JPS63139117A - Intraoral cleaning agent - Google Patents

Abstract

PURPOSE:To obtain a practicable intraoral cleaning agent, containing a solvent extract of a lauraceous plant as an active ingredient, having mild irritant feeling, taste and touch, high safety and excellent deodorizing as well as odor neutralizing action and comfortable feeling of use. CONSTITUTION:An intraoral cleaning agent containing a solvent extract of a lauraceous plant as an active ingredient. For example, Laurus nobilis L., Cinnamomum loureirii Nees, Cinnamomum camphora Sieb., etc., are cited as the lauraceous plant and raw leaves, barks and dried materials thereof are used. Ethanol, propanol, isopropanol, water, etc., are preferred as the solvent used for extraction. The extraction is carried out by a method for adding about 4-6pts. solvent to 1pts. raw material and heating the resultant mixture at the refluxing temperature of the solvent. The active ingredient is obtained as powder, paste, etc., of dark green greenish brown color, etc., by removing the solvent from the extract solution. The content of the solvent extract of the lauraceous plant is 0.01-5.0% based on the total amount of the intraoral cleaning agent.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a mouth cleanser, and more particularly to a mouth cleanser containing a solvent extract of a plant of the Lauraceae family.

Traditionally ■ Drumsticks Conventionally, there have been rutting agents as pharmaceuticals for removing odors and disinfecting during the day, and mouthwashes and mouth fresheners as quasi-drugs.

Rutting agents are mainly disinfectants and are used to sterilize, disinfect, deodorize, and clean the mouth and throat, while mouthwashes are used to prevent bad breath and cavities, and contain neutralizers and astringents. Antibiotics, bactericidal agents, anti-enzyme agents, etc. are mixed in, and some contain fluorine compounds to prevent cavities. Mouth fresheners are tablets, spray liquids, etc. whose main ingredients are acene group, licorice, etc., and are small and convenient to carry, and are considered etiquette products. One of the purposes of this mouth freshener is to prevent bad breath, but it is also intended to relieve motion sickness, hangovers, discomfort, etc., and mainly contains fragrance.
It gives a refreshing and refreshing feeling.

Similarly to this mouth freshener, there are also pharmaceutical tablets that contain chlorophyll for the purpose of eliminating bad breath and treating hangovers, and there are also products that can be taken to eliminate bad breath.

Problems to be Solved by the Invention These conventional mouth cleansers, such as mouth rinses, mouth fresheners, and laxatives, mainly contain bactericidal agents, anti-enzyme agents, fragrances, neutralizing agents, etc. To prevent bad breath, there are many masking methods using fragrances, but there are few that contain ingredients that can directly remove bad breath. Some cleaning agents are difficult to use because of their taste, feel, odor, etc.

As a result of various studies to solve the above-mentioned problems, the inventors of the present invention have found that a mouth cleanser containing a solvent extract of a Lauraceae plant is effective against these mouth cleansers themselves. We have arrived at the present invention by discovering that it alleviates the irritation and bad taste, eliminates bad breath, and enhances the bactericidal effect.

That is, the present invention relates to a mouth cleanser characterized by containing a solvent extract of a plant of the Lauraceae family.

Examples of the Lauraceae plants used as extraction raw materials in the present invention include laurel, cinnamon, camphor tree, and their fresh leaves, barks, and dried products.

In the present invention, the solvent used for extracting the active ingredient from the above-mentioned raw materials includes alcohol-based organic solvents such as ethanol, propatool, isopropatool, water, and mixed solvents thereof. From the viewpoint of efficiency, deodorizing effect, etc., ethanol, propatool, isopropateol, water, or a mixture thereof is preferable.

The method for extracting Lauraceae plants in the present invention is disclosed in Japanese Unexamined Patent Publication No. 5
It can be extracted by the method described in Japanese Patent No. 3-66434.

That is, about 4 to 6 parts of a solvent is added to 1 part of the above raw material; heating is carried out at the reflux temperature of the solvent. Although the extraction time varies slightly depending on the type of extraction device and raw materials, for example, when using a Soxhlet extraction device, it is preferably about 10 to 20 hours. Since the active ingredients in the raw material are transferred into the solvent and extracted, an extract containing the active ingredients can be obtained by removing the raw material residue by filtration or centrifugation.

-3= By removing the solvent from this extract, the active ingredient can be obtained as a dark green to greenish brown, reddish brown to dark brown powder, paste or solid.

Other solvent extraction methods can also be used.

The solvent extract of the present invention has deodorizing and deodorizing effects as described in JP-A-53-66434, and although its mechanism of action is not clear, it is extracted from fresh leaves of Lauraceae plants or their dried products. The active ingredients include flavone compounds, unsaturated aldehyde compounds, and organic acids (tannic acid, etc.).
For example, for mercaptan compounds, addition to flavone compounds or unsaturated aldehydes, for ammonia and amine compounds, reaction to aldehydes, etc.; It is presumed to be based on neutralization, etc., and is considered to be effective in deodorizing and removing bad breath. As is well known, halitosis includes physiological halitosis,
For example, there are bad breath caused by food such as garlic odor, tobacco odor, alcohol odor, etc. due to food or luxury goods, bad breath when waking up on an empty stomach, and pathological bad breath, such as bad breath caused by diseases of the respiratory system, digestive system, etc. Bad breath-4= is caused by, for example, amines, ammonia, or
Hydrogen sulfide, methyl mercaptan, etc., alcohol in alcohol,
It is also said to be caused by the presence of aldol, acetaldehyde, and trace amounts of amine, acetone, acetic acid, etc. in the mixture.

The mouth cleansing agent containing the solvent extract of the Lauraceae plant of the present invention exhibits excellent effects in removing these bad breaths.

Extracts from Lauraceae plants have excellent safety and lJ
It relieves the irritation of the medium cleaning agent itself and is extremely superior in handling and use.

Furthermore, since the solvent extract of the present invention has an excellent deodorizing effect, the irritating sensation among the ingredients effective as mouth cleansing agents can be alleviated or eliminated through its deodorizing and deodorizing effects. In the present invention, ingredients that are effective for mouth cleansing but are difficult to use due to irritation can be effectively used as mouth cleansing ingredients.

The mouth cleansing agent of the present invention is an ingredient used in a mouthwash, a mouth freshener, a mouthwash, a moisturizing agent, or a sweet preservative (e.g., glycerin, sorbitol, Seldex (registered trademark), etc.)
, solubilizers (polyoxyethylene hydrogenated castor oil, polyoxyethylene polypropylene glycol, etc.), preservatives (paraoxybenzoic acid ester, benzoic acid, etc.), pH adjusters (phosphoric acid-sodium hydrogen, hydroxide, etc.) (sodium, etc.), solvents (ethanol, etc.), fragrances (eucalyptus, thymol, peppermint, menthol, etc.), sweeteners (
saccharin sodium, etc.), coloring agents (Yellow No. 4, Blue No. 1)
caramel, etc.), anti-inflammatory agents (water-soluble azulene) disinfectants,
It is produced by containing the solvent extract of the Lauraceae plant of the present invention together with components such as anti-enzyme agents.

The content of the solvent extract of the Lauraceae plant of the present invention is 0.01 to 5.0% based on the total amount of the mouth cleanser.

In the present invention, a combination with azulene, which is useful as a deodorizing agent or as an antibacterial agent, is preferably used.

Water-soluble azulene is used as a mouthwash and has an anti-inflammatory effect, resulting in an effective mouthwash. However, it has a powdery and rough feel, but by containing the solvent extract of the present invention, It loses its bitterness and becomes milder.

Sub U1 By incorporating a mouth cleansing agent into the solvent extract of a Lauraceae plant, it can be made into an excellent mouth cleansing agent due to the deodorizing, deodorizing and bactericidal effects of the solvent extract. The irritation caused by the agent itself can be alleviated and the feeling can be made milder.

EXAMPLES The present invention will be explained below with reference to Examples, but it goes without saying that the present invention is not limited to these Examples.

Obtaining a Solvent Extract (1) 250 g of dried bay leaf powder and 600 m Q of isopropanol were placed in a Soxhlet extractor and heated under reflux for 20 hours. The raw material residue is removed from the extract, and the liquid is concentrated to dryness under reduced pressure to obtain 55 g of a dark green solid.

(2) Put 18 g of fresh bay leaves and 100 m of ethanol into a Soxhlet extractor, and heat and reflux for 12 hours.

Thereafter, 4.2 g of a dark green solid was obtained by processing in the same manner as in Example 1.

(3) Fresh camphor leaves and cinnamon bark to 10 parts ethanol
When the sample was immersed in 0 m Q and extracted under reflux, the results shown in Table 1 below were obtained.

Table 1 A deodorization test for the above solvent extract was conducted using the following method.

=8- 0.1 g of malodorous components (benzyl mercaptan and 30% aqueous trimethylamine solution) and 1 g of 10% ethanol extract solution are thoroughly mixed in a closed container. After that, the head space inside the sealed container was taken out with a gastight syringe, and a chromatogram was drawn using a gas chromatograph.
Find the peak area.

Separately, a blank test (in the case where no deodorant was added) was conducted, and the peak area of the chromatogram was set as 100, and the removal rates were determined, and the results shown in Table 2 were obtained.

Table 2 The measurement conditions of the gas chromatograph are as follows.

<Benzyl mercaptan> 5ilicon DC-7100, 6m5ens
1091. /4 15m (i temperature 150℃ <30% trimethylamine aqueous solution> 5ilicon DC-7102m 5ens 10g1/128 10mU temperature 7
0°C Example 1 Mouth cleansers shown in Table 4 were produced using a 2% aqueous ethanol solution (55% ethanol, 43% water) of an ethanol extract from bay leaves.

For comparison, a mouth cleanser was manufactured using chlorophyll (2% copper chlorophyllin sodium aqueous solution), which has been known to be effective in removing bad breath.

Table 3 These mouthwashes have a irritating flavor, whereas A has a irritating flavor.
In A-1 and A-2, the stimulation sensation becomes mellow.

Table 4 shows the results of a breath odor removal test using the mouth cleanser.

Table 4: Average value of 8 panelists The halitosis adjustment method and evaluation criteria in this halitosis test are as follows.

How to adjust bad breath A: Tobacco odor To get rid of cigarette odor, remove 3 highlights in 5 minutes before filtering 21
After smoking for up to 30 minutes, his breath smelled like cigarettes for 3Q. (Standard) B. Garlic odor After eating 2 servings (14 pieces) of gyoza, the garlic odor was obtained by taking 3ρ of the exhaled breath as a cosmetic (Standard) The Great Buddha on Death - After collecting the above bad breath, Prescription A mouth freshener 30m
After gargling with Q for 30 seconds, 3Q of exhaled air was collected immediately after. Prescriptions A-1 and A-2 were also carried out in the same manner.

The effectiveness of removing bad breath was evaluated using eight expert panelists. First, they smelled the standard odor, then smelled the beauty product immediately after the sample was taken, and evaluated the strength of the odor based on the evaluation score. It was expressed in 6 stages.

=12- Evaluation score for deodorizing effect Odor strength 5 Strong odor 4 Strong odor 3 Easily detectable odor 2 Odor that you can tell what kind of odor it is 1 Almost undetectable odor O odorless As is clear from Table 4, the mouthwash using the solvent extract of the present invention has a significantly superior effect compared to the conventionally used ones containing chlorophyll, and is an excellent mouthwash. It is.

Example 2 - Next, various medium cleaners were manufactured using the solvent extract of the present invention.

<Prescription Example 1> 1, -A 1. - B ethanol
15.0], 5.0 (weight%) (weight i%
) Sorbitol 12.0 12.0 Polyoxyethylene hydrogenated castor oil 0.3 0.3 Fragrance 1.0 1.0 Camphor leaf 3.0 - Water-soluble azulene 0.01 0.01 Roseoxybenzoic acid ester 0.1 0.1 purified water
11100.0 100.0 <Formulation example 2> 2-A 2-8 Ethanol
25.0 25.0 (wt%) (wt%) Sorbitol 15.0 15. O
Q-menthol 0.2 0.
2 Camphor leaves 2.0-Fragrance
1.0 1.0 Water-soluble azulene 0.01 0.01 Celldex 4.0 4.0 Purified water
11ioo, o too,.

Table 5 shows the results of the breath odor deodorization test for these mouth cleansers.

Table 5 The test method and evaluation method are the same as in Example 1.

These mouth cleansers (1-A, 2-A) all have a good aroma, do not have an unpleasant odor when used, and do not use the solvent extract of the present invention (1-B, 2- Compared to B), it had a milder odor and taste and was easier to use, and combined with the anti-inflammatory and antibacterial effects of azulene, it had an excellent effect, and was excellent as a mouthwash because it could remove bad breath.

15- The mouth cleanser of the present invention has a mild irritation, feel, and taste, so it is easy to use, and extracts of Lauraceae plants are highly safe, so they contain extracts of these plants. Mouth rinses and mouth fresheners can be used constantly or in the morning and evening to effectively remove physiological bad breath.

Since the mouth freshener of the present invention contains a solvent extract of a Lauraceae plant, the mouth freshener itself has a mild irritation, taste, and feel, making it comfortable to use. be able to. In addition, the solvent extract has no safety problems and is excellent as a mouth cleanser due to its excellent deodorizing and deodorizing effects and refreshing feeling, and can be used as a mouthwash or mouth cleanser for daily use. It is suitable as an agent and can be said to be highly practical.

Claims (4)

[Claims] (1) A mouth cleanser characterized by containing a solvent extract of a Lauraceae plant. (2) The mouth freshener according to claim 1, wherein the Lauraceae plant is laurel. (3) The mouth cleanser according to claim 1 or 2, wherein the solvent extract is alcohol, water, or a mixed solvent extract thereof. (4) The mouth cleanser according to claim 3, wherein the alcohol is selected from ethyl alcohol, propyl alcohol, and isopropyl alcohol.