JPS63227511A - Acidic water for cosmetic - Google Patents
Acidic water for cosmeticInfo
- Publication number
- JPS63227511A JPS63227511A JP5949687A JP5949687A JPS63227511A JP S63227511 A JPS63227511 A JP S63227511A JP 5949687 A JP5949687 A JP 5949687A JP 5949687 A JP5949687 A JP 5949687A JP S63227511 A JPS63227511 A JP S63227511A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- cosmetic
- skin
- distilled water
- acidic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 239000002537 cosmetic Substances 0.000 title claims abstract description 19
- 230000002378 acidificating effect Effects 0.000 title claims abstract description 17
- 239000012153 distilled water Substances 0.000 abstract description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract description 4
- 239000006210 lotion Substances 0.000 abstract description 4
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract description 2
- 239000004327 boric acid Substances 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000000174 gluconic acid Substances 0.000 abstract description 2
- 235000012208 gluconic acid Nutrition 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract description 2
- 239000011976 maleic acid Substances 0.000 abstract description 2
- 150000007522 mineralic acids Chemical class 0.000 abstract description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract description 2
- 208000010201 Exanthema Diseases 0.000 abstract 2
- 201000005884 exanthem Diseases 0.000 abstract 2
- 206010037844 rash Diseases 0.000 abstract 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005261 aspartic acid Drugs 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 17
- 238000004925 denaturation Methods 0.000 description 6
- 230000036425 denaturation Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 3
- 206010042496 Sunburn Diseases 0.000 description 3
- 241000212749 Zesius chrysomallus Species 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 239000002585 base Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- DSLZVSRJTYRBFB-LLEIAEIESA-N D-glucaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-LLEIAEIESA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- MSWZFWKMSRAUBD-UKFBFLRUSA-N alpha-D-glucosamine Chemical compound N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-UKFBFLRUSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 238000003505 heat denaturation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- -1 k-aspartic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〈産業上の利用分野〉
本発明は、化粧水、クリーム、乳液などの化粧品のベー
スとして使用できる化粧品用酸性水に関する。DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to acidic water for cosmetics that can be used as a base for cosmetics such as lotions, creams, and milky lotions.
〈従来の技術〉
従来、化粧品のベースは、通常ｐＨ７（中性）の水（滅
菌蒸溜水）を用いていたため、化粧品のｐＨは７〜８の
中性又は弱アルカリ性のものが多かった。<Prior Art> In the past, water (sterile distilled water) with a pH of 7 (neutral) was usually used as a base for cosmetics, so the pH of many cosmetics was neutral or weakly alkaline with a pH of 7 to 8.
〈発明が解決しようとする問題点〉
ところが、これら中性又は弱アルカリ性の化粧品を長期
間使用していると、肌に化粧ヤケ（素肌が黒ずんで見え
る現象）やシミが発生することがあった。<Problems to be solved by the invention> However, when these neutral or slightly alkaline cosmetics are used for a long period of time, makeup discoloration (a phenomenon in which bare skin appears darkened) and spots may occur on the skin. .
く問題点を解決するための手段〉
本発明者は、上記問題点を解決するために、鋭意開発に
努力する過程で、化粧ヤケやシミはタンパク買のアルカ
リ変性（人の皮膚がｐＨ５〜５．５の弱酸性であること
による）及び熱変性が原因であることを知見し、 ｐｎ
３．４〜４．４に調製された化粧品用酸性水に想到し
た。Means for Solving the Problems In order to solve the above problems, the present inventor discovered that in the process of making earnest efforts in development, makeup discoloration and stains are caused by alkaline denaturation (when human skin has a pH of 5 to 5). It was found that the cause was due to the weak acidity of .5) and thermal denaturation, and pn
We came up with an acidic water for cosmetics prepared from 3.4 to 4.4.
〈構成の詳細な説明〉 以下、本発明の構成について、詳細な説明を行なう。<Detailed explanation of the configuration> Hereinafter, the configuration of the present invention will be explained in detail.
水は、一般に、滅菌蒸溜水を使用する。As for water, generally sterile distilled water is used.
当該蒸溜水を酸性化するために使用する酸性薬品として
は、マレイン酸、クエン酸、リンゴ酸、グルコン酸、グ
ルカール酸、ゲルタール酸、ゲルコール酸、α−グルコ
ザミン、ｋ−アスパラギン酸、酢酸などの有機酸、及び
リン酸、ホウ酸などの無機酸を挙げることができる。The acidic chemicals used to acidify the distilled water include organic chemicals such as maleic acid, citric acid, malic acid, gluconic acid, glucaric acid, geltaric acid, gelcholic acid, α-glucosamine, k-aspartic acid, and acetic acid. Mention may be made of acids and inorganic acids such as phosphoric acid and boric acid.
本発明の化粧品用酸性水の調製方法は、上記粉状又は液
状の酸性薬品を、滅菌蒸溜水に直接添加溶解させて行う
か、又は塊状の酸性薬品を塔に充填しておき、蒸溜水を
連続的に流下させたりして行う。The method for preparing acidic water for cosmetics according to the present invention is carried out by directly adding and dissolving the powdered or liquid acidic chemicals in sterilized distilled water, or by filling a column with bulk acidic chemicals and adding distilled water to the solution. This is done by letting it flow down continuously.
そして、このようにして得た化粧品用酸性水の使用態様
としては、特に限定されない。The manner in which the cosmetic acidic water thus obtained is used is not particularly limited.
〈発明の作用・効果〉
本発明の化粧品用酸性水は、ｐＨ３，４〜４．４に調製
されているので、それをベースとした化粧品を用いた場
合、肌に化粧ヤケやシミが発生することがないことは勿
論、後述の実施例で示す如く、化粧ヤケやシミ（日焼け
に伴うものも含む）などの既に発生してしまった皮膚ト
ラブルも解消できるこれは、上記皮膚トラブルの原因と
みられる、肌を構成するタンパク質のアルカリ変性（化
粧ヤケ）又は熱変性（日ヤケ）が、上記ｐＨの酸性水な
用いた化粧品を使用することにより、酸変性されるため
と推定される。<Actions and Effects of the Invention> Since the acidic water for cosmetics of the present invention is prepared to have a pH of 3.4 to 4.4, when cosmetics based on it are used, makeup discoloration and stains occur on the skin. Of course, as shown in the examples below, it can also eliminate skin problems that have already occurred, such as makeup tanning and age spots (including those caused by sunburn).This is thought to be the cause of the skin problems mentioned above. This is presumed to be due to the fact that alkaline denaturation (makeup tanning) or thermal denaturation (sunburn) of proteins constituting the skin is acid-denatured by using cosmetics containing acidic water with the above pH.
なお、実願昭５９−１０１８０８号（実開昭６１−１９
４９９号）において、洗顔用の水とじて、 ｐＨ４，５
〜６．０のものが望ましい旨記載されているが、本発明
者らが確認したところ、この程度の酸性度では、アルカ
リ変性又は熱変性を起してしまったタンパク質な酸変性
させることは困難であることがわかった。In addition, Utility Application No. 1983-101808
No. 499), water for face washing has a pH of 4.5.
Although it is stated that an acidity of ~6.0 is desirable, the inventors have confirmed that with this level of acidity, it is difficult to acid-denature proteins that have already undergone alkali denaturation or heat denaturation. It turned out to be.
即ち、ｐ）Ｉ ４．４を越えると、酸変性が困難であり
、またｐＨ３，４未満となると 皮膚への刺激が強くな
りすぎて、かえって皮膚トラブルを起こしやすく望まし
くない。That is, if the p)I exceeds 4.4, acid denaturation is difficult, and if the pH is less than 3.4, the irritation to the skin becomes too strong, which is undesirable because it tends to cause skin trouble.
また、従来、本発明のようなｐｉの化粧品を用いた場合
、刺激が強すぎ、かつ、カユミなどの異常が発生するこ
とから、化粧品業界では化粧品としては不適とみなされ
ていた。Furthermore, in the past, when using pi cosmetics such as those of the present invention, they were considered unsuitable as cosmetics in the cosmetics industry because they were too irritating and caused abnormalities such as itching.
ところが、本発明者が確認したところによると、本発明
のｐｉ（３，４〜４．４の酸性水で洗顔（−日２〜３回
）を続けると、２〜３日で下記のような現象が肌に発生
したが、それらは、通常１週間から１箇月で消減し、い
わゆる好転反応であることがわかった。However, the inventor has confirmed that if you continue to wash your face (2 to 3 times a day) with the pi (3.4 to 4.4) acidic water of the present invention, the following symptoms will occur in 2 to 3 days. Phenomena occurred on the skin, but these usually disappeared within one week to one month, and were found to be a so-called improvement reaction.
■赤い斑点がでる。■Red spots appear.
■白い粉が吹き出る。■White powder comes out.
■皮膚がかゆくなる。■My skin becomes itchy.
■皮膚がつっばる。■My skin feels tight.
■古い角質がぼろぼろとれる。■Old dead skin cells are removed.
そして、上記洗顔を続けていくと、化粧ヤケの場合、８
０〜９０日で解消し、シミの場合８０〜９０日で薄くな
って、１２０〜１８０日でほとんど目立たなくなる。If you continue to wash your face as described above, in the case of makeup discoloration, 8.
It will disappear in 0 to 90 days, and in the case of stains, it will fade in 80 to 90 days and become almost unnoticeable in 120 to 180 days.
〈実施例〉
次に、３０代〜５０代の人の被検者について、ｐｉ（４
，０前後に調製した酸性水で洗顔（日に２〜３回）を、
６箇月から１年にわたり毎日続けてもらった結果の代表
例を下記に示す。<Example> Next, for subjects in their 30s to 50s, pi(4
Wash your face (2-3 times a day) with acidic water prepared around 0.
A typical example of the results obtained by having patients continue the test every day for 6 months to 1 year is shown below.
（１）被検者Ａ（５０才・主婦）
化粧層；２５年
洗顔前の肌の状態；化粧ヤケがひどく肌が黒ずんでいた
。(1) Subject A (50 years old, housewife) Makeup layer: Skin condition before face wash for 25 years; Skin was darkened due to severe makeup fading.
洗顔開始後の状況；１箇月経過頃まで赤い斑点が出たり
、かゆみが生じたりしたが、４箇月月頃から肌の黒ずみ
が薄くなり、６箇月経過後には、はとんど黒ずみが目立
たなくなった。Situation after starting to wash my face: Red spots and itching occurred until about 1 month later, but after about 4 months, the dark spots on my skin became lighter, and after 6 months, the dark spots were hardly noticeable. .
（２）被検者Ｂ（４３才・主婦） 化粧層；２５年 洗顔前の肌の状態；化粧ヤケによるシミがひどかった。(2) Subject B (43 years old, housewife) Makeup layer: 25 years The condition of my skin before washing my face: The stains caused by makeup tanning were severe.
洗顔開始後の状況；開始当初１週間くらいは、皮膚が突
っ張たり、赤い斑点が出たりしたが、１箇月経過頃には
、シミの色が薄くなり、６箇月経過頃にはシミがほとん
ど目立たなくなった。Situation after starting to wash your face: For about a week after starting, my skin felt tense and red spots appeared, but after a month, the color of the spots became lighter, and after 6 months, the spots were almost gone. It became less noticeable.
（３）被検者Ｃ（３０才・主婦）
化粧層；１０年
洗顔前の肌の状態；日焼けに伴なう目立つシミがあった
。(3) Subject C (30 years old, housewife) Makeup layer: Skin condition before face wash for 10 years: There were noticeable spots due to sunburn.
洗顔開始後の状況；開始当初１箇月頃までは肌が突っ張
ったり、カサカサしたりしたが、４〜５箇月経過頃には
、シミが薄くなり、８箇月経過後にはシミがほとんど目
立たなくなった。Situation after starting face washing: My skin felt tight and dry for about one month after starting, but after 4 to 5 months, the spots became lighter, and after 8 months, the spots were hardly noticeable.
Claims (1)
化粧品用酸性水。Acidic water for cosmetics, characterized in that the pH is adjusted to 3.4 to 4.4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5949687A JPS63227511A (en) | 1987-03-13 | 1987-03-13 | Acidic water for cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5949687A JPS63227511A (en) | 1987-03-13 | 1987-03-13 | Acidic water for cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63227511A true JPS63227511A (en) | 1988-09-21 |
Family
ID=13114950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5949687A Pending JPS63227511A (en) | 1987-03-13 | 1987-03-13 | Acidic water for cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63227511A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0852455A (en) * | 1994-08-10 | 1996-02-27 | Tokyo Yogyo Co Ltd | Fresh water generating apparatus for acidic water |
| WO2000037037A3 (en) * | 1998-12-18 | 2000-10-12 | H Michael Dosch | Composition for treatment of burns |
| EP0662946B2 (en) † | 1992-09-30 | 2001-12-12 | Unichema Chemie B.V. | Unsaturated aliphatic dicarboxylic acids |
| JP2009221179A (en) * | 2008-03-19 | 2009-10-01 | Kose Corp | Skin whitening agent containing maleic acid as active ingredient |
-
1987
- 1987-03-13 JP JP5949687A patent/JPS63227511A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0662946B2 (en) † | 1992-09-30 | 2001-12-12 | Unichema Chemie B.V. | Unsaturated aliphatic dicarboxylic acids |
| JPH0852455A (en) * | 1994-08-10 | 1996-02-27 | Tokyo Yogyo Co Ltd | Fresh water generating apparatus for acidic water |
| WO2000037037A3 (en) * | 1998-12-18 | 2000-10-12 | H Michael Dosch | Composition for treatment of burns |
| JP2009221179A (en) * | 2008-03-19 | 2009-10-01 | Kose Corp | Skin whitening agent containing maleic acid as active ingredient |
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