JPS63203162A - Gel matrix - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention is applicable to bedsore prevention, treatment bats, scented materials, heat insulating materials, fj
It relates to a gel matrix that is used as a protective material.

[Prior Art] Conventionally, natural polymers or natural polymer derivatives such as gelatin, sodium alginate, carboxymethyl cellulose, hydroxyethyl cellulose, starch, polyvinyl alcohol, polyacrylic acid, polyvinylpyrrolidone,
Hydrogels made from synthetic polymers such as carboxyvinyl polymers, and hydrogels made by impregnating hydrophobic polymers such as oil-based rubber, are used for cold insulation materials, moisturizing materials, fragrance materials, wound protection materials, therapeutic bats, etc. It has been widely used for various purposes.

For example, JP-A-55-20726 discloses an oil-based water-containing gel made of △BA star-shaped block polymer.
No. 5-102653 discloses an oil-based hydrogel using rubber latex, JP-A-56-18917 discloses a hydrogel containing a maleic acid copolymer cross-linked with aluminum, and JP-A-57-128734 discloses a hydrogel containing aluminum crosslinking. Polyvinyl alcohol hydrogel, Japanese Patent Publication No. 58-23410 @ a hydrogel made by crosslinking polyvinyl alcohol/gelatin, and Japanese Patent Publication No. 59-10695 an oil-based gel using styrene-isoprene-styrene block copolymer, etc. Water-containing gel, JP-A-59-93012, describes a water-containing gel in which sodium polyacrylate is cross-linked with metal,
21251 @ publication describes a hydrous gel obtained by impregnating liquid rubber with water and crosslinking it, and JP-A No. 61-106603 discloses a hydrous gel obtained by metal polymerizing acrylic acid, and JP-A-61-4192
Publication No. 6 discloses a hydrous gel made by crosslinking an aliphatic carboxylic acid with an aluminum compound, and Japanese Patent Publication No. 61-50493 discloses a hydrous gel made by crosslinking a maleic acid copolymer with a polyvalent amine. .

[Problems to be Solved by the Invention] According to the above-mentioned conventional methods, the presence of more or less water is essential in any case, and as long as volatile water is present, the following ~ It has its drawbacks.

1. Moisture is released relatively easily and it is difficult to maintain the initial properties.

2. When used in contact with the human body, auxiliary application means are required.

3. When trying to contain drugs, due to the influence of water,
Decomposition of the drug is likely to occur.

4. Difficult to maintain flexibility at freezing temperatures of water.

Therefore, in view of the above points, the present inventors aimed to provide a gel matrix that could solve these drawbacks. The present invention has been completed by discovering that these above-mentioned drawbacks can be overcome and put to practical use.

That is, the present invention provides a substantially anhydrous polymer comprising a water-soluble polymer having a hydroxyl group and/or a carboxyl group in the molecule and soluble in a polyhydric alcohol, a crosslinking agent thereof, and a polyhydric alcohol as essential components. gel matrix.

The water-soluble polymer used in the present invention has a hydroxyl group and/or a carboxyl group in its molecule and is soluble in polyhydric alcohol, such as methyl vinyl ether maleic anhydride copolymer, isobutylene- Examples include maleic anhydride copolymers, carboxy-modified polyvinyl alcohols, carboxymethyl cellulose, etc. Among them, methyl vinyl ether maleic anhydride copolymers, isobutylene maleic anhydride copolymers, etc. are particularly desirable.

As the crosslinking agent for this water-soluble polymer, those that act on functional groups such as carboxyl groups and hydroxyl groups of the water-soluble polymer to crosslink and insolubilize it, and conventionally known ones can be used. For example, compounds having at least two or more epoxy groups in the molecule, specifically polyethylene glycol diglycidyl ether, ethylene glycol diglycidyl ether, glycerin diglycidyl ether, glycerin triglycidyl ether, propylene glycol diglycidyl ether, glycerol polyglycidyl Examples include ether. Other crosslinking agents include polyvalent metal compounds, such as aluminum hydroxide, aluminum chloride,
Examples include calcium hydroxide, calcium chloride, magnesium hydroxide, potassium aluminum sulfate, and the like.

A preferred blend m of these crosslinking agents is water-soluble polymer 100%
It is 0.1 to 30 parts by weight, more preferably 1 to 10 parts by weight. If the crosslinking agent content exceeds this range, there will be problems such as decreased cohesiveness and shape retention, and loss of adhesion and hardness.

In addition, the polyhydric alcohols used in the present invention include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, glycerin,
, 3-butylene glycol, 1,4-butylene glycol, etc., among which glycerin, 1,3-butylene glycol, and ethylene glycol are particularly preferred.

The preferred blending ratio (weight ratio) of this polyhydric alcohol and the water-soluble polymer is 10:0.5-5.0, more preferably 10:1.2-2.5. If the blending ratio of the two deviates from this range, there will be problems such as a decrease in shape retention and cohesive force, and a decrease in workability.

The gel matrix of the present invention includes the above-mentioned water-soluble polymer,
In addition to the essential components consisting of the crosslinking agent and polyhydric alcohol, conventionally known compounding agents such as antioxidants, softeners, tackifiers, antiaging agents, and inorganic fillers are blended in appropriate amounts.

Next, as a method for producing the gel matrix of the present invention, any conventionally practiced method may be used. Add and mix the agent to form a gel matrix.

The gel matrix of the present invention obtained as described above is useful for prevention of bed sores, treatment bats, fragrance materials, heat insulation materials, wound protection materials, cold insulation materials, packs, controlled drug release agents, and the like.

[Example] Next, the present invention will be described in more detail based on examples and the like.

Example 1 (Gel fragrance material) Isobutylene maleic anhydride copolymer (trade name: Isopan, ■Cla-1) 12-layer equipment and 73 parts by weight of glycerin were mixed, and then 0.0% and 0% glycerol polyglycidyl ether was added as a crosslinking agent. 8 parts of ffi were added, and then 14.2 parts by weight of a floral type fragrance were added and mixed, and then poured into a container and gelled.

It was found that this product releases fragrance over a long period of time and is excellent as a fragrance material.

Example 2 (Wound protection material) Methyl vinyl ether maleic anhydride copolymer (trade name: Gauntlet, manufactured by G, A, F) 17.5 parts by weight and 80.0 parts by weight of glycerin were mixed, and then crosslinked. As an agent, 0.8 parts of potassium aluminum sulfate was added and mixed, and then 1.71 parts of hinokitiol was added and mixed, and the mixture was spread on a nonwoven fabric to prepare a wound protection material.

Example 3 (W healing bat) Isobutylene maleic anhydride copolymer (trade name: Isopan, ■Kuraray %J) 18.0 parts by weight and 79.9 parts by weight of glycerin.
After that, 1.2 parts by weight of ethylene glycol diglycidyl ether and 1 (o parts by weight) of isopropyl methylphenol were added and mixed as a crosslinking agent, and then spread on a nonwoven fabric to form a W residue batt.

Reference Example 1 5 parts by weight of sodium polyacrylate having an average degree of polymerization of 20,000 was dissolved in 80 parts by weight of water. On the other hand, 0.5 parts by weight of ethylene glycol glycidyl ether was dissolved in 10 parts by weight of water.

Next, while stirring the sodium polyacrylate aqueous solution,
Ethylene glycol diglycidyl ether water (f1't
il was added and mixed, heated to about 70°C, and spread on a nonwoven fabric to obtain a hydrogel sheet.

Test Examples The sheets obtained in Examples 2 to 3 and Reference Example 1 were subjected to an adhesive strength test, a heating change test, and a frozen storage test, and the results are shown in Table 1. In addition, the adhesive strength ((] /cd
) The test was carried out using a tack tester (Pikma Tack Tester, manufactured by Kikutoyo Seiki Co., Ltd.).

In addition, temperature change (60℃ x 24 hours) test, frozen storage (
-25°C) test was a comparative observation of the state of each gel at its initial stage and after oral administration.

Table 1 As shown in Table 1, since the gel matrices of Examples 2 and 3 do not contain water, they are more stable against temperature changes than the hydrous gel of Reference Example 1, and their initial physical properties are can be maintained for a long period of time, and also has a suitable adhesive strength, making it industrially useful.

[Effects of the Invention] The gel matrix of the present invention as described above has the following effects.

1. Since it does not contain water, there is no change in physical properties due to water scattering.
The initial good physical properties can be maintained as they are.

2. Flexible and stable against temperature changes.

3. It can stably contain drugs, fragrances, etc. and release them over a long period of time.

4. It maintains appropriate adhesiveness, so it can be attached to the human body without any assistance.

5. Since it uses water-soluble polymers and polyhydric alcohols, it is safe and does not pollute the environment.

Procedures Mountain - Original (spontaneous) May 90, 1988 Director General of the Patent Office Kunio Ogawa 1. Indication of the case 1988 Patent Application No. 35750 2. Name of the invention Gel Matrix 3. Amendment. Those who do! Relationship with the Ji case Patent applicant address 408 Tashiro Daikan-cho, Tosu City, Saga Prefecture Name Hisamitsu Pharmaceutical Co., Ltd. Representative Hirotaka Nakatomi 4, Agent 105 Address 2-8-1 Toranomon, Minato-ku, Tokyo Voluntary amendment 6. Target of amendment: “Detailed description of the invention column in the specification” 7. Contents of amendment ■: “Cross-linked hydrogel” in lines 13-14 of page 2 of the specification has been changed to “cross-linked hydrogel” correct.

2. Add "aluminum silicate, calcium phosphate, magnesium aluminate, aluminum glycinate, hydrotalcite" after "magnesium hydroxide" on page 5, line 13 of the same book.

3. In the same book, page 8, line 13, add the following sentence to the line after "I decided to bat."

“Example 4 (Backing agent)

Claims (1)

[Claims] A substantially anhydrous gel matrix characterized by containing a water-soluble polymer having a hydroxyl group and/or a carboxyl group in its molecule and soluble in a polyhydric alcohol, a crosslinking agent thereof, and a polyhydric alcohol. vinegar.