JPS6281306A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having improved quality and performance, by adsorbing aescin of the seed of horse chestnut with a synthetic polymeric adsorption resin having macro-network structure, desorbing the aescin and using the resultant purified aescin as a component. CONSTITUTION:Extract of the seed of horse chestnut is made to contact in the state of aqueous solution with a synthetic polymeric adsorption resin having macro-network structure to effect the adsorption of aescin from the extract to the adsorption resin and the adsorbed aescin is desorbed with a hydrophilic organic solvent or its mixture with water. The obtained pure aescin is compounded to a cosmetic to obtain the objective cosmetic. A cosmetic containing aescin in high concentration, resistant to discoloration, storable without causing precipitation nor demulsification and free from color development with heat or light can be easily produced by the addition of purified aescin.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to cosmetics containing escin.

Conventional technology Horse chestnut (Aesculus)
The seed extract of hil) pocasLanam L, ) contains escin, which is a mixture of 8 types of saponins, and this escin has anti-inflammatory and granulation-forming effects, so it can be used in basic cosmetics such as lotions, milky lotions, and creams. It is included in the ingredients. However, Escin, which has traditionally been incorporated into cosmetics, is simply an alcoholic extract of horse chestnut seeds treated with activated carbon, and contains sugars, amino acids,
Contains large amounts of impurities such as tannins, proteins, inorganic salts, and pigments. Therefore, not only is it highly hygroscopic and must be handled with care, cosmetics containing it will be colored, precipitate during storage, accelerate emulsion breakage, and become stiff, and will also be susceptible to heat and light. It was easy to cause various problems such as progress of coloring. For this reason, in conventional cosmetics containing escin, the content of escin has been limited to an extremely low level, or the above-mentioned problems have had to be solved by devising a solution that eliminates all cosmetics.

Problems to be Solved by the Invention The purpose of the present invention is to solve the above-mentioned problems in cosmetics containing escin from horse chestnut seeds, and to create a cosmetic containing escin that does not have the inconveniences associated with the combination of escin and has no manufacturing restrictions. The aim is to provide fees.

Means for Solving the Problems The present invention involves contacting a horse chestnut seed extract in the form of an aqueous solution with a synthetic polymer adsorption resin having a giant network structure to adsorb escin in the extract onto the adsorption resin. The above object has been achieved by using the purified escin obtained by desorbing the escin with a hydrophilic organic solvent or a mixture thereof with water as an escin for formulation in cosmetics.

It is not yet clear how much of the impurities derived from horse chestnut seeds are removed and the escin contained in the cosmetics of the present invention exhibits favorable properties. However, by using this, precipitation formation and demulsification of cosmetics can be satisfactorily eliminated.

Next, a method for purifying the artificial synthetic material used in the cosmetics of the present invention will be explained.

The escin-containing horse chestnut seed extract to be purified is not particularly limited, but includes those obtained by extracting crushed horse chestnut seeds with water or a hydrophilic organic solvent such as methanol, ethanol, acetone, or a mixture thereof; Alternatively, it is suitable that this has been subjected to a preliminary purification treatment by some method. If the extract contains the organic solvent used for extraction, it is distilled off and then converted into an aqueous solution.

The synthetic polymer adsorption resin with a giant network structure used for purification is of non-polar to intermediate polarity, and preferred specific examples include Diamond I (P-10, HP-20, H
P-30, Amberlite I (P-40, Amberlite HP-50 (all Mitsubishi Chemical products), Amberlite XAD-2, Amberlite XAD
-4 (both products of Rohm & Haas), Rebatt) QC-1031 (product of Bayer), etc. whose resin base is a styrene/novinylbenzene copolymer,
Alternatively, there are those whose resin base is polyacrylic ester, such as Amberlite XAD-7 and Amberlite XAD-8 (both products of Rohm and Haas).

The method of bringing the aqueous solution to be purified into contact with the adsorption resin may be either the punch method or the column method, but the column method is preferred in terms of operability and processing efficiency. The amount of adsorption resin required to adsorb all of the Escin in the liquid to be treated varies depending on the type of adsorbent and the quality of the extraction raw material, but is usually 0.5 to 10 times the weight of the horse chestnut seeds.
It's double the amount.

When an aqueous solution of horse chestnut seed extract containing escin is brought into contact with an adsorption resin as described above, escin is adsorbed (adsorbed by fat, while most impurities are not adsorbed and 6 escin remains in the solution). If the resin is thoroughly washed with water and then brought into contact with a hydrophilic organic solvent or a mixture of it and water, the escin will be attached to the skin, making it possible to obtain an escin fraction separated from impurities. Preferred desorption solvents Specific examples include hydrophilic organic solvents such as methanol, ethanol, and acetone, or mixtures of these and water (
Preferably, the proportion of water is about 50% or less).

In the above resin treatment, some components other than Essin are also adsorbed by the adsorption resin, which is desorbed together with Essin during the desorption treatment and becomes impurities. When brought into contact with a synthetic organic solvent (for example, 10 to 25 percent water-containing ethanol), escin is not desorbed, but the components of the pond are absorbed and separated, making it possible to obtain escin of higher purity.

If the obtained desorption liquid is further decolorized by a method such as activated carbon treatment, if necessary, and dried after concentration, light brown purified escin can be obtained. The escin content of this purified escin is about 50 to 70% (according to the escin content analysis method of the Japanese Pharmacopoeia Standard for Pharmaceutical Ingredients "Horse Chest Seed Extract").

Any method can be used to produce cosmetics by blending the purified escin obtained as described above. Usually, purified escin may be dissolved in water, aqueous ethanol, polyhydric alcohol, etc., and added at any stage of the cosmetic production process.

Specific examples of cosmetics containing purified escin according to the present invention include lotions, skin lotions, creams, rinses, hair lotions, and the like.

Effects of the Invention The cosmetics of the present invention, which use purified escin using the unique purification method described above, have little coloring due to escin, and do not cause precipitation or emulsion during storage without taking special measures in terms of formulation. Destruction is not encouraged. Therefore, according to the present invention, it is possible to easily produce a cosmetic containing escin at a higher concentration than conventional escin-containing cosmetics, and the quality and performance of the cosmetic can be improved.

Yoshihiroga Hereinafter, the present invention will be explained with reference to Examples.

Example 1 10e of a 50% by weight ethanol aqueous solution was added to Ikg of crushed horse chestnut seeds, and extraction was performed by standing at 40°C for 5 hours to obtain extract 9.4Q. The extraction residue was extracted again in the same manner as above, and the extract was combined with the first extract. The obtained extract 19.2e was heated under reduced pressure to distill off the ethanol, and the remaining liquid was treated with a synthetic polymer adsorbent.
Escin was adsorbed by passing the solution through a column packed with 2e of XAD-7 (Amberley) at a space velocity of IQ/Q·fir. Thereafter, the column was thoroughly washed with water, and then escin was desorbed with 10 ml of a 55% by weight aqueous ethanol solution.

The desorption solution was heated under reduced pressure to distill off the alcohol and further dried to obtain 35.2 g of light brown purified escin.

The escin content of this purified escin was 63.4%.

Next, a lotion with the following formulation was produced using the purified escin.

Purified Escin 0.2% Tsurpinto 3.0 Glycerin 4.0 Ethanol 10.0 Methylparaben 0.1 Citric acid 0.5 Fragrance 9 Coloring agent
Appropriate amount of purified water Separately, extract the horse chestnut seed extract of the same quality as that used in conventional cosmetics (add 50 g of activated carbon to the ethanolic extract of horse chestnut seeds obtained in the same manner as above and reflux it) After heating to a lower temperature, the activated carbon is filtered out,
Furthermore, it was filtered with diatomaceous earth, cooled with static carbon, and then dried. A lotion for JJJ was produced using the same recipe as above, except that Escin content (16.4%) was used instead of purified Escin.

When these lotions were allowed to stand at room temperature, the control product was
Although precipitation occurred on the 5th day, the product of the present invention using purified escin was stable after 90 days.

Example 2 Using the purified escin produced in Example 1, a milky lotion having the following formulation was produced.

Purified Escin 0.5% Stearic Acid 2.0 Lanolin
2.0 liquid paraffin
9.0 seta/-le 1.
5 Polyoxyethylene monooleate 12.0 Glycerin 5.0 Triethanolamine
1.0 Fragrance, preservative
Appropriate amount of purified water Separately, a control milky lotion was produced using the same formulation as above, except that the activated carbon-treated horse chestnut seed extract used for the control product in Example 1 was used instead of purified escin.

When these emulsions were left to stand at 35°C, the control product was 7.
On the 5th day, the aqueous layer began to separate, but the purified escin was
- Also, this product was stable after 90 days.

Example 3 Using the purified escin produced in Example 1, a cream with the following formulation was produced.

Purified Escin (), 5% squalane 6.0 stearic acid
2.5 stearylfurfur
6.0 reduced lanolin 2
．． 0 Polyoxyethylene heptyl ether 3.0 Glycerin monostearate 2.0 Octyl dodecamer 5.0 Glycerin
5. h) Fragrances, preservatives
Appropriate amount of purified water, depending on the remainder,
A control cream was produced using the same formulation as above, except that the activated carbon-treated horse chestnut seed extract used for the control product in Example 1 was used instead of purified diprotic acid.

When these creams were stored at 60°C, the emulsification of the control product was observed to be broken after 50 days, but the cream using purified escin remained stable after 90 days.

Claims (1)

[Claims] In cosmetics containing escin extracted from horse chestnut seeds, escin is extracted from the escin in the horse chestnut seed extract by contacting the horse chestnut seed extract in an aqueous solution state with a synthetic polymer adsorption resin having a large network structure. A cosmetic characterized in that it is purified escin obtained by adsorbing it on an adsorption resin and desorbing the adsorbed escin with a hydrophilic organic solvent or a mixture of it and water.