JPS6322508A - External preparation - Google Patents

Abstract

PURPOSE:An external preparation useful as a cosmetic or external quasi-drug, showing improved whitening effects and preventing effects on stain and freckle, safely usable without causing chapped skin, skin rash, etc., comprising tincture of Angelica acutiloba Kitagava as an active ingredient. CONSTITUTION:An external preparation containing tincture of Angelica acutiloba Kitagava as an active ingredient. The tincture of Angelica acutiloba Kitagava is readily prepared by moistening root of Angelica acutiloba Kitagawa or a relative plant thereof by steam, drying, powdering and leaching powder of Angelica acutiloba Kitagawa with ethanol by tincture manufacturing method recorded in Japanese Pharmacopoeia and shows improved inhibitory effects on melanin formation. The external preparation is used in the form of an ordinary cosmetic such as lotion, pack milky lotion, cream, etc., or in the form of external quasi-drug such as ointment, lotion, liniment, emulsion, etc. The external preparation contains 0.01-10wt% active ingredient in the case of cosmetic and 0.05-10% active ingredient in the case of a guasi-drug.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation containing a tincture of ginger as an active ingredient.

As used herein, the term "external preparation" is used to include not only cosmetics but also quasi-drugs used for external use (ointments, lotions, liniments, emulsions, etc.). therefore,
More specifically, the present invention relates to a cosmetic composition containing a tincture of cane as an active ingredient, which has an excellent skin-whitening effect, and a quasi-drug for external use, which has an excellent effect of preventing spots, freckles, and the like.

[Prior Art and Problems to be Solved by the Invention] Ethanol extract of Angelica chinensis powder, which is the active ingredient of the external preparation of the present invention, is effective for tonic blood supply, laxative analgesia, etc., with the aim of treating cold sensitivity, poor blood color, blood circulation disorders, etc. It is used as a medicine in Chinese medicine and home medicine preparations.

[Means for Solving the Problems] However, the present inventors have discovered that a tincture of cane extract prepared from the powder of cane extract using the tincture preparation method described in the Japanese Pharmacopoeia has a surprisingly remarkable effect of inhibiting melanin production, and has a whitening effect and a pigmentation effect. It was discovered that it has an excellent effect on preventing freckles and the like, leading to the completion of the present invention.

[Actions and Examples] Angelica accumica powder, which is the starting material for Angelica tincture, which is the active ingredient of the external preparation of the present invention, is derived from Angelica ac
It is made by blanching, drying, and powdering the roots of utlloba Kitagava or its related plants.

The angelica tincture used in the present invention can be easily prepared by leaching the angelica powder with ethanol according to the tincture preparation method described in the Japanese Pharmacopoeia.

As mentioned above, the cane tincture of the present invention exhibits a remarkable melanin production inhibiting effect, but the mechanism of action responsible for this has not yet been fully elucidated.

Culture B
This was investigated using LB mouse melanoma cells. 9.5 ml of ethanol was added to 0.5 ml of Touki tincture to make a 5.0% solution. This solution was appropriately diluted with Eagle HEM containing 10% fetal bovine serum to prepare an additive medium. Addition concentration of Touki tincture was 0.005.0, 01.0.03 and 0.
．． When the inhibitory effect on melanin production was examined at a concentration of 0.05% (V/V), melanin production was visually clearly inhibited at concentrations of 0.03 and 0.05%.

The external preparation of the present invention can be used in the form of general cosmetics such as lotions, packs, milky lotions, and creams, as well as in the form of external quasi-drugs such as ointments, lotions, liniments, and emulsions. .

The external preparation of the present invention contains 0.01 to 10%, preferably 0.1 to 5.
In the case of quasi-drugs, the content is 0.05 to 10%, preferably 0.5 to 10%.

Next, the present invention will be explained in more detail using Examples and Reference Examples, but the present invention is not limited to these.

Example 1 (Manufacture of Touki Tincture) Add 374 volumes of ethanol (45 to 52.5 ml) to 30 g (volume: 80 to 70 ml) of Touki powder, stir, seal with plastic wrap, and heat at room temperature with occasional stirring. After leaving it for a day, it was purified. One residue and 10 ml of ethanol were filtered through caroene. The resulting purified liquid was kept at room temperature for 2 days. In some cases, precipitation may occur. Finally, I filtered it again and got the tincture of the pepper.

Example 2 (Lotion) 1 Polyoxyethylene hydrogenated castor oil (60E, O,)
1.0g 2 Flavoring
Trace amount 3 Ethanol 10.0
g4 Paraoxybenzoic acid ester 0.1g5 Dipotassium glycyrrhizinate 0.1sr6 Sorbitol solution (70%) a, og 7 Concentrated glycerin 3.0g8 Touki tincture 3.0g9 Purified water
The total amount of ioo gl~9 was uniformly stirred and dissolved to prepare 100 g of lotion.

Example 3 (pack) 1 Polyvinyl alcohol 12.0g2 Titanium oxide 4.0g3 Propylene glycol 2.0g4 Polyethylene glycol 1500 2゜0'5 Ethanol
10.0g6 Touki tincture
1.0g7 Purified water Total amount 100g Stir and mix 1 to 7 evenly and pack 100
g was prepared.

Example 4 (Emulsion) 1 Polyoxyethylene sorbitan monostearate (20E, O,) 1.0 g
2 Polyoxyethylene sorbitol tetraoleate (80E, O,) 0.5 g
3 Lipophilic glyceryl monostearate 1.0g 4 Stearic acid 0.5g5 Behenyl alcohol 0.5g6 Avocado oil 4.0g7 Glyceryl trioctanoate 4.0g8 Natural vitamin E
O, 02g9 Paraoxybenzoic acid ester 0.2g-10 xanthan gum 0
．． 14 gll 1.3-butylene glyfur
5.0g12 ethanol
2.0g13 Touki tincture 2.
Og14 fragrance trace amount 1
5 Purified water total amount 100 g1~
9 was dissolved by heating (solution A), and separately, 10.11 and 15 were dissolved by heating (solution B). Solution B was added to solution A, stirred to emulsify, and cooled (solution C).

Add 12 to 14 to liquid C, stir and mix, cool and make emulsion 1.
00g was prepared.

Example 5 (cream) 1 Polyoxyethylene sorbitan monostearate (20E, O,) 1.0 g
2 Polyoxyethylene sorbitol tetraoleate (80E, 0.) 1.5g3
Lipophilic glyceryl monostearate 1.5g 4 White beeswax 2゜0g5 Paraffin 2.0g6 Stearic acid 3.0g7 Behenyl alcohol 3.0g8 Liquid paraffin
5.0g9 Almond oil
12.0g10 Natural vitamin E
O,02gll Methylpolysiloxane
O, 1g12 paraoxybenzoic acid ester
0.2g13 1.3-butylene glycol
5.0g14 Ethanol 2
．． 0g15 Touki tincture 5.0g
16 Fragrance trace amount 17
Purified water total amount 100 g1-12
was dissolved by heating (solution A), and separately 13 and 17 were dissolved by heating (solution B). Add liquid B to liquid A and stir to emulsify.
It was cooled (liquid C). 14 to 16 were added to Solution C, stirred and mixed, and cooled to prepare 100 g of cream.

Example 6 (Ointment) 1 Polyoxyethylene sorbitan monostearate (20E, O,) 1.0 g
2 Polyoxyethylene sorbitol tetraoleate (40E, O,) 1.5g3
Self-emulsifying glyceryl monostearate 1! zr 4 Sarasimillow 2.0g5 Paraffin 3.0g6 Stearic acid a, og7 Behenyl alcohol 3.0°8 Liquid paraffin
5.0g9 Glyceryl trioctanoate
20.0g10haloxybenzoic acid ester 0.
2g11 Glycerin 5.0g
■2 Sodium hydroxide 0.02 g
13 Ethanol 2.0g1
4 Touki tincture 5.0g15
Purified water 100g 1 to IO (solution A) by heating, and separately from this, 11.12 g and 15
was dissolved by heating (BeC). Solution B was added to A4, stirred to emulsify, and cooled (solution C).

13 and 14 were added to Solution C, stirred and mixed, and cooled to prepare 100 g of ointment.

Example 7 (Lotion) l Polyoxyethylene hydrogenated castor oil (80E, O,)
1.0g 2 Ethanol 15.0゜3
Paraoxybenzoic acid ester 0.1g-4 Citric acid 0.1g5 Sodium citrate 0.3゜61.3-butylene glycol 4.0g7 Touki tincture
2.0g8 Purified water Total amount 100 Stir and dissolve g1~8 uniformly to make lotion 1.
00g was prepared.

Example 8 (Liniment agent) 1 Tragacanth 5.0g-2 Glycerin 1O,0g3 Ethanol 10.0g4 Touki tincture
1.0g5 Purified water
A total of 100 g of liniment agents 1 to 5 were uniformly stirred and mixed to prepare 100 g of liniment agent.

Example 9 (emulsion) 1 Polyoxyethylene sorbita monostearate> (20E, O,) 1.0 g
2 Polyoxyethylene sorbitol tetraoleate (40E, 0.) 0.5g3
Lipophilic glyceryl monostearate L, Og 4 Stearic acid 0.5g5 Behenyl alcohol 0.5g6 Liquid paraffin 4.0g7 Glyceryl trioctanoate 4.0g8 Cetyl octoate
2.0g9 paraoxybenzoic acid ester
0.2g10 Carboxyvinyl polymer 0.0
5 gll 1.3-butylene glycol
5.0g12 Sodium hydroxide 0.
025r13 Ethanol 2
．． 0g14 Touki tincture ゛ 3.0g
15 Purified water total amount 100 g1
- 9 were dissolved by heating (liquid A), and separately, 10 to 12 and 15 were dissolved by heating (liquid B). Solution B was added to solution A, stirred to emulsify, and cooled (solution C).

13 and 14 were added to Solution C, stirred and mixed, and cooled to prepare 100 g of emulsion.

Example 10 For each of the cosmetics obtained in Examples 2 to 5, 60 randomly selected men and women (20 men, 40 women, age 20
Participants (approximately uniformly distributed between the ages of 50 to 50) used the product for 3 months and completed a questionnaire regarding safety and efficacy. The results are shown in the IT table.

[Blank below] Example 11 For each of the external quasi-drugs obtained in Examples 6 to 9, 50 randomly selected men and women (20 men, 30 women,
Participants (who were almost uniformly sampled between the ages of 20 and 50) used the product for three months and completed a questionnaire regarding safety and efficacy. The results are shown in Table 2.

[Margin below] From the results in Tables 1 and 2, it is clear that the external preparation of the present invention hardly causes any skin irritation or rash, and can be used safely. It can be seen that the effect is also excellent.

Reference Example A patch test of the Touki tincture obtained in Example 1 was conducted on 40 healthy adults (20 men, 20 women) aged 20 to 59 years.
The experiment was conducted under the following conditions.

Test drug Nidouki tincture 5.0% aqueous solution control (physiological saline) Application time: 48 hours Application site: Inner upper arm skin Patch: Patch test bandage (manufactured by Taisho Pharmaceutical Co., Ltd.) Judgment after 48 hours of application As a result, as with the control, there were no positive reactions with the Touki tincture.

[Effects of the Invention] The external preparation of the present invention can be safely used without causing skin irritation or rashes, and has excellent effects of whitening the skin and preventing spots and freckles.

Claims (1)

[Claims] 1. An external preparation containing Touki tincture as an active ingredient.