JPS63101760A - Automatic chemical analyzer - Google Patents

Abstract

PURPOSE:To simply deal with the alteration of a specification accompanied by the alteration of a nozzle stop position, by partially altering the content of a program through a setting means. CONSTITUTION:A moving block 6 and a nozzle 7a are moved by a distance h1 from the starting point by the execution of a program and stops. When a sample container is absent at this position and the difference up to a normal stop position is h, the movement alteration quantity corresponding to h is given to the operation part 10a of CPU 10 by operating a digital switch 21 to perform the alteration of the content of the program. Since the content of the program can be altered during the execution of the program, even when the measure of an unfixed part is altered or the original operation form is not obtained by time-dependent change, a simple measure can be taken so that the original analytical operation can be performed.

Description

[Detailed Description of the Invention] CObject of the Invention] (Industrial Field of Application) The present invention relates to an automatic chemical device for chemically analyzing a test sample (liquid) such as serum or urine using a spectrometer or the like. , relates to an automatic chemical analyzer equipped with effective means for changing the specifications of trays for samples, reagents, etc.

(Prior Art) Generally, this type of automatic chemical analyzer has a configuration as shown in FIG. That is, in FIG. 3, a turntable-type reaction line 1 that moves intermittently by a predetermined angle
A plurality of reaction tubes (cells) 1a are arranged in a ring. On one side of this reaction line 1, there are a plurality of reagent containers 2.
a reagent tray 2 in which a plurality of test sample containers 3a are arranged;
A test sample tray 3 and a probe cleaning section 4 are arranged side by side.

These reaction lines 1. Reagent tray 2 and test sample tray 3. An arm 5 is suspended above the probe cleaning section 4, and a moving block 6 is provided on the arm 5, which is moved in the longitudinal direction by a drive mechanism (not shown). Further, the moving block 6 is provided with a sample probe (nozzle>78) of the dispensing device 7.

Further, on the other side of the reaction line 1, a light source 8a is provided.

A spectrometer 8 consisting of a spectroscopic section 8b and the like equipped with a detector is provided to optically analyze the progress of the reaction of the reaction liquid in the reaction tube 1a and output it as an analog signal. The output of this spectrometer 8 is converted into a digital signal by an A/D converter 9, and is input to a CPU (computer) 10, where analysis data is calculated using a predetermined calculation method.

CPtJlo has display 11. A printer 12 and an operation panel 13 are connected. The automatic chemical analyzer also includes a constant temperature bath 141 of hot water for maintaining the reaction tube 1a at a predetermined temperature, a washing/drying unit 15 for washing and drying the reaction tube 1a, a reagent pump 16, and the like.

The details of the spectrometer 8 are constructed as shown in FIG.

That is, the light 18a is transmitted from the lamps 8a1. The window 1 of the reaction line 1 consists of a lens 8a2 that condenses the light.
The reaction liquid in the reaction tube 1a is transmitted through the spectroscopic section 8b.
leading to. The spectroscopic section 8b includes a lens 8b10 for condensing the light transmitted through the reaction solution, a reflection mirror 8b21, a grating 8b3 for spectroscopy. A photodiode array 8b4 or the like is used as a detector for the light separated by the grating 8b3, and the light transmitted through the reaction solution is separated.
guided by.

Further, the CPU 10 rotates the reaction line 1.

The movement of the arm 5 and the moving block 6, the movement of the trays 2 and 3, the movement of the dispensing device 7, etc. are controlled by executing a control program stored in the storage section. This Ill m program is a program for the moving operation of the moving block 6, and the dispensing all! 7, a program for operating the spectroscopic system 8, a program for operating the signal processing needle, and other various programs.

The operation of the apparatus shown in FIG. 3 is as follows. That is, arm 5. By operating the moving block 6 and the dispensing device 7, one test sample container 3 in the test sample tray 3 is
The test sample in a is dispensed into the reaction tube 1a, and then the reagent in the reagent container 2a is discharged into the reaction tube 1a to obtain a reaction liquid. The reaction tube 1a containing this reaction solution is moved to a spectrometer 8 where spectroscopic analysis is performed, and the CPU 1
0 gives the analysis result.

The specifications of the device described above may be changed due to the addition of options, the number of samples, changes in inspection items, etc. In this case, the device is functionally divided into an immobilized portion and a non-immobilized portion. That is, the immobilized parts include a frame (not shown), the arm 5, the movable block 6, the spectrometer 8, etc., and the non-immobilized parts include the test sample tray 1, the reagent tray 2, etc.

Here, considering that the specifications of the non-fixed portion are changed, the operating form (stop position) of the nozzle 7a is also changed, and in that case, it is necessary to change the control program.

In addition, the movement of the moving block 6 and the nozzle 7a is performed by transmitting the rotation of a pulse motor (not shown) to a belt, and the movement is performed by this belt. be. If this original operation mode is not obtained, there is a problem that liquid suction and discharge, such as dilution 9 dispensing, etc., cannot be performed correctly into the reaction tube 18 etc. (and the analysis operation itself cannot be performed).

(Problems to be Solved by the Invention) As described above, in the conventional technology, although it is assumed that the specification of the element is changed accompanied by a change in the nozzle stop position,
No measures have been taken to address this problem, and no effective measures have been taken against changes in the nozzle stop position due to aging or the like.

Therefore, an object of the present invention is to make it possible to easily deal with changes in the nozzle stop position due to changes in the nozzle stop position, such as changes in the specifications of elements that involve changes in the nozzle stop position, or changes in the nozzle stop position due to aging, etc. The purpose of the present invention is to provide an automated chemical analyzer with

[Structure of the Invention] (Means for Solving the Problems) The present invention is characterized by taking the following measures in order to solve the above problems and achieve the object. That is, a reaction line in which a plurality of reaction tubes are arranged, a reagent tray in which a plurality of reagent containers are arranged, a test sample tray in which a plurality of test sample containers are arranged, and an arm that spans between them. A nozzle of a dispensing device is disposed on a block movable on the arm, and the movement of the nozzle allows the test sample in the test sample container and the reagent in the reagent container to be transferred to the test sample container. An automatic chemical analyzer for dispensing a reaction solution into a reaction tube and optically analyzing the degree of reaction of the dispensed reaction solution in the reaction tube, comprising: a storage means for storing a program for controlling the moving operation of the nozzle; a calculation means for executing a program to calculate the movement amount of the nozzle; a driving means for driving the nozzle and the block based on the nozzle movement amount calculated by the calculation means; and a setting for changing the settings of the program. The configuration includes means.

(Function) In the present invention configured as described above, when the nozzle does not stop at the original stop position due to execution of the program, the contents of the program can be partially changed by operating the setting means to account for the variation. becomes possible.

(Example) The following is a third example of an automatic chemical analyzer according to the present invention.
The description will be made with reference to FIG. 1, in which the same parts as in the figures are given the same reference numerals.

In FIG. 1, a moving block 6 holding a nozzle 7a is shown.
is the belt 5 hung on the sprockets 5a1 and 5a2
b, it is movable in the left and right direction of the mouth surface, and a pulse motor 5C is used as its driving source. This pulse motor 5C includes a sensor 17 for detecting the home position and a sensor 18 for detecting the movement limit.
Drive control, that is, drive pulses are given by a controller 19 which receives signals from the controller 19. Also,
The controller 19 via the interface 20
Combined with PIJ 10.

Here, the CPU 10 includes at least an arithmetic unit 10a and a memory unit 10b, and the memory unit 10b stores a control program that performs only the moving operation of the moving block among the control programs that control the series of moving 9 dispensing 9 spectroscopy operations. Assume that a program P is stored. In addition, the calculation unit 10a includes
A digital switch 21 is connected to the program P in order to change its contents at any time when the program P is executed.

Next, the operation of this embodiment configured as described above will be explained. That is, in the program P, as shown in FIG. 2, the stop position of the nozzle 7a is set at a distance h1, h2, . Suppose that the content is included so that it stops at ....

Here, the device is started, and the moving block 6 and the nozzle 7 are moved by executing the program P during the measurement operation or the cleaning operation.
a moves a distance h1 from the starting point and stops. If there is no sample container at this stop position (broken line in the figure) and the difference between the correct stop position and the stop position is Δh, the operator sets the digital switch 21 to change the amount of movement corresponding to this Δh. 10a to change the contents of the program P. Here, the digital switch 21
Assume that the relationship between one pulse and the distance is known.

In this way, in this embodiment, the contents of the program P can be changed while it is being executed, so even if the specifications of the non-fixed part are changed or due to aging, etc., the original operating form cannot be obtained. Even in such cases, it can be easily handled so that the original analysis operation can be carried out.

In the above, the content settings of the program P are changed using the digital switch 21, but it is also possible to use the keyboard device of the operation panel (13) or use other external input devices. You can.

[Effects of the Invention] As described above, in the present invention, when the nozzle does not stop at the original stop position due to execution of the program, the content of the program can be partially changed by operating the setting means to account for the variation. This makes it possible to easily deal with changes in the nozzle stop position due to changes in the nozzle stop position, such as changes in the specifications of elements that involve changes in the nozzle stop position, or due to changes over time. This is what an automated chemical analyzer can provide.

[Brief explanation of the drawing]

Fig. 1 is a detailed diagram of an arm, moving block, and nozzle showing one embodiment of the present invention, Fig. 2 is a diagram explaining the contents of a program in the same embodiment, and Fig. 3 is a general diagram of an automatic chemical analyzer. The configuration diagram, FIG. 4, is a detailed diagram of the spectrometer. DESCRIPTION OF SYMBOLS 1... Reaction line, 1a... Reaction tube, 2... Reagent tray, 2a... Test stain container, 3... Test reagent tray, 3a... Test reagent container, 4...・Probe cleaning section,
5... Arm, 6... Moving block, 7... Dispensing device, 7a... Sample probe, 8... Spectrometer,
8a...Light source, 8al...Lamp, 8b...Spectroscopy unit, 8b4...Photodiode array, 9...A
/D converter, 1o...CPLJ, 10a...computing section, 10b...memory section, 11...display, 1
2...Printer, 13...Operation panel, 14...
Constant temperature bath, 15...Washing/drying unit, 16...Reagent pump, 17.18...Sensor, 19...Controller, 21...Digital switch.

Claims (3)

[Claims] (1) A reaction line in which a plurality of reaction tubes are arranged, a reagent tray in which a plurality of reagent containers are arranged, a test sample tray in which a plurality of test sample containers are arranged, and an arm that spans between them. and a nozzle of a dispensing device disposed on a block movable on the arm, and the movement of the nozzle causes the test sample in the test sample container and the reagent in the reagent container to be removed. In an automatic chemical analyzer for dispensing into the reaction tube and optically analyzing the degree of reaction of the dispensed reaction liquid in the reaction tube, a storage means for storing a program for controlling the moving operation of the nozzle; A calculation means that executes this program to calculate the movement amount of the nozzle, a drive means that drives the nozzle and the block based on the nozzle movement amount calculated by the calculation means, and changes the settings of the program. An automatic chemical analyzer characterized by comprising a setting means. (2) The first claim characterized in that the setting contents of the program are changed during the measurement operation or the cleaning operation.
Automated chemical analyzer as described in section. (3) The automatic chemical analyzer according to claim 1, characterized in that a digital switch is used as the setting means.