JPS6352015B2 - - Google Patents

Info

Publication number
JPS6352015B2
JPS6352015B2 JP58072330A JP7233083A JPS6352015B2 JP S6352015 B2 JPS6352015 B2 JP S6352015B2 JP 58072330 A JP58072330 A JP 58072330A JP 7233083 A JP7233083 A JP 7233083A JP S6352015 B2 JPS6352015 B2 JP S6352015B2
Authority
JP
Japan
Prior art keywords
drug
agent
adjuvant
acid
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP58072330A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58194819A (ja
Inventor
Ee Fuikusu Josefu
Ee Hoganii Sutefuano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS58194819A publication Critical patent/JPS58194819A/ja
Publication of JPS6352015B2 publication Critical patent/JPS6352015B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP58072330A 1982-04-26 1983-04-26 胃腸での薬剤吸収を促進する薬剤としてのα−ケトアルデヒド Granted JPS58194819A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US371873 1982-04-26
US06/371,873 US4440740A (en) 1982-04-26 1982-04-26 α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption

Publications (2)

Publication Number Publication Date
JPS58194819A JPS58194819A (ja) 1983-11-12
JPS6352015B2 true JPS6352015B2 (enExample) 1988-10-17

Family

ID=23465753

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58072330A Granted JPS58194819A (ja) 1982-04-26 1983-04-26 胃腸での薬剤吸収を促進する薬剤としてのα−ケトアルデヒド

Country Status (2)

Country Link
US (1) US4440740A (enExample)
JP (1) JPS58194819A (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732915A (en) * 1983-11-02 1988-03-22 Alza Corporation Process for increasing solubility of drug
US4639458A (en) * 1985-01-22 1987-01-27 Merck & Co., Inc. Tablet and formulation
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
ZA889189B (en) * 1986-06-16 1989-08-30 Merck & Co Inc Controlled release combination of carbidopa/levodopa
US4832957A (en) * 1987-12-11 1989-05-23 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
US4983400A (en) * 1986-06-16 1991-01-08 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
WO1991007971A1 (fr) * 1989-11-29 1991-06-13 Nippon Shinyaku Co., Ltd. Composition administree par voie rectale
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5849783A (en) * 1990-07-03 1998-12-15 Cell Research Corporation Autobiotics and their use in eliminating nonself cells
US5147652A (en) * 1990-07-03 1992-09-15 Cell Research Corporation Autobiotics and their use in eliminating nonself cells in vivo
DE10031043A1 (de) 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US6627613B2 (en) 2001-07-23 2003-09-30 Michael A. Strobel Application of water and organic solvent soluble ivermectin for topical and oral use
US20050009762A1 (en) * 2003-06-06 2005-01-13 Strobel Michael Albert Application of water and organic solvent soluble ivermectin for topical and oral use
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
DE60329211D1 (de) * 2002-10-31 2009-10-22 Metabasis Therapeutics Inc Cytarabin-monophosphate prodrugs
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20060088588A1 (en) * 2004-10-21 2006-04-27 Lourdes Pila-Collazo Medication administering device and system
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112015014349A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2015123352A1 (en) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US11077134B1 (en) 2020-11-10 2021-08-03 Mountain Valley Md Inc Water dissolvable macrocyclic lactone cyclodextrin complexes
US11638714B2 (en) 2020-11-10 2023-05-02 Mountain Valley Md Inc Water dissolvable macrocyclic lactone cyclodextrin complexes

Also Published As

Publication number Publication date
US4440740A (en) 1984-04-03
JPS58194819A (ja) 1983-11-12

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