JPS6327324B2 - - Google Patents
Info
- Publication number
- JPS6327324B2 JPS6327324B2 JP60172925A JP17292585A JPS6327324B2 JP S6327324 B2 JPS6327324 B2 JP S6327324B2 JP 60172925 A JP60172925 A JP 60172925A JP 17292585 A JP17292585 A JP 17292585A JP S6327324 B2 JPS6327324 B2 JP S6327324B2
- Authority
- JP
- Japan
- Prior art keywords
- bath
- tablets
- tablet
- lubricant
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 20
- 239000000314 lubricant Substances 0.000 claims description 14
- 239000001361 adipic acid Substances 0.000 claims description 10
- 235000011037 adipic acid Nutrition 0.000 claims description 10
- -1 alkali metal salt Chemical class 0.000 claims description 9
- 239000013040 bath agent Substances 0.000 claims description 7
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- GCHCGDFZHOEXMP-UHFFFAOYSA-L potassium adipate Chemical compound [K+].[K+].[O-]C(=O)CCCCC([O-])=O GCHCGDFZHOEXMP-UHFFFAOYSA-L 0.000 description 1
- 239000001608 potassium adipate Substances 0.000 description 1
- 235000011051 potassium adipate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- WXRGTYANXHSUOX-UHFFFAOYSA-M potassium;hexanedioate;hydron Chemical compound [K+].OC(=O)CCCCC([O-])=O WXRGTYANXHSUOX-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- KYKFCSHPTAVNJD-UHFFFAOYSA-L sodium adipate Chemical compound [Na+].[Na+].[O-]C(=O)CCCCC([O-])=O KYKFCSHPTAVNJD-UHFFFAOYSA-L 0.000 description 1
- 239000001601 sodium adipate Substances 0.000 description 1
- 235000011049 sodium adipate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- GOGGIOPQLKEIGC-UHFFFAOYSA-M sodium;hexanedioate;hydron Chemical compound [Na+].OC(=O)CCCCC([O-])=O GOGGIOPQLKEIGC-UHFFFAOYSA-M 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
産業上の利用分野
本発明は、溶中で発泡しつつ溶解する浴用材
料、いわゆる発泡性浴用錠剤（以下単に浴用錠剤
という）の製造方法に関する。
従来技術とその問題点
公知の浴用錠剤は、通常その重量が15乃至50ｇ
程度であつて、通常クエン酸、コハク酸、りんご
酸、酒石酸等の有機酸と炭酸ナトリウム、炭酸水
素ナトリウム、炭酸カリウム、炭酸水素カリウム
等の炭酸塩とを主成分とし、更に所望の浴用効果
等に応じて、硫酸ナトリウム、塩化ナトリウム、
ホウ酸、生薬、油脂類、香料、色素等を適宜配合
した組成を有している。そして、錠剤化に際して
は、原料配合物をそのまま直接打錠するか、或い
は原料配合物に結合剤を加えて顆粒化した後打錠
することが行なわれている。結合剤としては、主
成分と反応して発泡させてしまうことがない様
に、繊維素グリコール酸ナトリウム、ポリアクリ
ル酸ナトリウム、メチルセルローズ、ポリビニル
ピロリドン、アルギン酸ナトリウム等を粉末の形
態で使用して、原料配合物を乾式造粒することが
好ましいとされている。しかしながら、従来の打
錠方法においては、打錠完了後に錠剤を型（臼と
もいわれる）から取り出す際に錠剤の一部が剥離
するキヤツピング現象や、打錠時の圧縮過程で原
料配合物の一部が押型（杵ともいわれる）に付着
して錠剤表面を損傷するステイツキング現象等の
障害が発生しやすいので、連続的な打錠は困難で
ある。この様な問題を解決する為に、ステアリン
酸、ステアリン酸カルシウム、ステアリン酸マグ
ネシウム、ポリエチレングリコール、安息香酸、
安息香酸ナトリウム、澱粉、タルク、シリコン樹
脂等を滑沢剤として原料配合物に添加して打錠す
ることが行なわれている。この様な滑沢剤の使用
により、打錠時の問題点は、若干軽減されたもの
の、浴用錠剤としての性能が阻害されることが判
明した。即ち、滑沢剤の種類によつては、(イ)多量
の使用を必要とするので、浴用錠剤の浴中での崩
壊性を低下させる、(ロ)水に溶解しないので、浴に
白濁を生じさせる、(ハ)浴表面に油状に浮んで、不
快感を与える、(ニ)浴用錠剤から発生した泡の消滅
を妨げる、等の新たな問題点を生じている。
問題点を解決するための手段
本発明者は、このような現状に鑑みて種々研究
を重ねた結果、浴用剤原料配合物に対し、特定量
のアジピン酸とそのアルカリ金属塩の少なくとも
１種を添加する場合には、これが、浴用錠剤の打
錠製造時の滑沢剤として優れた効果を発揮するの
みならず、浴用錠剤としての性能を損なわないこ
とを見出した。即ち、本発明は、重量15〜50ｇの
発泡性浴用剤を打錠するに際し、浴用剤成分に対
しアジピン酸及びアジピン酸のアルカリ金属塩の
少なくとも１種１〜10重量％を滑沢剤として添加
することを特徴とする発泡性浴用剤の打錠方法に
係る。
本発明で使用する滑沢剤以外の浴用錠剤成分
は、特に限定されず、前記の如くクエン酸等の有
機酸と炭酸ナトリウム等の無機酸塩とを発泡性主
成分とし、更に必要に応じて他の添加剤を配合し
たものであり、錠剤としての重量も、常法通り15
〜50ｇの範囲内にある。
滑沢剤としては、アジピン酸及びそのアルカリ
金属塩の少なくとも１種を使用する。アルカリ金
属塩としては、アジピン酸ナトリウム、アジピン
酸水素ナトリウム、アジピン酸カリウム、アジピ
ン酸水素カリウム等が例示される。
本発明方法は、例えば、次の様にして実施され
る。先ず、クエン酸等の有機酸と炭酸ナトリウム
等の無機酸塩とを発泡性主成分とし、必要に応じ
これに他の添加剤を配合した原料配合物を乾式造
粒機により顆粒化する。該顆粒の粒径は、32〜
100メツシユ程度であることが好ましく、必要な
らば、選別して粒度調整を行なう。次いで、該顆
粒重量の１〜10重量％程度より好ましくは３〜６
重量％程度の割合で、アジピン酸及びアジピン酸
のアルカリ金属塩の少なくとも１種を加え、均一
に混合した後、常法に従つて打錠を行なつて、浴
用錠剤を得る。
発明の効果
本発明によれば、浴用錠剤の打錠製造時のキヤ
ツピングやステイツキングが防止されるのみなら
ず、使用した滑沢剤により浴用錠剤の性能が阻害
されることもない。
実施例
以下に実施例及び比較例を示し、本発明の特徴
とするところを更に一層明らかにする。
実施例１〜２及び比較例１
第１表に示す(A)成分から得た顆粒（32〜100メ
ツシユ）に(B)成分を添加混合し、直径35mm、厚さ
10mmの碁石状円形錠剤を打錠した。尚、第１表に
示す数値は、重量部を示す。
滑沢剤としてタルクを使用する比較例１におい
ては、４錠打錠後にステイツキング現象を生じ
て、打錠を継続し得なくなつたのに対し、実施例
１〜２では、1000錠以上の正常な連続打錠が可能
であり、不良率も著るしく低下した。
INDUSTRIAL APPLICATION FIELD The present invention relates to a method for producing a bath material that dissolves while foaming in a solution, a so-called effervescent bath tablet (hereinafter simply referred to as a bath tablet). Prior art and its problems Known bath tablets usually weigh between 15 and 50 g.
The main ingredients are usually organic acids such as citric acid, succinic acid, malic acid, and tartaric acid, and carbonates such as sodium carbonate, sodium hydrogen carbonate, potassium carbonate, and potassium hydrogen carbonate, and further have desired bath effects, etc. Sodium sulfate, sodium chloride, depending on
It has a composition that appropriately contains boric acid, herbal medicines, oils and fats, fragrances, pigments, etc. When making tablets, the raw material mixture is either directly compressed into tablets as it is, or a binder is added to the raw material mixture and the mixture is granulated and then tableted. As a binder, sodium cellulose glycolate, sodium polyacrylate, methylcellulose, polyvinylpyrrolidone, sodium alginate, etc. are used in powder form so as not to react with the main component and cause foaming. It is said that dry granulation of the raw material blend is preferred. However, in conventional tabletting methods, there is a capping phenomenon in which part of the tablet peels off when the tablet is removed from the mold (also called a mortar) after completion of tabletting, and a part of the raw material mixture is removed during the compression process during tabletting. Continuous tableting is difficult because it tends to cause problems such as statesking phenomenon in which the tablets adhere to the press die (also called a punch) and damage the tablet surface. In order to solve these problems, stearic acid, calcium stearate, magnesium stearate, polyethylene glycol, benzoic acid,
Sodium benzoate, starch, talc, silicone resin, etc. are added as lubricants to the raw material mixture and then tableted. Although the use of such a lubricant somewhat alleviated the problems encountered during tableting, it was found that the performance as bath tablets was impaired. That is, depending on the type of lubricant, (a) it requires a large amount to be used, which reduces the disintegration of bath tablets in the bath, and (b) it does not dissolve in water, so it may cause cloudiness in the bath. (3) It floats on the bath surface in an oily form, giving a feeling of discomfort; and (2) It prevents the bubbles generated from the bath tablet from disappearing. Means for Solving the Problems In view of the current situation, the present inventor has conducted various studies, and as a result, the present inventor has added a specific amount of adipic acid and at least one of its alkali metal salts to a bath agent raw material formulation. It has been found that when added, it not only exhibits an excellent effect as a lubricant during the production of tablets for bath use, but also does not impair the performance of tablets for bath use. That is, in the present invention, when tabletting an effervescent bath agent weighing 15 to 50 g, 1 to 10% by weight of at least one of adipic acid and an alkali metal salt of adipic acid is added as a lubricant to the bath agent components. The present invention relates to a method for tabletting an effervescent bath agent. The bath tablet components other than the lubricant used in the present invention are not particularly limited, and as described above, the effervescent main components are organic acids such as citric acid and inorganic acid salts such as sodium carbonate, and if necessary, It is formulated with other additives, and the weight of the tablet is 15% as usual.
~50g. As the lubricant, at least one of adipic acid and its alkali metal salt is used. Examples of the alkali metal salt include sodium adipate, sodium hydrogen adipate, potassium adipate, potassium hydrogen adipate, and the like. The method of the present invention is carried out, for example, as follows. First, a raw material mixture containing an organic acid such as citric acid and an inorganic acid salt such as sodium carbonate as main foaming components and other additives as necessary is granulated using a dry granulator. The particle size of the granules is 32~
It is preferable that the size is about 100 meshes, and if necessary, the particle size is adjusted by sorting. Next, about 1 to 10% by weight of the granules, preferably 3 to 6% by weight.
At least one of adipic acid and an alkali metal salt of adipic acid is added in a proportion of about % by weight, mixed uniformly, and then tableted according to a conventional method to obtain bath tablets. Effects of the Invention According to the present invention, not only capping and staking during the production of tablets for bath use are prevented, but also the performance of the tablet for bath use is not inhibited by the lubricant used. Examples Examples and comparative examples are shown below to further clarify the characteristics of the present invention. Examples 1 to 2 and Comparative Example 1 Component (B) was added and mixed to the granules (32 to 100 mesh) obtained from component (A) shown in Table 1, and the mixture was made to a diameter of 35 mm and a thickness of 35 mm.
A 10 mm Go stone-shaped circular tablet was compressed. Note that the numerical values shown in Table 1 indicate parts by weight. In Comparative Example 1, in which talc was used as a lubricant, the statesking phenomenon occurred after 4 tablets were compressed, making it impossible to continue tableting, whereas in Examples 1 and 2, talc was used as a lubricant. Normal continuous tablet compression was possible, and the defective rate was significantly reduced.
【表】
実施例３〜４及び比較例２
第２表に示す(A)成分から得た顆粒（32〜100メ
ツシユ）に(B)成分を添加混合し、直径40mm、厚さ
20mmの凸円形錠剤に打錠した。
滑沢剤としてポリエチレングリコールを使用す
る比較例２においては、キヤツピング現象が短時
間内に発生し、又錠剤の強度が十分でない為摩損
が大きかつた。これに対し、実施例３〜４では、
1000錠打錠後にもキヤツピング現象は発生せず、
成型性に優れた錠剤が得られた。[Table] Examples 3 to 4 and Comparative Example 2 Component (B) was added and mixed to the granules (32 to 100 mesh) obtained from component (A) shown in Table 2, and the mixture was made with a diameter of 40 mm and a thickness of
It was compressed into 20 mm convex circular tablets. In Comparative Example 2 in which polyethylene glycol was used as a lubricant, the capping phenomenon occurred within a short period of time, and the strength of the tablet was not sufficient, resulting in large wear and tear. On the other hand, in Examples 3 and 4,
No capping phenomenon occurred even after 1000 tablets were compressed.
Tablets with excellent moldability were obtained.
【表】【table】
【表】
参考例
実施例１のアジピン酸に代えて第３表に示す各
物質を滑沢剤として使用した場合の(a)打錠前の配
合物の流動性付与効果、(b)ステイツキング防止効
果、(c)キヤツピング防止効果及び(d)浴用錠剤を温
水に溶解した際の問題点を第３表に示す。[Table] Reference example: (a) Effect of imparting fluidity to the formulation before tableting, (b) Prevention of staking when each substance shown in Table 3 is used as a lubricant in place of adipic acid in Example 1 Table 3 shows the effects, (c) capping prevention effect, and (d) problems when the bath tablets are dissolved in hot water.
【表】
なり効果あり、：著るしく効果あり。
実施例５及び比較例３〜４
第４表に示すＡ成分から得た顆粒（32〜100メ
ツシユ）にＢ成分を添加混合し、直径40mm、厚さ
20mmの凸円形錠剤に打錠した。
実施例５の場合には、連続的な打錠が可能であ
り、錠剤の強度及び摩損度も十分満足すべきもの
であつた。また、温水にも完全に溶解した。
これに対し、滑沢剤の量が過剰である比較例３
の場合には、実施例５以上の打錠性の向上は認め
られなかつた。また、温水に溶解した際に水面に
浮游物が発生し、浴用錠剤として不適当であつ
た。
更に、アジピン酸を大過剰量使用する比較例４
においては、錠剤の強度が低くなり、摩損が認め
られた。また、温水に溶解した際の浮游物の量も
多かつた。[Table] Effective: Significantly effective.
Example 5 and Comparative Examples 3 to 4 Component B was added and mixed to the granules (32 to 100 mesh) obtained from component A shown in Table 4, and the granules had a diameter of 40 mm and a thickness of 40 mm.
It was compressed into 20 mm convex circular tablets. In the case of Example 5, continuous tableting was possible, and the strength and friability of the tablets were sufficiently satisfactory. It also completely dissolved in hot water. On the other hand, Comparative Example 3 in which the amount of lubricant is excessive
In the case of Example 5, no improvement in tableting properties was observed compared to Example 5. Further, when dissolved in hot water, floating substances were generated on the water surface, making it unsuitable as a bath tablet. Furthermore, Comparative Example 4 using a large excess amount of adipic acid
In this case, the strength of the tablet decreased and wear and tear was observed. Furthermore, the amount of suspended matter when dissolved in hot water was also large.
Claims (1)
し、浴用剤成分に対しアジピン酸及びアジピン酸
のアルカリ金属塩の少なくとも１種１〜10重量％
を滑沢剤として添加することを特徴とする発泡性
浴用剤の打錠方法。1. When tabletting an effervescent bath agent weighing 15 to 50 g, 1 to 10% by weight of at least one of adipic acid and an alkali metal salt of adipic acid is added to the bath agent components.
1. A method for tabletting an effervescent bath agent, which comprises adding as a lubricant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17292585A JPS6233114A (en) | 1985-08-05 | 1985-08-05 | Tableting method of foaming bath agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17292585A JPS6233114A (en) | 1985-08-05 | 1985-08-05 | Tableting method of foaming bath agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6233114A JPS6233114A (en) | 1987-02-13 |
| JPS6327324B2 true JPS6327324B2 (en) | 1988-06-02 |
Family
ID=15950894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17292585A Granted JPS6233114A (en) | 1985-08-05 | 1985-08-05 | Tableting method of foaming bath agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6233114A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0512040Y2 (en) * | 1986-08-14 | 1993-03-26 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006248937A (en) * | 2005-03-09 | 2006-09-21 | Pola Chem Ind Inc | Solid bath agent and its manufacturing method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5444013A (en) * | 1977-08-15 | 1979-04-07 | Kuroisutaa Kemikaruzu Kk | Production of foamable tablet |
| JPS5444722A (en) * | 1977-08-23 | 1979-04-09 | Furukawa Battery Co Ltd | Device for automatically stacking plate group for storage battery |
-
1985
- 1985-08-05 JP JP17292585A patent/JPS6233114A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5444013A (en) * | 1977-08-15 | 1979-04-07 | Kuroisutaa Kemikaruzu Kk | Production of foamable tablet |
| JPS5444722A (en) * | 1977-08-23 | 1979-04-09 | Furukawa Battery Co Ltd | Device for automatically stacking plate group for storage battery |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0512040Y2 (en) * | 1986-08-14 | 1993-03-26 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6233114A (en) | 1987-02-13 |
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