JPS6322161B2 - - Google Patents
Info
- Publication number
- JPS6322161B2 JPS6322161B2 JP58044351A JP4435183A JPS6322161B2 JP S6322161 B2 JPS6322161 B2 JP S6322161B2 JP 58044351 A JP58044351 A JP 58044351A JP 4435183 A JP4435183 A JP 4435183A JP S6322161 B2 JPS6322161 B2 JP S6322161B2
- Authority
- JP
- Japan
- Prior art keywords
- freeze
- blood cells
- liquid nitrogen
- producing
- red blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 239000007900 aqueous suspension Substances 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 210000000601 blood cell Anatomy 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 239000000463 material Substances 0.000 claims 2
- 239000000047 product Substances 0.000 description 10
- 210000003743 erythrocyte Anatomy 0.000 description 9
- 241000710799 Rubella virus Species 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 108010023197 Streptokinase Proteins 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 235000011089 carbon dioxide Nutrition 0.000 description 3
- 230000003067 hemagglutinative effect Effects 0.000 description 3
- 229960005202 streptokinase Drugs 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000003223 protective agent Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000007982 barbital buffer Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58044351A JPS59169504A (ja) | 1983-03-18 | 1983-03-18 | 凍結乾燥物の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58044351A JPS59169504A (ja) | 1983-03-18 | 1983-03-18 | 凍結乾燥物の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59169504A JPS59169504A (ja) | 1984-09-25 |
| JPS6322161B2 true JPS6322161B2 (fr) | 1988-05-11 |
Family
ID=12689089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58044351A Granted JPS59169504A (ja) | 1983-03-18 | 1983-03-18 | 凍結乾燥物の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59169504A (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0432232B1 (fr) * | 1989-05-01 | 1994-01-05 | Alkermes Controlled Therapeutics, Inc. | Procede de production de petites particules de molecules biologiquement actives |
| WO1995027721A1 (fr) * | 1994-04-07 | 1995-10-19 | Akzo Nobel N.V. | Compositions lyophilisees comprenant de l'arn |
| GB2399084B (en) | 2002-07-30 | 2007-01-31 | Univ Liverpool | Porous beads and method of production thereof |
| US7089681B2 (en) | 2002-11-26 | 2006-08-15 | Alkermes Controlled Therapeutics, Inc. | Method and apparatus for filtering and drying a product |
| US8549768B2 (en) * | 2011-03-11 | 2013-10-08 | Linde Aktiengesellschaft | Methods for freeze drying |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5949801A (ja) * | 1982-09-13 | 1984-03-22 | Fuji Photo Film Co Ltd | 液状物の凍結乾燥方法 |
-
1983
- 1983-03-18 JP JP58044351A patent/JPS59169504A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59169504A (ja) | 1984-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3338081B2 (ja) | 物質の貯蔵 | |
| Lee | Spray-drying of proteins | |
| US6890512B2 (en) | Methods of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby | |
| US6221575B1 (en) | Methods for producing dried storage-stable platelets and compositions obtained thereby | |
| Bernfeld et al. | Antigens and enzymes made insoluble by entrapping them into lattices of synthetic polymers | |
| US4891319A (en) | Protection of proteins and the like | |
| RE | Protein turnover and the formation of protein inclusions during sporulation of Bacillus thuringiensis. | |
| US4073886A (en) | Blood fractionation process using block copolymers of ethylene oxide and polyoxypropylene | |
| EP0483329B1 (fr) | Nouvelles compositions de cellules reconstituees et lyophilisees | |
| US20100120014A1 (en) | Stability Drying | |
| US3876501A (en) | Binding enzymes to activated water-soluble carbohydrates | |
| WO1993000807A1 (fr) | Procede de stabilisation de biomateriaux | |
| FI85285C (fi) | Tvaerbundet, vattenoloesligt glukosisomeras och foerfarande foer framstaellning daerav. | |
| JPS60258125A (ja) | 蛋白性生理活性物質を含有する水溶性乾燥物 | |
| JPH02265984A (ja) | 物質の貯蔵 | |
| JPS6322161B2 (fr) | ||
| JP2003215127A (ja) | 固相化免疫試薬の安定化方法およびこれに用いる安定化溶液 | |
| JPS6261321B2 (fr) | ||
| EP0954326B2 (fr) | Procede d'inactivation de virus dans des proteines sanguines lyophilisees | |
| JPS62209362A (ja) | 免疫凝集反応用組成物 | |
| US2847350A (en) | Preparation of highly active thromboplastin | |
| Muramatsu et al. | Platelet adhesion onto artificial red blood cells | |
| CN111537326B (zh) | 制备冻干血小板的方法及其应用 | |
| US2475793A (en) | Preparation of cholinesterase | |
| JPH0920687A (ja) | 凍結乾燥血液の戻し液 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees | ||
| S199 | Written request for registration of transfer of right |
Free format text: JAPANESE INTERMEDIATE CODE: R313I99 Free format text: JAPANESE INTERMEDIATE CODE: R313199 |
|
| R370 | Written measure of declining of transfer procedure |
Free format text: JAPANESE INTERMEDIATE CODE: R370 |