CN214105230U - Continuous production equipment for traditional Chinese medicine solid preparation - Google Patents
Continuous production equipment for traditional Chinese medicine solid preparation Download PDFInfo
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- CN214105230U CN214105230U CN202020948412.9U CN202020948412U CN214105230U CN 214105230 U CN214105230 U CN 214105230U CN 202020948412 U CN202020948412 U CN 202020948412U CN 214105230 U CN214105230 U CN 214105230U
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Abstract
The utility model discloses a traditional chinese medicine solid preparation serialization production facility, characterized by: comprises a feeding station, an automatic batching system, a horizontal continuous granulating dryer, a granulating machine, an auxiliary material temporary storage tank, a continuous mixer, a tablet press, a capsule filling machine, a granule packaging machine and a continuous coating machine; the system can monitor the state of materials in production in real time, such as moisture, content, particle size and the like in the granulation process; mixing uniformity in the mixing process; tablet weight, hardness, size during tabletting; coating in-process capsule thickness etc. data's on-line measuring, according to the data that detect, form the closed loop, adjust the parameter of corresponding equipment, realize serialization, intelligent production to ensure that the quality is qualified, adopt the utility model discloses a serialization production facility can reduce the transportation of material, buffer memory, improves dust scheduling problem in the production, improves production efficiency.
Description
Technical Field
The utility model relates to a pharmaceutical production preparation technical field, in particular to traditional chinese medicine solid preparation serialization production facility.
Background
The production of the traditional Chinese medicine solid preparation usually comprises the procedures of dosing, granulating, mixing, tabletting, coating and the like, and the prior art has a plurality of defects in the aspects of application of continuous equipment, real-time state and end point judgment of materials, intelligent control of the equipment, transfer between the equipment and the like in each procedure, firstly, the continuous production equipment cannot be used, secondly, no data guidance is provided for the real-time state and end point judgment of the materials in the production process, and in addition, the problems of large dust amount, large temporary storage space, low efficiency and the like exist in the transfer between the procedures. Therefore, it is necessary to provide a new technical solution to improve the existing production state, improve the continuity and intelligence of production, and improve the production efficiency.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a traditional chinese medicine solid preparation serialization production facility.
The above technical purpose of the present invention can be achieved by the following technical solutions:
a continuous production device of a traditional Chinese medicine solid preparation is characterized in that: comprises a feeding station, an automatic batching system, a horizontal continuous granulating dryer, a granulating machine, an auxiliary material temporary storage tank, a continuous mixer, a tablet press, a capsule filling machine, a granule packaging machine and a continuous coating machine; the feeding station is connected with a vacuum feeder six arranged on an automatic batching system through a pipeline, the discharge port of the automatic batching system is connected with a vacuum feeder five arranged on a horizontal continuous granulating drier through a pipeline, a gas type air inlet system two, a dust removing device two and an exhaust fan two are arranged on the horizontal continuous granulating drier, the discharge port of the horizontal continuous granulating drier is connected with the feed port of a granulating machine, the outlet of the granulating machine and the outlet of an auxiliary material temporary storage tank are connected with a vacuum feeder four arranged on a continuous mixer through pipelines, the discharge port of the continuous granulating drier is respectively connected with a vacuum feeder one arranged on a tablet press, a vacuum feeder two arranged on a capsule filling machine and a vacuum feeder three arranged on a particle packing machine through pipelines, and is preferred, and a material conveying device is arranged at the bottom of the discharge port of the tablet press, the terminal of the material conveying device is connected with the feeding hole of the cache charging barrel, the discharging hole of the cache charging barrel is connected with the continuous coating machine through the conveying device, and the continuous coating machine is provided with a gas type air inlet system I, a first dust removing device I and a first air exhaust fan I.
Wherein, the working principle of the horizontal continuous granulating drier is as follows: the method comprises the steps of performing primary-effect filtration and intermediate-effect filtration on two pairs of air through a gas type air inlet system, heating to a target temperature (for example, 90-120 ℃) by using a gas type air heater, enabling the heated air to reach a cleaning requirement through a high-efficiency filter, enabling the heated air to enter equipment from the bottom of a horizontal continuous granulation dryer to enable materials to be in a fluidized state, enabling a plurality of adhesive spray guns on the upper portion of the horizontal continuous granulation dryer to start spraying liquid, enabling particles to polymerize, meeting the requirements of required moisture and particle size under the action of hot air, and enabling exhaust air to reach two pairs of exhaust air purification of a dust removal device from the upper portion of the equipment through a pipeline and then to be discharged outdoors.
Further, the automatic blending system includes a jar and a plurality of material storage tank of keeping in, the jar of keeping in is installed in the bottom of a plurality of material storage tanks, and the discharge gate of the jar bottom of keeping in passes through the pipeline and installs the three connections of glassware on the vacuum on the whole grain machine, and wherein the quantity of material storage tank can be selected according to the quantity that the kind of production medicine corresponds required raw materials.
Furthermore, a first near-infrared online detection device is installed in the continuous horizontal continuous granulating dryer, and the first near-infrared online detection device is used for monitoring the moisture, content, particle size and the like of particles in the granulating process in real time on line and controlling parameters such as air quantity, temperature, liquid spraying amount and the like of the granulator of the horizontal continuous granulating dryer according to data feedback.
Further, near-infrared online detection equipment II is installed at the position, close to the discharge port, of the inner cavity of the continuous mixer, and the near-infrared online detection equipment II is installed at the position, close to the discharge port, so that qualified discharge medicines can enter the next procedure.
Furthermore, online tablet detecting equipment is installed on a discharge port of the tablet press, and the online tablet detecting equipment (the Checkmaster of the company fiett) detects the weight, hardness and size of the tablets and controls the adjustment of parameters such as filling amount and pressure of the tablet press according to data feedback.
Furthermore, a third near-infrared online detection device is installed inside the continuous coating machine, the third near-infrared online detection device monitors the coating thickness in real time on line in the coating process and controls the adjustment of parameters such as air quantity, temperature and liquid spraying quantity of the continuous coating machine according to data feedback, and the like, so that the finished product of the tablet product is finished.
Preferably, the near-infrared online detection device adopts the following specifications (the specifications of the device can be adopted: micro NIR PAT-W/PAT-U/OnSite-W of VIAVI company, USA; DA7440 of Sweden wave-communication company; Antaris MX of Sammer fly company, GSA101/102/103 of Shandong gold jade-ingot Reinforcement Intelligent technology Limited liability company), and the operating principle of the near-infrared online detection device is as follows: the near infrared device light source irradiates on the detected material to generate diffuse reflection effect, the reflected light returns to the device, the energy of chemical bonds of different detected substances is different, the reflected near infrared spectra are different, the spectra and laboratory detection data are related by a mathematical method to form a mathematical model, and the mathematical model can be used for detecting the moisture, content, particle size, mixing uniformity, coating thickness and the like of particles.
To sum up, the utility model discloses following beneficial effect has:
1. by adopting the continuous production equipment of the utility model, the transfer and buffer storage of materials can be reduced, the problems of dust and the like in production can be improved, and the production efficiency can be improved;
2. monitoring the state of the materials in production in real time, such as moisture, content, particle size and the like in the granulation process; mixing uniformity in the mixing process; tablet weight, hardness, size during tabletting; and in the coating process, the online detection of the data such as the coating thickness and the like forms a closed loop according to the detected data, adjusts the parameters of corresponding equipment, realizes continuous and intelligent production and ensures that the quality is qualified.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the connection structure between the feeding station and the automatic batching system of the present invention;
FIG. 3 is a schematic view of the connection structure of the horizontal continuous granulating dryer, the granulator and the auxiliary material temporary storage tank of the present invention;
FIG. 4 is a schematic structural view of a continuous mixer portion of the present invention;
FIG. 5 is a schematic diagram of the tablet press, capsule filling machine, pellet wrapping machine and continuous coater portions of the present invention;
in the figure, 1 a feeding station, 2 a temporary storage tank, 3 a horizontal continuous granulating dryer, 4 a first near-infrared online detection device, 5 a granulator, 6 an auxiliary material temporary storage tank, 7 a continuous mixer, 8 a second near-infrared online detection device, 9a tablet press, 10 a capsule filling machine, 11 a granule packaging machine, 12 a tablet online detection device, 13 a buffer storage barrel, 14 a continuous coating machine, 15 a third near-infrared online detection device, 16 a first exhaust fan, 17 a first dust removal device, 18 a gas type air inlet system, 19a first vacuum material loading device, 19b second vacuum material loading device, 19c third vacuum material loading device, 20 a fourth vacuum material loading device, 21 a second exhaust fan, 22 a second dust removal device, 23 a fifth vacuum material loading device, 24 a second gas type air inlet system, 25 material storage tank and 26 a sixth vacuum material loading device.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in fig. 1-5, a continuous production apparatus for solid traditional Chinese medicine preparations comprises a feeding station 1, an automatic batching system, a horizontal continuous granulating dryer 3, a granulating machine 5, an auxiliary material temporary storage tank 6, a continuous mixer 7, a tabletting machine 9, a capsule filling machine 10, a granule packaging machine 11 and a continuous coating machine 14; the feeding station 1 is connected with a vacuum feeder six 26 arranged on an automatic batching system through a pipeline, a discharge port of the automatic batching system is connected with a vacuum feeder five 23 arranged on a horizontal continuous granulating drier 3 through a pipeline, the horizontal continuous granulating drier 3 is provided with a gas type air inlet system two 24, a dust removing device two 22 and an exhaust fan two 21, the discharge port of the horizontal continuous granulating drier 3 is connected with a feed port of a granulating machine 5, an outlet of the granulating machine 5 and an outlet of an auxiliary material temporary storage tank 6 are connected with a vacuum feeder four 20 arranged on a continuous mixer 7 through pipelines, a discharge port of the continuous mixer 7 is respectively connected with a vacuum feeder one 19a arranged on a tablet press 9, a vacuum feeder two 19b arranged on a capsule filling machine 10 and a vacuum feeder three 19c arranged on a particle packing machine 11 through pipelines, preferably, a material conveying device is installed at the bottom of a discharge port of the tablet press 9, the terminal of the material conveying device is connected with a feed port of a cache charging barrel 13, the discharge port of the cache charging barrel 13 is connected with a continuous coating machine 14 through a conveying device, and a gas type air inlet system 18, a first dust removing device 17 and a first exhaust fan 16 are installed on the continuous coating machine 14.
Wherein, the above-mentioned 3 theory of operation of horizontal continuous granulation desiccator: the air is primarily filtered and intermediately filtered through a gas type air inlet system II 24, the air is heated to a target temperature (for example, 90-120 ℃) in a gas type, the heated air reaches a cleaning requirement through a high-efficiency filter, the air enters the equipment from the bottom of the horizontal continuous granulating dryer to enable the materials to be in a fluidized state, a plurality of adhesive spray guns on the upper portion of the horizontal continuous granulating dryer 3 start spraying liquid to polymerize particles, the required moisture and particle size requirements are met under the action of hot air, and exhaust air reaches the dust removal equipment II 22 from the upper portion of the equipment through a pipeline and is discharged out of the room after being purified.
Further, automatic blending system includes a jar 2 and a plurality of material storage tank 25 of keeping in, jar 2 of keeping in is installed in the bottom of a plurality of material storage tanks 25, and the discharge gate of jar 2 bottoms of keeping in passes through the pipeline and is connected with the three 19c of glassware in the vacuum of installing on whole grain machine 5, and wherein the quantity of material storage tank 25 can be selected according to the quantity that the kind of production medicine corresponds required raw materials.
Further, a near-infrared online detection device I4 is installed in the continuous horizontal continuous granulating dryer 3, and the near-infrared online detection device I4 controls parameters such as air quantity, temperature and liquid spraying quantity of the horizontal continuous granulating dryer granulator to adjust through online real-time monitoring on particle moisture, content and particle size in the granulating process and according to data feedback control.
Further, a second near-infrared online detection device 8 is installed at a position, close to the discharge port, of the inner cavity of the continuous mixer 7, and the second near-infrared online detection device 8 is installed at a position, close to the discharge port, so that qualified discharged medicines can enter a next procedure.
Further, a tablet online detection device 12 is installed at a discharge port of the tablet press machine 9, the online detection device 12, preferably, the online detection device 12 adopts a Checkmaster of the fiett company), the weight, hardness and size of the tablet are detected through the online detection device 12, and the adjustment of parameters such as filling amount and pressure of the tablet press machine is controlled according to data feedback.
Further, a third near-infrared online detection device 15 is installed inside the continuous coating machine 14, the third near-infrared online detection device 15 monitors the coating thickness in the coating process in real time in an online manner, and controls parameters of the continuous coating machine such as air quantity, temperature and liquid spraying amount to be adjusted according to data feedback, so that the finished product of the tablet product is finished.
Preferably, the near-infrared online detection device adopts the following specifications (the specifications of the device can be adopted: micro NIR PAT-W/PAT-U/OnSite-W of VIAVI company, USA; DA7440 of Sweden wave-communication company; Antaris MX of Sammer fly company, GSA101/102/103 of Shandong gold jade-ingot Reinforcement Intelligent technology Limited liability company), and the operating principle of the near-infrared online detection device is as follows: the near infrared device light source irradiates on the detected material to generate diffuse reflection effect, the reflected light returns to the device, the energy of chemical bonds of different detected substances is different, the reflected near infrared spectra are different, the spectra and laboratory detection data are related by a mathematical method to form a mathematical model, and the mathematical model can be used for detecting the moisture, content, particle size, mixing uniformity, coating thickness and the like of particles.
The working process is as follows: according to the continuous production technology of the traditional Chinese medicine solid preparation, raw materials are conveyed to a material storage tank 25 in an automatic batching system under the action of a vacuum feeder six 26 through a feeding station 1 and a pipeline, the prepared materials are conveyed to a horizontal continuous granulating and drying machine granulator 3 under the action of a vacuum feeder five 23 through a pipeline from a temporary storage tank 2, a near infrared online detection device 4 is additionally arranged on the horizontal continuous granulating and drying machine granulator 3, the near infrared online detection device 4 monitors the moisture, the content, the particle size and the like of particles in a granulating process in an online real-time mode, and the air volume, the temperature, the liquid spraying amount and other parameters of the horizontal continuous granulating and drying machine granulator are controlled according to data feedback.
The prepared granules are granulated by a granulator 5, qualified granules are conveyed to a continuous mixer 7 under the action of a vacuum feeder 20 through a pipeline, other auxiliary materials are conveyed to the continuous mixer 7 from an auxiliary material temporary storage tank 6, near-infrared online detection equipment 8 is additionally arranged on the continuous mixer 7, the near-infrared online detection equipment 8 is used for monitoring the mixing uniformity in the mixing process in real time on line and controlling the mixing speed, mixing time and other parameters of the continuous mixer to be adjusted according to data feedback, the mixed qualified materials are conveyed to a tablet press 9 (or the mixed qualified materials can be conveyed to a capsule filling machine 10 or a granule packing machine 11 to complete production of capsule products or granule products) under the action of a vacuum feeder 19 through a pipeline, and the online detection equipment 12 is arranged beside the tablet press for detecting the weight, hardness and size of the tablets. According to the data feedback control tablet press filling amount, pressure and other parameter adjustment, qualified tablets are conveyed to a continuous coating machine 14 through a conveying belt and a cache charging barrel 13, the cache charging barrel plays a role in prolonging cache time and releasing stress of plain tablets, a near infrared online detection device 15 is additionally arranged on the continuous coating machine 14, the near infrared online detection device 15 monitors the coating thickness in the coating process in an online and real-time mode and controls the continuous coating machine air volume, temperature, liquid spraying amount and other parameter adjustment according to the data feedback control, and therefore the finished product of the tablets is finished.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications to the present embodiment without inventive contribution as required after reading the present specification, but all of them are protected by patent laws within the scope of the claims of the present invention.
Claims (6)
1. A continuous production device of a traditional Chinese medicine solid preparation is characterized in that: comprises a feeding station (1), an automatic batching system, a horizontal continuous granulating dryer (3), a granulating machine (5), an auxiliary material temporary storage tank (6), a continuous mixer (7), a tablet press (9), a capsule filling machine (10), a granule packaging machine (11) and a continuous coating machine (14); the feeding station (1) is connected with six vacuum feeders (26) installed on an automatic batching system through a pipeline, a discharge port of the automatic batching system is connected with five vacuum feeders (23) installed on a horizontal continuous granulating dryer (3) through a pipeline, a gas type air inlet system II (24), a dust removing device II (22) and an exhaust fan II (21) are installed on the horizontal continuous granulating dryer (3), a discharge port of the horizontal continuous granulating dryer (3) is connected with a feed inlet of a granulating machine (5), outlets of the granulating machine (5) and outlets of auxiliary material temporary storage tanks (6) are connected with four vacuum feeders (20) installed on a continuous mixer (7) through pipelines, and a discharge port of the continuous mixer (7) is respectively connected with a first vacuum feeder (19 a) installed on a tablet press (9), a second vacuum feeder (19 b) installed on a capsule filling machine (10) and a particle packing machine (2) 11) On the vacuum loading device (19 c), a material conveying device is installed at the bottom of a discharge hole of the tablet press (9), the terminal of the material conveying device is connected with a feed inlet of a cache charging barrel (13), the discharge hole of the cache charging barrel (13) is connected with a continuous coating machine (14) through a conveying device, and a gas type air inlet system (18), a dust removing device (17) and an air exhaust fan (16) are installed on the continuous coating machine (14).
2. The continuous production equipment of the solid traditional Chinese medicine preparation, according to claim 1, is characterized in that: the automatic batching system comprises a temporary storage tank (2) and a plurality of material storage tanks (25), the temporary storage tank (2) is installed at the bottoms of the material storage tanks (25), and a discharge port at the bottom of the temporary storage tank (2) is connected with a vacuum feeder (19 c) installed on a granulating machine (5) through a pipeline.
3. The continuous production equipment of the solid traditional Chinese medicine preparation, according to claim 2, is characterized in that: and a first near-infrared online detection device (4) is arranged in the continuous horizontal continuous granulating dryer (3).
4. The continuous production equipment of the solid traditional Chinese medicine preparation, according to claim 3, is characterized in that: and a second near-infrared online detection device (8) is arranged at the position, close to the discharge hole, of the inner cavity of the continuous mixer (7).
5. The continuous production equipment of the solid traditional Chinese medicine preparation, according to claim 4, is characterized in that: and a discharge port of the tablet press (9) is provided with tablet on-line detection equipment (12).
6. The continuous production equipment of the solid traditional Chinese medicine preparation, according to claim 5, is characterized in that: and a third near-infrared online detection device (15) is arranged in the continuous coating machine (14).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113730249A (en) * | 2020-05-29 | 2021-12-03 | 江中药业股份有限公司 | Continuous production method and equipment for traditional Chinese medicine solid preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113730249A (en) * | 2020-05-29 | 2021-12-03 | 江中药业股份有限公司 | Continuous production method and equipment for traditional Chinese medicine solid preparation |
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