JPS628749B2 - - Google Patents
Info
- Publication number
- JPS628749B2 JPS628749B2 JP1752078A JP1752078A JPS628749B2 JP S628749 B2 JPS628749 B2 JP S628749B2 JP 1752078 A JP1752078 A JP 1752078A JP 1752078 A JP1752078 A JP 1752078A JP S628749 B2 JPS628749 B2 JP S628749B2
- Authority
- JP
- Japan
- Prior art keywords
- syringe
- tip member
- detection agent
- insolubilized
- tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000243 solution Substances 0.000 claims description 86
- 238000000034 method Methods 0.000 claims description 78
- 238000003556 assay Methods 0.000 claims description 76
- 239000000126 substance Substances 0.000 claims description 75
- 238000001514 detection method Methods 0.000 claims description 51
- 239000003795 chemical substances by application Substances 0.000 claims description 49
- 239000012491 analyte Substances 0.000 claims description 47
- 239000003153 chemical reaction reagent Substances 0.000 claims description 41
- 239000000427 antigen Substances 0.000 claims description 29
- 102000036639 antigens Human genes 0.000 claims description 29
- 108091007433 antigens Proteins 0.000 claims description 29
- 238000012360 testing method Methods 0.000 claims description 29
- 239000003446 ligand Substances 0.000 claims description 25
- 230000027455 binding Effects 0.000 claims description 20
- 239000000470 constituent Substances 0.000 claims description 17
- 238000003018 immunoassay Methods 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 10
- 230000002285 radioactive effect Effects 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 6
- 230000009870 specific binding Effects 0.000 claims description 6
- 238000012546 transfer Methods 0.000 claims description 5
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims 4
- QGUPBYVADAJUNT-UHFFFAOYSA-N 6-morpholin-4-ium-4-yl-4,4-diphenylheptan-3-one;chloride Chemical compound Cl.C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)CC)CC(C)N1CCOCC1 QGUPBYVADAJUNT-UHFFFAOYSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000941 radioactive substance Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 56
- 238000006243 chemical reaction Methods 0.000 description 21
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 21
- 239000000463 material Substances 0.000 description 15
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 13
- 229940098773 bovine serum albumin Drugs 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 13
- 210000002381 plasma Anatomy 0.000 description 13
- 238000003127 radioimmunoassay Methods 0.000 description 13
- 238000005259 measurement Methods 0.000 description 12
- 238000003860 storage Methods 0.000 description 12
- 239000000872 buffer Substances 0.000 description 11
- 229960000890 hydrocortisone Drugs 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 239000000700 radioactive tracer Substances 0.000 description 10
- 239000002699 waste material Substances 0.000 description 10
- 239000007790 solid phase Substances 0.000 description 9
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 239000012086 standard solution Substances 0.000 description 7
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000003908 quality control method Methods 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 150000002463 imidates Chemical class 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 241001015476 Botria Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000473945 Theria <moth genus> Species 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001409 amidines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000001837 anti-cortisol effect Effects 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 150000001886 cortisols Chemical class 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000011197 physicochemical method Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 238000005464 sample preparation method Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1752078A JPS54111892A (en) | 1978-02-17 | 1978-02-17 | Method and device for inspecting numerous data |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1752078A JPS54111892A (en) | 1978-02-17 | 1978-02-17 | Method and device for inspecting numerous data |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54111892A JPS54111892A (en) | 1979-09-01 |
| JPS628749B2 true JPS628749B2 (fr) | 1987-02-24 |
Family
ID=11946221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1752078A Granted JPS54111892A (en) | 1978-02-17 | 1978-02-17 | Method and device for inspecting numerous data |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54111892A (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ199286A (en) * | 1980-12-22 | 1986-05-09 | Commw Serum Lab Commission | A method of detecting antibodies or an antigenic or haptenic substance in a sample |
| IL63363A (en) * | 1981-07-20 | 1986-08-31 | Cais Michael | Non-centrifugation method for immunoassay of materials |
| NZ201901A (en) * | 1981-09-25 | 1986-11-12 | Commw Serum Lab Commission | An apparatus suitable for performing automated heterogeneous immunoassays in a plurality of samples |
| JPS59147268A (ja) * | 1983-01-21 | 1984-08-23 | ザ パーキン―エルマー コーポレイション | 複数の容器間に液体サンプルを自動移動する方法と装置 |
| US4555957A (en) * | 1983-10-14 | 1985-12-03 | Cetus Corporation | Bi-directional liquid sample handling system |
| SE8306052D0 (sv) * | 1983-11-03 | 1983-11-03 | Pharmacia Ab | Anordning for hantering av porosa analysmatriser |
| CA1230552A (fr) * | 1983-11-07 | 1987-12-22 | Howard M. Chandler | Dispositif et methode pour effectuer des dosages enzymatiques qualitatifs |
| JP3473409B2 (ja) * | 1998-06-11 | 2003-12-02 | 松下電器産業株式会社 | 分注装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA990416A (en) * | 1972-04-19 | 1976-06-01 | Sieuwko J. Mantel | Device suitable for use in radioimmunoassay and method of determining the content of a specific hormone in a serum sample |
| CA1054050A (fr) * | 1973-05-01 | 1979-05-08 | Stuart J. Updike | Colonne de gel utilisee dans la purification de sang et les dosages immunologiques |
| US3951605A (en) * | 1974-08-08 | 1976-04-20 | Rohe Scientific Corporation | Instrument for automated immunochemical analysis |
-
1978
- 1978-02-17 JP JP1752078A patent/JPS54111892A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS54111892A (en) | 1979-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4087248A (en) | Multiple assay machine and method | |
| EP0103622B1 (fr) | Procede et dispositif pour l'execution d'analyses | |
| US3951605A (en) | Instrument for automated immunochemical analysis | |
| US4244694A (en) | Reactor/separator device for use in automated solid phase immunoassay | |
| JP3521144B2 (ja) | 自動連続ランダム・アクセス分析システムおよびその構成要素 | |
| US5260028A (en) | Method and apparatus for effecting solid phase extraction | |
| US4205058A (en) | Column chromatography specific binding assay method and test kit | |
| EP0480497B1 (fr) | Appareil pour l'exécution d'un dosage à la main unique et rapide | |
| JPH01314967A (ja) | 免疫検定法を行う装置及び方法 | |
| JP2641986B2 (ja) | 新規かつ改良された液体標本吸引及び分配プローブ | |
| JPH07119769B2 (ja) | 自動分析装置 | |
| JPH01229969A (ja) | 改良されたメンブレン支持形式の免疫分析法 | |
| US20100267771A1 (en) | Automated immunossay apparatus with flexible pick-up arm | |
| JPS6311627B2 (fr) | ||
| JPS628749B2 (fr) | ||
| US4832916A (en) | Chromatographic column for immunological determining methods | |
| JPH0118383B2 (fr) | ||
| GB1601242A (en) | Multiple assay machine and method | |
| CA1128857A (fr) | Compose sec de cation de metal lourd avec un ligand et un anticorps | |
| JPH04233464A (ja) | 粒子の凝集反応分析装置とその使用方法 | |
| JP2883347B2 (ja) | 自動免疫測定装置のカートリッジ洗浄装置 | |
| JP3001994B2 (ja) | 自動分析装置 | |
| JPH02228562A (ja) | 自動免疫測定装置 | |
| CN111521831B (zh) | N-端脑利钠肽前体检测试剂盒及其制备方法 | |
| JPH11352028A (ja) | 分光光度計用自動試料搬送装置 |