JPS63134043A - Automatic continuous mixing and granulating method - Google Patents
Automatic continuous mixing and granulating methodInfo
- Publication number
- JPS63134043A JPS63134043A JP27941386A JP27941386A JPS63134043A JP S63134043 A JPS63134043 A JP S63134043A JP 27941386 A JP27941386 A JP 27941386A JP 27941386 A JP27941386 A JP 27941386A JP S63134043 A JPS63134043 A JP S63134043A
- Authority
- JP
- Japan
- Prior art keywords
- raw material
- amount
- binder
- granulation
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims description 15
- 239000002994 raw material Substances 0.000 claims abstract description 47
- 239000011230 binding agent Substances 0.000 claims abstract description 36
- 238000005303 weighing Methods 0.000 claims abstract description 18
- 238000001514 detection method Methods 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 6
- 238000005469 granulation Methods 0.000 claims description 33
- 230000003179 granulation Effects 0.000 claims description 33
- 238000003860 storage Methods 0.000 claims description 11
- 239000011812 mixed powder Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 229940095686 granule product Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 abstract description 15
- 239000007921 spray Substances 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000009775 high-speed stirring Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 238000000275 quality assurance Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Glanulating (AREA)
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、自動連続混合造粒方法に関する。[Detailed description of the invention] [Industrial application field] The present invention relates to an automatic continuous mixing and granulation method.
医薬品の顆粒の生産のための造粒作業は、その製品中の
成分含量を保証する必要があす、一般にバッチ式の混合
造粒装置が使用されている。BACKGROUND OF THE INVENTION Batch-type mixing and granulation equipment is generally used in granulation operations for the production of pharmaceutical granules, as it is necessary to guarantee the content of ingredients in the product.
しかしながら、近年製造コス）・節減のｔ二めに、自動
化装置が開発されている。この自動化装置による混合造
粒方法は、貯槽内の原料を原料秤量機に設定量搬出供給
し、この秤量された設定量の原料を、例えば流動層造粒
乾燥機に仕込み投入したのち、上記設定量の原料に対応
する設定量の結合剤をスプレーして造粒し、乾燥して顆
粒製品を得、これを製品貯槽へ貯溜するようにしたもの
である。However, in recent years, automated devices have been developed to reduce manufacturing costs. In this mixed granulation method using an automated device, a set amount of raw materials in a storage tank is delivered to a raw material weighing machine, and this weighed set amount of raw materials is charged into, for example, a fluidized bed granulation dryer, and then the above-mentioned settings are set. A predetermined amount of binder corresponding to the amount of raw material is sprayed, granulated, and dried to obtain a granulated product, which is stored in a product storage tank.
この自動化装置による混合造粒方法は、製品顆粒中の成
分含量がきわめて不安定で、信頼性に乏しいという問題
点がある。即ち、この装置によると、原料秤量機に、例
えば設定量である１００ｋｇの原料が秤量供給されたと
しても、フィーダーなどの機械的性質から、必ずしも１
００ｋｇの原料が払い出される保証はなく、切り出し実
質量が９８ｋｇ、即ち、２ ｋｇ少なく切り出されるこ
ともある。This mixed granulation method using automated equipment has the problem that the component content in the product granules is extremely unstable and is unreliable. That is, according to this device, even if a set amount of 100 kg of raw material is weighed and supplied to the raw material weighing machine, for example, due to the mechanical properties of the feeder, etc.
There is no guarantee that 00 kg of raw material will be discharged, and the actual amount of raw material to be cut may be 98 kg, that is, 2 kg less.
そして、原料の設定量に対応して定められた量の結合剤
が５０ｋｇであったとし、何らの損失もなく結合剤が１
００％供給されたとすると、製品顆粒中の成分含量は適
正を欠き、医薬品としての品質保証上その信頼性に不安
があり、医薬品として採用し得ないという問題点がある
。Assume that the amount of binder determined in accordance with the set amount of raw materials is 50 kg, and that the amount of binder is 1 kg without any loss.
If the product is supplied at 0.00%, the content of the ingredients in the product granules will be inappropriate, and there will be concerns about its reliability in terms of quality assurance as a pharmaceutical product, resulting in the problem that it cannot be used as a pharmaceutical product.
〔発明の目的〕
本発明は、このような実情に鑑みなされたもの、 で、
簡単な而も合理的手段によって従来技術の問題点を解消
せしめ、原料の切り出し実質量の検知信号により結合剤
の設定値の再設定を行わせ、原料量に見合った結合剤が
混合されるようにし、医薬品顆粒の成分含量の適正化が
計れ、かつ、昼夜を問わず無人運転が可能な混合造粒方
法を提供せんとするものである。[Object of the invention] The present invention was made in view of the above circumstances, and
The problems of the prior art are solved by simple and rational means, and the set value of the binder is reset based on the detection signal of the actual amount of raw material cut out, so that the binder corresponding to the amount of raw material is mixed. It is an object of the present invention to provide a mixed granulation method that can optimize the component content of pharmaceutical granules and can be operated unmanned day and night.
従来技術の問題点を解決する本発明の構成は、シーケン
サ−およびパーソナルコンピュータにて制御を行い、設
定条件に従い一連の操作は自動で行われるもので、貯槽
に収容せる単末、混合末などの原料を原料秤量機に設定
量供給し、原料秤量機内の原料を混合造粒乾燥機に送り
出し、この原料の実質的切り出し量の検知信号により、
上記制御装置に、あらかじめ、キーインしてある結合剤
の設定量を再設定し、原料の切り出し量に対応（７た結
合剤の所要量を自動算出するとともに、この算出された
量の結合剤を混合造粒乾燥機内の原料に供給して、原料
の造粒、乾燥を行って顆粒製品を得、得られた顆粒製品
を、製品貯槽、まｔコは、製品秤ｉ機に自動排′出して
出来上がり重量を自動秤量し、この秤量値が、上記制御
装置に、あらかじめ設定しキーインしてある１バッチの
仕上量の許容範囲、あるいは、原料と結合剤の実供給量
より制御装置内で算出した仕上量の許容範囲にあれば１
バクチの造粒工程が終り、以上の工程を１サイクルとし
て、連続的に次バッチ以降の造粒を行うことを特徴とす
るものである。The configuration of the present invention, which solves the problems of the prior art, is controlled by a sequencer and a personal computer, and a series of operations are automatically performed according to set conditions. A set amount of raw material is supplied to the raw material weighing machine, the raw material in the raw material weighing machine is sent to the mixing granulation dryer, and a detection signal indicating the actual cut-out amount of this raw material is used to
The preset amount of binder that has been keyed into the above control device is reset, and the required amount of binder corresponding to the amount of raw material cut out (7) is automatically calculated, and the calculated amount of binder is The raw materials in the mixing granulation dryer are fed, the raw materials are granulated and dried to obtain granule products, and the resulting granule products are automatically discharged to a product storage tank and a product weigher. The finished weight is automatically weighed, and this weighed value is calculated in the control device from the permissible finished amount of one batch that is preset and keyed into the control device, or from the actual supply amount of raw materials and binder. 1 if the finished amount is within the allowable range
After the bacterium granulation process is completed, the above process is regarded as one cycle, and the next batch and subsequent batches are continuously granulated.
図面について、本発明方法の実施例を説明する。 An embodiment of the method of the invention will be described with reference to the drawings.
第１図は本発明方法を実施するに当たり使用する装置の
説明図、第２図は混合造粒機の別実施例を示す説明図で
ある。FIG. 1 is an explanatory diagram of an apparatus used in carrying out the method of the present invention, and FIG. 2 is an explanatory diagram showing another embodiment of a mixing granulator.
貯槽１内に収容されている単末、混合末などの原料を、
あらかじめ、シーケンサ−１および、パーソナルコンピ
ュータなどによりなる制御装置（図示略）に設定量をキ
ーインした原料秤量４！Ｉ２に空気搬送手段などにより
設定量供給する。供給後設定時間が経過した後、あるい
は、流！ｆｉ！１層造粒乾燥機３内が設定温度に加温さ
れたとき、温度センサー１３の検知信号により原料秤量
機２内の原料をフィーダーなどの搬送手段により流ａ層
造粒乾燥機３に投入し、切り出し実質重量の秤量値信号
を上記制御装置にて処理し、この制御装置に、あらかじ
めキーインしてある結合剤の設定値を再設定、つまり、
設定値を原料の切り出し量に対応するように補正′する
。この再設定値により、結合剤タンク４内の結合剤は、
ポンプ５により再設定値量にα量を加えた量の結合剤が
結合剤秤量装置６のタンク７に供給されろ。そして、切
換三方弁８をもつスプレーガン９から結合剤が流動層造
粒乾燥機３内に噴霧されるが、初期動作として、切換三
方弁８によりスプレーガン９への流路を断ち、この状態
でポンプ１０を作動させ、タンク７内の結合剤を循環さ
せ、管路１１．１２中に結合剤を充満させろ。尚、ポン
プ１０の作動は続行させておく。The raw materials such as single powder and mixed powder stored in the storage tank 1 are
The raw material weighing amount 4 is entered in advance by keying in the set amount into the sequencer 1 and a control device (not shown) that includes a personal computer or the like. A set amount is supplied to I2 by air conveying means or the like. After the set time has elapsed after supply, or flow! Fi! When the inside of the single-layer granulation dryer 3 is heated to the set temperature, the raw material in the raw material weighing machine 2 is fed into the flow A-layer granulation dryer 3 by a conveying means such as a feeder based on a detection signal from the temperature sensor 13. , the weighing value signal of the cut actual weight is processed by the control device, and the setting value of the binder that has been keyed in in advance is reset in this control device, that is,
The set value is corrected to correspond to the amount of material to be cut out. With this reset value, the binder in the binder tank 4 is
An amount of binder equal to the reset value amount plus the amount α is supplied by the pump 5 to the tank 7 of the binder weighing device 6. Then, the binder is sprayed into the fluidized bed granulation dryer 3 from a spray gun 9 having a three-way switching valve 8, but as an initial operation, the flow path to the spray gun 9 is cut off by the three-way switching valve 8, and this state Activate pump 10 to circulate the binder in tank 7 and fill line 11.12 with binder. Note that the operation of the pump 10 is continued.
性状によって異なるが、原料量などの供給後、設定時間
が経過した後、あるいは、流動層造粒乾燥機３内の原料
が所定の温度に加温されると、温度センサー１３の検温
信号により上記切換三方弁８を動作させ、結合剤をスプ
レーガン９より噴塀させ造粒と乾燥を行わせる。結合剤
の噴霧量が再設定された算出量に達すると、スプレーが
自動的に停止され、所定の時間経過後、または、排気温
度などが設定の条件に達したとき所定の顆粒が得らし、
一連の造粒工程が終わる。Although it varies depending on the properties, after the set time has elapsed after supplying the amount of raw material, or when the raw material in the fluidized bed granulation dryer 3 is heated to a predetermined temperature, the temperature signal from the temperature sensor 13 indicates that the above-mentioned The three-way switching valve 8 is operated, and the binder is sprayed from the spray gun 9 to perform granulation and drying. When the amount of binder sprayed reaches the calculated amount that has been reset, the spraying is automatically stopped, and the desired granules are obtained after a predetermined period of time or when the exhaust temperature, etc. reaches the preset conditions.
A series of granulation steps are completed.
得られた顆粒を製品として流動層造粒乾燥機３から製品
秤量機１４に自動排出して出来上がり重量を自動秤量し
、この秤量値が、上記制御装置に、あらかじめ設定しキ
ーインしてある１バッチの仕上量の許容範囲、あるいは
、原料と結合剤の実供給量より制御装置内で算出した仕
上量の許容範囲にあれば、この製品顆粒を空気搬送手段
などにより輸送膜Ｗｉ１５に送り、更に、整粒装置１６
を経て貯槽１７に貯溜させ１バッチが終了する。また、
流動層造粒乾燥機３から自動排出された製品顆粒を製品
秤量８！１４で秤量せずに、空気搬送手段などで輸送設
備１５を経て貯槽１７に搬送し、該貯槽１７において出
来上がり重量を自動秤量することも可能である。The obtained granules are automatically discharged as a product from the fluidized bed granulation dryer 3 to the product weighing machine 14, and the weight of the finished product is automatically weighed. If the finished amount is within the allowable range, or within the allowable range of the finished amount calculated in the control device from the actual supply amount of raw materials and binder, the product granules are sent to the transport membrane Wi15 by an air conveying means or the like, and further, Particle regulating device 16
One batch is completed after being stored in the storage tank 17. Also,
The product granules automatically discharged from the fluidized bed granulation dryer 3 are conveyed to the storage tank 17 via the transportation equipment 15 using an air conveyance means or the like without being weighed at the product weight 8!14, and the finished weight is automatically measured in the storage tank 17. It is also possible to weigh.
上述のように１バッチの造粒工程が終わった信号により
、上記工程を１サイクルとした次バッチ以降の造粒作業
が初続して行われる。そして、あらかじめ設定したバッ
チ数の生産が終了すると、一連の生産は終了となり、全
ての装置は停止する。As described above, in response to a signal indicating that one batch of granulation process has been completed, the granulation process for the next batch and subsequent batches, in which the above process is one cycle, is initially carried out. When the production of the preset number of batches is completed, the series of production ends and all the devices are stopped.
若し、出来上がり重量が設定された仕上量より大ｒｌＪ
に少ない場合には、流動層造粒乾燥４Ｊ３内においてト
ラブルがあったことを示し、異常停止となる。If the finished weight is larger than the set finished amount
If the amount is less than 1, it indicates that there is a trouble in the fluidized bed granulation drying 4J3, and it will be abnormally stopped.
第２図は、造粒手段として高速攪拌型混合造粒機１８を
使用した例を示し、この高速攪拌型混合造粒機１８で造
粒された原料が流動層式乾燥機１９に投入され、ここで
乾燥されて製品顆粒として自動排出される。この場合、
結合剤は噴霧状でなく、単に高速攪拌型混合造粒機１８
に注入供給されろ。その他の工程は上述実施例と同様で
あるので詳細は省略する。FIG. 2 shows an example in which a high-speed stirring type mixing granulator 18 is used as the granulation means, and the raw material granulated by this high-speed stirring type mixing granulator 18 is charged into a fluidized bed dryer 19. Here, it is dried and automatically discharged as product granules. in this case,
The binder is not in a spray form, but simply in a high-speed stirring type mixing granulator18
be injected and supplied. The other steps are the same as those in the above embodiment, so details will be omitted.
上述のように本発明の構成によれば、次のような効果が
得られろ。According to the configuration of the present invention as described above, the following effects can be obtained.
（ａ） 造粒乾燥機内の設定量の原料に対し、この原
料の設定量に対応した設定量の結合剤が供給され、造粒
作用により製品顆粒が自動連続的に得られることは勿論
のこと、
（ｂ） 特に本発明においては、造粒乾燥機に搬入さ
れる切り出し実質重量の秤量値により結合剤の設定量が
再設定され、原料量に対する正しい量の結合剤供給付加
がなされるため、医薬品の顆粒成分含量の信頼性、即ち
、医薬品としての品質保証の高い顆粒が得られろ。(a) It goes without saying that a set amount of binder corresponding to the set amount of raw material is supplied to the set amount of raw material in the granulation dryer, and product granules are automatically and continuously obtained by the granulation action. (b) In particular, in the present invention, the set amount of binder is reset based on the weighed value of the actual weight of the cut material carried into the granulation dryer, and the correct amount of binder is supplied and added to the amount of raw materials. It is possible to obtain granules with high reliability in the content of granule components of pharmaceuticals, that is, with high quality assurance as pharmaceuticals.
（ｅｌ あらかじめ設定したパッチ数の生産が無人化
で自動連続して行われ、生産性、および、省力化の向上
が計れる。(el) Production of a preset number of patches is automatically and continuously performed unmanned, improving productivity and labor saving.
図は本発明方法を実施するに当たり使用する装置を示し
、第１図はシステム説明図、第２図は原料造粒、および
、乾燥装置の別個を示す要部の説明図である。
１・貯槽、２・・・原料秤量機、３・・流動層造粒乾燥
機、４・・結合剤タンク、５・・・ポンプ、６・・結合
剤秤量装置、７・タンク、８・切換三方弁、９・・・ス
プレーガン、１０・ポンプ、 １１．１２ 管路、１
３−・温度センサー、１４・製品秤量機、 １５・輸送
設備。
１６・・整粒装置、 １７ 貯槽、１８ 高速攪拌
型混合造粒機、１９・・流動層式乾燥機。The figures show the apparatus used to carry out the method of the present invention; FIG. 1 is an explanatory diagram of the system, and FIG. 2 is an explanatory diagram of main parts showing separate raw material granulation and drying equipment. 1. Storage tank, 2. Raw material weighing machine, 3. Fluidized bed granulation dryer, 4. Binder tank, 5. Pump, 6. Binder weighing device, 7. Tank, 8. Switching. Three-way valve, 9...Spray gun, 10. Pump, 11.12 Pipe line, 1
3-.Temperature sensor, 14.Product weighing machine, 15.Transportation equipment. 16... Particle size regulating device, 17 Storage tank, 18 High speed stirring type mixing granulator, 19... Fluidized bed dryer.
Claims (1)
ピュータにて制御を行い、設定条件に従い一連の操作は
自動で行われるもので、貯槽に収容せる単末、混合末な
どの原料を原料秤量機に設定量供給し、 （ｂ）原料秤量機内の原料を混合造粒乾燥機に送り出し
、この原料の実質的切り出し量の検知信号により、上記
制御装置に、あらかじめ、キーインしてある結合剤の設
定量を再設定し、原料の切り出し量に対応した結合剤の
所要量を自動算出するとともに、この算出された量の結
合剤を混合造粒乾燥機内の原料に供給して、原料の造粒
、乾燥を行って顆粒製品を得、 （ｃ）得られた顆粒製品を、製品貯槽、または、製品秤
量機に自動排出して出来上がり重量を自動秤量し、この
秤量値が、上記制御装置に、あらかじめ設定しキーイン
してある１バッチの仕上量の許容範囲、あるいは、原料
と結合剤の実供給量より制御装置内で算出した仕上量の
許容範囲にあれば１バッチの造粒工程が終り、以上の工
程を１サイクルとして、連続的に次バッチ以降の造粒を
行うことを特徴とする自動連続混合造粒方法。[Claims] (a) A series of devices is controlled by a sequencer and a personal computer, and a series of operations are automatically performed according to set conditions, and raw materials such as single powder and mixed powder are stored in a storage tank. (b) The raw material in the raw material weighing machine is fed to the raw material weighing machine in a set amount, and (b) the raw material in the raw material weighing machine is sent to the mixing granulation dryer, and based on the detection signal of the actual cut-out amount of this raw material, the above-mentioned control device is connected in advance by keying in. The set amount of agent is reset, and the required amount of binder corresponding to the amount of raw material cut out is automatically calculated, and this calculated amount of binder is supplied to the raw material in the mixing granulation dryer to reduce the amount of raw material. Granulation and drying are performed to obtain a granule product; (c) the obtained granule product is automatically discharged to a product storage tank or a product weighing machine, and the finished weight is automatically weighed; The granulation process for one batch is completed if the finished amount is within the permissible range set in advance and keyed in for one batch, or within the allowable range for the finished amount calculated in the control device from the actual supply amount of raw materials and binder. Finally, an automatic continuous mixing and granulation method characterized in that the above steps are considered as one cycle, and granulation of subsequent batches is continuously performed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27941386A JPS63134043A (en) | 1986-11-21 | 1986-11-21 | Automatic continuous mixing and granulating method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27941386A JPS63134043A (en) | 1986-11-21 | 1986-11-21 | Automatic continuous mixing and granulating method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63134043A true JPS63134043A (en) | 1988-06-06 |
| JPH0376178B2 JPH0376178B2 (en) | 1991-12-04 |
Family
ID=17610745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27941386A Granted JPS63134043A (en) | 1986-11-21 | 1986-11-21 | Automatic continuous mixing and granulating method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63134043A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6178430A (en) * | 1984-09-26 | 1986-04-22 | Fuji Paudaru Kk | Control method in granulation/coating apparatus |
-
1986
- 1986-11-21 JP JP27941386A patent/JPS63134043A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6178430A (en) * | 1984-09-26 | 1986-04-22 | Fuji Paudaru Kk | Control method in granulation/coating apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0376178B2 (en) | 1991-12-04 |
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| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |