JPS6314990B2 - - Google Patents

Info

Publication number

JPS6314990B2

JPS6314990B2 JP60007955A JP795585A JPS6314990B2 JP S6314990 B2 JPS6314990 B2 JP S6314990B2 JP 60007955 A JP60007955 A JP 60007955A JP 795585 A JP795585 A JP 795585A JP S6314990 B2 JPS6314990 B2 JP S6314990B2

Authority

JP

Japan

Prior art keywords

hydroxyapatite

bone

synthetic hydroxyapatite

reaction

product

Prior art date

1985-01-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 29
• 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 28
• 239000000463 material Substances 0.000 claims description 27
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 14
• 239000000047 product Substances 0.000 claims description 12
• 239000008187 granular material Substances 0.000 claims description 11
• 238000004519 manufacturing process Methods 0.000 claims description 10
• 238000000034 method Methods 0.000 claims description 8
• 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 7
• AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 7
• 239000000920 calcium hydroxide Substances 0.000 claims description 7
• 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 7
• 238000001035 drying Methods 0.000 claims description 7
• 239000000203 mixture Substances 0.000 claims description 6
• 239000007795 chemical reaction product Substances 0.000 claims description 5
• 210000000988 bone and bone Anatomy 0.000 description 16
• 210000001519 tissue Anatomy 0.000 description 15
• 239000002245 particle Substances 0.000 description 8
• 239000000126 substance Substances 0.000 description 7
• 230000007547 defect Effects 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• 238000002441 X-ray diffraction Methods 0.000 description 3
• 239000012620 biological material Substances 0.000 description 3
• 239000012065 filter cake Substances 0.000 description 3
• 238000000465 moulding Methods 0.000 description 3
• 238000003756 stirring Methods 0.000 description 3
• 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 2
• 241000700157 Rattus norvegicus Species 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 239000000919 ceramic Substances 0.000 description 2
• 238000011109 contamination Methods 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 239000013078 crystal Substances 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 239000012535 impurity Substances 0.000 description 2
• 235000012149 noodles Nutrition 0.000 description 2
• 230000011164 ossification Effects 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 230000008929 regeneration Effects 0.000 description 2
• 238000011069 regeneration method Methods 0.000 description 2
• 238000005245 sintering Methods 0.000 description 2
• 239000011343 solid material Substances 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 1
• 208000018084 Bone neoplasm Diseases 0.000 description 1
• 230000000735 allogeneic effect Effects 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 229910052586 apatite Inorganic materials 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• 239000012237 artificial material Substances 0.000 description 1
• 210000002449 bone cell Anatomy 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 238000002050 diffraction method Methods 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 239000010419 fine particle Substances 0.000 description 1
• 238000010304 firing Methods 0.000 description 1
• 230000035876 healing Effects 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
• 201000001245 periodontitis Diseases 0.000 description 1
• 238000010298 pulverizing process Methods 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 229910001220 stainless steel Inorganic materials 0.000 description 1
• 239000010935 stainless steel Substances 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• 239000011882 ultra-fine particle Substances 0.000 description 1