JP3260412B2 - Polymer gel composition - Google Patents
Polymer gel compositionInfo
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- JP3260412B2 JP3260412B2 JP10216792A JP10216792A JP3260412B2 JP 3260412 B2 JP3260412 B2 JP 3260412B2 JP 10216792 A JP10216792 A JP 10216792A JP 10216792 A JP10216792 A JP 10216792A JP 3260412 B2 JP3260412 B2 JP 3260412B2
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- gel composition
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Description
【０００１】[0001]
【産業上の利用分野】本発明は治療用パット、褥瘡予防
剤、保温材、保冷材、創傷保護剤、パック剤、貼付剤、
薬物徐放剤として利用される高分子ゲル組成物に関する
ものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic pad, a pressure ulcer preventive, a heat insulating material, a cold insulating material, a wound protectant, a pack, a patch,
The present invention relates to a polymer gel composition used as a drug sustained release agent.
【０００２】[0002]
【従来の技術】従来より、ゼラチン、アルギン酸ナトリ
ウム、カルボキシメチルセルロース、デンプンなどの天
然高分子ないし天然高分子誘導体、ポリビニルアルコー
ル、ポリアクリル酸ナトリウム、ポリビニルピロリド
ン、カルボキシビニルポリマーなどの合成高分子を利用
した高分子ゲルが、治療用パット、褥瘡予防剤、保温
材、保冷材、創傷保護剤、パック剤、貼付剤、薬物徐放
剤として各種用途に広く用いられてきた。2. Description of the Related Art Conventionally, natural polymers or natural polymer derivatives such as gelatin, sodium alginate, carboxymethylcellulose and starch, and synthetic polymers such as polyvinyl alcohol, sodium polyacrylate, polyvinylpyrrolidone and carboxyvinyl polymer have been used. Polymer gels have been widely used in various applications as therapeutic pads, pressure ulcer preventives, heat insulators, cold insulators, wound protectants, packs, patches, and drug sustained release agents.
【０００３】例えば、特開昭５９−９３０１２号公報に
はポリアクリル酸ナトリウムと金属架橋させた含水ゲ
ル、特開昭６１−１０６６０３号公報にはアクリル酸を
金属重合させた含水ゲル、特開平１−２６６３３号公報
にはポリビニルアルコールをグルタルアルデヒドで架橋
させた水性ゲル、特開平１−２９７４８４号公報にはゼ
ラチンと無水マレイン酸共重合体との反応によって得ら
れる水性ゲルがそれぞれ開示されている。For example, JP-A-59-93012 discloses a hydrogel obtained by metal-crosslinking sodium polyacrylate, JP-A-61-106603 discloses a hydrogel obtained by polymerizing acrylic acid with a metal, JP-A-26633 discloses an aqueous gel obtained by crosslinking polyvinyl alcohol with glutaraldehyde, and JP-A-1-297484 discloses an aqueous gel obtained by reacting gelatin with a maleic anhydride copolymer.
【０００４】[0004]
【発明が解決しようとする課題】本発明は、従来の高分
子ゲルが有していた問題点、即ち、ゲル強度が弱い点、
水分を比較的容易に離脱しやすく初期の特性を保持しな
い点、ｐＨや電解質に対して不安定な点、経時的安定性
に欠ける点などの問題を有していた。そこで、本発明者
らは上記の問題点を解決する目的で、種々検討を重ねた
結果、新規でかつ化学的安定性に優れた特性をもつ高分
子ゲル組成物を見い出し本発明を完成するにいたった。DISCLOSURE OF THE INVENTION The present invention has a problem that a conventional polymer gel has, that is, the gel strength is weak,
There were problems such as the fact that water was easily released relatively easily, the initial properties were not maintained, the pH and the electrolyte were unstable, and the stability over time was lacking. The inventors of the present invention have conducted various studies with the aim of solving the above problems, and as a result, have found a polymer gel composition having novel properties and excellent chemical stability, and have completed the present invention. It was just.
【０００５】[0005]
【課題を解決するための手段】本発明は、Ｎ−ビニルア
セトアミドとアクリル酸及び／又はアクリル酸塩との共
重合体に、エポキシ化合物、湿潤剤を必須成分として構
成される新規な高分子ゲル組成物である。DISCLOSURE OF THE INVENTION The present invention provides a novel polymer gel comprising a copolymer of N-vinylacetamide and acrylic acid and / or acrylate with an epoxy compound and a wetting agent as essential components. A composition.
【０００６】本発明で用いられる共重合体は、Ｎ−ビニ
ルアセトアミドとアクリル酸及び／又はアクリル酸塩モ
ノマーとの共重合体（モノマー重量比＝９９：１〜１：
９９）である。また、アクリル酸塩としては、アルカリ
金属のナトリウム、リチウム、カリウムが好ましい。The copolymer used in the present invention is a copolymer of N-vinylacetamide and an acrylic acid and / or acrylate monomer (monomer weight ratio = 99: 1 to 1: 1).
99). As the acrylate, alkali metals sodium, lithium and potassium are preferable.
【０００７】これら共重合体の架橋剤としては、エポキ
シ化合物が適しており、架橋により不溶化される。例え
ば、エポキシ化合物としては、ポリエチレングリコール
ジグリシジルエーテル、エチレングリコールジグリシジ
ルエーテル、グリセリンジグリシジルエーテル、グリセ
リントリグリシジルエーテル、プロピレングリコールジ
グリシジルエーテル、ポリグリセロールポリグリシジル
エーテル、ソルビトールポリグリシジルエーテル、ソル
ビタンポリグリシジルエーテル、トリメチロールプロパ
ンポリグリシジルエーテル、ペンタエリスリトールポリ
グリシジルエーテル、レゾルシノールジグリシジルエー
テル、ネオペンチルグリコールジグリシジルエーテル、
ビスフェノール型エポキシ樹脂などが上げられる。Epoxy compounds are suitable as a crosslinking agent for these copolymers, and are insolubilized by crosslinking. For example, as the epoxy compound, polyethylene glycol diglycidyl ether, ethylene glycol diglycidyl ether, glycerin diglycidyl ether, glycerin triglycidyl ether, propylene glycol diglycidyl ether, polyglycerol polyglycidyl ether, sorbitol polyglycidyl ether, sorbitan polyglycidyl ether , Trimethylolpropane polyglycidyl ether, pentaerythritol polyglycidyl ether, resorcinol diglycidyl ether, neopentyl glycol diglycidyl ether,
Examples include bisphenol type epoxy resins.
【０００８】これら架橋剤の好ましい配合量は、共重合
体１０重量部に対して０．０１〜５重量部、更に好まし
くは０．１〜３重量部である。架橋剤の配合量がこの範
囲を逸脱すると、凝集性、保型性が低下したり、あるい
は架橋密度が高くなり製造中にゲル化が進行するという
問題が生じる。[0008] The preferred compounding amount of these crosslinking agents is 0.01 to 5 parts by weight, more preferably 0.1 to 3 parts by weight, based on 10 parts by weight of the copolymer. If the amount of the cross-linking agent is out of this range, there is a problem that the cohesiveness and the shape retention are reduced, or the cross-linking density is increased and gelation proceeds during the production.
【０００９】また、本発明に用いられる湿潤剤は、先の
共重合体の分散・溶解あるいは可塑剤として用いられ
る。湿潤剤としては、水あるいはアルコールを単独もし
くは混合して用いることができる。アルコールとして
は、メタノール、エタノール、プロパノール、イソプロ
パノール、ブタノール等の１価アルコールやエチレング
リコール、ジエチレングリコール、トリエチレングリコ
ール、ポリエチレングリコール、プロピレングリコー
ル、ジプロピレングリコール、ポリプロピレングリコー
ル、１．３−ブチレングリコール、１．４−ブチレング
リコール、イソブチレングリコール、グリセリン、ジグ
リセリン、ソルビトール等の多価アルコールが上げられ
る。The wetting agent used in the present invention is used as a dispersing or dissolving agent for the above copolymer or as a plasticizer. As the wetting agent, water or alcohol can be used alone or as a mixture. Examples of the alcohol include monohydric alcohols such as methanol, ethanol, propanol, isopropanol, and butanol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, 1.3-butylene glycol, and 1. Polyhydric alcohols such as 4-butylene glycol, isobutylene glycol, glycerin, diglycerin, sorbitol and the like can be mentioned.
【００１０】この湿潤剤と共重合体との好ましい配合比
（重量比）は、１０：０．１〜１０、更に好ましくは、
１０：０．５〜５重量部である。両者の配合比がこの範
囲を逸脱すると、保型性、凝集力が低下したり、作業性
が低下するという問題が生じる。The preferred blending ratio (weight ratio) of the wetting agent to the copolymer is 10: 0.1 to 10, more preferably
10: 0.5 to 5 parts by weight. If the mixing ratio of the two deviates from this range, problems such as a decrease in shape retention and cohesion and a decrease in workability arise.
【００１１】本発明の高分子ゲル組成物には、上記の共
重合体、エポキシ化合物、湿潤剤からなる必須成分に加
えて、従来公知のｐＨ調製剤、酸化防止剤、粘着付与
剤、防腐剤、溶解剤、薬物、香料、界面活性剤、紫外線
吸収剤、吸収促進剤、無機充填剤などの配合剤が適宜適
量配合される。In the polymer gel composition of the present invention, in addition to the essential components comprising the above-mentioned copolymer, epoxy compound and wetting agent, conventionally known pH adjusters, antioxidants, tackifiers, preservatives Compounding agents such as a solubilizer, a drug, a fragrance, a surfactant, an ultraviolet absorber, an absorption promoter, and an inorganic filler are appropriately compounded.
【００１２】次に、本発明の高分子ゲル組成物の製造方
法としては、撹拌機中で、共重合体と湿潤剤を分散・溶
解させた後、エポキシ化合物を添加・混合することによ
り、高分子ゲルとする。ゲル化は、数日内で進行する
が、加熱処理により数時間に短縮させることができる。Next, the method for producing the polymer gel composition of the present invention is as follows. A copolymer and a wetting agent are dispersed and dissolved in a stirrer, and then an epoxy compound is added and mixed. Molecular gel. Gelation proceeds within a few days, but can be reduced to several hours by heat treatment.
【００１３】[0013]
【作用】本発明の高分子ゲル組成物は以下の優れた特徴
を示す。 ａ．保型性が良く、ゲル強度が高い。 ｂ．水分などの離脱がなく、初期特性が保持される。 ｃ．ｐＨや電解質に対して安定である。 ｄ．温度変化を受けにくく、経時的安定性に優れる。 ｅ．薬物や香料などを保持する基剤として利用できる。 ｆ．皮膚に対する刺激性が少なく適度な粘着性を有する
ので、人体に直接適用できる。The polymer gel composition of the present invention has the following excellent characteristics. a. Good shape retention and high gel strength. b. There is no separation of moisture and the like, and the initial characteristics are maintained. c. It is stable to pH and electrolyte. d. Resistant to temperature change and excellent in stability over time. e. It can be used as a base for holding drugs and fragrances. f. Since it has little irritation to the skin and has an appropriate tackiness, it can be applied directly to the human body.
【００１４】[0014]
【実施例】以下、本発明を、実施例及び試験例によって
更に詳しく述べる。The present invention will be described in more detail with reference to the following examples and test examples.
【００１５】実施例１ Ｎ−ビニルアセトアミド・アクリル酸ナトリウム共重合
体（モノマー重量比；７０：３０）１０重量部を精製水
８６重量部に混合溶解し、その後、エチレングリコール
ジグリシジルエーテル４重量部を添加し、更に均一にな
るまで混合し、透明の高分子ゲル組成物を得た。EXAMPLE 1 10 parts by weight of an N-vinylacetamide / sodium acrylate copolymer (monomer weight ratio: 70:30) was mixed and dissolved in 86 parts by weight of purified water, and then 4 parts by weight of ethylene glycol diglycidyl ether Was added and mixed until uniform, to obtain a transparent polymer gel composition.
【００１６】実施例２ Ｎ−ビニルアセトアミド・アクリル酸ナトリウム共重合
体（モノマー重量比；９５：５）１０重量部をグリセリ
ン６０重量部、エタノール２８重量部に混合溶解し、そ
の後、ネオペンチルジグリシジルエーテル２重量部を添
加し、更に均一になるまで混合し、透明の高分子ゲル組
成物を得た。Example 2 10 parts by weight of an N-vinylacetamide / sodium acrylate copolymer (monomer weight ratio: 95: 5) were mixed and dissolved in 60 parts by weight of glycerin and 28 parts by weight of ethanol, and then neopentyl diglycidyl was added. 2 parts by weight of ether was added and mixed until the mixture became more uniform to obtain a transparent polymer gel composition.
【００１７】実施例３ Ｎ−ビニルアセトアミド・アクリル酸ナトリウム共重合
体（モノマー重量比；９０：１０）１５重量部とグリセ
リン３０重量部を混合し、精製水５４．８重量部に溶解
し、その後、トリメチロールプロパンポリグリシジルエ
ーテル０．２重量部を添加し、更に均一になるまで混合
した。この組成物を５０℃で５時間加熱処理し、透明の
高分子ゲル組成物を得た。Example 3 15 parts by weight of an N-vinylacetamide / sodium acrylate copolymer (weight ratio of monomers: 90:10) and 30 parts by weight of glycerin were mixed and dissolved in 54.8 parts by weight of purified water. And 0.2 parts by weight of trimethylolpropane polyglycidyl ether were added and mixed until uniform. This composition was heated at 50 ° C. for 5 hours to obtain a transparent polymer gel composition.
【００１８】実施例４ Ｎ−ビニルアセトアミド・アクリル酸ナトリウム共重合
体（モノマー重量比；８０：２０）５重量部とグリセリ
ン６４重量部を混合し、精製水３０重量部に溶解し、そ
の後、ペンタエリスリトールポリグリシジルエーテル１
重量部を添加し、更に均一になるまで混合し、透明の高
分子ゲル組成物を得た。Example 4 5 parts by weight of an N-vinylacetamide / sodium acrylate copolymer (monomer weight ratio: 80:20) and 64 parts by weight of glycerin were mixed and dissolved in 30 parts by weight of purified water. Erythritol polyglycidyl ether 1
By weight, the mixture was further mixed until it became uniform to obtain a transparent polymer gel composition.
【００１９】比較例１ 平均重合度２００００のポリアクリル酸６部とグリセリ
ン３０部を混合し、精製水５２部に溶解した。その後、
乳酸アルミニウム２部、精製水１０部の水溶液を添加
し、更に均一になるまで混合し、透明の高分子ゲル組成
物を得た。Comparative Example 1 6 parts of polyacrylic acid having an average degree of polymerization of 20,000 and 30 parts of glycerin were mixed and dissolved in 52 parts of purified water. afterwards,
An aqueous solution of 2 parts of aluminum lactate and 10 parts of purified water was added and mixed until the mixture became more uniform to obtain a transparent polymer gel composition.
【００２０】比較例２ ゼラチン５部を６０℃に加温した精製水７２部に溶解さ
せた後に、平均重合度２０００のポリビニルアルコール
３部とグリセリン２０部の混合物を添加し、更に均一に
なるまで撹拌した。この混合物を５℃に冷却し透明の高
分子ゲル組成物を得た。Comparative Example 2 After 5 parts of gelatin was dissolved in 72 parts of purified water heated to 60 ° C., a mixture of 3 parts of polyvinyl alcohol having an average degree of polymerization of 2000 and 20 parts of glycerin was added until the mixture became more uniform. Stirred. This mixture was cooled to 5 ° C. to obtain a transparent polymer gel composition.
【００２１】試験例 実施例１〜４及び比較例１〜２で得られた高分子ゲルに
ついて以下の試験を行ない表１に示した。Test Examples The polymer gels obtained in Examples 1 to 4 and Comparative Examples 1 and 2 were subjected to the following tests and are shown in Table 1.
【００２２】１）ゲルの保型性 試料を室温で７日間放置し、ゲルの流動性を観察した。 ○ ： 保型性良好 △ ： 若干流動する × ： 流動（保型性なし）1) Gel Retainability The sample was left at room temperature for 7 days, and the fluidity of the gel was observed. ：: Good shape retention △: Slightly flowing ×: Flowable (no shape retention)
【００２３】２）ゲルの膨潤試験 試料１ｇを精製水５００ｍｌにいれ、ゲルの状態を観察
した。 ○ ： 膨潤 △ ： 膨潤〜溶解 × ： 溶解2) Gel Swelling Test 1 g of a sample was placed in 500 ml of purified water, and the state of the gel was observed. : Swelling: swelling to dissolution ×: dissolution
【００２４】３）ゲルの安定性 試料を４０℃に７日間放置し、室温に戻したときの性状
を観察した。 ○ ： 保型性良好 △ ： 離水し、保型性が一部失われる。 × ： 保型性なし3) Gel Stability The sample was left at 40 ° C. for 7 days, and the properties when the temperature was returned to room temperature were observed. : Good shape retention △: Water is released and the shape retention is partially lost. ×: No shape retention
【００２５】[0025]
【表１】 [Table 1]
【００２６】表１に示されるように、実施例１〜４の高
分子ゲル組成物は、比較例１〜２の含水ゲルに比べ、保
型性が良好であり、精製水中においても溶解することな
く、しかもに安定性においても優れていた。As shown in Table 1, the polymer gel compositions of Examples 1 to 4 have better shape retention than the hydrogels of Comparative Examples 1 and 2, and dissolve even in purified water. And also excellent in stability.
【００２７】[0027]
【発明の効果】以上のように、本発明の高分子ゲル組成
物は、化学的特性及び経時的安定性に優れ、人体にも適
用されるため、医療材料、医薬部外品、化粧品、医薬品
等の各分野での応用が可能である。特にその中でも治療
用パット、褥瘡予防剤、保温材、保冷材、創傷保護剤、
パック剤、貼付剤、薬物徐放剤等に利用することがで
き、産業上極めて有用なものである。As described above, the polymer gel composition of the present invention is excellent in chemical properties and stability over time and can be applied to the human body, so that it can be used for medical materials, quasi-drugs, cosmetics, and pharmaceuticals. And so on. Especially among them, therapeutic pad, pressure ulcer prevention agent, heat insulation material, cold insulation material, wound protection agent,
It can be used for packs, patches, sustained release drugs and the like, and is extremely useful industrially.
フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ Ｃ０８Ｌ 63:00） Ｃ０８Ｌ 63:00） (Ｃ０８Ｌ 39/02 (Ｃ０８Ｌ 39/02 33:02 33:02 63:00） 63:00） (72)発明者 古瀬 靖久 佐賀県鳥栖市田代大官町408番地 久光 製薬株式会社内 (56)参考文献 特開 平３−223304（ＪＰ，Ａ) 特開 平２−292309（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) C08L 33/02 C08L 39/00 - 39/02 C08L 63/00 - 63/10 C08G 59/42 Continued on the front page (51) Int.Cl. 7 Identification code FI C08L 63:00) C08L 63:00) (C08L 39/02 (C08L 39/02 33:02 33:02 63:00) 63:00) ( 72) Inventor Yasuhisa Furuse 408, Tashiro Daigakucho, Tosu City, Saga Prefecture Hisamitsu Pharmaceutical Co., Ltd. (56) References JP-A-3-223304 (JP, A) JP-A-2-292309 (JP, A) (58) ) Surveyed field (Int.Cl. 7 , DB name) C08L 33/02 C08L 39/00-39/02 C08L 63/00-63/10 C08G 59/42
Claims (4)
リル酸及び／又はアクリル酸塩との共重合体１０重量部
に対してエポキシ化合物０．０１〜５重量部、及び湿潤
剤１０重量部に対して上記共重合体０．１〜１０重量部
になるようにこれら３者を混合して成る、高分子ゲル組
成物。1. An epoxy resin having a component ratio of 0.01 to 5 parts by weight based on 10 parts by weight of a copolymer of N-vinylacetamide and acrylic acid and / or acrylate, and 10 parts by weight of a wetting agent A polymer gel composition comprising a mixture of the above three components in an amount of 0.1 to 10 parts by weight.
後、エポキシ化合物を添加し、均一になるまで混合する
ことにより得られる請求項１に記載の高分子ゲル組成
物。2. The polymer gel composition according to claim 1, which is obtained by dispersing and dissolving the copolymer and the wetting agent, adding an epoxy compound, and mixing until uniform.
に記載の高分子ゲル組成物。3. The method according to claim 2, wherein the mixture is heated after being mixed.
4. The polymer gel composition according to item 1.
冷剤、創傷保護材、パック剤、貼付剤又は薬物徐放剤と
して用いられる、請求項１〜３の何れかに記載の高分子
ゲル組成物。4. The polymer according to any one of claims 1 to 3, which is used as a therapeutic pad, an agent for preventing pressure ulcers, an agent for keeping warmth, an agent for keeping cold, an agent for protecting wounds, a pack, a patch or a sustained release agent for drugs. Gel composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10216792A JP3260412B2 (en) | 1992-03-27 | 1992-03-27 | Polymer gel composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10216792A JP3260412B2 (en) | 1992-03-27 | 1992-03-27 | Polymer gel composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05271517A JPH05271517A (en) | 1993-10-19 |
| JP3260412B2 true JP3260412B2 (en) | 2002-02-25 |
Family
ID=14320153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10216792A Expired - Lifetime JP3260412B2 (en) | 1992-03-27 | 1992-03-27 | Polymer gel composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3260412B2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08243377A (en) * | 1995-03-09 | 1996-09-24 | Showa Denko Kk | Alcohol-containing gel body |
| US6599999B1 (en) * | 1997-02-04 | 2003-07-29 | National Starch And Chemical Investment Holding Corporation | Hair care compositions containing polymeric N-vinyl acetamide and methods of treating hair |
| JPH1180716A (en) * | 1997-09-03 | 1999-03-26 | Showa Denko Kk | Cold insulator composition and cold insulator |
| JP2001064472A (en) * | 1999-09-01 | 2001-03-13 | Showa Denko Kk | Boric acid-containing gel |
| JP2002080681A (en) * | 2000-09-11 | 2002-03-19 | Showa Denko Kk | Fragrant and/or deodorant gel composition |
| JP6878273B2 (en) * | 2015-05-11 | 2021-05-26 | 昭和電工株式会社 | Copolymers, binders for electrodes of secondary batteries, compositions for electrodes of secondary batteries, electrodes for secondary batteries |
-
1992
- 1992-03-27 JP JP10216792A patent/JP3260412B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05271517A (en) | 1993-10-19 |
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