JPS6385458A - Automatic analyzer - Google Patents

Abstract

PURPOSE:To permit quick, simple and easy reanalysis by connecting a designation code reader disposed around the transfer path of a conveyor for transferring sample vessels for reanalysis to controllers for the conveyor and nozzles. CONSTITUTION:The designation codes of the specimen vessels requiring the reanalysis are inputted from a reinspection deciding device to the designation code readers 48, 49. The readers feed the signals to announce the reading of the designation code of the specimen vessel 33 for specimen analysis requiring the reanalysis to the controller for the driving motor of the conveyor path 30 for transferring racks for reanalysis and the controller for the driving motors of the sampling nozzles 7, 9 when the readers read the above-mentioned designation code. The controllers are thereby operated to stop the specimen vessel contg. the specimen requiring the reanalysis when said vessel arrives at sampling positions 26, 27. The specimen is sucked and drawn from the inside of the specimen vessel by the nozzle 7 or 8 and is dispensed into the reaction vessel in a specimen dispensing position 38 or 39 of a reaction line 5 or 6 through a route 51 or 50, by which the reanalysis is started.

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Industrial Application Field The present invention relates to an automatic analyzer, and more particularly, to a multiple-item automatic analyzer for specimens such as blood, plasma, serum, urine, and other body fluids and secretions. .

The present invention also relates to a sampling system in an automatic analyzer, and particularly to a sampling system suitable for reanalysis in an automatic analyzer.

(B) Prior art Analysis of samples such as blood, plasma, blood, urine, and other body fluids and secretions is used, for example, for diagnosis, determination of treatment disease status and treatment effectiveness, treatment guidelines, etc. Moreover, in order to improve diagnostic accuracy, this medical information is divided into multiple items and requires high segmentation accuracy, but on the other hand, the amount of specimens such as blood to be collected is limited, especially for patients and infants. is limited.

In the analysis of such samples, it is necessary to analyze many samples and analysis items in a short period of time, and a multi-item IJ automatic chemical analyzer is used to speed up the analysis, improve accuracy, and increase efficiency. ing.

Accuracy management of analytical values in such automatic analysis methods is
This is done by sandwiching a reference serum between the supplied samples and performing measurements together, and comparing the obtained measured values and indicated values.

(c) Problems to be solved by the invention However, this type of accuracy management of analytical values requires a considerable amount of time to obtain accurate values because they are known after the analysis is completed. was considered a problem. Therefore, the automatic analyzer is equipped with an analysis value inspection device for reanalysis.
In addition to comparison with 77-lens serum, for example, glutamate oxaloacetate transaminase (
GOT) to glutamate pyruvate transaminase (GPT) or total bilirubin (T-BIL) to direct bilirubin (D-BIL), e.g.
The GPT ratio, T-B I L/D-B I L ratio, etc. are obtained, and the beta analysis value to be reanalyzed is detected. However, even if a sample that should be reanalyzed is detected in this way, it is not easy to identify the relevant sample from among the many analyzed samples.
This is a problem as it requires a lot of time and effort.

An object of the present invention is to solve the problem of determining a sample for reanalysis during analysis using such an automatic analyzer.

(d) Means for Solving the Problems The present invention provides an automatic analyzer for multiple items, which can simply and easily identify samples for re-analysis during analysis by the automatic analyzer. be.

That is, the present invention includes an automatic analysis section including a sampling nozzle, an analysis sample container transfer conveyor device which can be driven intermittently and which extends through the suction position of the sampling nozzle, and a conveyor device with the analysis section in between. A conveyor device for transporting samples for reanalysis, which extends partially in parallel with both, and has a suction position for a sampling nozzle, and an inlet and an outlet []
section, and the outlet section is an analysis sample container transfer conveyor 1fc.
It has an analysis sample container accommodating part that is connected to the transfer path of the reanalysis sample container transfer conveyor device and whose inlet part is connected to the transfer path of the reanalysis sample container transfer conveyor device. The analyzed sample container storage section is connected to the transfer of the conveyor device, and the outlet portion is connected to the transfer path of the reanalysis sample container transfer conveyor device, and is arranged around the transfer path of the reanalysis sample transfer conveyor device. An automatic analysis device is characterized in that it is equipped with a marking code reading device.

In the present invention, the term "sample container" refers to sample containers such as sample cups and test tubes, as well as sample container storage such as sample racks.

In the present invention, the analyzed sample container can be sent from the analyzed sample container accommodating section to the analytical sample container accommodating section via the sampling nozzle suction position in order to perform reanalysis. A re-analysis conveyor path connecting between the container accommodating section and both analyzed sample container accommodating sections is provided separately from the routine analysis conveyor path.

These conveyor paths can be driven or stopped precisely intermittently, and power sources such as servo motors, step motors, air cylinders, and raschets are used, for example.

In order to re-analyze only the analytical samples that need to be re-analyzed, the analysis sample containers of the present invention or the racks that accommodate the sample containers are provided with a bar code that identifies and indicates the sample name for sample retrieval. Marking symbols such as etc. are attached.

In the present invention, in order to read such marking codes and perform re-analysis, a marking code reading device is installed around the transfer path of the sample transport conveyor device for re-analysis on the upstream side of the sample collection position. It will be done. This reading device is selected in accordance with the marking code.

For example, if the marking code is a bar code, a reflective phototransistor or a bar code league can be used. Also, depending on the position of the through hole provided in the label, the encoder etc. will come off during use.

The output end of such a marking code reading device is connected to an input part of a power unit for driving the reanalysis sample container transfer conveyor path, such as a motor control unit, and a human power unit of a motor control unit for driving the sampling nozzle. It will be established.

By doing this, it is possible to detect a sample to be reanalyzed that is being transferred along the conveyor path, stop the sample container containing the sample that needs to be reanalyzed at the suction position of the sampling nozzle, and remove the sample contained in the sample container. Samples such as specimens are collected by suction into a sampling nozzle.

In the present invention, detection of whether or not an analysis value is abnormal is performed in a retest determination device.

In the present invention, it is sufficient that the reexamination determination device can compare the analysis result with a normal value and determine whether or not the analysis result is abnormal. For example, various arithmetic and logic devices can be used as these devices, such as GOT/GPT ratio,
Alternatively, it can be performed by determining the ratio of component analysis values that are correlated with each other, such as the T-BIL/D-BTI ratio. Of course, it may also be carried out to compare the 'J7 Allens serum.

In the present invention, the output end of the re-examination determination position can be connected to a display device in order to notify an analysis worker of an abnormality in the analysis value and have him or her perform a re-analysis. Examples of indicating devices include alarms, signal lights, display devices, and the like.

However, if the output end of the re-examination determination device is connected to the drive power unit of the conveyor device of the sample container transfer unit for re-analysis, for example, the control unit of the motor, re-analysis can be started automatically. .

In this case, a position sensor for detecting the sample container, such as a proximity switch or a charging switch, is provided in the analyzed sample container storage section in order to detect the end of analysis, and the signal from this sensor is sent to the re-examination determination device. It is preferable to connect the signal so that it is input as an operation signal for starting the judgment because automation becomes easy.

(E) Function In the present invention, a marking code reading device is arranged around the transfer path of the reanalysis sample container transfer conveyor device, and its output end is connected to the control device of the driving power device of the conveyor device d. At the same time, since it is connected to the control device 6 of the power VC for driving the sampling nozzle, the re-inspection determination device can display the marking code of the sample that needs to be re-analyzed when it is necessary to re-analyze it. During the process of transporting sample containers from the analyzed sample container accommodating section to the analysis sample container accommodating section by the re-analysis sample container transfer conveyor device, the re-analysis sample containers are stored in the reading device by reading and comparing the marking codes on each sample container. It is possible to mechanically search for a sample container containing a sample that requires analysis, automatically aspirate it into a sampling nozzle, dispense it into a reaction container, and perform reanalysis.

(f) *Example Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings, but the present invention is not limited in any way by the following description and examples.

The figure is a partially omitted schematic plan view illustrating an embodiment of the present invention. In the present invention, for convenience of explanation, the material nozzle cleaning section, the first reagent, and the second reagent cleaning section are omitted,
Not shown.

The automatic analyzer 1 is provided with two turntables 2 and 3, and reaction vessels 4 are arranged on each turntable. The rows of reaction vessels 4 form reaction lines 5 and 6, respectively, and are gradually moved by intermittent driving of turntables 2 and 3. Around the turntables 2 and 3, there are sample dispensers 7 and 8, first reagent racks 9 and 10, first reagent dispensers 11 and 12, second reagent racks 13 and 14, and second reagent dispenser. 15 and 16, measuring instruments 17 and 18, and cleaning devices 19 and 20 are arranged extensively. In this example, a rack supply section 21 and a rack storage section 22 are installed on both sides of the reaction section configured as described above.
is provided. The outlet section 23 of the rack supply section 21 and the inlet section 24 of the rack storage section 22 are connected by a conveyor path 25 for transferring racks for analysis. The analytical rack transfer conveyor path 25 of this example stops at the sample collection positions 26 and 27 of the rack transfer conveyor path, and the sample dispensers 7 and 8 supply the sample to the reaction vessels 4 of the reaction lines 5 and 6. For dispensing, it is connected to a power source (not shown) such as a pulse motor so as to be capable of intermittent drive + IF function and fast forward drive/stop.

Furthermore, a similar analysis rack transfer conveyor path 30 is connected between the inlet section 27) of the rack supply section 21 and the outlet section 29 of the rack storage section 22. This analysis rack transfer conveyor path 30 is for +1T analysis, and is provided with a position for sucking and collecting a sample using a sampling nozzle.

The rack supply section 21 can accommodate a plurality of racks 34 on which a plurality of analysis sample containers 33 are placed, and can gradually move the racks 34 toward the exit 23 side in accordance with the intermittent drive of the analysis rack transfer conveyor path 25. A conveyor path 35 is also connected or connectable to a power source (not shown), such as a pulse motor. Rack storage section 2
2 is provided with a conveyor path 36 similar to that of the rack supply section 21 so as to accommodate the rack 34 after sample collection by the sample dispensers 7 and 8. A reflective photo sensor 37 for rack detection is provided at the back of the rack storage section 22, and when the rack 34 is transferred from the entrance section 24 of the rack storage section to the back and stored, a re-inspection determination device is installed. (not shown).

Further, the back of the rack housing section 22 is open as an exit, and is connected to a reanalysis rack transfer conveyor path 30. This re-analysis rack transfer conveyor path 30 is operated by a signal from the re-examination determination device (not shown) when the re-examination determination device (not shown) detects an analysis value requiring re-analysis. It is set in. The reanalysis rack transfer conveyor device 30 is controlled so that racks of samples that require one analysis are fast-forwarded, and samples that require reanalysis are stopped at the sample collection position. For this purpose, the sample container containing the sample that requires reanalysis is easily distinguished from other sample containers.
Sensors 48 and 49 are provided between the sample collection positions 31 and 32 and the outlet 29 of the rack accommodating section 22 for reading marking codes such as bar codes attached to each sample container.

These sign code reading devices 48 and 4! ” output end is
The feedback system controls the conveyor system of the sampling nozzle and rack transfer section! It is connected to the control section of the IIJ1 device, and by reading the code of this sign code reading device, the driving of the sampling nozzle and the conveyor device can be controlled.

Since the automatic analyzer 1 of this example is configured as described above, the analysis sample container 33 containing the sample to be tested is accommodated in the rack 34, placed in the rack supply section 21, and analysis is started. . First, the movement of the analysis rack transfer conveyor path 25 is started, and the conveyor path 3 of the rack supply section 21 is started.
5 starts moving.

The analysis sample container 33 containing the test sample is placed on the rack 34 in advance. The rack 34 on which the analytical sample container 33 is mounted is supplied to the rack by, for example, a rack pushing device (not shown) operated by a binion rack mechanism when the analytical rack transport conveyor path 25 is stopped intermittently. Analytical rack transfer conveyor path 2 from section 21
5, and is intermittently moved in the direction of the rack storage section 22 by the analysis rack transfer conveyor path 25.

Due to this intermittent movement, the analysis rack transfer conveyor path 25
The sample from the analysis sample container 33 that has reached the sample collection positions 26 and 27 is aspirated by the nozzles (not shown) of the sample dispensers 7 and 8, respectively, and is transferred to the sample portions of the turntables 2 and 3. -12 = dispensed into reaction vessels 4 at injection positions 38 and 39, respectively;
be collected. Turntable 2 rotates counterclockwise,
The turntable 3 rotates clockwise.

The reaction container 4 into which the sample has been dispensed is moved by intermittent rotation of the turntables 2 and 3 to the first reagent dispensing position 40.
and 41, the first reagent is dispensed and mixed by the first reagent dispensers 11 and 12 into the first reagent containers 42 and 43 arranged in the first reagent racks 9 and 10, respectively. Then,
The reaction vessels 4 are further moved intermittently and when they reach the second reagent dispensing positions 44 and 45, the second reagent dispensers 15 and 16 respectively move the first reagent rack 1.
The second reagent is dispensed and mixed from reagent containers 46 and 47 arranged at 3 and 14, respectively.

The reaction container into which the second reagent has been dispensed reacts during the intermittent feeding process, and when it reaches the measuring position (not shown) below the measuring devices 17 and 18, the measuring devices 17 and 18
can be measured directly or sent to a 70-cell for measurement. The measured values are stored in a storage device (not shown) for each sample.

After the measurement, the reaction vessel 4 is further moved intermittently, and when it reaches the washing position below the washing devices 19 and 20, it is washed and cleaned. Note positions 38 and 391 are sent.

At the sample collection position 27, the sample container after the suction collection of the sample from the sample container is transferred to the analysis rack transfer conveyor w.
I25''2 is intermittently fed, and when it reaches the entrance 24 of the rack storage section 22, it is pulled into the rack storage section 22 by a rack pulling device (not shown) that operates with a binion rack mechanism. When the racks 34 are stored in the rack housing section 22 and the racks 34 are full, the reflective photo sensor 3 for detecting the racks is moved.
7 sends a signal to the reexamination determination device. Based on the signal from the reflective photosensor 37 for rack detection, the analysis results in the storage device are transferred to the item open calculation circuit, and the GOT/G is calculated for each sample.
The PT ratio is determined, and the G OT /GPT ratio of each sample is sent from the inter-item calculation determination circuit to the re-examination determination circuit.

On the other hand, in this example, the re-examination determination device is provided with upper limit and lower limit determination circuits (not shown) in addition to the inter-item calculation determination circuit. Through the circuit, upper and lower limits of the GOT/GPT ratio of a retest determination circuit (not shown) are set. In this example, the lower limit value of the GOT/GPT ratio is set to 0.8, and the upper limit value is similarly set to 1.2.

Therefore, each GOT sent from the re-examination judgment circuit
/GPT ratio is compared with the upper and lower limit values listed in -H, and if an analysis value of the sample is detected that does not fall within the range of these @calculated values, it will be indicated by a marker light (not shown). be able to. In this case, at the same time, the movement of the reanalysis rack transfer conveyor path 3 () is started to start the reanalysis.

The marking code of the specimen container of the sample requiring reanalysis is input from the retest determination device to the Wc devices 48 and 49 that read the marking code. The marking code reading devices i114B and 49 monitor the marking code attached to the analysis sample container 33 or rack 34 as it is transferred from the rack storage section 22 to the sample container supply section by the reanalysis rack transfer conveyor path 30. . When the marking code on the analysis sample container 33 of the sample requiring reanalysis is read, a signal indicating the reading is sent to the control device for the drive motor of the reanalysis rack transfer conveyor path 30 and the drive motors of the sampling nozzles 7 and 8. conveyor device (none of which are shown), actuate the control device, and stop driving the conveyor device when the sample container containing the sample requiring reanalysis reaches the sample collection position 26 or 27; A sample is aspirated from inside the sample container using the sampling nozzle 7 or 8, and the sample is taken through route 5.
1 or 50 to the reaction vessel at the sample dispensing position 3B or 39 of the reaction line 5 or 6, and the analysis 111 is started.

If the re-analysis results are unsuccessful, the re-examination judgment device is used to test again, and after confirming that the analysis values are normal, the sample container containing the next analysis sample is placed in the rack supply section, and the next analysis is carried out. Start analyzing.

In this example, explanation has been made based exclusively on the GOT/Gl)T ratio, but in addition to this, T-r311, /D
- Re-examination can be determined based on BIL ratio, reference serum, etc.

Further, in the present invention, the analysis work tool can operate the reanalysis rack transfer conveyor path 30 upon seeing the display of the marker light, and perform analysis on a sample that requires reanalysis. Samples that do not require retesting are skipped and fast-forwarded, and the bar food in the sample container of the sample that requires retesting, for example, is read by the laser bar food league 48 or 49, then switched to intermittent forwarding, and the sample for reanalysis is transferred. It is also possible to collect the sample using the injection device 7.

(G) Effects of the Invention The present invention provides the conveyor path of the sample container transfer section so as to be capable of forward and reverse rotation, and also provides a sign code reading device around the conveyor path to read the sign code of the sample name. The output end of the device is connected to the control device for the conveyor path and the drive motor of the sampling nozzle, so that when re-analysis is required, unlike conventional devices, it is possible to
The sample container stored in the analyzed sample container storage section is
This means that the sample can be searched and reanalyzed while being transferred to the analysis sample container accommodating section, and reanalysis can be performed quickly, easily, and more easily than with conventional devices.

Moreover, according to the present invention, the determination of whether to retest can be automatically performed immediately after analysis using a simple mechanism, making it easy to automate retesting.

Therefore, an automatic analyzer that can obtain accurate analysis results without delaying other analysis results can be provided at a low cost.

[Brief explanation of the drawing]

The figure is a partially omitted schematic plan view illustrating an embodiment of the present invention. Regarding the symbols in the figure, 1 is an automatic analyzer, 2 and 3 are turntables, 4 is a reaction container, 5 and 6 are reaction lines,
7 and 8 are sample dispensers, 9 and 10 are first reagent racks,
11 and 12 are first reagent dispensers, 13 and 14 are second reagent racks, 15 and 16 are second reagent dispensers, 17 and 1
19 and 20 are measuring instruments, 21 is a rack supply section, 22 is a rack storage section, 23 is an exit section of the rack supply section, 24 is an entrance section of the rack storage section, and 25 is an analytical rack transfer conveyor path. , 26 and 27 are sample collection positions, 28 is the entrance of the rack supply section, 29 is the exit of the rack storage section,
30 is a conveyor path for reanalysis, 31 and 32 are sample collection positions, 33 is a sample container for analysis, 34 is a rack,
35 and 36 are conveyor paths, 37 is a reflective photo sensor for rack detection, 38 and 39 are sample dispensing positions, 40 and 4
1 is a first reagent dispensing position, 42 and 43 are first reagent chambers, 44 and 45 are second reagent dispensing positions, 46 and 47 are second reagent containers, 48 and 49 are sign code reading devices or Leather barcode leagues, 50 and 51 are routes. agent

Claims (1)

[Claims] an automatic analysis section including a sampling nozzle, an analysis sample container transfer conveyor device that can be driven intermittently and extending through the suction position of the sampling nozzle, and at least partially parallel to the conveyor device with the analysis section in between. a conveyor device for transferring samples for re-analysis, which extends and has a suction position for a sampling nozzle; an inlet portion and an outlet portion; the outlet portion is connected to a transfer path of the conveyor device for transferring sample containers for analysis; an analysis sample container accommodating part connected to a transfer path of a sample container transfer conveyor device, an inlet part and an outlet part,
An analyzed sample container accommodating part whose inlet part is connected to the transfer of the analysis sample container transfer conveyor apparatus and whose outlet part is connected to the transfer path of the reanalysis sample container transfer conveyor apparatus, and the transfer of the reanalysis sample transfer conveyor apparatus. An automatic analysis device characterized by comprising a sign code reading device disposed around a road.