CN86103541A - Mixer for quantitative feeding of granulous and powdery materials - Google Patents

Mixer for quantitative feeding of granulous and powdery materials Download PDF

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Publication number
CN86103541A
CN86103541A CN 86103541 CN86103541A CN86103541A CN 86103541 A CN86103541 A CN 86103541A CN 86103541 CN86103541 CN 86103541 CN 86103541 A CN86103541 A CN 86103541A CN 86103541 A CN86103541 A CN 86103541A
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Prior art keywords
powder body
raw material
storage tank
metering
measuring container
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CN 86103541
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Chinese (zh)
Inventor
森本清
森山圭雄
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KH Neochem Co Ltd
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Kyowa Hakko Kogyo Co Ltd
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Priority to CN 86103541 priority Critical patent/CN86103541A/en
Publication of CN86103541A publication Critical patent/CN86103541A/en
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Abstract

The invention relates to powder body automatic ration feed mixing arrangement.This device is to be fitted together by following array apparatus to constitute.That is: the storage tank of at least two kinds of different material powders of splendid attire body; From each storage tank, measure the metering device of the raw meal plastochondria of requirement; The powder body that is measured is discharged the device that moves to mixing channel; The device that mixes of powder body with metering respectively; And the device of storing a certain amount of mixture.

Description

Mixer for quantitative feeding of granulous and powdery materials
The invention relates to the quantitative feed mixing arrangement of powder body.
More particularly, be about can be automatically with at least two kinds of powder body raw materials, the device that mixes according to certain amount respectively.This device and tablet press machine etc. are used, can be automatically, efficiently raw material is made tablet.
In recent years, utilize the scope of application that compression forming or process technology are processed into tablet, capsule preparations to enlarge various powder bodies.For example, the tablet of medical supplies has certainly needless to say also adopted these technology even food, electronic component, machine components, chemicals etc. are compressed into the manufacturing of type article.What this processing method was so surprising popularize, and is to be background to utilize powder body formed (Gu type) change method, can expect to improve the quality of these products, to improve, improve its performance.
In the past, sold on the market be a kind of raw material is packed into be arranged in the hopper on the tablet press machine, the device of compressing tablet automatically.For the situation of two or more raw materials, the general employing in advance mixed these raw materials, and then with the method for carrying out film-making in its hopper of packing into.But, do not develop all the time at least two kinds of raw materials are automatically mixed according to certain ratio, and to the device of tablet press machine feed.
Different types of raw material is being mixed, and in the engineering reality of trend tablet press machine feed, existing many problems.
For example, in the engineering reality of utilizing compacting shape machine with the compression forming of powder body, as its preparatory process, form by following technical process, that is: will be not the powder body of homogeneous raw material, such as in the tablet moulding, be that main material powder body and lubricated polishing material (generally adopting stearic inorganic salts and talcum etc.) are mixed.
Below, the occasion of making at the tablet of medical supplies is illustrated relevant problem, still,, also can produce same problem for the compression forming of other field etc.
General tablet manufacture process can be expressed as follows:
1, wet method pressed disc method
Raw material metering-mixing-mixing granulation drying-whole grain-lubricated polishing material mixing-compressing tablet-coding-check-
(main material+lubricated polishing material)
2, direct compression process
Raw material metering-lubricated polishing material mixing-compressing tablet-
(main material+lubricated polishing material)
-coding-check
In these production processes, the main purpose of mixing roughly can be divided into the uniform content that makes main component, and makes the lubricated polishing material that adds for fear of some effect in the tablet manufacture process mix equal one or two kind with other compositions.For the former because before the mixing before the compressing tablet, i.e. carried out after the raw material metering main ingredient with the mixing of medicine, perhaps granulating working procedure has below been carried out the homogenization processing, so problem is fewer.
For the latter, in the powder body aspect the main material of having handled (main ingredient and medicine bond etc.) by comminutor, perhaps in the particle of the powder body of not granulation, suitably add and the mixed lubrication polishing material, its objective is: the pressure transmission when 1. managing to make compression forming is gentle; 2. manage to improve the flowability of powder body, make it have good die filling capacity, control weight change etc. are to keep tablet characteristic value homogeneous, steady quality all the time; 3. make tablet have good demolding performace, the coefficient of friction of the die wall when reducing its demoulding.Therefore, the married operation before the compressing tablet has important role.Usually, here the kind of employed mixer, the batch (-type) that mainly is the container rotation (is applicable to a small amount of, many kind, its production lot batch size is that the embedding rate size by the volume of mixer decides), it has V-type, the vertical pair of garden type, upright square, horizontal garden cartridge type, inclination garden cartridge type etc.
In the operation of utilizing these batch mixers to mix, and supply with in the operation of powder body, can exemplify out following point at the tablet press machine of downward one engineering.1. owing to mixer being installed, being carried out married operation, need very big space; 2. operations such as the feed of mixer, discharge, a lot of aspects all need to depend on the operator, and owing to reasons such as generation dust, working environment is can be not gratifying; 3. main material (utilizing the powder body after comminutor etc. carries out granulation) and lubricated polishing material carry out batch-mixed, with mixture in air when the tablet press machine hopper is carried, in case produce the separation segregation phenomena of lubricated polishing material, will cause phenomenons such as tablet deviation of weight in the compressing tablet, tablet content heterogeneity, top are split, layering, sticking, hardness reduction, quality problems occur; 4. owing to restriction, become the obstacle of operation continuous and automatic before and after realizing to powder body tablet press machine method for carrying; 5. since married operation to depend on the place of staff very big, thereby destroyed sealing, can produce the danger of sneaking into foreign matter.
If develop at least two kinds of automatic mixing feed devices of raw material, just can all address the above problem.
The invention relates to powder body automatic ration feed mixing arrangement (being designated hereinafter simply as apparatus of the present invention).This device comprises: the storage tank of at least two kinds of different types of raw meal plastochondrias of splendid attire; From each storage tank, measure the metering device of the raw meal plastochondria of required quantity; Make the powder body that is measured discharge mobile device to mixing channel; The device that mixed of powder body with metering respectively; The container that keeps a certain amount of mixture.
Compacting shape machines such as apparatus of the present invention and tablet press machine, capsule filling machine, particle are divided the processing device of powder bodies such as chartered plane combine, become compact conformation, be convenient to process, device easy to use.
An embodiment when Fig. 1 device that to be expression unite use with apparatus of the present invention and tablet press machine is used for two kinds of different materials.
Below, we describe the present invention in detail according to this figure, and still, the device with said function for other can certainly adopt the present invention.
In feed sump (1) 3, the powder body of a kind of raw material of having packed into utilizes electromagnetism feed appliance 6, by electromagnetism chute feeder 5 to measuring container (1) 7 feed that meter 8 is housed.Similarly, being contained in the another kind of raw meal plastochondria in the feed sump (2) 16, is by electromagnetism feed appliance 18, delivers in the measuring container (2) 19 that meter 20 is housed by electromagnetism chute feeder 17.
When the raw material of sending in each measuring container one reached predefined weight, by the effect of meter, the electromagnetism feed appliance just stopped feeding at once.
The raw material of sending into measuring container is predefined weight, is to set comparator 26 by weight to differentiate that it is whether within the error range of setting.In case it is accurately that metering is identified,, various raw materials are delivered to mixer 11 by discharging the controlled valve 10 or 22 that raw material is used.
Whether remaining in each measuring container have a powder body, is by each meter, utilizes weight to set comparator 26 or be installed in raw material on each measuring container and discharge and confirm that sensor 9 or 21 determines.
Then, the mixer stirring motor 13 of blender 11 is started working, and utilizes stirring vane 14 that raw material is mixed.Through after the mixing of certain hour, stir on one side, by powder body waste cock valve 15 mixture is delivered to powder body hold-up vessel 23 on one side.When the powder body detecting sensor 24 on the mixture storage container 23 that is arranged on the powder body detected the amount that reaches predetermined, this controlled valve 15 was just closed.
Mixture in the powder body hold-up vessel by suitable feeding device, is sent into the tablet press machine compressing tablet.
Above-mentioned valve can adopt and utilize electric power or the compressed air valve for power, instant shut-in valve etc.Also can utilize feeding screw, belt feeder etc. to replace the electromagnetism feed appliance.And, the controlled valve that can also utilize the above-mentioned discharge raw materials of replacement such as electromagnetism feed appliance, feeding screw, belt feeder to use.
Raw material when a container is sent into another container, is installed if each container is pressed the upper-lower position relation, and as mobile former materials device, valve is eaily.And in the time the raw material of sending into need being carried out trace control, adopt electromagnetism feed appliance etc., can obtain gratifying effect.
These operations can be started in turn since first procedure, but for there not being interactional operation, also can work alone.
When starting in turn, finish in order to ensure a last operation, subsequent processing is started working again, though can utilize timer to come setting-up time to control,, preferably arrangement software utilizes microcomputer to determine the beginning and the end of each operation.This design for the people who is engaged in this work, is extremely to be easy to thing.If can write down the variable of each operation automatically, later management work also can become and be easy to.Safety return circuit preferably is set, when each operation notes abnormalities phenomenon, gives the alarm, and the part that will install and even all quit work.
When raw material different more than three kinds or three kinds, in order automatically raw material to be delivered to the mixer from material container, only need will be identical with the raw material type number one group of corresponding machine enroll in the device and get final product.
In apparatus of the present invention, oversimplify for the loading and unloading that make the processing device feeding of operation rearwards, realize utilizing the whole devices of cleaning such as water, can in device, adopt various methods and measure.For example,, taked following measures, that is, utilize special compound resin to carry out skin covering of the surface for contact site and handle, and the angle, garden all has been processed into to remove the dead angle in corner with the powder body at the powder agglomates that is trapped in the container.For making the loading and unloading of main position easy, all adopt disposable connection.Valve type is health class material, is convenient to clean up; Each detection means and metering section use the place of bearing to adopt measures such as waterproof construction.
Below, introduce the summary of experimental example of the present invention.At first, in table 1, the material name and the degree thereof that are used to test have been introduced; Then in table 2, introduced the characteristic of these raw materials through the powder body after fluidized bed pelletizer granulation, the preparation; Table 3 has been introduced the operating condition of tablet press machine.
Table 1
Figure 86103541_IMG1
Main material powder body is to utilize fluidized bed pelletizer, and with the aqueous solution of HPC-L and the mixture of lactose and farina, mist projection granulating is made under the condition of heating.
Table 2
Figure 86103541_IMG2
Annotate) ON: expression remains on the sieve;
P: expression is by (Pass).
Table 3
Figure 86103541_IMG3
Test example 1:
In order to examine or check the influence of apparatus of the present invention, this device and tablet press machine interlock control used in continuous 5 hours, and observe its working condition tablet characteristics such as the variation of tablet weight in a period of time, hardness, layering, stickings.As a comparison, adopt the V-Mixer of general frequent use, main material powder body shown in the table 1 and lubricated polishing material were mixed 5 minutes with 99: 1 ratio.
In the table 4, exemplified when utilizing V-Mixer to handle respectively and the tablet characteristic under two kinds of conditions when using this device.
Take 50 of samplings in per 30 minutes, observed continuously 5 hours, obtained aspect deviation of weight, hardness, to surpass the good result that V-Mixer is processed the tablet of handling.And, in these two experiments, all do not find to produce layering, stuck phenomenon.
Table 4
CV: coefficient of alteration, with σ/X * 100 expressions
X: mean value; σ: standard deviation
Hardness: utilize Meng Sangtuo (Moh santo) tablet hardometer to measure
Test example 2:
Utilize atomic absorption method, analyze in above-mentioned experimental example 1 in the resulting tablet content of magnesium in the contained dolomol quantitatively, the containing ratio that V-Mixer processing and apparatus of the present invention are processed in the resulting tablet compares.As shown in table 5, the mix deviations of apparatus of the present invention in a period of time are little, also are favourable aspect content uniformity.
Test example 3:
In the tablet characteristic, also measured difference in a period of time in measuring above-mentioned test example 1, the variation of the compression forming pressure and the ejection pressure of emitting from die according to lubricated polishing material degree of mixing.Introduced measurement result in the table 6.Therefrom can see, use the situation of V-Mixer relatively, apparatus of the present invention be because the effect of internal lubrication gloss can be transmitted pressure preferably, thus the pressure when having reduced compression forming, and then the tablet ejection pressure also can reduce from the die wall.
Table 6
Figure 86103541_IMG6
And the needed time of drying is cleaned in the dismounting of apparatus of the present invention, is approximately 40 minutes, can be sure of that apparatus of the present invention are very durable.
Fig. 1 represents in the present invention, with one of the structure chart that fits together about mixer for quantitative feeding of granulous and powdery materials and tablet press machine example.The each several part title is as follows among the figure:
1: device is whole; 2: the feed line road; 3: feed sump (1); 4: the raw material detecting sensor; 5: electromagnetism feeding groove (1); 6: electromagnetism feed appliance (1); 7: measuring container (1); 8: meter (1); 9: confirm raw material discharge sensor (1); 10: discharge raw material switch valve (1); 11: mixer; 12: powder body capacity check device; 13: the mixer stirring motor; 14: stirring vane; 15: discharge powder body and function switch valve; 16: feed sump (2); 17: electromagnetism feeding groove (2); 18: electromagnetism feed appliance (2); 19: measuring container (2); 20: meter (2); 21: confirm raw material discharge sensor (2); 22: discharge raw material switch valve (2); 23: mixture is stored container; 24: the powder body detecting sensor; 25: CD-ROM drive motor; 26: weight is set comparator; 27: logger; 28: control cabinet.

Claims (9)

1, powder body automatic ration feed mixing arrangement.It is characterized in that fitting together and constitute, that is: the storage tank of at least two kinds of different material powders of splendid attire body by following array apparatus; Measure the metering device of the raw meal plastochondria of requirement from each storage tank; The powder body that is measured is discharged the device that moves to mixing channel; With the device that mixes of powder body of metering respectively, and the device of storing a certain amount of mixture.
2, device according to claim 1 is characterized in that: powder body automatic ration feed mixing arrangement and compression-molding apparatus, processing device are fitted together.
3, device according to claim 2 is characterized in that: compression-molding apparatus is a tablet press machine.
4, device according to claim 2 is characterized in that: processing device is that capsule filling machine or particle divide chartered plane.
5, device according to claim 1, it is characterized in that: on the metering device of the needed raw meal plastochondria of metering from each storage tank, the device of following controlling organization is housed, that is: by the electromagnetism feed appliance powder body is delivered to measuring container from each storage tank, when the raw material in this container reaches a certain amount of, be arranged on the meter on the measuring container, the electromagnetism feed appliance is quit work.
6, device according to claim 5 is characterized in that: having the material quantity that affirmation supplies with to this measuring container is the device of the mechanism of predefined amount.
7, device according to claim 5 is characterized in that: have the raw material confirmed in this measuring container after mixer is discharged, the no longer residual device that the mechanism of raw material is arranged in this measuring container.
8, device according to claim 1 is characterized in that: have the raw material that can make from raw meal plastochondria storage tank, realize the device of the mechanism of automation to whole courses of work of mixture being delivered to the quantitative storage container of mixture.
9, device according to claim 8 is characterized in that: when producing abnormal conditions in the course of the work, one of just must install the device of portion or whole out-of-work mechanisms.
CN 86103541 1986-05-28 1986-05-28 Mixer for quantitative feeding of granulous and powdery materials Pending CN86103541A (en)

Priority Applications (1)

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CN 86103541 CN86103541A (en) 1986-05-28 1986-05-28 Mixer for quantitative feeding of granulous and powdery materials

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Application Number Priority Date Filing Date Title
CN 86103541 CN86103541A (en) 1986-05-28 1986-05-28 Mixer for quantitative feeding of granulous and powdery materials

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CN86103541A true CN86103541A (en) 1987-12-09

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CN 86103541 Pending CN86103541A (en) 1986-05-28 1986-05-28 Mixer for quantitative feeding of granulous and powdery materials

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102670000A (en) * 2011-03-15 2012-09-19 株式会社Jvm Medicine feeding apparatus
CN104857888A (en) * 2015-05-20 2015-08-26 卓达新材料科技集团有限公司 Automatic batching system
CN105030539A (en) * 2015-05-25 2015-11-11 绍兴海邦药业有限公司 Fully-automatic and quantitative capsule filling machine
CN106036428A (en) * 2016-06-29 2016-10-26 哈尔滨华藻生物科技开发有限公司 Production and conveying device of spirulina flour
CN108407376A (en) * 2013-06-27 2018-08-17 Gea工艺工程有限公司 For the quantity-produced method of tablet, the purposes of sheeting system and sheeting system
CN113698070A (en) * 2021-08-09 2021-11-26 郑州旭飞光电科技有限公司 Mixing device for glass batch

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102670000A (en) * 2011-03-15 2012-09-19 株式会社Jvm Medicine feeding apparatus
CN108407376A (en) * 2013-06-27 2018-08-17 Gea工艺工程有限公司 For the quantity-produced method of tablet, the purposes of sheeting system and sheeting system
CN104857888A (en) * 2015-05-20 2015-08-26 卓达新材料科技集团有限公司 Automatic batching system
CN105030539A (en) * 2015-05-25 2015-11-11 绍兴海邦药业有限公司 Fully-automatic and quantitative capsule filling machine
CN106036428A (en) * 2016-06-29 2016-10-26 哈尔滨华藻生物科技开发有限公司 Production and conveying device of spirulina flour
CN113698070A (en) * 2021-08-09 2021-11-26 郑州旭飞光电科技有限公司 Mixing device for glass batch

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