CN216318879U - Traditional chinese medicine serialization wet granulation system - Google Patents

Traditional chinese medicine serialization wet granulation system Download PDF

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Publication number
CN216318879U
CN216318879U CN202121185007.7U CN202121185007U CN216318879U CN 216318879 U CN216318879 U CN 216318879U CN 202121185007 U CN202121185007 U CN 202121185007U CN 216318879 U CN216318879 U CN 216318879U
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China
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equipment
traditional chinese
chinese medicine
particle
wet granulation
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刘振峰
周友华
赖小锋
易小禄
赖勇
夏国民
熊洪峰
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Yichun Wanshen Intelligent Equipment Co ltd
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Yichun Wanshen Pharmaceutical Machinery Co Ltd
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Abstract

The utility model provides a continuous wet granulation system for traditional Chinese medicines, which comprises a feeding assembly for forming continuous granulation, material mixing equipment, a wet granulation mechanism, particle screening equipment and particle subpackaging equipment, wherein the feeding assembly is used for feeding the materials; further comprising: the material uniformity inspection equipment is used for inspecting the uniformity of the mixed material obtained by mixing the materials by the material mixing equipment; and the particle parameter checking equipment is used for checking the parameters of the traditional Chinese medicine particles prepared by the wet granulation mechanism. By adopting continuous production equipment, the utility model can reduce the transfer and buffer of materials, realize continuous production, improve the problems of dust and the like in production and improve the production efficiency; in addition, the key position is also provided with an inspection device to monitor the state of the material in production in real time, so that closed-loop control can be formed by feeding back the detected data, thereby effectively adjusting the parameters of the corresponding equipment, realizing continuous and intelligent production and ensuring qualified quality.

Description

Traditional chinese medicine serialization wet granulation system
Technical Field
The utility model relates to the technical field of pharmacy, in particular to a traditional Chinese medicine continuous wet granulation system.
Background
The production process of the traditional Chinese medicine granules generally needs to carry out the working procedures of material preparation, mixing, wet granulation, granule finishing, drying, subpackaging and the like. However, in the prior art, the current processes are independent from each other and cannot be granulated continuously, so that the problems of large dust amount, large temporary storage space, low efficiency, large labor intensity and the like caused by the need of transferring materials among the processes are solved; in addition, currently, no data guidance is provided for judging the real-time state and the end point of the material in the production process.
SUMMERY OF THE UTILITY MODEL
Based on the above, the utility model aims to provide a continuous wet granulation system for traditional Chinese medicines, so as to solve the technical problem of low granulation efficiency of the traditional Chinese medicines.
According to the embodiment of the utility model, the continuous wet granulation system for the traditional Chinese medicine comprises:
a plurality of feeding assemblies, wherein each feeding assembly is correspondingly supplied with one material;
the feed inlet of the material mixing equipment is connected with each feeding assembly so as to receive the materials fed by the feeding assemblies and stir the materials;
the wet granulation mechanism is connected with the discharge port of the material mixing equipment to receive the mixed material obtained by mixing the material mixing equipment and perform wet granulation;
the particle screening equipment is connected with a discharge hole of the wet granulator and is used for receiving and screening the traditional Chinese medicine particles prepared by the wet granulator;
the particle subpackaging equipment is connected with the particle screening equipment and is used for subpackaging the qualified traditional Chinese medicine particles screened by the particle screening equipment;
the material uniformity inspection equipment is arranged on a discharge port of the material mixing equipment and is used for inspecting the uniformity of mixed materials obtained by mixing the materials by the material mixing equipment;
and the particle parameter checking equipment is arranged on the wet granulation mechanism and is used for checking the parameters of the traditional Chinese medicine particles prepared by the wet granulation mechanism.
Further, the wet granulation mechanism comprises a wet granulator, a rotary granulator and a particle drying device which are connected in sequence;
the feed inlet of wet granulator is connected the discharge gate of material mixing equipment, the discharge gate of granule drying equipment is connected the feed inlet of granule screening equipment.
Further, the feed assembly comprises:
a dust-free feeding station;
the first temporary storage bin is connected with the dust-free feeding station;
the vacuum feeding machine is connected with the first temporary storage bin and is used for sucking materials thrown by the dust-free feeding station into the first temporary storage bin;
and a feed port of the automatic feeding machine is connected with a discharge port of the first temporary storage bin, and a discharge port of the automatic feeding machine is connected with a feed port of the material mixing equipment.
Further, the feeding assembly further comprises a second temporary storage bin, and a discharge hole of the automatic feeder is connected with a feed inlet of the material mixing device through the second temporary storage bin.
Further, the continuous wet granulation system for traditional Chinese medicines further comprises a first support frame and a second support frame positioned above the first support frame;
the feeding assembly and the material mixing equipment are fixedly arranged on the second support frame, and the wet granulator, the particle screening equipment and the particle subpackaging equipment are fixedly arranged on the first support frame.
Further, the particle screening device comprises a first outlet for discharging qualified traditional Chinese medicine particles and a second outlet for discharging unqualified traditional Chinese medicine particles;
the first outlet of the particle screening device is connected with the particle subpackaging device;
the traditional Chinese medicine continuous wet granulation system further comprises a third temporary storage bin, and the third temporary storage bin is connected with a second outlet of the particle screening device.
Further, the continuous wet granulation system for traditional Chinese medicines further comprises a fourth temporary storage bin, and the first outlet of the particle screening device is connected with the particle subpackaging device through the fourth temporary storage bin.
Further, the wet granulation mechanism further comprises:
and the discharge hole of the granulator is connected with the feed inlet of the rotary granulator through the fifth temporary storage bin.
Further, the particle parameter checking device is arranged on a discharge hole of the particle drying device.
Compared with the prior art: by adopting continuous production equipment, the transfer and buffer storage of materials can be reduced, continuous production is realized, the problems of dust and the like in production are solved, and the production efficiency is improved; in addition, the key position is also provided with an inspection device to monitor the state of the material in production in real time, so that closed-loop control can be formed by feeding back the detected data, thereby effectively adjusting the parameters of the corresponding equipment, realizing continuous and intelligent production and ensuring qualified quality.
Drawings
Fig. 1 is a schematic view of the overall structure of a continuous wet granulation system for traditional Chinese medicine according to a first embodiment of the present invention;
FIG. 2 is a schematic structural view of a feeding assembly and a material mixing apparatus in a first embodiment of the present invention;
fig. 3 is a schematic structural diagram of a wet granulation mechanism and a particle screening device in a first embodiment of the present invention.
The following detailed description will further illustrate the utility model in conjunction with the above-described figures.
Detailed Description
To facilitate an understanding of the utility model, the utility model will now be described more fully with reference to the accompanying drawings. Several embodiments of the utility model are presented in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the utility model herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example one
Referring to fig. 1 to 3, a continuous wet granulation system for traditional Chinese medicine according to a first embodiment of the present invention is shown, which includes a feeding assembly 10, a material mixing device 20, a wet granulation mechanism 30, a granule sieving device 40, a granule dispensing device 50, a material uniformity checking device 60, and a granule parameter checking device 70. Wherein:
the feeding assembly 10 comprises a dust-free feeding station 11, a first temporary storage bin 12, a vacuum feeding machine 13 and an automatic feeding machine 14, the dust-free feeding station 11 is connected with the first temporary storage bin 12 through a pipeline, the vacuum feeding machine 13 is connected with the first temporary storage bin 12 and used for sucking materials fed into the dust-free feeding station 11 into the first temporary storage bin 12, a feeding hole of the automatic feeding machine 14 is connected with a discharging hole of the first temporary storage bin 12, and a discharging hole of the automatic feeding machine 14 is connected with a feeding hole of the material mixing equipment 20 so as to automatically feed the materials in the first temporary storage bin 12 into the material mixing equipment 20.
In practical applications, the automatic feeder 14 may be a screw feeder, and the screw feeder can control the feeding amount of different materials. In addition, the number of the feeding assemblies 10 is several, and each feeding assembly 10 is correspondingly supplied with one material. The specific number of the feeding components 10 is not limited, and can be determined according to the type of the materials contained in the finally prepared traditional Chinese medicine particles; by way of example and not limitation, four feeding assemblies 10 may be arranged accordingly, for example, when the final prepared chinese medicine granule contains 4 materials.
Wherein, the feed inlet of the material mixing device 20 is connected to the discharge outlet of the automatic feeder 14 of each feeding assembly 10 to receive the material fed by each feeding assembly 10 and stir the material. In practice, the material mixing device 20 may be a continuous mixer. In this embodiment, the feeding assembly 10 further includes a second temporary storage bin 15, and the discharge port of the automatic feeder 14 is connected to the feed port of the material mixing device 20 through the second temporary storage bin 15. The material of the automatic feeder 14 is temporarily fed into the second temporary storage bin 15, and the material is continuously dropped into the material mixing device 20 by the second temporary storage bin 15, so as to achieve the effect of continuous feeding.
In practical implementation, the number of the second temporary storage bins 15 can be selected according to specific situations, for example and without limitation, for example, when four feeding assemblies 10 are arranged, one second temporary storage bin 15 can be selected to be shared by four feeding assemblies 10, or one second temporary storage bin 15 can be shared by two feeding assemblies 10 (i.e. two second temporary storage bins 15).
Wherein, the feed inlet of wet granulation mechanism 30 passes through the discharge gate of pipe connection material mixing apparatus 20 to receive the mixed material that material mixing apparatus 20 mixes and obtain and carry out wet granulation. Specifically, in the present embodiment, the wet granulation mechanism 30 includes a wet granulator 31, a granulator 32, a rotary granulator 33, and a granule drying device 34, which are connected in sequence, and a feeding port of the wet granulator 31 is connected to a discharging port of the material mixing device 20 through a pipeline. That is, the mixture obtained by mixing in the material mixing device 20 enters the wet granulator 31 for wet granulation to form traditional Chinese medicine granules, the traditional Chinese medicine granules enter the granulator 32 for granulation, and then enter the rotary granulator 33 for rotary granulation after granulation, and finally reach the granule drying device 34 for drying. In specific implementation, the particle drying device 34 may be a continuous horizontal dryer, and the working principle of the continuous horizontal dryer is as follows: introducing clean hot air with the temperature (for example 90-120 ℃) into the equipment from the bottom of the continuous horizontal dryer to ensure that the material is in a fluidized state, and meeting the requirements of required moisture and particle size under the action of the hot air.
Be provided with valve device (not shown) on the pipeline that material mixing equipment 20 and wet granulator 31 are connected, valve device and material homogeneity check out set 60 electric connection, material homogeneity check out set 60 is used for checking the homogeneity of the mixed material that material mixing equipment 20 mixes and obtains, only when the mixed material reaches the homogeneity standard, valve device just can open to send qualified mixed material into wet granulation mechanism 30 and carry out wet granulation, thereby the quality of effect control traditional chinese medicine granule. In a specific implementation, the valve device may be a butterfly valve.
Specifically, in this embodiment, the material uniformity inspecting device 60 is disposed at the discharge port of the material mixing device 20, which is beneficial to detecting the material mixing uniformity in the material mixing process and ensuring that the mixed material is qualified to enter the wet granulation mechanism 30. Meanwhile, the material uniformity inspecting apparatus 60 may monitor the uniformity of the mixed material on line in real time, so as to feed back data and control the material mixing apparatus 20, thereby implementing closed-loop control. In a specific implementation, the material uniformity inspecting apparatus 60 may be a near-infrared online detecting apparatus.
Wherein, the discharge port of the particle drying device 34 is connected to the feed port of the particle sieving device 40 to receive and sieve the traditional Chinese medicine particles prepared by the wet granulation mechanism 30. Specifically, the granule sorting apparatus 40 includes a first outlet for discharging the qualified Chinese medicine granules and a second outlet for discharging the unqualified Chinese medicine granules; a first outlet of the particle screening device 40 is connected with a feed inlet of the particle subpackaging device 50; the continuous wet granulation system for traditional Chinese medicine further comprises a third temporary storage bin (not shown in the figure), wherein the third temporary storage bin is connected with the second outlet of the particle screening device 40 to store the unqualified traditional Chinese medicine particles through the third temporary storage bin, and the qualified traditional Chinese medicine particles are discharged into the particle subpackaging device 50 through the first outlet of the qualified traditional Chinese medicine particles, so that the qualified traditional Chinese medicine particles screened out by the particle screening device 40 are subpackaged by the particle subpackaging device 50.
In addition, in this embodiment, the system for continuous wet granulation of traditional Chinese medicine further comprises a fourth temporary storage 90, and the first outlet of the particle sieving device 40 is connected to the particle dispensing device 50 through the fourth temporary storage 90, so that the fourth temporary storage 90 is utilized to buffer the traditional Chinese medicine particles that are too late for the particle dispensing device 50 to dispense. In specific implementation, the granule dispensing device 50 may be, but is not limited to, a tablet press, a capsule filling machine, a granule packing machine, or the like, and performs packing production of tablet products, capsule products, or granule products, respectively. The particle dispensing apparatus 50 may more specifically be a vacuum loading dispenser.
In addition, in this embodiment, the wet granulator 31 further includes a fifth temporary storage bin 35, and the discharge port of the granulator 32 is connected to the feed port of the rotary granulator 33 through the fifth temporary storage bin 35, so as to temporarily store the granules that cannot be processed by the rotary granulator 33 in time through the fifth temporary storage bin 35.
Wherein, the granule parameter checking device 70 is arranged on the discharge port of the granule drying device 34 and is used for checking the parameters of the qualified traditional Chinese medicine granules screened by the granule screening device 40. Parameters described herein include, but are not limited to, particle moisture, particle size, content, and the like. By arranging the particle parameter checking device 70 on the fourth temporary storage bin 90, the particle parameters are finally monitored and judged on line in real time before particle split charging, and the particle parameters are fed back and controlled by the wet granulation mechanism 30, so that closed-loop control is realized, and the particle preparation quality is improved. In particular implementation, the particle parameter inspection device 70 may be specifically a near-infrared online detection device.
In specific implementation, the near-infrared online detection device may adopt devices with corresponding specifications and models of the following companies, for example: MicroNIR PAT-W/PAT-U/OnSite-W, VIAVI, USA; swedish botton DA 7440; antaris MX, American Saimeri). Wherein, the operating principle of near-infrared on-line measuring equipment does: the near infrared device light source irradiates on the detected material to generate diffuse reflection effect, the reflected light returns to the device, the energy of chemical bonds of different detected substances is different, the reflected near infrared spectra are different, the spectra and laboratory detection data are related by a mathematical method to form a mathematical model, and the mathematical model can be used for detecting the moisture, the particle size, the mixing uniformity, the content and the like of particles.
In addition, in order to reduce the floor area of the equipment, the continuous wet granulation system for traditional Chinese medicine further comprises a first support frame 90 and a second support frame 100 positioned above the first support frame 90; the feeding assembly 10 and the material mixing device 20 are fixedly arranged on the second support frame 100, and the wet granulation mechanism 30, the particle screening device 40 and the particle subpackaging device 50 are fixedly arranged on the first support frame 90. The vertical lamination design is adopted, so that the occupied space is small, the procedure connection is compact, the utilization rate of equipment is increased, and the production cost and the occupied area of the equipment are reduced.
Based on the system for continuous wet granulation of traditional Chinese medicine in this embodiment, the present embodiment further provides a method for continuous wet granulation of traditional Chinese medicine, which comprises the following specific production steps:
materials used for producing granules are taken, the name, specification, batch number, inspection sheet number and quantity of the materials are checked, and the materials are put into a dust-free feeding station;
the raw materials are conveyed to a first temporary storage bin 12 through a dust-free feeding station 11 and a vacuum feeding machine 13, the materials are mixed according to the formula amount and then are conveyed into a material mixing device 20 from an automatic feeding machine 14 to be mixed, and the mixed materials are subjected to online real-time monitoring on uniformity, moisture, content and the like through a material uniformity detection device; the mixed material with qualified uniformity enters a wet granulator 31;
starting the wet granulator 31, preparing a soft material by the extract and the mixed material, granulating the soft material by the granulator 32, then entering the fifth temporary storage bin 35, granulating by the rotary granulator 33, and dropping the prepared granules into the granule drying equipment 34;
starting the particle drying equipment 34, carrying out particle forming on the particles in the particle drying equipment 34 by sequentially carrying out preheating, drying and cooling treatment, carrying out online real-time monitoring on parameters such as particle moisture, content and particle size of the formed particles through particle parameter inspection equipment, and carrying out feedback control on parameters such as air quantity, temperature and feeding quantity of the particle drying equipment 34 according to monitoring data to form closed-loop control, wherein the final particle moisture is controlled by about 3%, and the coarse and fine particle contents which do not pass through a 10-80-mesh screen are less than or equal to 10%;
the dried particles are screened by a particle screening device 40, the qualified screened particles fall to a fourth temporary storage bin 90, and the unqualified particles fall to a third temporary storage bin;
qualified particles in the fourth temporary storage bin 90 are subpackaged by the particle subpackaging equipment 50, and the qualified materials can be used for a tablet machine, a capsule filling machine or a particle packaging machine to produce tablet products, capsule products or particle products respectively.
In summary, compared with the prior art, the continuous wet granulation system for traditional Chinese medicine in the embodiment has at least the following beneficial effects:
1. by designing a continuous traditional Chinese medicine continuous wet granulation system, the transfer and cache of materials can be reduced, the continuous production is realized, the problems of dust and the like in the production are solved, the production efficiency is improved, and the labor intensity is reduced;
2. monitoring the state of the material in production in real time, such as the mixing uniformity (the material mixing uniformity RSD is less than or equal to 5 percent), the moisture content, the particle size and the like of the particles in the material process; feeding back according to the detected data to form closed-loop control, adjusting parameters of corresponding equipment, realizing continuous and intelligent production and ensuring qualified quality;
3. the design of upper and lower layers occupies less space, the procedure is connected compactly, the utilization rate of equipment is increased, and the production cost and the floor area of the equipment are reduced.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (9)

1. A continuous wet granulation system for traditional Chinese medicines is characterized by comprising:
a plurality of feeding assemblies, wherein each feeding assembly is correspondingly supplied with one material;
the feed inlet of the material mixing equipment is connected with each feeding assembly so as to receive the materials fed by the feeding assemblies and stir the materials;
the wet granulation mechanism is connected with the discharge port of the material mixing equipment to receive the mixed material obtained by mixing the material mixing equipment and perform wet granulation;
the particle screening equipment is connected with a discharge hole of the wet granulator and is used for receiving and screening the traditional Chinese medicine particles prepared by the wet granulator;
the particle subpackaging equipment is connected with the particle screening equipment and is used for subpackaging the qualified traditional Chinese medicine particles screened by the particle screening equipment;
the material uniformity inspection equipment is arranged on a discharge port of the material mixing equipment and is used for inspecting the uniformity of mixed materials obtained by mixing the materials by the material mixing equipment;
and the particle parameter checking equipment is arranged on the wet granulation mechanism and is used for checking the parameters of the traditional Chinese medicine particles prepared by the wet granulation mechanism.
2. The continuous wet traditional Chinese medicine granulating system of claim 1, wherein the wet granulating mechanism comprises a wet granulator, a rotary granulator and a granule drying device which are connected in sequence;
the feed inlet of wet granulator is connected the discharge gate of material mixing equipment, the discharge gate of granule drying equipment is connected the feed inlet of granule screening equipment.
3. The system for continuous wet granulation of traditional Chinese medicine according to claim 1, wherein said feeding assembly comprises:
a dust-free feeding station;
the first temporary storage bin is connected with the dust-free feeding station;
the vacuum feeding machine is connected with the first temporary storage bin and is used for sucking materials thrown by the dust-free feeding station into the first temporary storage bin;
and a feed port of the automatic feeding machine is connected with a discharge port of the first temporary storage bin, and a discharge port of the automatic feeding machine is connected with a feed port of the material mixing equipment.
4. The continuous wet traditional Chinese medicine granulating system according to claim 3, wherein the feeding assembly further comprises a second temporary storage bin, and the discharge port of the automatic feeder is connected with the feed port of the material mixing device through the second temporary storage bin.
5. The system for continuous wet granulation of traditional Chinese medicine according to claim 1, further comprising a first support frame and a second support frame positioned above the first support frame;
the feeding assembly and the material mixing equipment are fixedly arranged on the second support frame, and the wet granulator, the particle screening equipment and the particle subpackaging equipment are fixedly arranged on the first support frame.
6. The continuous wet traditional Chinese medicine granulating system of claim 1, wherein the granule screening device comprises a first outlet for discharging qualified traditional Chinese medicine granules and a second outlet for discharging unqualified traditional Chinese medicine granules;
the first outlet of the particle screening device is connected with the particle subpackaging device;
the traditional Chinese medicine continuous wet granulation system further comprises a third temporary storage bin, and the third temporary storage bin is connected with a second outlet of the particle screening device.
7. The system for continuous wet granulation of traditional Chinese medicine according to claim 6, further comprising a fourth temporary storage bin, wherein the first outlet of the particle sieving device is connected to the particle dispensing device through the fourth temporary storage bin.
8. The system for continuous wet granulation of traditional Chinese medicine according to claim 2, wherein the wet granulation mechanism further comprises:
and the discharge hole of the granulator is connected with the feed inlet of the rotary granulator through the fifth temporary storage bin.
9. The system for continuous wet granulation of traditional Chinese medicine according to claim 2, wherein the granule parameter check device is disposed on the discharge port of the granule drying device.
CN202121185007.7U 2021-05-31 2021-05-31 Traditional chinese medicine serialization wet granulation system Active CN216318879U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115590222A (en) * 2022-10-17 2023-01-13 广东容大生物股份有限公司(Cn) Preparation method of feed additive granules and granulating and shot blasting equipment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115590222A (en) * 2022-10-17 2023-01-13 广东容大生物股份有限公司(Cn) Preparation method of feed additive granules and granulating and shot blasting equipment

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Address after: No.28 Chunfeng Road, Yichun economic and Technological Development Zone, Jiangxi Province

Patentee after: Yichun Wanshen Intelligent Equipment Co.,Ltd.

Address before: No.28 Chunfeng Road, Yichun economic and Technological Development Zone, Jiangxi Province

Patentee before: YICHUN WANSHEN PHARMACEUTICAL MACHINERY Co.,Ltd.