JPS6251951B2 - - Google Patents
Info
- Publication number
- JPS6251951B2 JPS6251951B2 JP55136784A JP13678480A JPS6251951B2 JP S6251951 B2 JPS6251951 B2 JP S6251951B2 JP 55136784 A JP55136784 A JP 55136784A JP 13678480 A JP13678480 A JP 13678480A JP S6251951 B2 JPS6251951 B2 JP S6251951B2
- Authority
- JP
- Japan
- Prior art keywords
- propionylcarnosine
- aluminum
- aluminum salt
- ulcer
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 10
- -1 aluminum alkoxide Chemical class 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
- 208000025865 Ulcer Diseases 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 208000008469 Peptic Ulcer Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 208000011906 peptic ulcer disease Diseases 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- JPUHCPXFQIXLMW-UHFFFAOYSA-N aluminium triethoxide Chemical compound CCO[Al](OCC)OCC JPUHCPXFQIXLMW-UHFFFAOYSA-N 0.000 description 1
- VAYMRGDBPHCZCI-NUBCRITNSA-N aluminum;(2r)-2-acetamido-5-amino-5-oxopentanoic acid Chemical compound [Al+3].CC(=O)N[C@@H](C(O)=O)CCC(N)=O VAYMRGDBPHCZCI-NUBCRITNSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 230000002656 inhibitory effect on ulcer Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55136784A JPS5762266A (en) | 1980-10-02 | 1980-10-02 | N-propionylcarnosine aluminum salt and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55136784A JPS5762266A (en) | 1980-10-02 | 1980-10-02 | N-propionylcarnosine aluminum salt and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5762266A JPS5762266A (en) | 1982-04-15 |
| JPS6251951B2 true JPS6251951B2 (enrdf_load_stackoverflow) | 1987-11-02 |
Family
ID=15183432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55136784A Granted JPS5762266A (en) | 1980-10-02 | 1980-10-02 | N-propionylcarnosine aluminum salt and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5762266A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882324A (en) * | 1986-11-21 | 1989-11-21 | Wright Arthur P G | Essentially pure acid hydroxyl ligand aluminum complexes and their preparation |
-
1980
- 1980-10-02 JP JP55136784A patent/JPS5762266A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5762266A (en) | 1982-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2024419C (fr) | Nouveaux sels de metaux bivalents de l'acide n,n-di(carboxymethyl) amino-2cyano-3carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant | |
| JP6799178B2 (ja) | ４−メトキシピロール誘導体の中間体の製造方法 | |
| US10710961B2 (en) | Method for preparing intermediate of 4-methoxypyrrole derivative | |
| JPS6229566A (ja) | 新規グアニジノメチル安息香酸誘導体 | |
| JP2010138193A (ja) | ７−カルボキシメチルオキシ−３’，４’，５−トリメトキシフラボン一水和物、その製造方法及び用途 | |
| KR870001537B1 (ko) | 페닐지방성 카복실린산유도체의 제조방법 | |
| JPS6312844B2 (enrdf_load_stackoverflow) | ||
| JPS6251951B2 (enrdf_load_stackoverflow) | ||
| JPH0135829B2 (enrdf_load_stackoverflow) | ||
| US4473583A (en) | Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them | |
| JPS6316382B2 (enrdf_load_stackoverflow) | ||
| WO1992016496A1 (en) | N-[[4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl]carbonyl]amino acids useful in the therapy of osteoarticular affections | |
| JPS6315275B2 (enrdf_load_stackoverflow) | ||
| US4229446A (en) | Aluminum acetylsalicylate glutaminate | |
| JPH0135828B2 (enrdf_load_stackoverflow) | ||
| JPS6313989B2 (enrdf_load_stackoverflow) | ||
| US4061668A (en) | Process for the preparation of 2-(4-isobutylphenyl)-propiohydroxamic acid | |
| JP2589245B2 (ja) | Ｎ−（３−アルキル（またはアルケニル）−４−ヒドロキシベンゾイル）グリシン亜鉛錯体 | |
| JPH07165684A (ja) | フェネチルアミン誘導体及びその製法 | |
| US4339379A (en) | N-Acrylcarnosine aluminum salts | |
| JPS6330462A (ja) | 新規グアニジノメチルベンツアミド誘導体およびそれを有効成分とする抗潰瘍剤 | |
| JP4225600B2 (ja) | クロモン類の製造法 | |
| JPH0323526B2 (enrdf_load_stackoverflow) | ||
| JPH07502039A (ja) | 新規テトラヒドロナフタレン誘導体 | |
| JPS6328050B2 (enrdf_load_stackoverflow) |