JP2003113101A - Method for preventing discoloration and water-borne cataplasm containing discoloration inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for preventing discoloration of a seed extract from Aesculus hippocastanum L., and a water-borne cataplasm free from discoloring. SOLUTION: This method for preventing discoloration of the seed extract from the Aesculus hippocastanum L. comprises making a tar dye exist in a water-borne base containing the seed extract from the Aesculus hippocastanum L. The water-borne cataplasm is obtained by formulating the water-borne base containing the seed extract from the Aesculus hippocastanum L. with the tar dye for preventing the discoloration.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an aqueous patch containing horse chestnut seed extract,
The present invention relates to a method for preventing discoloration of horse chestnut seed extract and an aqueous patch containing a discoloration preventive agent.

[0002]

Horse chestnut seed extract contains components such as triterpene saponins, flavones, and coumarins, and has excellent anti-inflammatory and astringent effects, and further reduces vascular permeability to prevent It is a component that also has an effect of exerting an edema effect. In addition, as a patch preparation, a poultice containing horse chestnut seed extract (Japanese Patent Laid-Open No. 7-
173067) was disclosed. However, horse chestnut seed extract has a problem that it tends to discolor over time in a water-containing preparation, and thus methods for preventing discoloration by titanium oxide have been carried out, but it is not sufficient and satisfactory discoloration does not occur. No viable formulation was obtained.

[0003]

DISCLOSURE OF THE INVENTION It is an object of the present invention to find that discoloration of horse chestnut seed extract can be prevented by incorporating a tar dye in a patch composition, and an object thereof is to provide the patch and patch. And

[0004]

Means for Solving the Problems The present inventors have conducted various studies in view of the above-mentioned circumstances, and as a result, it has been found that when a tar-based pigment is contained in an aqueous base compounded with horse chestnut seed extract, it is excellent. The inventors have found that they exhibit a discoloration preventing effect and have completed the present invention.

That is, the present invention provides a method for preventing discoloration of horse chestnut seed extract, which comprises coexisting a tar dye in an aqueous base containing horse chestnut seed extract. A water-based patch comprising a seed extract and a tar-based pigment for preventing discoloration of horse chestnut seed extract.

In the present invention, the horse chestnut seed extract is not particularly limited, and for example, a soft extract or a powder extract obtained by extracting the seeds of horse chestnut with water-containing ethanol or ethanol and then reducing the concentration under reduced pressure can be used. The content of horse chestnut seed extract is 0.05 to 5% by weight based on the total amount of the base composition of the patch,
Preferably 0.1 to 3% by weight, particularly preferably 0.1 to
It is compounded in the range of 0.2% by weight.

The tar dye used in the present invention is
Red No. 2, Red No. 3, Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Yellow 4
No. 5, Yellow No. 5, Green No. 3, Blue No. 1, Blue No. 2, Red 2
01, red 202, red 203, red 204,
Red 205, Red 206, Red 207, Red 20
No. 8, Red 213, Red 214, Red 215, Red 218, Red 220, Red 221, Red 223
No., Red 225, Red 226, Red 227, Red 228, Red 230 (1), Red 230 (2), Red 231, Red 232, Orange 201,
Orange No. 203, Orange No. 204, Orange No. 205, Orange 20
No. 6, Orange No. 207, Yellow No. 201, Yellow No. 202 (1), Yellow No. 202 (2), Yellow No. 203, Yellow 2
05, green 201, green 202, green 204,
Green 205, Blue 201, Blue 202, Blue 20
Including dyes such as No. 3, blue No. 204, blue No. 205, brown No. 201, and purple No. 201,

Among them, high water-soluble red No. 104, red No. 106, yellow No. 4, yellow No. 5, green No. 3, blue No. 1
No. 203, yellow No. 203 and green No. 201 are mentioned, yellow No. 4 and yellow No. 5 are particularly preferable, and yellow No. 5 is more preferable. Although not particularly limited, when the base is an aqueous base containing water, these water-soluble dyes can be used in an amount of 0.0001 to 1.0% by weight based on the entire composition.

The present invention is characterized in that a tar pigment is added to horse chestnut seed extract. The content ratio of both components is not particularly limited, but when the component of horse chestnut seed extract is 1 by weight ratio, the ratio of horse chestnut seed extract 0.0005 to 1, particularly 0.001 to 0.1 Is preferred.

In the present invention, the patch base used is not particularly limited, and a general patch base is used.
In particular, a crosslinkable hydrogel base using a polyacrylic acid-based water-soluble polymer is more preferable.

The polyacrylic acid-based water-soluble polymer is not particularly limited, and those conventionally used in patches can be used. Specifically, polyacrylic acid (eg: Jurimer AC10H; manufactured by Nippon Pure Chemical Co., Ltd.), sodium polyacrylate (eg: Viscomate F-480SS; manufactured by Showa Denko), partially neutralized polyacrylic acid (eg: Aronbis AH)
-105; manufactured by Nippon Pure Chemical Co., Ltd., Viscomate NP700; manufactured by Showa Denko Co., Ltd., carboxyvinyl polymer (Example: Junron PW110; manufactured by Nippon Pure Chemical Co., Ltd.), etc. A partially neutralized acrylic acid, particularly a partially neutralized polyacrylic acid having a degree of neutralization of 40 to 70% is preferable. These polyacrylic acid-based water-soluble polymers can be used alone or in combination of two or more, but it is preferable to use a partially neutralized polyacrylic acid and a carboxy polymer in combination.

As the cross-linkable hydrogel using the polyacrylic acid-based water-soluble polymer, polyacrylic acid, sodium polyacrylate, partially neutralized polyacrylic acid, carboxyvinyl polymer and the like are crosslinked with a metal compound. However, in the present invention, the polyacrylic acid partially neutralized product 2 to 8% by weight and the carboxyvinyl polymer 0.5 to 3% by weight relative to the total amount of the patch composition are treated with an aluminum compound in the presence of water. Those mainly composed of a cross-linked hydrogel are suitable. Such a patch consisting of a base mainly composed of a crosslinked hydrous gel, horse chestnut seed extract, arnica extract composition, good transdermal permeability and absorbability of glycol salicylate and excellent anti-inflammatory analgesic effect, It excels in skin adhesiveness and shape retention, and has the effect of suppressing skin irritation.

In this case, as the aluminum compound, a hydroxide such as aluminum hydroxide, a normal salt of an inorganic or organic acid such as aluminum chloride or aluminum sulfate, or a basic salt thereof can be used. .

In the patch of the present invention, its base pH
Considering skin irritation by the base component, discoloration of horse chestnut seed extract, and the like, the range of 4.5 to 5.5 is preferable. Horse chestnut seed extract is easily affected by pH and may discolor in an alkaline region.

The adjustment of pH is not particularly limited, and a general p
An H regulator can be used, but it is preferable to use an inorganic acid, or an inorganic acid and an organic acid. As the inorganic acid, phosphoric acid is preferable, and as the organic acid, lactic acid, tartaric acid, acetic acid,
Citric acid and the like are preferred.

In the present invention, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone, or
Methyl vinyl ether / maleic anhydride copolymer, gelatin, thickeners such as polyethylene oxide, kaolin,
Extenders such as titanium oxide, light anhydrous silicic acid and hydrous silicon dioxide, oil components such as light liquid paraffin, polybutene, squalane, moisturizers such as glycerin, propylene glycol, sorbitol, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, etc. Other surfactants, menthols (1-menthol, dl-menthol, etc.), cooling agents such as peppermint oil, etc. can be added.
If necessary, one or more other active ingredients such as vitamin E and capsicum extract can be used in combination.

The patch of the present invention is usually provided in such a form that it is applied or spread on an appropriate support in advance, and a release paper or the like that can be peeled off at the time of use is attached to the application surface side. In such a case, as the support, any material such as cloth, non-woven fabric, plastic sheet or film, and paper can be used. In addition, the patch of the present invention,
By using a cross-linking type hydrogel base containing a polyacrylic acid-based water-soluble polymer, an excellent patch having high adhesive strength and no backing can be obtained.

[0018]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

[Example 1: Method for producing aqueous patch] 50
50 parts by weight of purified water, 0.1 parts by weight of horse chestnut seed extract, 0.1 parts by weight of sodium edetate, light anhydrous silicic acid (trade name: Aerosil 2
00) 1 part by weight, titanium oxide 1 part by weight, yellow No. 4 0.0
To a liquid in which 015 parts by weight was sequentially added and dissolved and dispersed, a liquid (preliminary liquid A) in which 1 part by weight of sodium carboxymethyl cellulose was dispersed in advance in 3 parts by weight of glycerin was added and dissolved by stirring for 10 minutes. Next, gradually add 3 parts by weight of gelatin to 1
The mixture is stirred and dissolved for 0 minutes, and the obtained paste solution is transferred to a kneader heated to 40 ° C. Next, 2 parts by weight of light liquid paraffin, 0.3 parts by weight of sorbitan fatty acid ester, and carboxyvinyl polymer (trade name: Junron PW-110).
A liquid in which 1 part by weight is dispersed (prepared liquid B) is added and kneaded for 10 minutes. Further, a solution prepared by dispersing 6 parts by weight of partially neutralized polyacrylic acid (Aronbis AH-105) and 0.1 part by weight of dry aluminum hydroxide gel in 26 parts by weight of glycerin was gradually added and kneaded for 10 minutes, followed by arnica tincture beforehand. (Containing 20% of Arnica extract composition) 1 part by weight to 1 part by weight of glycol salicylate, 0.5 part by weight of 1-menthol, 0.3 part by weight of polyoxyethylene hydrogenated castor oil (HCO-60; Nikko Chemicals). Solution (partial solution C)
Was added and kneaded for 10 minutes, then a solution prepared by dissolving 1 part by weight of lactic acid in 1.6 parts by weight of purified water was gradually added and kneaded for 40 minutes to obtain a patch plaster. This plaster was applied to a non-woven fabric, covered with a plastic film, and cut into 10 cm × 14 cm to prepare a patch.

Among the patches used in the other tests, Examples 2 to 8 and Comparative Examples 1 and 2 were compounded with yellow No. 4, yellow No. 5 and titanium oxide according to Tables 1 and 2, and the rest were carried out. Example 1
The production was adjusted according to the production method of. In addition, Examples 9 to 1
2 and Comparative Example 3 were blended according to Table 3 and were manufactured and adjusted according to the manufacturing method of Example 1.

Discoloration evaluation method: 40 patches for each test
The chromaticity after storage for 1 to 4 weeks at 60 ° C and 60 ° C is determined by JIS
It was measured by the color display method described in Z 8730, and the difference (ΔE) from the initial value was obtained according to the following formula. In addition, Example 9
.About.12, Comparative Example 3 was evaluated visually.

ΔE = √ [(ΔL (difference from initial value) ² + Δ
a (difference from initial value) ² + Δb (difference from initial value) ² ]

The results of the color change evaluation are shown in Tables 1 and 2. The patch containing Yellow No. 4 or Yellow No. 5 clearly has a small ΔE and suppresses discoloration.

[0024]

[Table 1]

[0025]

[Table 2]

Other examples are listed in Table 3. Yellow 4
The patch containing No. 5 or Yellow No. 5 was an excellent patch without any discoloration.

[0027]

[Table 3]

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Claims (8)

[Claims] 1. A method for preventing discoloration of horse chestnut seed extract, which comprises allowing a tar dye to coexist in an aqueous base containing horse chestnut seed extract. 2. An aqueous patch comprising an aqueous base containing horse chestnut seed extract, and a tar-based pigment for preventing discoloration of horse chestnut seed extract. 3. An aqueous patch comprising an aqueous base containing horse chestnut seed extract and a tar dye and titanium oxide for preventing discoloration of horse chestnut seed extract. 4. The method for preventing discoloration or the aqueous patch according to claim 1, wherein the tar-based dye is Yellow No. 4 or Yellow No. 5. 5. The horseradish seed extract in an amount of 0.05 to 5% by weight and the tar-based pigment in an amount of 0.
The water-based patch according to any one of claims 2 to 4, wherein the water-based patch is contained in an amount of 0001 to 1% by weight. 6. A cross-linking type in which the patch base contains one or more water-soluble polymers selected from polyacrylic acid, partially neutralized polyacrylic acid, sodium polyacrylate, and carboxyvinyl polymer. The water-based patch according to any one of claims 2 to 5, which is a hydrogel base. 7. A patch base is an aluminum compound in the presence of water containing 2 to 8% by weight of partially neutralized polyacrylic acid and 0.5 to 3% by weight of carboxyvinyl polymer, based on the total amount of the base composition. The aqueous patch according to any one of claims 2 to 5, which is a base mainly composed of a water-containing gel having a pH of 4.5 to 5.5 crosslinked with. 8. The aqueous patch according to any one of claims 2 to 7, which contains arnica tincture, glycol salicylate and horse chestnut seed extract.