects of chlorine peroxide and not complex with this reactive substance, but also be compatible with alkali chlorite and acids.

Many substances are not compatible with chlorine peroxide. For example, fragrances and colorants will react with chlorine peroxide. Although Canadian Patent No. 955848 discloses the addition of such substances, their addition reduces the disinfecting effectiveness of chlorine peroxide and thus shortens the shelf life of the product. Another example of incompatibility is hydrogen peroxide. This gelled well with the glycerin base. However, since glycerin reacts with chlorine peroxide, it cannot be used as a "thickener" for substrates containing components that produce chlorine peroxide. The gelling agent must, of course, be non-toxic, non-irritating, and easily removable from the skin.

Thus, the main object of the invention is to prepare a material containing sodium chlorite on the one hand and lactic acid on the other hand.
The present invention provides improved cleaning, deodorizing, and disinfecting agents, including separately packaged gels, soap products, and toothpastes, in amounts sufficient to reduce the final product pH to about 7 or less when combined.

FIG. 1 is a longitudinal cross-sectional view of a dual syringe used to dispense a sterilizing composition.

FIG. 2 is a longitudinal cross-sectional view of a single syringe with two septa.

FIG. 3 is a schematic diagram of a spreader with two storage compartments.

FIG. 4 is a perspective view of the bottle squeezing container.

FIG. 5 is a perspective view of the two-tube dispensing device.

FIG. 6 is a detailed sectional view of the trigger type double dispensing device.

FIG. 7 is a perspective view of the double dispensing device.

FIG. 8 is a front view of a dual-dispensing plastic pack with a removable separator.

Figure 9 is the dispensing device shown in Figure 8 with the separator removed.

FIG. 10 is a detailed cross-sectional view of a bottle squeeze container with a central dividing wall.

FIG. 11 is a detailed sectional view of the means for preventing the outflow of unequal amounts of contents;

FIG. 12 is a detailed sectional view of another means for controlling outflow.

FIG. 13 is a detailed sectional view of yet another control means.

FIG. 1 shows a dual syringe, particularly for use in dispensing solutions or gels, having an injection container 20 incorporating a separating wall 22. In FIG. The pusher 24 can control two plungers 26 and 28. The plunger then simultaneously expels the contents from the injection container 20 as shown at 30.
It can then be spread over the surface to be treated.

A single injection container is shown in FIG. 2 with a single extrusion 42 controlling a single plunger 44. In FIG. When the plunger 44 is pushed in,
The contents 46 break through the breakable septum 48 and are mixed with the contents 50 and the mixture becomes a mixed gel 52 ready for use and extruded.

FIG. 3 shows two reservoirs 6 connected by a tube 64 with isolation control valves 66, 68 and a stop valve 70 for controlling flow in the direction of arrow 72.
0.62 is shown.

FIG. 4 shows a bottle-shaped squeeze container containing breakable containers 82, 84, and compressing the squeeze container ruptures the inner container, mixes the contents, and creates a cotton container. It is simply sent out through the coating section 86.

Figure 5 shows two different types of contents.
A dual applicator is shown having two containers, both of which have separate sponge applicators at the tips that can apply separate substances at the same time. The two containers 90 and 92 are connected by adhesive or the like.

In FIG. 6, a trigger dispensing device is shown consisting of a container 100 with a separating wall 102 for separating solutions 104 and 106. When the known trigger 108 of the pump actuator 110 is pulled, the contents are drawn up and sprayed simultaneously from each of the tubes 112 and 114.

FIG. 7 shows a dual dispenser similar to the frothy shaving cream dispenser sold commercially by Gillette Company. Here, the outer container 130 contains a first content and the inner container contains a second content. Both are under gas pressure, and when actuator 134 is depressed, both contents are dispensed by gas pressure.

8 and 9, a plastic container 200 is shown which is initially filled with a first solvent and, after being partially filled, is fitted with a removable separator 202. Thereafter, the remaining portion is filled with the contents through the mouth 204 of the tube, and the cap 206 is attached. When it is desired to use the contents, the separator is removed and the entire contents are mixed and ready for use, as shown in FIG.

A tube or vessel 220 with a separator 22 is shown in FIG. In order to dispense the contents of the container 220 in equal amounts, the lift key 22 is pressed.
A tab 224 is attached so that 6 can be used.

FIG. 11 shows a container 240 with a separation wall 242.
It is shown. Container 240 contains two different gels 244 and 246, and when gel 244 emerges from its outlet at a velocity that is inconsistent with gel 246, the velocity of the other gel is The movement moves the swirl valve 250 and is adapted to prevent other gel movement. For example, when gel 244 is extruded and gel 246 is not extruded, the bounce 254
6, the valve head 25
8 contacts the outlet 260 of the container and impedes the flow of the gel 246. An equal amount of gel passes around the vanes and an equal amount of extrusion is achieved.

Another type of container 280 is shown in FIG. 12, which includes a guide 286 at the waist 288 and a separating wall 282.
is attached. Then, one of the valve blades 290 and 292 is operated until the extrusion amount of both gels becomes equal.
Guide 286 only one of the gels in the container to prevent it from flowing out any further.
It is made to stop the flow.

Another embodiment of the invention is shown in FIG. The container 300 has compartments 304 and 306 partitioned by a separation wall 302, in which different gels are separated. A valve structure 310 is rotatably attached to the separation wall 302 and has means for preventing the separated gel from flowing in only one direction.

The present invention will be explained below with reference to Examples. Examples and percentages are parts by weight unless otherwise specified.

Example 1 Example 1 describes the preparation of an in situ mixed gel.

Gel A thickener Methyl cellulose (high viscosity
4000CPS) 8.0%w/w Preservative Benzyl alcohol 5.0%w/w Water 85.7%w/w Lactic acid 1.3%w/w Agent B Methyl cellulose (high viscosity 4000CPS)
8.0%w/w Benzyl alcohol 5.0%w/w Water 86.8%w/w Sodium chlorite 0.2%w/w Manufacturing method of Part A Heat 85.7% water powder until boiling, and add methyl cellulose while stirring constantly. Add. Add the remaining water containing benzyl alcohol and lactic acid as ice water (approximately 5°C). The ingredients are first stirred to mix and then allowed to cool to room temperature with occasional stirring to allow the ingredients to gel.

Manufacturing method for Form B The manufacturing method for Form A is exactly the same as that for Form A, except that sodium chlorite is used instead of lactic acid.

Place Part A and Part B in separate tubes, and instruct the patient to mix equal amounts before use.

Example 2 This example describes a soap product with lactic acid and sodium chlorite.

Lined soap bar cleaner IGEPON AC-78 (83% solids) (1)
58%w/w Preservative VANCIDE89RE(2) 1%w/w Thickner VEEGUM F(2) 1%w/w Emollients Cetyl Alcohol 2%w/w Emulsifier Glyceryl Monostearate AS
6% w/w Emulsifier Stearyl alcohol 7% w/w Emollients MODULAN (3) 3% w/w Wetting agent Polyethylene glycol 600013% w/w Water 9% w/w Note (1) Commercially available from GAF ( 2) Commercially available from RT Vanderbilt Company (3) American Cholesterol Products Inc.
Manufacturing method commercially available from the company: Add Banside 89RE and Begum F to one part of Igepon AC-78, and while mixing, add Igepon AC-78.
Add the remainder of 78. Wash the remaining mixture at 75 °C.
Heat to. While stirring, add the Igepon mixture to the remaining wash and stir until homogeneous. This mixture is divided into Part A and Part B. Part A contains 1
Add % w/w sodium chlorite and to part B add 6% w/w lactic acid and 1% w/w tartrazine dye (F.D&C.). Allow parts A and B to cool to room temperature, and slowly mix them to form a swirl of yellow part B in white part A. Press this mixture into bars or cakes.

Example 3 The invention can also be used to make toothpastes as described below.

Thickener Veegum F 1.25% w/w Thickener Methylcellulose (moderate viscosity,
400CPS) 0.70%w/w Water 24.00%w/w Wetting agent Sorbitol (70% aqueous solution)
25.00%w/w Abrasive Dicalcium phosphate dihydrade
45.00%w/w Detergent 1.00%w/w Detergent Sodium lauryl sulfate 1.50%w/w Preservative Methylparaben 0.25%w/w Lactic acid 1.30%w/w Note that all the thickeners may be made of methylcellulose.

Production method: Veegum F and methylcellulose are mixed in a dry manner. Add this mixture slowly to water heated to 70°C, stir constantly until homogeneous, and cool to room temperature. Sorbitol solution and calcium phosphate dihydrate are added alternately to this Veegum F/methylcellulose mixture to make it smooth. The lactic acid, methylparaben and sodium lauryl sulfate are then added sequentially and carefully mixed with the sodium lauryl sulfate using a gentle stirrer, avoiding the introduction of air.

Separately, prepare the following gel.

Thickener Methylcellulose (high viscosity
4000CPS) 8.0% w/w Preservative Benzyl alcohol 5.0% w/w Coloring agent Erythrozine J (F.S&C) 1.0% w/w Water 85.8% w/w Sodium chlorite 0.2% w/w Manufacturing method Above water Heat half of the mixture until it boils and add the methylcellulose, stirring constantly. Add the remaining water as ice water at about 5° C. containing benzyl alcohol, Erythrozine J (Thierry red colorant) and sodium chlorite. The ingredients are first stirred, mixed and then allowed to cool to room temperature with occasional stirring to form a gel.

White toothpaste and red gel are placed in plastic tubes separated by component. The plastic tube is equipped with an extrusion orifice so that the toothpaste comes out in one stream, and the gel comes out around the periphery of the toothpaste. Comes with toothpaste. The principles, preferred embodiments, and methods of operation of the invention have been detailed. However, these are examples rather than limitations, and the invention desired to be protected herein is not limited to the particular methods set forth herein. Various modifications can be considered by those skilled in the art without departing from the spirit of the invention.

[Brief explanation of drawings]

FIG. 1 is a longitudinal cross-sectional view of a double syringe used in the present invention. FIG. 2 is a longitudinal cross-sectional view of a similar single syringe. FIG. 3 is a schematic diagram of another embodiment of the invention. Fourth
The figure is a tilted view of another embodiment. FIG. 5 is a perspective view of yet another embodiment. FIG. 6 is a sectional view of another embodiment.
FIG. 7 is a side view of another embodiment. FIGS. 8 and 9 are front views showing the dispensing device of the present invention in use.
FIG. 10 is a cross-sectional view of another embodiment;
12 and 13 are cross-sectional views showing various outlets. 20, 40, 80, 90, 92... injection container,
82, 84...Destructible container, 26, 28, 44
... plunger, 108 ... trigger, 48 ... destructible bulkhead, 110 ... pump actuation device, 60,
62...Reservoir, 202...Removable separator, 250...Swivel valve, 290...Valve blade, 258
... Valve head, 310 ... Valve structure, 286 ... Guide.

Claims (1)

[Claims] 1. The pH of the composition after mixing with the aqueous first gel containing 0.2% by weight of sodium chlorite is about 7.
A composition for surface disinfection consisting of two sets of gels suitable for simultaneous use and mixing in situ, characterized in that it consists of an aqueous second gel containing 1.3% by weight of lactic acid in an amount that reduces . 2 The first gel and the second gel are each about 8% by weight.
2. The surface disinfecting composition of claim 1, comprising: methylcellulose and about 5% by weight benzyl alcohol. 3. The surface disinfection composition of claim 1, wherein the first gel and the second gel each contain a thickener and a preservative. 4 Claim 1 in which the thickener is methylcellulose and the preservative is benzyl alcohol
A composition for surface disinfection. 5 an aqueous first gel containing 0.2% by weight of sodium chlorite forming a composition and a second aqueous gel containing 1.3% by weight of lactic acid in an amount sufficient to reduce the PH of the composition to below about 7. A sterilization method characterized by mixing the composition with the following and treating the surface of the human body, excluding the skin, with this composition. 6. Disinfection method according to claim 5, characterized in that the two gels are mixed in situ on the surface of the human body to be treated, excluding the skin. 7. A sterilization method according to claim 6, characterized in that the two gels are mixed before the surface of the human body to be treated, excluding the skin, is treated with the composition of the invention.