JPS6258265B2 - - Google Patents
Info
- Publication number
- JPS6258265B2 JPS6258265B2 JP55133168A JP13316880A JPS6258265B2 JP S6258265 B2 JPS6258265 B2 JP S6258265B2 JP 55133168 A JP55133168 A JP 55133168A JP 13316880 A JP13316880 A JP 13316880A JP S6258265 B2 JPS6258265 B2 JP S6258265B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- container
- filter
- components
- transporting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004369 blood Anatomy 0.000 claims description 69
- 239000008280 blood Substances 0.000 claims description 69
- 238000001914 filtration Methods 0.000 claims description 12
- 238000000926 separation method Methods 0.000 claims description 9
- 230000007723 transport mechanism Effects 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 2
- 210000000601 blood cell Anatomy 0.000 description 9
- 238000010586 diagram Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 239000012982 microporous membrane Substances 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002637 fluid replacement therapy Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000001940 Massive Hepatic Necrosis Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/302—Details having a reservoir for withdrawn untreated blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/303—Details having a reservoir for treated blood to be returned
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/305—Control of inversion point between collection and re-infusion phase
- A61M1/308—Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
- A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Filtration Of Liquid (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
【発明の詳細な説明】
発明の背景
技術分野
この発明は血液のろ過分離回路装置に係り、特
に、シヤントを形成していない供血者からの血液
をろ過分離するに好適な回路装置に関する。BACKGROUND OF THE INVENTION TECHNICAL FIELD The present invention relates to a blood filtration and separation circuit device, and more particularly to a circuit device suitable for filtering and separating blood from a donor who has not formed a shunt.
先行技術および問題点
劇症肝炎、薬物中毒、重筋無力症、急性腎不全
等血液中に不要または毒性物質が蓄積することに
よつて発現する重篤な疾患患者の治療には不要ま
たは毒性物質を血液から分離する必要がある。 Prior art and problems Unnecessary or toxic substances are used in the treatment of patients with serious diseases caused by accumulation of unnecessary or toxic substances in the blood, such as fulminant hepatitis, drug addiction, myasthenia gravis, and acute renal failure. must be separated from the blood.
このため、従来、患者から血液を体外に取り出
し、これをポンプによつてろ過器に搬送し、該ろ
過器によつて血液を不要成分である血漿成分と必
要成分である血球成分に分離することがおこなわ
れている。不要物質または毒性物質を含有する血
漿成分はこれをろ過器から系外に排出し、一方血
球成分はこれをそのままろ過器から患者へと戻
す。ろ過器から系外に排出された血漿成分相当量
の補液は別径路によつて患者になされる。 For this reason, conventional methods have been to take blood from a patient outside the body, transport it to a filter using a pump, and use the filter to separate the blood into plasma components, which are unnecessary components, and blood cell components, which are necessary components. is being carried out. Plasma components containing unnecessary or toxic substances are discharged from the filter to the outside of the system, while blood cell components are returned directly from the filter to the patient. Fluid replacement in an amount equivalent to the plasma components discharged from the filter to the outside of the system is provided to the patient through a separate route.
このような従来の血液のろ過分離方法におい
て、患者にシヤントが形成されている場合はとも
かく、シヤントを形成していない患者例えばシヤ
ント形成が間に合わない急性症患者あるいはシヤ
ント形成が不可能な患者もしくは供血者の場合、
血液流量が50〜60ml／分程度とシヤントを形成し
た場合の1/4〜1/5と少ないので、これだけの血液
流量では実質的に充分に満足できる血漿成分の分
離除去が不可能であつた。 In such conventional blood filtration and separation methods, regardless of whether a shunt has been formed in the patient, patients who have not formed a shunt, such as acutely ill patients who cannot form a shunt in time, patients for whom it is impossible to form a shunt, or donated blood. In the case of
Since the blood flow rate is about 50 to 60 ml/min, which is 1/4 to 1/5 of that when a shunt is formed, it is practically impossible to sufficiently separate and remove plasma components with this blood flow rate. .
発明の目的
したがつて、この発明の目的はろ過器へ導入さ
れる血液の流量を充分に大きくすることができ、
したがつてシヤントを形成していない供血者にあ
つても効率よく血液のろ過分離をおこなうことが
できかつ血球の洗浄が可能な血液のろ過分離回路
装置を提供することにある。 Purpose of the Invention Therefore, the purpose of the present invention is to sufficiently increase the flow rate of blood introduced into the filter,
Therefore, it is an object of the present invention to provide a blood filtration and separation circuit device which can efficiently filter and separate blood even in the case of a blood donor who has not formed a shunt, and which can wash blood cells.
この発明によれば、供血者から所定量の血液を
収容するための容器、該血液を必要成分と不要成
分とに分離し該不要成分を系外に排出するための
ろ過器、および前記容器および前記ろ過器を接続
し閉回路を構成する管体を具備し、前記容器と前
記ろ過器間の管体部に、前記容器が所定量の血液
を収容した後該容器から該血液を充分な流量で前
記ろ過器へ搬送するとともに、該ろ過器によつて
分離された必要成分を後流側の管体部内に搬送す
るための搬送機構を設置したことを特徴とする血
液のろ過分離回路装置が提供される。 According to this invention, there is provided a container for storing a predetermined amount of blood from a blood donor, a filter for separating the blood into necessary components and unnecessary components and discharging the unnecessary components out of the system, and the container and A tube connecting the filter to form a closed circuit is provided, and after the container contains a predetermined amount of blood, the blood is transferred from the container at a sufficient flow rate to the tube between the container and the filter. A blood filtration and separation circuit device is provided, characterized in that a transport mechanism is installed for transporting the necessary components separated by the filter to the filter and transporting the necessary components separated by the filter into the pipe body on the downstream side. provided.
この発明の一態様において、管体によつて構成
される回路以外の場所で、容器に接続して１つ以
上の血液収容容器をさらに設けている。 In one aspect of the invention, one or more blood storage containers are further provided connected to the container at a location other than the circuit formed by the tube.
また、この発明の別の態様において、管体によ
つて構成される回路以外の場所で供血者から容器
に血液を搬送し、かつ容器から供血者へ血液を搬
送するための搬送機構を有する。 In another aspect of the invention, there is provided a transport mechanism for transporting blood from the donor to the container and from the container to the donor at a location other than the circuit formed by the tubular body.
発明の具体的説明および作用
以下、この発明を添付の図面に沿つて説明す
る。 Detailed Description and Effects of the Invention The present invention will be described below with reference to the accompanying drawings.
第２図に示すように、この発明の第１の態様に
従う血液のろ過分離回路装置は供血者例えば患者
Ａから所定量（患者の状態にもよるが、最大約
500ml）の血液を収容するための容器１を備えて
いる。この容器１はポリ塩化ビニル樹脂シートを
重ね合せてその周端部を融着してなるバツグ状の
柔軟なものが好ましい。この容器１には血液用ポ
ート２および３を持つている。 As shown in FIG. 2, the blood filtration and separation circuit device according to the first aspect of the present invention receives a predetermined amount of blood from a blood donor, for example, patient A (up to about
It is equipped with a container 1 for containing 500 ml of blood. The container 1 is preferably a flexible bag-shaped container made by stacking polyvinyl chloride resin sheets and fusing the peripheral edges thereof. The container 1 has ports 2 and 3 for blood.
この容器１と接続して血液を血漿成分と血球成
分とに分離するためのろ過器４が設けられてい
る。このろ過器４はハウジング５と、これにそれ
ぞれ対向して設けられた血液流入口６および流出
口７と、血漿流出口８とろ材９とによつて構成さ
れる。ろ材９は例えばニトロセルロース、酢酸セ
ルロース、ポリカーボネート等で形成された孔径
0.1ないし１μｍ通常0.4ないし0.6μｍの微細孔膜
からなり、その下側に該微細孔膜の孔径よりも大
きな孔径のメツシユが設けられている。このろ材
９は血液流入出口６および７を有するアクリル板
とその下側のパツキングよりなる上側ハウジング
部材と血漿流出口８を有するアクリル板よりなる
下側ハウジング部材によつて挾まれている。 A filter 4 is provided connected to the container 1 to separate blood into plasma components and blood cell components. The filter 4 is composed of a housing 5, a blood inlet 6 and an outlet 7 provided opposite to the housing 5, a plasma outlet 8, and a filter medium 9. The filter medium 9 has a pore size made of, for example, nitrocellulose, cellulose acetate, polycarbonate, etc.
It consists of a microporous membrane of 0.1 to 1 μm, usually 0.4 to 0.6 μm, and a mesh with a pore diameter larger than that of the microporous membrane is provided below. This filter medium 9 is sandwiched between an upper housing member made of an acrylic plate having blood inflow ports 6 and 7 and packing below the same, and a lower housing member made of an acrylic plate having a plasma outflow port 8.
これら容器１およびろ過器４を接続して柔軟な
管体１０が設けられ、これによつて閉回路が構成
されている。 A flexible tube body 10 is provided to connect the container 1 and the filter 4, thereby forming a closed circuit.
容器１からろ過器４へ血液を導く管体部１０ａ
には、容器１に所定量の血液が収容された後該血
液をろ過器４へと搬送するための搬送機構例えば
ポンプ１１が設けられている。 Pipe body portion 10a that guides blood from container 1 to filter 4
is provided with a transport mechanism, such as a pump 11, for transporting a predetermined amount of blood into the container 1 and then transporting the blood to the filter 4.
このような装置により、血液を分離し、分離さ
れた血球成分を患者へ戻すには、次のようにおこ
なう。 To separate blood and return the separated blood cell components to the patient using such a device, proceed as follows.
まず、第１図に示すように、患者Ａと容器１と
を分岐管１３を有する柔軟な管体１２で接続し、
この管体１２の分岐管１３の接続点より上流側に
クランプ１４を設けておく。その際、容器１には
血液抗凝固剤例えばヘパリンまたはACD１５を
入れておく。この状態でクランプ１４を開き、自
然落下により患者Ａから容器１内に所定量の血液
を採取する。容器１内に所定量の血液を採取した
後クランプ１４を閉じ、分岐管１３の所で第２図
に示すような回路装置を構成する。しかる後、ポ
ンプ１１を動作させ血液を容器１から充分な流量
（通常100〜400ml／分）でろ過器４へ搬送する。
ろ過器４へ至つた血液はろ材９によつて血球成分
と血漿成分とに分離され、不要または毒性成分を
含む血漿成分はろ材９を横切つて流出口８から系
外へ排出されるとともに血球成分は流出口７から
管体１０を介して容器１へと戻される。このよう
な循環をおこない、所要の血漿成分が分離除去さ
れ、実質的に血球成分のみが容器１に収容された
後、容器１を回路装置から取り出し、第３図に示
されるように、該血球成分を分離された血漿成分
の相当量の補液１７とともに輸血セツト１６等に
より患者Ａに戻す。 First, as shown in FIG. 1, the patient A and the container 1 are connected by a flexible tube 12 having a branch tube 13.
A clamp 14 is provided on the upstream side of the connection point of the branch pipe 13 of the tube body 12. At this time, a blood anticoagulant such as heparin or ACD15 is placed in the container 1. In this state, the clamp 14 is opened and a predetermined amount of blood is collected from the patient A into the container 1 by natural fall. After collecting a predetermined amount of blood into the container 1, the clamp 14 is closed, and a circuit device as shown in FIG. 2 is constructed at the branch pipe 13. Thereafter, the pump 11 is operated to transport the blood from the container 1 to the filter 4 at a sufficient flow rate (usually 100 to 400 ml/min).
The blood that has reached the filter 4 is separated into blood cell components and plasma components by the filter material 9, and the plasma component containing unnecessary or toxic components is discharged from the system through the outlet 8 across the filter material 9, and the blood cells are removed. The components are returned to the container 1 from the outlet 7 via the tube 10. After such circulation is performed, necessary plasma components are separated and removed, and substantially only blood cell components are accommodated in the container 1, the container 1 is taken out from the circuit device and the blood cells are collected as shown in FIG. The components are returned to the patient A through a blood transfusion set 16 or the like together with a replacement fluid 17 corresponding to the separated plasma components.
このような操作は第４図ないし第５図に示すよ
うに、患者Ａからの血液を収容するための容器を
さらに１つ以上（図中２つ）設けることによつて
さらに効率よくおこなうことができる。すなわ
ち、第４図に示すように管体１２から分岐させて
２つの容器１′および１″を設け、クランプ１４′
および１４″を閉じた状態で、既述のように容器
１に血液を採取する。この容器１に所定量の血液
を採取した後、第５図に示すように、第２図につ
いて説明したと同様に血液の分離をおこなう。こ
れと同時にクランプ１４′を開き容器１′へ血液を
採取し始める。容器１′に所定量の血液を採取し
た後、クランプ１４″を開いて容器１″に血液を採
取すると同時に、容器１′に対して同様の回路装
置を構成し血液の分離をおこなう。このとき、容
器１からの輸血を補液１７とともに輸血セツト１
６によつて患者Ａに対しておこなう（第６図）。
以後、同様の操作を容器１′および１″に対してお
こなう。なおこの場合、容器１，１′および１″に
収容される血液の総量は最大約500mlとする。こ
のような操作にあたり、採血、ろ過分離、返血の
時間を調整し、３回の工程が同時間内に終了する
ように設定することによりほぼ連続したろ過分離
がおこなえることとなる。 Such operations can be carried out more efficiently by providing one or more (two in the figure) more containers for storing blood from patient A, as shown in Figures 4 and 5. can. That is, as shown in FIG. 4, two containers 1' and 1'' are provided by branching from the tube body 12, and a clamp 14' is provided.
14'' is closed, blood is collected into the container 1 as described above.After collecting a predetermined amount of blood into the container 1, as shown in FIG. Blood is separated in the same way. At the same time, clamp 14' is opened and blood begins to be collected into container 1'. After collecting a predetermined amount of blood into container 1', clamp 14" is opened and blood is collected into container 1". At the same time, a similar circuit device is configured for container 1' to separate the blood. At this time, the blood transfused from container 1 is transferred to blood transfusion set 1 along with replacement fluid 17.
6 for patient A (Fig. 6).
Thereafter, similar operations are performed for containers 1' and 1''. In this case, the total amount of blood contained in containers 1, 1' and 1'' is at most about 500 ml. In such an operation, by adjusting the time of blood collection, filtration separation, and blood return so that the three steps are completed within the same time, almost continuous filtration separation can be performed.
この発明の別の態様によれば、血液のろ過分離
がさらに効率よくおこなえる。すなわち、第７図
に示すように、患者Ａからポンプ２１により管体
２２を介して容器１に血液を採取する。所定量の
血液を採取した後、同じポンプ２１により管体２
３を介して血液を患者Ａに戻す。ポンプ２１によ
る潅流が始まつた後第２図に示したと同様の回路
装置において、同様にポンプ１１を動作させ容器
１から血液をろ過器４に搬送し、血液の分離をお
こない血球成分を容器１に戻す。分離された血漿
成分相当量の補液２４が容器１、患者Ａまたは返
血用管体２３に対しておこなう（図中、容器１に
補液がおこなわれている）。この操作によれば、
連続操作がおこなえる。 According to another aspect of the present invention, blood can be filtered and separated more efficiently. That is, as shown in FIG. 7, blood is collected from a patient A into a container 1 through a tube body 22 using a pump 21. After collecting a predetermined amount of blood, the tube 2 is pumped using the same pump 21.
Blood is returned to patient A via 3. After the perfusion by the pump 21 has started, the pump 11 is operated in the same manner as shown in FIG. Return to Replacement fluid 24 in an amount equivalent to the separated plasma component is applied to container 1, patient A, or blood return tube 23 (in the figure, fluid replacement is performed in container 1). According to this operation,
Continuous operation is possible.
なお、ろ過器の微細孔膜の孔径を変えることに
よつてこの発明の装置は血液中の中分子量物質を
除去するろ過型人工腎臓としても利用できる。 By changing the pore size of the microporous membrane of the filter, the device of the present invention can also be used as a filtration type artificial kidney for removing medium molecular weight substances from blood.
発明の具体的効果
以上述べたように、この発明に従う血液のろ過
分離回路装置によれば、シヤントを形成していな
い供血者からの血液を分離するに際し、流量不足
分をポンプ１１によつて補うことができるので、
ろ過効率を高めることができる。 Specific Effects of the Invention As described above, according to the blood filtration and separation circuit device according to the present invention, when separating blood from a donor who has not formed a shunt, the pump 11 compensates for the insufficient flow rate. Because you can
Filtration efficiency can be increased.
また、容器１として柔軟なバツク状のものを用
いれば特別な血液回路を必要とせず、しかもポン
プ１１としては流量200ml／分程度を生じさせる
ことのできる比較的小型のもので充分に操作が可
能であり、特別に高価な制御装置や複雑な操作が
不要であり、コスト面、緊急時の取扱い等に有利
である。 In addition, if a flexible bag-shaped container is used as the container 1, no special blood circuit is required, and the pump 11 can be operated sufficiently with a relatively small device that can generate a flow rate of about 200 ml/min. This eliminates the need for particularly expensive control devices or complicated operations, and is advantageous in terms of cost and handling in emergencies.
第１図ないし第３図はこの発明の一態様を説明
するための概略図、第４図ないし第６図はこの発
明の他の態様を説明するための概略図、第７図は
この発明のさらに他の態様を説明するための概略
図。
１，１′，１″…容器、４…ろ過器、１０…管
体、１１，２１…ポンプ。
1 to 3 are schematic diagrams for explaining one embodiment of this invention, FIGS. 4 to 6 are schematic diagrams for explaining other embodiments of this invention, and FIG. 7 is a schematic diagram for explaining another embodiment of this invention. Schematic diagram for explaining still another aspect. 1, 1', 1''...container, 4...filter, 10...pipe body, 11, 21...pump.
Claims (1)
器、該血液を必要成分と不要成分とに分離し該不
要成分を系外に排出するためのろ過器、および前
記容器および前記ろ過器を接続し閉回路を構成す
る管体を具備し、前記容器と前記ろ過器間の管体
部に、前記容器が所定量の血液を収容した後該容
器から該血液を充分な流量で前記ろ過器へ搬送
し、該ろ過器によつて分離された必要成分を後流
側の管体部内に搬送するための搬送機構を設置し
たことを特徴とする血液のろ過分離回路装置。 ２ 管体によつて構成される回路以外の場所で、
容器に接続して１つ以上の血液収容容器をさらに
設けた特許請求の範囲第１項記載の装置。 ３ 管体によつて構成される回路以外の場所で供
血者から容器に血液を搬送し、かつ容器から供血
者へ血液を搬送するための搬送機構を有する特許
請求の範囲第１項記載の装置。[Scope of Claims] 1. A container for storing a predetermined amount of blood from a blood donor, a filter for separating the blood into necessary components and unnecessary components and discharging the unnecessary components from the system, and the container. and a pipe body connecting the filter to form a closed circuit, and after the container contains a predetermined amount of blood, enough blood is transferred from the container to the pipe body portion between the container and the filter. A blood filtration and separation circuit device, characterized in that a transport mechanism is installed for transporting the necessary components to the filter at a flow rate and transporting the necessary components separated by the filter into a pipe body on the downstream side. 2. In places other than the circuit constituted by pipes,
2. The device of claim 1 further comprising one or more blood containing containers connected to the container. 3. The device according to claim 1, which has a transport mechanism for transporting blood from the donor to the container at a location other than the circuit constituted by the tube, and for transporting blood from the container to the donor. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55133168A JPS5757259A (en) | 1980-09-25 | 1980-09-25 | Circuit device for filtering and separating blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55133168A JPS5757259A (en) | 1980-09-25 | 1980-09-25 | Circuit device for filtering and separating blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5757259A JPS5757259A (en) | 1982-04-06 |
| JPS6258265B2 true JPS6258265B2 (en) | 1987-12-04 |
Family
ID=15098263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55133168A Granted JPS5757259A (en) | 1980-09-25 | 1980-09-25 | Circuit device for filtering and separating blood |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5757259A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0611225B2 (en) * | 1983-12-29 | 1994-02-16 | 株式会社新潟鐵工所 | Method and apparatus for producing blood product from animal blood |
| EP0266683B1 (en) * | 1986-10-29 | 1993-07-21 | ASAHI MEDICAL Co., Ltd. | A blood components collector unit |
-
1980
- 1980-09-25 JP JP55133168A patent/JPS5757259A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5757259A (en) | 1982-04-06 |
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