WO1987007182A1

WO1987007182A1 - Apparatus for constant feeding and mixing of granular or powder materials

Info

Publication number: WO1987007182A1
Application number: PCT/JP1986/000264
Authority: WO
Inventors: Kiyoshi Morimoto; Masuo Moriyama
Original assignee: Kyowa Hakko Kogyo Co., Ltd.
Priority date: 1986-05-23
Filing date: 1986-05-23
Publication date: 1987-12-03
Also published as: EP0299065A4; EP0299065A1; KR880701131A

Abstract

Apparatus for automatic weighing, feeding and mixing of raw granular or powder materials, consisting of storage tanks for at least two different kinds of materials, means for weighing desired quantities of the raw materials from the storage tanks, means for discharging and transferring the weighed granular or powder materials into a mixing tank, a means for mixing the weighed granular or powder materials, and a means for holding a constant quantity of the resultant mixture, all of these means being integrally arranged.

Description

Technical Specification Field of quantitative supply and mixing equipment for powder and granules.

TECHNICAL FIELD The present invention relates to an apparatus for quantitatively supplying and mixing powders and granules. More particularly, the present invention relates to an apparatus capable of automatically mixing at least two types of raw material particles in a predetermined amount. By combining such a device with a tablet manufacturing machine or the like, it is possible to automatically and efficiently produce raw materials to tablets.

Background technology

In recent years, the range of application of compression molding or processing of various powders to tablets, forceps and the like has been expanding. For example, it is used not only for pharmaceutical tablets, but also for compression molded products such as foods, electronic parts, mechanical parts, and chemicals. This remarkable spread has the background that the value and function of each quality can be expected to be improved and improved by molding (solidifying) the granules.

Conventionally, there is a commercially available device that inserts one type of raw material into a hopper provided in a tableting machine and automatically compresses it. When two or more raw materials are used, they are mixed in advance and then put into a hopper and compressed.

However, no device has been developed that automatically mixes at least two types of raw materials at a fixed ratio and feeds them to the tablet press.

There are many problems with mixing different types of ingredients and automatically feeding them to the tablet press.

For example, when powders are compressed by a compression molding machine, different raw material powders are used as pre-processes, for example, in tablet molding, the main raw material powders and a lubricant (usually, an inorganic salt of stearate, talc, etc. Process to be used.

In the following, problems are explained in the case of manufacturing tablets for pharmaceuticals. Similar problems also occur in compression molding etc. in the field of

1 shows a general tablet manufacturing process.

① Wet tableting Raw material meter: Mixing Mixing, granulation, drying and sizing Lubricant mixing

(Main material + lubricant)

② Direct compression method Raw material meter: Lubricant mixed

(Main material + lubricant)

The purpose of mixing in these processes is mainly divided into the main component uniformity and the fact that the lubricant added to avoid problems in tablet manufacturing is mixed with other components uniformly. Is done. In the former, comparison is made by mixing before the tableting before mixing, that is, by mixing the active ingredient and excipients after the raw materials are weighed, or because it is homogenized in the next granulation step. There are few problems.

The latter, on the other hand, is based on the main raw material side granules formulated by a granulator, such as the drug (drug, excipient, binder, etc.), or the particles between ungranulated granules. By adding and mixing an appropriate amount of ①, the pressure transmission during compression molding is alleviated. 臼 The mortar filling is improved by increasing the fluidity of the powder, and the tablet characteristic values such as suppressing weight fluctuations are always uniform. ③ Improve the release of tablets from punches and reduce the friction coefficient of mortar wall during release The mixing operation before tableting has a very important role. In general, the type of mixer used here is a batch type with a rotating container (used for small quantities and many items, and the volume of the mixer = lot / batch size depending on the insertion rate). V type-double vertical type, square cubic type, horizontal cylindrical type, inclined cylindrical type. The mixing process using these batch mixers and the next process In the process of supplying the granules to the tableting machine, the following problems are raised.

1) Mixer installation space · Large space is required for mixing operation. 2) There are many parts that depend on workers, such as the supply and discharge of powder and granules to the mixer. (3) When the main raw material (granulated granules by a granulator, etc.) and a lubricant are mixed in batches, and the mixture is pneumatically transported to a tableting machine hopper, if the lubricant segregates and segregates, Poor quality in tablet quality due to variations in tablet weight in tablets, uneven drug content, capping, lamination, staying, reduced hardness, etc. The method of transporting the mixture to the process is limited, which hinders the continuous automation of the pre- and post-processes.

Most of the above problems will be solved if a device that automatically mixes and supplies at least two types of raw materials is developed.

Disclosure of the invention

The present invention relates to a storage tank for at least two different types of raw material powders, a device for measuring a desired amount of raw material powder from each storage tank, a device for discharging and moving the measured powder and granular material to a mixing tank, The present invention relates to a device for mixing powder and granules, and a device for automatically dispensing and dispensing powder and granules in which a container for holding a certain amount of the mixture is integrally provided (hereinafter referred to as the device of the present invention).

By integrating the device of the present invention with a compacting machine such as a tableting machine, a capsule filling machine, a granule sizing machine and the like, the whole device is compact and convenient for processing. It is a device that is easy to do. FIG. 1 shows an example in which two types of raw materials are used for an apparatus in which the apparatus of the present invention is combined with a tableting machine.

Although the present invention will be described in detail with reference to this figure, it is needless to say that the devices of the respective parts can be used in the present invention even if they are other devices having the same function.

The raw material storage tank (1) 3 contains one raw material powder and is supplied to the measuring vessel (1) 7 with the measuring device 8 via the electromagnetic feeder trough 5 by the electromagnetic feeder 16 Is done. Similarly, the powder material of the other raw material in the raw material storage tank (2) 16 is weighed by the electromagnetic feeder 18 through the electromagnetic feeder trough 17 and the measuring device 20 (2) Supplied to 19.

When a predetermined weight of raw material is supplied to each measuring container, the electromagnetic feeder stops via the measuring device.

It is confirmed by the weight setting comparator 26 that the raw material supplied to the weighing container has a predetermined weight within the set error range. When the measurement is confirmed, each raw material is sent to the mixer 11 by the raw material discharge on-off valve 10 or 2. -The presence or absence of particulate matter in each weighing container is confirmed by the weight setting comparator 26 via each weighing device or by the raw material discharge confirmation sensor 9 or 21 provided in each weighing container. You.

Then, the mixer stirring motor 13 of the mixer 11 operates to mix the raw materials by the stirring blade 14. After mixing for a certain period of time, until a predetermined amount is detected by the powder / particle detection sensor 24 provided in the container 23 for holding the powder / particle mixture via the powder / particle discharge on-off valve 15 The mixture is supplied to the powder-particle holding container with stirring, and the on-off valve 15 is stopped.

The mixture in the container for holding the granular material is supplied to a tableting machine via a suitable feeding device and tableted.

As the above valve, a valve, a shutter, or the like using electricity or compressed air can be used. Instead of the electromagnetic feeder, a screw feeder, a table feeder, etc. can be used. Also, An electromagnetic feeder, a screw feeder, a table feeder, or the like may be used in place of the raw material discharge on-off valve.

When supplying raw materials from one container to the next, a valve is convenient as a raw material transfer device if the containers are arranged in a vertical relationship, but if a small amount supply control is required, an electromagnetic feeder etc. Is preferred. .

These steps may be operated sequentially from st art, but steps that do not affect each other may be operated independently.

When operating sequentially, the timer can be set to control the time schedule so that the next process starts after confirming the end of the previous process, but it is possible to start each process using a computer. What is necessary is just to set up software so that the termination can be confirmed, and such a design is extremely easy for those skilled in the art. Automatically recording the weighed value in each process makes subsequent management easier. A circuit should be set up so that an alarm is issued when an abnormality occurs in each process and a part or the whole of the device is stopped.

An example of a system for automatically controlling the present invention device provided in a tableting machine will be described with reference to FIG.

(a) Put different kinds of raw materials in two raw material storage tanks _Q Raw material (1) is sent from a raw material storage tank 3 to a measuring vessel 7 by an electromagnetic feeder 6. The electromagnetic feeder 16 is activated when the amount of the mixture in the mixer becomes equal to or less than a predetermined amount and the powder volume detector 12 detects this. When the weight setting comparator confirms that the amount detected by the weighing device 8 is the preset amount, the electromagnetic loudspeaker 6 is stopped.

(b) When this stop is confirmed, the same process as in) is repeated, and the raw material (2) is supplied from the raw material storage tank (2) 16 to the measuring vessel 19.

(c) When the completion of the steps (a) and (b) is confirmed, the raw material discharge on-off valve 10 or 22 is activated and the raw material is sent to the mixer 11. When it is confirmed that no raw material remains in each measuring container, the valve is stopped.

(d) (c) When the end of the process is confirmed, the mixer stirring motor 13 is started, Stir for a certain time.

(e) After confirming that the motor has stopped, the on / off valve 15 for discharging the particulates operates to supply the mixture to the container 23 for retaining the particulates, and the amount predetermined by the particulate detection sensor 24 is used. When confirmed, the on-off valve stops. Also, this valve is controlled so as to stop while any of the steps (1) to (c) is operating.

The above control is one example, and various kinds of changes can be made, and such changes can be easily implemented by those skilled in the art.

When there are three or more different raw materials, the necessary number of sets of equipment necessary for the automatic supply of raw materials from the raw material container to the mixer are set in the equipment corresponding to the number of raw materials. You only need to incorporate it.

The device of the present invention can take various measures to simplify the attachment / detachment to / from the processing device in the subsequent process and to enable the entire device to be washed with water or the like. For example, as a measure against dust accumulation inside the container, the contact area between the powder and granules is treated with a special composite resin, and all corners are rounded to eliminate blind spots. A one-touch coupling is used for easy attachment / detachment of main parts. C All valves are sanitary type and easy to clean. Each detector, weighing unit, and bearing use part are made waterproof.

The outline of the test examples according to the present invention will be described below. Table 1 shows the names and amounts of raw materials for conducting the test, and Table 2 shows the characteristics of the granules obtained by granulating them with a fluid bed granulator and formulating them. Table 3 shows the conditions.

1

The main raw material granules were produced by spray granulation of an aqueous solution of HPC-L into a mixture of lactose and potato starch while heating using a fluid bed granulator.

Note): It means to remain on the sieve. P: means pass. Three

Test example 1.

In order to investigate the effects of the device of the present invention on the tablet characteristics such as the change in tablet weight over time, hardness, cabbing, sticking, etc., the behavior was controlled by interlocking with a tableting machine for a continuous 5 hours. Control 4 The main raw material powder and the lubricant shown in Table 1 were mixed at a ratio of 9: 1 for 5 minutes using a V-type mixer which is frequently used.

Table 4 shows the tablet characteristics in the case of processing by the V-type mixer and in the case of using the apparatus of the present invention.

Sampling 50 tablets every 30 minutes, and looking at the behavior for a total of 5 hours, showed better results than the V-type mixer in terms of weight variation and hardness. In both tests, neither cabbing nor staying was observed.

4 hours use V-type mixer

(Min) Average: Weight C V Average Weight Weight C V

(mg) (¾) (kg) (mg) (kg)

0 99.8 0.82 6.2 100.1 0.77 6.4 30 99.6 0.88 6.0 99.9 0.79 6.8 60 99.7 0.87 6.4 100. 0 0.73 6.6 90 100.2 0.90 5.6 100.1 0.73 6.6 120 99.5 0.96 6.6 99.80.75 6.2 150 100.4 0 99 5.4 99.9 0.72 6.8 180 100.4 0.98 6.2 100.2 0.76 6.0 210 99.9 0.88 6.2 100.1 0.74 6 2 240 99.7 0.91 5.4 100.2 0.74 6.4 270 100.5 0.98 5.8 100.1 0.74 6.4 300 99.8 0.88 6.2 99.8 0.76 6.4 τ 99.95 0.914 6.0 100.02 0.748 6.44 a 0.356 0.4.04.147 0.25

CV 0.356¾ 6.67% 0.147¾ 3.88¾

CV: Coefficient of variation / expressed by f x 100

f: average, and: standard deviation

Hardness: Measured with a Mont Saint hardness meter

Test example 2.

Of magnesium stearate contained in the tablets obtained in Test Example 1, magnesium was quantified by atomic absorption spectrometry, and the percentage of ownership by the V-type mixer treatment and the treatment with the present apparatus was determined. Compared. As shown in Table 5, the device of the present invention has a small mixing variation with time, and is advantageous in terms of content uniformity. number 5

Test example 3.

In addition to the tablet characteristics over time in Test Example 1, the tablet compression molding pressure and the release pressure from the die based on the degree of mixing of the lubricant were measured. Table 6 shows the results. Compared to the case of using a V-type mixer, the device of the present invention showed good pressure transmission, reduced the pressure during compression molding, and tended to decrease the tablet discharge pressure from the die wall. 6

The time required for disassembly, washing, and drying of the apparatus of the present invention was about 40 minutes, and it was confirmed that the apparatus could sufficiently withstand use.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 shows an example of a diagram in which the powdered and granular material quantitative supply mixing device according to the present invention is combined with a tableting machine. In the figure, the names of each part are as follows.

1: whole equipment, 2: raw material transport pipe, 3: raw material storage tank (1), 4: raw material detection sensor, 5: electromagnetic feeder trough (1), 6: electromagnetic feeder 1 (1) , 7: Measuring container (1), 8: Measuring device (1), 9: Raw material discharge confirmation sensor (1), 10: Open / close valve (1) for raw material discharge, 11: Blender, 12: Powder Body volume detector, 13: Mixer agitation motor, 14: Agitating blade, 15: On-off valve for discharging powder, 16: Raw material storage tank (2),

17 Electromagnetic feeder trough (2), 18: Electromagnetic feeder (2), 19: Measuring container (2). 20 Meter (2), 21: Material discharge confirmation sensor (2) , 22: Opening / closing valve for discharging raw materials (2) 23 Mixture holding container, 24: Powder detection sensor, 25: Drive motor, 26 Weight setting · Comparator, 27: Recorder, 28: Control box

Claims

The scope of the claims

1. A storage tank for at least two different types of raw material powders, a device that weighs the desired amount of raw material particles from each storage tank, a device that discharges and transfers the weighed powder material to the mixing tank, and each weighed powder An automatic powder and granule mixing and mixing device in which a device for mixing granules and a device for holding a certain amount of the mixture are integrated.

2. The apparatus for automatically supplying and dispensing powder and granules according to claim 1, wherein the apparatus for automatically supplying and dispensing powder and particles is combined with a compression molding apparatus or a processing apparatus.

3. The automatic quantitative supply and mixing device according to claim 2, wherein the compression molding device is a tableting machine.

4. The automatic quantitative supply and mixing device for powder and granules according to claim 2, wherein the processing device is a force press filling machine or a granule separating machine.

5. A device that weighs the desired amount of raw material particles from each storage tank is sent from each storage tank to the measuring container by an electromagnetic feeder, and when the amount of raw material in the container reaches a certain amount, measurement is performed. 2. The apparatus for automatically supplying and dispensing powder and granules according to claim 1, wherein the apparatus has a mechanism for stopping an electromagnetic feeder by a measuring device provided in a container.

6. The automatic powdery and granular material mixing apparatus according to claim 5, further comprising a mechanism for confirming that an amount supplied to the measuring container is a predetermined amount.

7. The granular material according to claim 5, further comprising a mechanism for confirming that substantially no raw material remains in the measuring container after the raw material in the measuring container is discharged to the mixer. Automatic metering and mixing equipment.

8. The automatic powder and granular material according to claim 1, further comprising a mechanism for automatically performing all processes from the supply of the raw material in the storage tank for the raw material to the device for holding a fixed amount of the mixture. Metering and mixing equipment.

9. The mixing apparatus according to claim 8, further comprising a mechanism for stopping a part or all of the apparatus when an abnormality occurs in the process.