JPS59219205A - Production of expandable tablet - Google Patents

Abstract

PURPOSE:To obtain an expandable tablet capable of dissolving in water while dropping and expanding on pouring into water without forming a zone with a high concentration of chlorine at the bottom of a container, by incorporating a dichloroisocyanurate with a carbonate, etc. as a foaming agent and a solid acid, compressing and granulating the resultant mixture, tableting the granulated mixture. CONSTITUTION:(A) Sodium or potassium dichloroisocyanurate having 20-300mu, preferably 40-150mu fine particle diameter is incorporated with (B) a salt selected from sodium or potassium hydrogencarbonate or sodium or potassium sesquicarbonate having the same particle diameter range and (C) a solid organic or inorganic acid having the same particle diameter range, and the resultant mixture is uniformly mixed, compressed and granulated by a dry pressure roll to give a granular material having preferably 200-3,300mu grain diameter, which is then tableted to afford the aimed expandable tablet. The mixing ratios of the respective components are as follows; 100pts.wt. component (A), 10-400pts.wt., preferably 20-200pts.wt. component (B) and 10-400pts.wt., preferably 20- 200pts.wt. component (C). In this case, proper expansion and dispersion performance can be imparted.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing tablets comprising dichloroisocyanurate and an effervescent agent. More specifically, the present invention relates to a method for producing tablets that completely melt while foaming in a short period of time after being placed in water, and in which the tablets or disintegrated particles do not remain at the bottom of the water for a long time.

In recent years, chlorinated isocyanuric acid has been widely used as a chlorine agent due to its excellent storage stability. Up until now, its main use was to sterilize pool water and septic tank wastewater, but a new trend is Use as a household bath water purifier, sterilize and bleach clothes and kitchen utensils, use as an aqueous solution to remove mold and sterilize walls and floors, and sterilize animal cages and tropical fish tanks for the purpose of deodorizing. It has been used as a product for sterilization, bleaching, and deodorization that can be easily handled, especially by housewives.

Previously, this type of product was called sodium hypochlorite solution, but due to the difficulty of handling this product,
It was a product that I wanted to avoid using if possible. In other words, because of its strong alkaline nature, it causes damage and deterioration to the skin even if it adheres to thermal clothing, and it also irritates the eyes when handled, making it extremely dangerous if it gets into the eyes.

Also, since it is a liquid, spilling it or letting it get on the outside of the container would be very troublesome as it is both a chlorine agent and an alkaline agent. However, the current situation is that there is no other agent other than chlorine-based agents that can replace this sodium hypochlorite solution with broad and strong antibacterial activity, and under these circumstances, it is far more effective than sodium hypochlorite solution. Chlorinated isocyanuric acid has attracted attention as it is easy to handle, and has begun to be used in various forms. For example, powders, granules and tablets of chlorinated isocyanuric acid or its salts are commonly known.

Powders have a high dissolution rate, but are undesirable because they cause irritation to the eyes and nose and the powder floats on the water surface.

On the other hand, with granules and tablets, there is little dusting or powder floating, but dissolution is slow and, of course, only the bottom of the water tends to have a high chlorine concentration, so uniform diffusion of the active ingredient cannot be expected.

On the other hand, in JP-A-55-155792, a tablet obtained by blending a disintegrant such as cellulose calcium glycolate with a chlorinated isocyanuric acid composition and then compression molding is disclosed in JP-A-56-142210. In this issue, a tablet consisting of a crystalline organic carboxylic acid and an alkali metal carbonate is proposed.

However, these tablets simply disintegrate at the bottom of the water, or they simply foam and disintegrate at the bottom of the water, and the powder or grains settle at the bottom of the water and have no diffusion effect, so they cannot be used at the bottom of the water or at the stopper of the aquarium. It is easily corroded. In order to increase the dissolution rate of tablets, it is possible to obtain tablets using powder with a fine particle size, but when producing tablets by continuous tableting, it is necessary that the powder has high fluidity and moldability. Therefore, it is necessary to use particles with a large particle size.

In this way, in order to eliminate the harmful effects of tablets containing active chlorine agents remaining at the bottom of the water, they are foamed in water and moved up and down for 30 to 60 seconds without staying at the bottom of the water. A patent application has already been filed in 1973 for a method for producing expandable granules that are uniformly melted.
No. 8-2849.52 is pending.

However, as the granules are foamed and dissolved per gram, each particle becomes smaller and tends to float on the water surface, resulting in a slight decrease in dispersibility.

As a result of extensive research into the composition, particle size, etc. of these effervescent granules, we found that the dissolution rate of conventional effervescent tablets made by mixing granular effervescent agents and chlorinated isocyanurate and compressing them into tablets as is (
We have now found a way to obtain tablets that are much faster than those described in Comparative Examples) and in which powders and particles do not settle to the bottom of the water after foaming is complete.

That is, the present invention uses the following three components (al, (bl, and (C
) (al Sodium or potassium salt of dichloroisocyanuric acid (bl) A substance selected from the group consisting of sodium or potassium bicarbonate, sodium or potassium sesquicarbonate, sodium or potassium carbonate (C) Contains a solid organic or inorganic acid. , is a method for producing effervescent tablets, characterized in that granules obtained by compression granulation using a pressure roll are made into tablets.

More specifically, 20 to 300 μ, preferably 40 to
Sodium or potassium salt of dichloroisocyanuric acid having a fine particle size of 150μ is mixed with sodium or potassium bicarbonate, sodium or potassium sesquicarbonate, sodium or potassium carbonate and a solid organic or inorganic acid in the same particle size range. After uniformly mixing, granulation is performed using a pressure roll to form particles of 100 to 4,000μ, preferably 20
This is a method for producing effervescent tablets, in which granules with a particle size range of 0 to 3,000 μ are formed and the granules are molded using a tabletting machine or a briquetting machine.

At this time, in order to improve granulation properties, it is preferable to add a lubricant such as stearate, talc, or boric acid. Furthermore, the storage stability of the product is better when the water content in the formulation is as low as possible. Preferably, the water content is less than 1% by weight in the formulation.

In order to impart further long-term storage stability, boric anhydride may be added.

Mixing and granulation are easier when the particle size of each of these raw materials is 20 to 300 μm, preferably 40 to 200 μm. If the particle size is outside this range, the powder will not be fed smoothly, it will be difficult to obtain granules with uniform thickness and hardness, roll slip will easily occur, and the granulation yield will be low.

The solid acid in the blended composition is not particularly limited, but it is preferable that the I)H value of a 1% aqueous solution thereof is in the range of 1.7 to 4.0, and it is preferable that the solid acid has low hygroscopicity. Solid acids applicable to these include organic acids such as citric acid, tartaric acid, adipic acid, and succinic acid, and inorganic acids such as acidic phosphates.

If the pH value of the acid is outside this range, for example, if the pH value is 1' or less than 7, the stability of the product will be poor, and if the pH value is 4 or more, foaming will be extremely small and the product will not be of practical use.

In addition, the blending ratio of the compound is 10% of chlorinated isocyanuric acid.
0 parts by weight, bicarbonate, sesquicarbonate or carbonate is 10 to 400 parts by weight, preferably 20 to 200 parts by weight, and solid acid is 10 to 400 parts by weight, preferably 20 to 200 parts by weight. Appropriate foaming and dispersion performance can be imparted when

A lubricant may be used as necessary, but the amount of lubricant to be added may be 0.01 to 5 parts by weight per 100 parts by weight of the above +a), (b) and (C1) formulations. The amount of boric anhydride that imparts storage stability is preferably 1 to 40 parts by weight, preferably 1 to 10 parts by weight, based on the chlorinated isocyanuric acid.Additionally, if necessary, fillers, surfactants, It is a further preferred embodiment of the present application to add auxiliary agents such as metal chelating agents, rust preventives, and pigments.

After uniformly mixing these compounds, they are pressure-molded using a dry pressure roll such as a compacting machine or a briquetting machine, coarsely crushed, and sieved to a particle size of r100 to 4000μ, preferably 200 to 3300μ. Granules are obtained, and the desired effervescent tablets are obtained using a briquetting machine or a tabletting machine. The size of this tablet varies depending on the purpose and use, but it is usually 0.5 to 10 g/tablet for household use such as in the kitchen or bath, and 5 to 100 g/tablet for use in sterilizing stored water and controlling slime.

When the effervescent tablets obtained in this way are placed in water,
While falling to the bottom of the water, it foams and dissolves within 1 to 3 minutes after foaming ends. Since it is a tablet, there is no powder left behind when you put it in, unlike powder. Because it dissolves so quickly, it does not create a high chlorine concentration zone at the bottom of the container like conventional tablets, which causes material deterioration, and it is easier to handle than liquid chlorine agents. .

The present invention will be further explained in detail with reference to comparative examples and examples, but the technical scope of the present application is not limited thereto.

Example 1 Moisture is 1.00% by weight or less and the particle size of each formulation is 40~
Sodium dichloroisocyanurate 3, which is 150μ
0% by weight, 34.8% by weight of sodium bicarbonate, 35% by weight of tartaric acid, and 0.2% by weight of magnesium stearate, and the mixture was formed into a thin plate using a pressure roll granulator. A molded product was obtained, which was crushed using a breaker, and then classified into 8 mesh (2,400 μ) passes and 48 mesh (300 μ) stops to obtain granules.

Then, 99.8% by weight of the obtained granules and 0.2% by weight of magnesium stearate having a particle size of 8θμ or less were uniformly mixed and 3.0g was filled into a mortar with a diameter of 20 mm. The surface pressure is 600kg/c using a hydraulic press.
A pressure of IIY was applied and compression molding was performed to obtain a tablet having a diameter of 20 mm, a thickness of 5.5 mm, and a density of 1.74 g/C-. Note that the operating conditions of the pressure roll machine are as follows.

Roll; Diameter 160+U Width 6oII 11 flakes Thickness: 2.3-3.2 Roll rotation speed: 15 rpm Oil pressure: 87 kg/cJ, linear pressure: 1.5 t/cm The dissolution rate of the tablets obtained in this way is described below. As a result of the evaluation, the results of the dissolution rate are summarized in Table 3. Foaming and dissolution were completed in 95 seconds, and no powder was deposited on the bottom of the water.

(Method for evaluating melting speed) 1. Bee power and 1. pure water. 000 ml/liter, maintained at 30 tL, drop the tablet gently into it, observe the foaming, disintegration, and melting status of the tablet immediately after adding it, and measure the time until complete dissolution is completed.

Examples 2 to 4 The same procedure as in Example 1 was carried out except that the formulation and composition for obtaining granules were changed as shown in Table 1. The obtained tablets had a thickness of 5.3 to 5.6 g/cm and a density of 1.7 to 1.8 g/cn (
Met. Evaluation of melting speed is shown in Table-3. The values in the table are in % by weight.

Table-1 Composition Comparison Examples 1 to 3 Tablets were made using the same tableting method as Example 1 without granulation using the composition shown in Table-2, and dissolved using the same method as Example 1. The speed was measured. The results are shown in Table-3. Note that the water content of each formulation is 1% by weight or less.

Table-2 Mixing composition The numbers in parentheses represent the particle size of each formulation.

Table 3 Evaluation of Dissolution Rate As shown in Table 3, the tablets of the present invention have a fast dissolution rate, and no powder is deposited on the bottom of the water as soon as foaming is completed.

Comparative Example 4 - Tablets that were directly made into tablets without being granulated remained undissolved even after foaming, and powder was deposited on the bottom of the water.

Claims (1)

[Claims] l) The following three components (al, (b), and (0) (a)
Sodium or potassium salt of dichloroisocyanuric acid (bl) A salt selected from the group consisting of sodium or potassium hydrogen carbonate, sodium or potassium sesquicarbonate, sodium or potassium carbonate (C1) containing a solid organic or inorganic acid and pressurizing A method for producing effervescent tablets, which comprises tableting granules obtained by compression granulation using rolls. 2) The particle size of the three components (al, (bl, and C1) to be mixed is 20 to 300μ 3) A method for manufacturing an effervescent tablet according to claim 1, characterized in that the granules obtained by compression granulation using a pressure roll have a particle size of 100 to 4,000 μ. A method for producing an effervescent tablet according to claim 1.