JPS58105757A - Sterilizing composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to agents for disinfection, particularly for use on surfaces to taminate, amphibiate, deodorize and disinfect them.

Chlorine perbide C (#02) has been tried as a paste for dissipating skin waste, but the results have been limited. Such a chlorine peroxide formulation is manufactured by International Dioxide and is called Cryofrepe.

However, rather than having antimicrobial effects in the body, chlorine peroxide has been successful as a pharmaceutical additive for inhibiting microbial decapitation, as described in Canadian Patent No. 4955.848.

The conventional method for using and incorporating chlorine peroxide gas has been to dissolve the gas in a liquid to create a liquid solution. This method has a number of drawbacks. Chlorine peroxide gas is
Due to its number of baths, it tends to evaporate, so its shelf life is relatively short compared to other skin racks. When the product is applied to the skin in liquid form, the contact time is short due to the lack of adhesion to the skin or lesions. Mold disease and other types of diseased fruit removal require prolonged contact over several days, so the use of charcoal bales must be used to ensure adequate young fruit production. These disadvantages of using chlorine peroxide can be overcome or substantially reduced by incorporating the gas into the gel matrix.

The high viscosity of these gels and their adhesion to skin debris prevents the release of gas, especially when combined with common closed-base barriers such as, for example, plastic film bands for topical treatment. The gel retains gas and can be brought into contact with the skin for a long period of time.The method of making sodium chloride hostile by accumulating chlorine peroxide in the gel is novel. The gel material must not only be compatible with the strong oxidizing effects of chlorine peroxide and not complex with this reactive substance, but must also be compatible with the alkaline chlorite solution.

Many substances are not compatible with peroxides; for example, fragrances and colorants will react with low peroxides. Canadian Patent No. 74955.848 discloses the addition of this type of material, but their addition reduces the oxidation effect of salt accumulation, thus shortening the shelf life of the product. An example of incompatibility is peroxide ice cream, which gelled well with the glycerin base. However, since glycerin reacts with chlorine peroxide, it cannot be used as a thickener for wood that contains components that produce chlorine peroxide. Naturally, gelling agents are non-browning and non-irritating. gender,
In addition, it must be able to be easily removed from the skin.

Thus, the primary object of the present invention is to provide a gel packaged with materials containing sodium chlorite on the one hand and lactic acid on the other hand in a quantity sufficient to reduce the pH of the final product to about 7 or less when the two are mixed together. , provides improved cleaning agents, deodorizers and depots, including soap products, toothpastes, etc. FIG. Longitudinal cross-sectional view.

FIG. 2 is a vertical view of a single syringe with two compartments.

Figure 3 is a schematic diagram of Miyashin with two hoarding traits 04- FIG. 4 is a perspective view of the bottle-shaped squeeze container.

FIG. 5 is a perspective view of the two-tube dispensing device.

FIG. 6 is a detailed sectional view of the trigger type double dispensing device.

FIG. 7 is a perspective view of the two-liter dispensing device.

FIG. 8 is a front view of a dual-dispensing plastic pack with a removable separator.

Figure 9 is the dispensing device shown in Figure 8 with the separator removed.

Figure 10 is a detailed sectional view of a bottle-shaped squeeze container with a central dividing wall; Figure 11 is an evaluation of means for preventing the outflow of unequal amounts of contents;
I sectional view 0 Figure 12 is a detailed sectional view of another:1 = precept that controls the outflow amount.

FIG. 13 is a detailed sectional view of yet another control means.

FIG. 1 shows a two-year syringe specifically for use in dispensing liquids or gels, in which the extrusion part 24, which has an injection container 20 incorporating a separating wall 22, has two Plungers 26 and 28 can be controlled. The plunger then simultaneously forces out the contents from the injection container 20 in the same amount as shown at 30. It then comes in 4 pieces that can be spread over the surface to be treated.

A single injection container is shown in FIG. 2 with a single extrusion 42 controlling a single plunger 44. In FIG. When the plunger 44 is depressed, the contents 46 break through the breakable septum 48 and mix with the contents 50, and the mixture becomes a mixed gel 52 ready for use and is extruded.

FIG. 3 shows a tube 64 with isolation control valves 66, 68 and a shutoff valve 70 for controlling flow in the direction of arrow 72.
Two reservoirs 60, 62 are shown connected together.

FIG. 4 shows a bottle-shaped squeeze container containing the entire breakable container 82.84, and by compressing the squeeze container, the inner container is ruptured and the contents are mixed.
It is simply fed out through the cotton coated part 86.

Figure 5 shows a two-way applicator with two containers containing two different contents, both of which have sponge applicators that allow separate applications to be applied at the same time. There is one man in the division.

The two containers 90 and 92 are connected by a shielding agent or the like.

FIG. 6 shows a trigger dispensing device consisting of a container 100 with a separating wall 102 for separating bath liquids 104 and 106. Known, pump 1'l: ! d-mount + ii
When trigger 108 of l 10 is pulled, the contents are siphoned from each of tubes 112 and 114, and 10''
Sometimes it gets sprayed.

FIG. 7 shows a two-voltage dispensing device similar to the foam shaping cream dispensing device marketed by the Gillette Company. Here, outside 1 + 11 valley device 130 is,
The inner 111II container contains a second content. Both provinces are under gas pressure and 1
'When the excitation pupil 134 is depressed, both contents are dispensed by the pressure of the gas.

FIGS. 8 and 9 show a plastic container 200, which is filled with a first solvent in the tiers,
After being partially flushed, a removable separator 202 is installed. Thereafter, the remaining portion is filled with the contents through the tube's mouth 204, and the cap 204 is filled with the contents.
6 is installed. When it is desired to use the contents, the separator is removed and the entire contents are mixed and ready for use, as shown in FIG.

In FIG. 10, a tube or container 220 with a separator 22 is shown. A tab 224 is provided so that a lift key 226 can be used to dispense the contents of the container 220 in equal amounts.

In FIG. 11, a container 240 is shown having a separating wall 242. As shown in FIG. Container 240 contains two different gels 244 and 2
46 and when gel 244 emerges from its outlet with a slowness inconsistent with gel 246, the excitation of the other gel moves the swirl valve 250 and the other It seems to impede the movement of the gel. For example, when gel 244 is extruded and gel 2468- is not extruded, bun 254
56, the valve head 258 contacts the container outlet 260 and prevents the flow of the gel 246. Equal volumes of gel flow bypass the vanes and achieve equal volume extrusion.

FIG. 12 shows another type of container 280 having a guide 286 at a waist 288 and a housing or separating wall 282. Then, the valve blade 290 is pressed until the amount of extrusion of both gels becomes equal.
．． One of the gels in the container is made so that the guide 286 stops only one of the gels from flowing out any further. Another aspect of is shown. The container 300 has a partition M304 partitioned by a separation wall 302.
, 306, and different gels are separated. A valve structure 310 is rotatably attached to the separation wall 302 and has means for preventing the separated gel from flowing in only one direction.

The present invention will be explained below with reference to Examples. Example parts and percentages are 1 part by weight unless otherwise specified.

Example 1 Example 1 describes the preparation of an in situ mixed gel. This gel is most effective in treating burns and is effective in killing all surface-enhancing bacteria. It is particularly effective in treating acne.

Gel A preservative P/D alcohol 5, Q %w
/w water 85°7%w/w lactic acid
1.3% w/w B agent benzyl alcohol 5, 0% w/w water
86.8% w/w Sodium chlorate 0.2% w/w A preparation method 85.Heat 7% water powder until boiling and add methylcellulose while stirring constantly.

Add the remaining water containing benzyl alcohol and lactic acid as ice water (approximately 5°C). First, the ingredients are stirred to mix them, and then allowed to cool to room temperature with occasional stirring, allowing the ingredients to gel.

Production method of B agent: A except that sodium chlorite is used instead of lactic acid.
The method of manufacturing the drug is exactly the same.

Place Part A and Part B in separate tubes, and instruct the patient to mix equal amounts before use.

Example 2 This ψ value describes a lithobacterium with lactic acid and sodium 111 salt.

IGEPON AC-78 (83% solids) (1) 58% w/w Preservative VANCIDE 89 RE (2)
1%w/w chicta■UIVf F (2)
1%w, emollient cetyl alcohol
2% W/W emulsifier Glyceryl monostear% A, 8.6% ψ Emulsifier Stearyl alcohol 7% W/W emollient IVD
DtJI, AN (3) 3% caustic to wet liquid Polyethylene Gutskol 6000
13% W/W Note (1) Commercially available from GAF Company/I (2) R,T. Commercially available from Vanderbilt I
(3) American Cholesterol Soil Tact
Commercially available manufacturing method Panside 89RE and Begum F from Igepon A, Inc.
C-78 plus the remainder of Igepon AC-78 while mixing. Heat the remaining detergent mixture to 75°C. Add the Igepon mixture to the remaining cleaning agent while stirring;
Stir until homogeneous. This mixture is divided into parts A and B. In the OA part, 1% w/w sodium chlorite is added, and in the B part, 6 times w/w milk and 1% w/w are added.
Add w tartrazine nutrients (F, D&C,). Allow parts A and B to cool to room temperature and slowly mix them together to create a swirl of yellow part B in white part A.

Press this mixture into bars or cakes.

Example 3 This invention can also be used to make kneaded polishes as described below.

Veegum F 1.25%w/w
Wednesday 24.00
%w/w wetting agent Nrubitol (70% aqueous solution)
25.00%w/w Shin-F abrasive dicalum phosphate dihydra) 45.00%w/w Hatsuka
1.00% w/w detergent Sodium lauryl sulfate 1.50% w/w preservative Methylparabaa 0.25% w/w lactic acid
1.30% w/w Note that all thickeners may be methyl cellulose.

Production method: Veegum F and methyl cellulose are mixed in a dry manner. This mixture is slowly added to water heated to 70° C., stirred constantly until homogeneous and cooled to room temperature. Sorbitol solution and dicalcium phosphate dihydrate are added alternately to this Veegum F/methyl cellulose mixture to make it smooth. Next, lactic acid, methylparaben, and sodium lauryl sulfate are added to the mixture, and carefully mixed with the sodium lauryl sulfate using a slow stirrer while avoiding the introduction of air.

Separately, prepare the following gel.

〃Sword Kasho Seven Hits (High Viscosity 1i4,0OOCPS) s
, oak//W preservative henosyl alcohol 5.
0% w/W Shishiiro Eris o Jin J (F, S&C)
1.0% w/w water 85.
Transferable 7W Sodium Salt Accumulate 0.2%W Manufacturing Method Heat half of the above water until it boils, and add methylcellulose while stirring constantly.

Add the remaining water as ice water at approximately 5°C containing benzyl alcohol, erythrosin J (cherry red coloring) and chlorite. The ingredients are first stirred, mixed and then allowed to cool to room temperature with occasional stirring to form a gel.

White toothpaste and red gel are charged into the compartments of the plastic tube in a bottom-separated manner. The plastic tube is equipped with an extrusion orifice so that the paste comes out in one stream, and the gel comes out around the periphery of the toothpaste, so when extruding it there is a streak. A preliminary review will appear.

The principles of the present invention, preferred actual measurement modes, and operational methods were explained in detail. However, these are not intended to be limiting, and the invention discussed in the Examples and desired to be excluded herein is not limited to the specific method set forth herein. Various modifications can be considered by those skilled in the art without departing from the spirit of the invention.

[Brief explanation of the drawing]

FIG. 1 is a longitudinal cross-sectional view of a double syringe used in the present invention. FIG. 2 is a longitudinal cross-sectional view of a similar single syringe. FIG. 3 is a schematic diagram of another embodiment of the invention. FIG. 4 is a tilted view of another embodiment. FIG. 5 is a perspective view of yet another embodiment. FIG. 6 is a sectional view of another embodiment. FIG. 7 is a side view of another embodiment. FIGS. 8 and 9 are front views showing the dispensing device of the present invention in use. FIG. 10 is a cross-sectional view of another embodiment;
and 13 are cross-sectional views showing various exits. 20.40,80,90.92 Injection container 82.8
4 Destructible container 26.28.44 Plunger 108 Trigger 48 Destructible bulkhead
110 Pump operating device 60, 62 Paper storage 202 Removable separator 16- 250 Swivel valve 290 Valve vane 258
Valve head 310 Valve cypress structure 286
Guide Dai Houto (7127) ft Rido Goto Yosuke Tokukai 1986-1
05757(6) FIG, 6 FIG, 7FIG,
10 FIG, 12 FIG, 1l FIG, 13

Claims (8)

[Claims] (1) An aqueous first gel containing sodium chlorite and an aqueous second gel containing lactic acid in an amount sufficient to lower the pH of the composition after mixing to about 7 or less; A skin disinfectant composition consisting of two sets of gels suitable for use and mixing on the spot. (2) The composition according to claim (1), wherein the first gel contains 0.2N% by weight of sodium chlorite, and the second gel contains 1.3% by weight of lactic acid. (3) Claims (1) and (2) wherein the first gel and the second gel each contain about 8 weight parts of methyl cellulose and about 5 weight parts of benzyl alcohol.
Composition of. (4) The composition 'i of claim (1) that the first gel and the second gel contain in the thickener and preservation Mll', respectively.
Fl. (5) The composition according to claim (4), wherein the thickener is methylcellulose and the preservative is benzyl alcohol. (6) Mixing an aqueous first gel containing sodium chlorite forming the vI11 composition with an aqueous second gel containing total lactic acid in an amount sufficient to lower the pH of the composition to below about 7; A method for sterilizing surfaces such as animal skin waste, which comprises treating the entire surface with a composition. (7) A method according to claim 6, characterized in that the two gels are mixed in situ on the next surface to be treated. (8) A method according to claim 6, characterized in that the surfaces to be treated with the two gels are mixed before being treated with the composition of the invention.